Gene Symbol: Ing2
Description: inhibitor of growth family, member 2
Alias: Ing1l, inhibitor of growth protein 2, inhibitor of growth family, member 1-like
Species: rat
Products:     Ing2

Top Publications

  1. Shi X, Hong T, Walter K, Ewalt M, Michishita E, Hung T, et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006;442:96-9 pubmed
    ..The ING PHD domains are specific and highly robust binding modules for H3K4me3 and H3K4me2. ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the ..
  2. Chattopadhyay C, Hawke D, Kobayashi R, Maity S. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004;32:3632-41 pubmed
    ..Altogether, our study identified p32 as a novel and specific corepressor of CBF-mediated transcription activation in vitro. ..
  3. Saito M, Kumamoto K, Robles A, Horikawa I, Furusato B, Okamura S, et al. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS ONE. 2010;5:e15541 pubmed publisher
    b>ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors...
  4. Vicinanza M, Korolchuk V, Ashkenazi A, Puri C, Menzies F, Clarke J, et al. PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015;57:219-34 pubmed publisher
  5. Sarker K, Kataoka H, Chan A, Netherton S, Pot I, Huynh M, et al. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. J Biol Chem. 2008;283:13269-79 pubmed publisher
    ..Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway...
  6. Watanabe Fukunaga R, Iida S, Shimizu Y, Nagata S, Fukunaga R. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Genes Cells. 2005;10:851-60 pubmed
    ..These results indicate that the SEI family of nuclear proteins regulates p53 transcriptional activity and a p53-independent signaling pathway leading to growth inhibition. ..
  7. Kaadige M, Ayer D. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. J Biol Chem. 2006;281:28831-6 pubmed
    ..The precise function of PHD domains is currently unknown; however, the PHD domains of the ING1 and ING2 tumor suppressors have been shown recently to bind phosphoinositides (PIs)...