interleukin 18 binding protein


Gene Symbol: interleukin 18 binding protein
Description: interleukin 18 binding protein
Alias: Igifbp, interleukin-18-binding protein, interferon gamma inducing factor binding protein
Species: rat

Top Publications

  1. Novick D, Kim S, Fantuzzi G, Reznikov L, Dinarello C, Rubinstein M. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 1999;10:127-36 pubmed
    ..3 kb genomic sequence. Several Poxviruses encode putative proteins highly homologous to IL-18BP, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response. ..
  2. Mallat Z, Corbaz A, Scoazec A, Graber P, Alouani S, Esposito B, et al. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Circ Res. 2001;89:E41-5 pubmed
    ..The full text of this article is available at ..
  3. Chandrasekar B, Colston J, de la Rosa S, Rao P, Freeman G. TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochem Biophys Res Commun. 2003;303:1152-8 pubmed
    ..Presence of both ligand and receptors suggests IL-18 impacts myocardial biology through an autocrine pathway. ..
  4. Ono S, Obara H, Takayanagi A, Tanabe M, Kawachi S, Itano O, et al. Suppressive effects of interleukin-18 on liver function in rat liver allografts. J Surg Res. 2012;176:293-300 pubmed publisher
    ..These results suggest that IL-18 has an important role in liver allograft rejection through IFN-? and chemokines and that specific suppression of IL-18 may improve liver function early after transplantation. ..
  5. Im S, Kim S, Azam T, Venkatesh N, Dinarello C, Fuchs S, et al. Rat interleukin-18 binding protein: cloning, expression, and characterization. J Interferon Cytokine Res. 2002;22:321-8 pubmed
    ..Thus, rat IL-18BP can be employed to antagonize the proinflammatory responses induced by endogenous IL-18 in rat models of autoimmune diseases. ..
  6. Wheeler R, Young E, Rothwell N, Hall M, Luheshi G. Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine. 2003;21:161-6 pubmed
    ..This ability of LPS to up-regulate expression of the endogenous IL-18 inhibitor may indicate a mechanism by which the inflammatory response to LPS is regulated. ..
  7. Lee H, Lee Y, Kang C, Bae S, Jeoung D, Jang J, et al. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Radiat Res. 2008;170:579-90 pubmed publisher
    ..tumor tissues, revealed that stanniocalcin 2 (Stc2), interferon regulatory factor 1 (Irf1), interleukin 18 binding protein (Il18bp), and chloride channel calcium activated 3 (Clca3) were expressed in both, and that ..
  8. Wang M, Tan J, Wang Y, Meldrum K, Dinarello C, Meldrum D. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Proc Natl Acad Sci U S A. 2009;106:17499-504 pubmed publisher
    ..This study provides the concept that IL-18BP genetically modified stem cells improve cardioprotection over that observed with unmodified stem cells. ..
  9. Reeves E, Williamson M, Byrne B, Bergin D, Smith S, Greally P, et al. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol. 2010;184:1642-52 pubmed publisher
    ..In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung. ..

More Information


  1. Liu X, Pan Z, Su D, Yang Z, Zheng B, Wang X, et al. Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling. Transplantation. 2015;99:2109-17 pubmed publisher
    ..Remifentanil protects the liver against I/R injury. Modulating the hepatic IL-18/IL-18BP balance and inhibiting IL-18 signaling mediate, at least in part, the hepatoprotective effects of remifentanil. ..
  2. Plitz T, Saint Mezard P, Satho M, Herren S, Waltzinger C, De Carvalho Bittencourt M, et al. IL-18 binding protein protects against contact hypersensitivity. J Immunol. 2003;171:1164-71 pubmed
    ..Taken together with the evidence that IL-18 is present in tissue samples of the human disease, our data reinforces IL-18BP as a candidate for this therapeutic indication. ..
  3. Venkatachalam K, Prabhu S, Reddy V, Boylston W, Valente A, Chandrasekar B. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. J Biol Chem. 2009;284:7853-65 pubmed publisher
    ..These results indicate that IL-18 plays a critical role in I/R injury and thus represents a promising therapeutic target. ..