Gene Symbol: Ina
Description: internexin neuronal intermediate filament protein, alpha
Alias: Inexa, Intlaa, Nf66, alpha-Inx, alpha-internexin
Species: rat
Products:     Ina

Top Publications

  1. Athlan E, Mushynski W. Heterodimeric associations between neuronal intermediate filament proteins. J Biol Chem. 1997;272:31073-8 pubmed
    ..The modified version of blue native gel electrophoresis described here may be useful in monitoring the impact of post-translational modifications and mutations on the dimerization of intermediate filament proteins. ..
  2. Yuan A, Rao M, Kumar A, Julien J, Nixon R. Neurofilament transport in vivo minimally requires hetero-oligomer formation. J Neurosci. 2003;23:9452-8 pubmed
    ..They also show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits in neurons to support slow transport and possibly other functions of neuronal intermediate filaments. ..
  3. Fliegner K, Ching G, Liem R. The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein. EMBO J. 1990;9:749-55 pubmed
  4. Faussone Pellegrini M, Matini P, DeFelici M. The cytoskeleton of the myenteric neurons during murine embryonic life. Anat Embryol (Berl). 1999;199:459-69 pubmed
  5. Levavasseur F, Zhu Q, Julien J. No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res Mol Brain Res. 1999;69:104-12 pubmed
    ..Ours results do not support the hypothesis of a role for type IV intermediate filaments in axonal outgrowth during development of nervous system. ..
  6. Dickson T, Chuckowree J, Chuah M, West A, Vickers J. alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury. Neurobiol Dis. 2005;18:286-95 pubmed
    ..These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD. ..
  7. Remmers E, Griffiths M, Longman R, Gulko P, Kawahito Y, Chen S, et al. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Transplant Proc. 1999;31:1549-54 pubmed
  8. Suzuki T, Li W, Zhang J, Tian Q, Sakagami H, Usuda N, et al. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Eur J Neurosci. 2005;21:339-50 pubmed
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins. ..
  9. Yuan A, Rao M, Sasaki T, Chen Y, Kumar A, Veeranna -, et al. Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci. 2006;26:10006-19 pubmed

Scientific Experts

More Information


  1. Ching G, Liem R. Structure of the gene for the neuronal intermediate filament protein alpha-internexin and functional analysis of its promoter. J Biol Chem. 1991;266:19459-68 pubmed
    ..Sequence analysis shows that the -254 to -78 region contains several potential positive regulatory elements. ..
  2. McGraw T, Mickle J, Shaw G, Streit W. Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. J Neurosci. 2002;22:4955-63 pubmed
    ..neurofilament (NF) triplet proteins NF-L, NF-M, and NF-H and also the more recently characterized alpha-internexin-NF66. It is well established that NF-L, -M, and -H protein and mRNA are downregulated after peripheral nerve injury...
  3. Chien C, Liu T, Ho C, Lu K. Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells. J Neurosci Res. 2005;80:693-706 pubmed
    ..Apoptosis-like cell death could also be induced by the overexpression of alpha-internexin-EGFP in PC12 cells after NGF induction. ..
  4. Karpova A, Mikhaylova M, Bera S, Bar J, Reddy P, Behnisch T, et al. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 2013;152:1119-33 pubmed publisher
    ..In the nucleus, the phosphorylation state of Jacob determines whether it induces cell death or promotes cell survival and enhances synaptic plasticity. ..