Gene Symbol: Irak2
Description: interleukin-1 receptor-associated kinase 2
Alias: interleukin-1 receptor-associated kinase-like 2, IRAK-2
Wesche H, Gao X, Li X, Kirschning C, Stark G, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999;274:19403-10 pubmed
..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family. ..
Mamidipudi V, Li X, Wooten M. Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J Biol Chem. 2002;277:28010-8 pubmed
..Altogether, our data provide novel information regarding the proximal components involved in p75 receptor signaling and underscore the importance of the atypical PKC interacting protein p62 in this process. ..
Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) pathway. Sci Signal. 2010;3:cm1 pubmed publisher
..Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses. ..
Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16-34 pubmed publisher
..In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs. ..
Rosati O, Martin M. Identification and characterization of murine IRAK-2. Biochem Biophys Res Commun. 2002;297:52-8 pubmed
Hardy M, O Neill L. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem. 2004;279:27699-708 pubmed
..Herein, we show a detailed analysis of the genomic region encompassing the murine Irak2 gene and the molecular cloning of four isoforms of Irak2 (designated Irak2a, Irak2b, Irak2c, and Irak2d) generated ..
Elzinga B, Twomey C, Powell J, Harte F, McCarthy J. Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis. J Biol Chem. 2009;284:1394-409 pubmed publisher
..These findings also suggest that regulated intramembrane proteolysis may be a control mechanism for IL-1R1-mediated signaling. ..
Liu Z, Zhao N, Zhu H, Zhu S, Pan S, Xu J, et al
. Circulating interleukin-1Î² promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2. Cardiovasc Diabetol. 2015;14:125 pubmed publisher
..siRNA was used to knockdown the irak2 gene expression. Apoptosis was evaluated by Hoechst and TUNEL staining...