Genomes and Genes
Gene Symbol: Ina
Description: internexin neuronal intermediate filament protein, alpha
Alias: Inexa, Intlaa, Nf66, alpha-Inx, alpha-internexin
- Ching G, Liem R. Structure of the gene for the neuronal intermediate filament protein alpha-internexin and functional analysis of its promoter. J Biol Chem. 1991;266:19459-68 pubmed..Sequence analysis shows that the -254 to -78 region contains several potential positive regulatory elements. ..
- McGraw T, Mickle J, Shaw G, Streit W. Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. J Neurosci. 2002;22:4955-63 pubmed..neurofilament (NF) triplet proteins NF-L, NF-M, and NF-H and also the more recently characterized alpha-internexin-NF66. It is well established that NF-L, -M, and -H protein and mRNA are downregulated after peripheral nerve injury...
- Chien C, Liu T, Ho C, Lu K. Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells. J Neurosci Res. 2005;80:693-706 pubmed..Apoptosis-like cell death could also be induced by the overexpression of alpha-internexin-EGFP in PC12 cells after NGF induction. ..
- Karpova A, Mikhaylova M, Bera S, Bar J, Reddy P, Behnisch T, et al. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 2013;152:1119-33 pubmed publisher..In the nucleus, the phosphorylation state of Jacob determines whether it induces cell death or promotes cell survival and enhances synaptic plasticity. ..