Insig1

Summary

Gene Symbol: Insig1
Description: insulin induced gene 1
Alias: insulin-induced gene 1 protein, INSIG-1, growth response protein (CL-6), immediate-early protein CL-6, insulin-induced growth response protein CL-6
Species: rat
Products:     Insig1

Top Publications

  1. Yang T, Espenshade P, Wright M, Yabe D, Gong Y, Aebersold R, et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 2002;110:489-500 pubmed
    ..Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis. ..
  2. Takaishi K, Duplomb L, Wang M, Li J, Unger R. Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. Proc Natl Acad Sci U S A. 2004;101:7106-11 pubmed
    ..However, the increase in endogenous insig-1 expression associated with augmented lipogenesis may limit it, but is insufficient to prevent it. ..
  3. Yabe D, Brown M, Goldstein J. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A. 2002;99:12753-8 pubmed publisher
    ..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
  4. Li J, Takaishi K, Cook W, McCorkle S, Unger R. Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proc Natl Acad Sci U S A. 2003;100:9476-81 pubmed
    ..The results suggest that insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes. ..
  5. Engelking L, Liang G, Hammer R, Takaishi K, Kuriyama H, Evers B, et al. Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005;115:2489-98 pubmed
    ..We produced mice with germline disruption of the Insig2 gene and Cre-mediated disruption of the Insig1 gene in liver. On a chow diet, these double-knockout mice overaccumulated cholesterol and triglycerides in liver...
  6. Koch A, König B, Spielmann J, Leitner A, Stangl G, Eder K. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. J Nutr. 2007;137:2018-23 pubmed
  7. Palaniappan M, Menon K. Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. Biol Reprod. 2009;81:284-92 pubmed publisher
    ..The hCG and insulin significantly reduced insulin-induced gene 1 (INSIG1) protein, a negative regulator of SREBF processing...
  8. Osborne T, Espenshade P. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev. 2009;23:2578-91 pubmed publisher
    ..This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth. ..
  9. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, et al. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat Med. 2006;12:107-13 pubmed
    ..TFE3 also induced hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)...

More Information

Publications19

  1. Chen K, Jin P, He H, Xie Y, Xie X, Mo Z. Overexpression of Insig-1 protects ? cell against glucolipotoxicity via SREBP-1c. J Biomed Sci. 2011;18:57 pubmed publisher
    ..There results suggest that Insig-1 may play a critical role in protecting ? cells against glucolipotoxicity by regulating the expression of SREBP-1c. ..
  2. Wu X, Pang S, Sahlin L, Blanck A, Norstedt G, Flores Morales A. Gene expression profiling of the effects of castration and estrogen treatment in the rat uterus. Biol Reprod. 2003;69:1308-17 pubmed
    ..The present study identifies novel mediators of estrogen actions in the uterus and provides genome-wide expression data from which novel hypotheses regarding uterine function can be generated. ..
  3. Wang S, Liang Q, Li G, Gao K. Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion. World J Gastroenterol. 2005;11:885-9 pubmed
    ..The functions of the novel genes identified in our study need to be clarified further. ..
  4. Sun L, Li L, Goldstein J, Brown M. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem. 2005;280:26483-90 pubmed publisher
    ..This hexapeptide acts as a sterol-regulated ER sorting signal. These studies define the biochemical parameters responsible for regulated sorting of an ER membrane protein into COPII-coated vesicles...
  5. Diamond R, Du K, Lee V, Mohn K, Haber B, Tewari D, et al. Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. J Biol Chem. 1993;268:15185-92 pubmed
    ..Given the dramatic increase in RNA production during late G1, proteins induced by mitogens like insulin that control RNA processing are likely to have important roles in cell cycle regulation. ..
  6. Engelking L, Evers B, Richardson J, Goldstein J, Brown M, Liang G. Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest. 2006;116:2356-65 pubmed
  7. Tong X, Christian P, Zhao M, Wang H, Moreau R, Su Q. Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid. J Nutr Biochem. 2015;26:921-8 pubmed publisher
    ..These findings provide novel insight into the therapeutic potential of LA as an anti-hypertriglyceridemia dietary molecule. ..
  8. Botolin D, Wang Y, Christian B, Jump D. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. J Lipid Res. 2006;47:181-92 pubmed
    ..Thus, 22:6,n-3 suppresses hepatocyte nSREBP-1 through 26S proteasome- and Erk-dependent pathways. These studies reveal a novel mechanism for n-3 PUFA regulation of hepatocyte nSREBP-1 and lipid metabolism. ..
  9. Bonzon Kulichenko E, Schwudke D, Gallardo N, Moltó E, Fernández Agulló T, Shevchenko A, et al. Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. Endocrinology. 2009;150:169-78 pubmed publisher
  10. Boden G, Salehi S, Cheung P, Homko C, Song W, Loveland Jones C, et al. Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. Obesity (Silver Spring). 2013;21:1208-14 pubmed publisher