interleukin 18 binding protein
Gene Symbol: interleukin 18 binding protein
Description: interleukin 18 binding protein
Alias: Igifbp, interleukin-18-binding protein, interferon gamma inducing factor binding protein
Novick D, Kim S, Fantuzzi G, Reznikov L, Dinarello C, Rubinstein M. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 1999;10:127-36 pubmed
..3 kb genomic sequence. Several Poxviruses encode putative proteins highly homologous to IL-18BP, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response. ..
Mallat Z, Corbaz A, Scoazec A, Graber P, Alouani S, Esposito B, et al
. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Circ Res. 2001;89:E41-5 pubmed
..The full text of this article is available at http://www.circresaha.org. ..
Chandrasekar B, Colston J, de la Rosa S, Rao P, Freeman G. TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochem Biophys Res Commun. 2003;303:1152-8 pubmed
..Presence of both ligand and receptors suggests IL-18 impacts myocardial biology through an autocrine pathway. ..
Ono S, Obara H, Takayanagi A, Tanabe M, Kawachi S, Itano O, et al
. Suppressive effects of interleukin-18 on liver function in rat liver allografts. J Surg Res. 2012;176:293-300 pubmed publisher
..These results suggest that IL-18 has an important role in liver allograft rejection through IFN-? and chemokines and that specific suppression of IL-18 may improve liver function early after transplantation. ..
Im S, Kim S, Azam T, Venkatesh N, Dinarello C, Fuchs S, et al
. Rat interleukin-18 binding protein: cloning, expression, and characterization. J Interferon Cytokine Res. 2002;22:321-8 pubmed
..Thus, rat IL-18BP can be employed to antagonize the proinflammatory responses induced by endogenous IL-18 in rat models of autoimmune diseases. ..
Wheeler R, Young E, Rothwell N, Hall M, Luheshi G. Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine. 2003;21:161-6 pubmed
..This ability of LPS to up-regulate expression of the endogenous IL-18 inhibitor may indicate a mechanism by which the inflammatory response to LPS is regulated. ..
Lee H, Lee Y, Kang C, Bae S, Jeoung D, Jang J, et al
. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Radiat Res. 2008;170:579-90 pubmed publisher
..tumor tissues, revealed that stanniocalcin 2 (Stc2), interferon regulatory factor 1 (Irf1), interleukin 18 binding protein (Il18bp), and chloride channel calcium activated 3 (Clca3) were expressed in both, and that ..
Wang M, Tan J, Wang Y, Meldrum K, Dinarello C, Meldrum D. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Proc Natl Acad Sci U S A. 2009;106:17499-504 pubmed publisher
..This study provides the concept that IL-18BP genetically modified stem cells improve cardioprotection over that observed with unmodified stem cells. ..
Reeves E, Williamson M, Byrne B, Bergin D, Smith S, Greally P, et al
. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol. 2010;184:1642-52 pubmed publisher
..In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung. ..