Gene Symbol: Ing2
Description: inhibitor of growth family, member 2
Alias: Ing1l, inhibitor of growth protein 2, inhibitor of growth family, member 1-like
Shi X, Hong T, Walter K, Ewalt M, Michishita E, Hung T, et al
. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006;442:96-9 pubmed
..The ING PHD domains are specific and highly robust binding modules for H3K4me3 and H3K4me2. ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the ..
Chattopadhyay C, Hawke D, Kobayashi R, Maity S. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004;32:3632-41 pubmed
..Altogether, our study identified p32 as a novel and specific corepressor of CBF-mediated transcription activation in vitro. ..
Saito M, Kumamoto K, Robles A, Horikawa I, Furusato B, Okamura S, et al
. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS ONE. 2010;5:e15541 pubmed publisher
b>ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors...
Vicinanza M, Korolchuk V, Ashkenazi A, Puri C, Menzies F, Clarke J, et al
. PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015;57:219-34 pubmed publisher
Sarker K, Kataoka H, Chan A, Netherton S, Pot I, Huynh M, et al
. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. J Biol Chem. 2008;283:13269-79 pubmed publisher
..Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway...
Watanabe Fukunaga R, Iida S, Shimizu Y, Nagata S, Fukunaga R. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Genes Cells. 2005;10:851-60 pubmed
..These results indicate that the SEI family of nuclear proteins regulates p53 transcriptional activity and a p53-independent signaling pathway leading to growth inhibition. ..
Kaadige M, Ayer D. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. J Biol Chem. 2006;281:28831-6 pubmed
..The precise function of PHD domains is currently unknown; however, the PHD domains of the ING1 and ING2 tumor suppressors have been shown recently to bind phosphoinositides (PIs)...