Il6st

Summary

Gene Symbol: Il6st
Description: interleukin 6 signal transducer
Alias: Ac1055, Gp130, Il-6rb, interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, membrane glycoprotein 130, oncostatin-M receptor subunit alpha
Species: rat
Products:     Il6st

Top Publications

  1. Dina O, Green P, Levine J. Role of interleukin-6 in chronic muscle hyperalgesic priming. Neuroscience. 2008;152:521-5 pubmed publisher
    ..hyperalgesia, lasting several hours, that was prevented by intrathecal injection of antisense to glycoprotein 130 (gp130), an IL-6 receptor subunit. Furthermore, following complete recovery from i.m. IL-6-induced hyperalgesia, i.m...
  2. Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, et al. Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem. 2003;278:9528-35 pubmed
    ..of the CNTF alpha-receptor (CNTFR), which is not involved in signal transduction, and the beta-receptors gp130 and leukemia inhibitory factor receptor (LIFR)...
  3. Dendekker A, Xu X, Vaughn M, Puckett A, Gardner L, Lambring C, et al. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. Cancer Res. 2012;72:6002-12 pubmed publisher
    ..These data suggest that the human 5q11.2 breast cancer risk allele marked by rs889312 is mammary gland autonomous, and MIER3 is a candidate breast cancer susceptibility gene. ..
  4. Fujisawa M, Okuda Y, Fujioka H, Kamidono S. Expression and regulation of gp130 messenger ribonucleic acid in cultured immature rat Sertoli cells. Endocr Res. 2002;28:1-8 pubmed
    The expression of glycoprotein 130 (gp130) was studied in rat primary Sertoli cells by Northern blot analysis. Gp130 mRNA of 9.0 and 7.5 kb were detected in a variety of rat tissues including the testis...
  5. Kurdi M, Booz G. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. J Cell Physiol. 2007;212:424-31 pubmed
    ..JAK1-mediated phosphorylation of the LIF receptor subunits LIF receptor (LIFR) alpha and glycoprotein 130 (gp130), and reduced the LIF-induced increase in JAK1 association with both components...
  6. Hilton D, Hilton A, Raicevic A, Rakar S, Harrison Smith M, Gough N, et al. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994;13:4765-75 pubmed
    ..The capacity to bind IL-11 with high affinity (Kd = 300-800 pM) appeared to require coexpression of both NR1 and gp130, the common subunit of the IL-6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic ..
  7. Ha B, King J. Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat. 2000;19:129-41 pubmed
    ..hematopoietic, and nervous system, which is believed to result from sharing of the signal transducing receptor gp130. IL-6 type cytokines and their binding receptors have been localized in the adult cerebellum...
  8. Kim S, Park H, Choi J, Lee J, Cha J, Choi Y, et al. Ischemic preconditioning-induced expression of gp130 and STAT3 in astrocytes of the rat hippocampus. Brain Res Mol Brain Res. 2004;129:96-103 pubmed
    We investigated the distribution and time course of expression of both gp130 mRNA and signal transducer and activator of transcription factor-3 (STAT3) in a rat model of ischemic tolerance induction...
  9. Nonogaki K, Pan X, Moser A, Shigenaga J, Staprans I, Sakamoto N, et al. LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats. Am J Physiol. 1996;271:E521-8 pubmed
    ..combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp130 transduction system...

More Information

Publications56

  1. Watanabe D, Yoshimura R, Khalil M, Yoshida K, Kishimoto T, Taga T, et al. Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Eur J Neurosci. 1996;8:1630-40 pubmed
    The localization of gp130, the signal transducing receptor component used in common for interleukin (IL)-6, IL-11, ciliary neurotrophic factor (CNTF), LIF and OSM, in the rat brain was demonstrated by immunohistochemistry using an ..
  2. Boettger M, Leuchtweis J, Kümmel D, Gajda M, Bräuer R, Schaible H. Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. Arthritis Res Ther. 2010;12:R140 pubmed publisher
    ..neutralization of IL-6/sIL-6R (and possibly other cytokines which use the transmembrane signal-transducing subunit gp130) directly at the site of joint inflammation seems to be effective in the prevention of joint destruction.
  3. Nakaoka Y, Shioyama W, Kunimoto S, Arita Y, Higuchi K, Yamamoto K, et al. SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene. J Mol Cell Cardiol. 2010;49:157-64 pubmed publisher
    ..in all directions with an increase in skeletal alpha-actin (alpha-SKA) gene expression, while stimulation of gp130 receptor by interleukin-6 (IL-6)-related cytokines induces longitudinal elongation with no increase in alpha-SKA ..
  4. Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S. Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci. 2003;23:1730-41 pubmed
    Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs...
  5. Hampel H, Teipel S, Padberg F, Haslinger A, Riemenschneider M, Schwarz M, et al. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Brain Res. 1999;823:104-12 pubmed
    ..with components of the soluble interleukin-6 receptor complex (sIL-6RC: IL-6, soluble IL-6 receptor and soluble gp130), putative markers of neuroregulatory and inflammatory processes in the brain...
  6. Cittadini A, Monti M, Iaccarino G, Castiello M, Baldi A, Bossone E, et al. SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway. Cardiovasc Res. 2012;96:381-90 pubmed publisher
    ..and reduced fractional shortening (-32%) compared with AB + HA; apoptotic rate was increased three-fold and the gp130 pathway was inhibited...
  7. Matsui T, Kinoshita T, Hirano T, Yokota T, Miyajima A. STAT3 down-regulates the expression of cyclin D during liver development. J Biol Chem. 2002;277:36167-73 pubmed
    ..Thus, STAT3-mediated down-regulation of cyclin D expression is rather specific to fetal hepatocytes that are undergoing maturation processes including a reduction of their proliferation potential. ..
  8. Tebbutt N, Giraud A, Inglese M, Jenkins B, Waring P, Clay F, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002;8:1089-97 pubmed
    ..STAT1/3) and the Src-homology tyrosine phosphatase 2 (SHP2)-Ras-ERK, emanating from the common signal transducer, gp130, in the gastrointestinal tract...
  9. Choi J, Kim S, Park H, Cha J, Choi Y, Kang J, et al. Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures. Brain Res Mol Brain Res. 2003;119:10-8 pubmed
    ..protein kinases (MAPKs) following kainic acid (KA)-induced seizures, in relation to the expression of gp130, a common cytokine signal transducer for the interleukin (IL)-6 family of cytokines...
  10. Thompson L, Holland N, Snyder R, Luo B, Becak D, Odom J, et al. Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling. Am J Physiol Lung Cell Mol Physiol. 2016;310:L142-54 pubmed publisher
    ..in increased epithelial barrier permeability by 24 h postexposure and initiate a signaling process involving IL-6/gp130 transsignaling in peripheral vascular tissue...
  11. Abe S, Mizusawa I, Suto M, Kato N, Yabashi A, Honda T, et al. A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion. Neuroreport. 2005;16:1889-92 pubmed
    ..The induction of interleukin-6 expression is likely to play a role in the protection of injured neurons perhaps related to growth of their axons. Glycoprotein 130 might also account for the inhibitory effects following nerve injury. ..
  12. Bradesi S, Karagiannides I, Bakirtzi K, Joshi S, Koukos G, Iliopoulos D, et al. Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat. PLoS ONE. 2015;10:e0130938 pubmed publisher
    ..Quantitative real time RT-PCR for Interleukin 6 signal transducer (gp130), the Signal Transducer And Activator Of Transcription 3 (STAT3), glial fibrillary acidic protein and mir-17-5p ..
  13. Rosell D, Nacher J, Akama K, McEwen B. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Neuroscience. 2003;122:329-48 pubmed
    Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner...
  14. Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, et al. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999;18:2127-36 pubmed
    ..Consistent with these in vitro observations, livers from mice deficient for gp130, an OSM receptor subunit, display defects in maturation of hepatocytes...
  15. Choi J, Kim S, Cha J, Choi Y, Sung K, Oh S, et al. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Glia. 2003;41:237-46 pubmed
    ..the pathophysiological processes after transient forebrain ischemia are mediated via a signal pathway involving gp130 (a signal transducer for the interleukin-6 family), we analyzed changes in the expression of gp130 and its ..
  16. Kamaraju A, Adjalley S, Zhang P, Chebath J, Revel M. C/EBP-delta induction by gp130 signaling. Role in transition to myelin gene expressing phenotype in a melanoma cell line model. J Biol Chem. 2004;279:3852-61 pubmed
    ..We previously observed that triggering of the gp130 receptor system by the IL6RIL6 ligand, comprising interleukin-6 (IL-6) fused to the soluble IL-6 receptor, induces ..
  17. Chen K, Hsieh C, Peng C, Peng R. Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3 pathway. Eur J Prev Cardiol. 2014;21:507-20 pubmed publisher
    ..groups, the signals cardiotrophin-1 (CT-1), interleukin 6 (IL-6), leukaemia inhibitory factor receptor (LIFR), and gp130 were upregulated and janus kinase (JAK) and signal transducer and activation of transcription (STAT) were ..
  18. Jones S, Scheller J, Rose John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011;121:3375-83 pubmed publisher
    ..has emphasized the clinical importance of cytokines that signal through the ?-receptor subunit glycoprotein 130 (gp130)...
  19. Boulanger M, Chow D, Brevnova E, Garcia K. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science. 2003;300:2101-4 pubmed
    ..signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3...
  20. Derouet D, Rousseau F, Alfonsi F, Froger J, Hermann J, Barbier F, et al. Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A. 2004;101:4827-32 pubmed publisher
    ..It acts through a membrane receptor complex comprising CNTF receptor-alpha component (CNTFRalpha), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling ..
  21. Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993;82:1120-6 pubmed
    The interleukin-6 (IL-6) signal is transduced through membrane-anchored gp130, which is associated with IL-6 receptor (IL-6R) in the presence of IL-6...
  22. Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond). 2012;122:143-59 pubmed publisher
    ..IL-6 exerts its biological activities through two molecules: IL-6R (IL-6 receptor) and gp130. When IL-6 binds to mIL-6R (membrane-bound form of IL-6R), homodimerization of gp130 is induced and a high-..
  23. Graciarena M, Carbia Nagashima A, Onofri C, Perez Castro C, Giacomini D, Renner U, et al. Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model. Eur J Endocrinol. 2004;151:595-604 pubmed
    b>gp130 cytokines are placed as auto-paracrine regulators of pituitary function, since they, as well as their receptors, have been shown to be expressed in and to act in normal and tumoral anterior pituitary cells...
  24. Wang X, Qiu Y, Peng Y. Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity. Sheng Li Xue Bao. 2007;59:150-6 pubmed
    ..Anti-gp130 monoclonal antibody (75 ng/mL) was employed to the cultured CGNs with IL-6 to inhibit IL-6 activity so as to ..
  25. Man D, He W, Sze K, Gong K, Smith D, Zhu G, et al. Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J Biol Chem. 2003;278:23285-94 pubmed
    The functional receptor complex of ciliary neurotrophic factor (CNTF), a member of the gp130 family of cytokines, is composed of CNTF, the CNTF receptor alpha (CNTFR), gp130, and the leukemia inhibitory factor receptor (LIFR)...
  26. Matsuo R, Morihara H, Mohri T, Murasawa S, Takewaki K, Nakayama H, et al. The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. PLoS ONE. 2014;9:e111097 pubmed publisher
    ..IL-6 cytokines bind to their specific receptors and activate glycoprotein 130 (gp130), a common receptor, followed by further activation of STAT3 and extracellular signal-regulated kinase (ERK)1/2 ..
  27. Ueki Y, Le Y, Chollangi S, Muller W, Ash J. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc Natl Acad Sci U S A. 2009;106:21389-94 pubmed publisher
    ..Some of the factors shown to be associated with protection bind and activate the signal transducing receptor gp130. To determine whether stress-induced endogenous protection of photoreceptors requires gp130, we generated ..
  28. Graf D, Haselow K, Münks I, Bode J, Haussinger D. Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130. Arch Biochem Biophys. 2008;477:330-8 pubmed publisher
    ..CD95L-induced caspase activation leads to degradation of gp130, thereby suppressing IL-6-induced phosphorylation of STAT3 (Tyr(705)) and of tyrosine phosphatase SHP2 (Tyr(580))...
  29. Luchtefeld M, Schunkert H, Stoll M, Selle T, Lorier R, Grote K, et al. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med. 2007;204:1935-44 pubmed
    ..We report that the gp130 receptor, which is a key component of the inflammatory signaling pathway within hepatocytes, influences the risk ..
  30. Li Y, Wang Y, Qi L. [Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance]. Zhonghua Fu Chan Ke Za Zhi. 2001;36:18-9 pubmed
    To observe the changes of serum soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) in patients with pregnancy induced hypertension...
  31. Escobar Morreale H, Calvo R, Villuendas G, Sancho J, San Millan J. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Obes Res. 2003;11:987-96 pubmed
    ..two membrane-bound glycoproteins: an 80-kDa IL-6 binding unit (IL6R-alpha) and a 130-kDa IL-6 signal transducer (gp130). Genetic variability at these loci might contribute to explain the development of obesity and hyperandrogenism...
  32. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990;63:1149-57 pubmed
    Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein, gp130, which associates with IL-6 receptor (IL-6-R)...
  33. Stahl N, Davis S, Wong V, Taga T, Kishimoto T, Ip N, et al. Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component. J Biol Chem. 1993;268:7628-31 pubmed
    ..One of these proteins is the interleukin-6 signal-transducing molecule gp130, which is required for signal transduction by both CNTF and LIF...
  34. Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed
    ..The effect of sIL-6R or sIL-6R/IL-6 proved to be dependent on gp130 availability, which is expressed by MSCs, and involves stat-3 phosphorylation...
  35. Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park L, et al. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem. 1996;271:32635-43 pubmed
    ..granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1), many of which utilize gp130 as a common receptor subunit...
  36. Lam S, Luk J, Man K, Ng K, Cheung C, Rose John S, et al. Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration. Liver Transpl. 2010;16:1195-206 pubmed publisher
    ..in ?-catenin expression associated with the up-regulation of Wnt-5a in MSCs via activating the glycoprotein 130 (gp130)-mediated STAT3 signaling pathway, which indicates the operation of the trans-signaling mechanism...
  37. Castro C, Giacomini D, Nagashima A, Onofri C, Graciarena M, Kobayashi K, et al. Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells. Endocrinology. 2003;144:693-700 pubmed
    ..These and others like IL-11 and ciliary neurotrophic factor are referred to as the gp130 cytokines because they share the gp130 glycoprotein as a common receptor initial signal transducer...
  38. Wang D, Liu Z, Li Q, Karpurapu M, Kundumani Sridharan V, Cao H, et al. An essential role for gp130 in neointima formation following arterial injury. Circ Res. 2007;100:807-16 pubmed
    ..In addition, IL-6 stimulated tyrosine phosphorylation of gp130, resulting in the recruitment and activation of STAT-3...
  39. Rose J, Bealmear B, Nedelkoska L, Studzinski D, Lisak R, Benjamins J. Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia. J Neurosci Res. 2009;87:3098-106 pubmed publisher
    ..However, expression of a closely related gene, the interleukin-6 signal transducer or gp130 (IL-6st), showed no changes at 6 hr...
  40. Melnick M, Chen H, Zhou Y, Jaskoll T. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001;168:233-45 pubmed
    ..Taken together, our experimental results indicate that IL-6 signaling is important to SMG developmental homeostasis. ..
  41. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan J, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol. 2004;172:2225-31 pubmed
    ..In this study, we describe that WSX-1 together with gp130 constitutes a functional signal-transducing receptor for IL-27...
  42. Ling P, Smith R, Kie S, Boyce P, Bistrian B. Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats. Am J Physiol Regul Integr Comp Physiol. 2004;287:R801-8 pubmed
    ..Under basal conditions, the abundance of the IL-6 receptor, gp130, JAK1, STAT1, and STAT3 proteins and levels of phosphorylation of ERK1/2 and p38 were significantly increased in ..
  43. Hirota H, Chen J, Betz U, Rajewsky K, Gu Y, Ross J, et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 1999;97:189-98 pubmed
    ..By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent ..
  44. Wang Y, Nesbitt J, Fuentes N, Fuller G. Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130. Genomics. 1992;14:666-72 pubmed
    ..This interaction leads to the association and activation of a second membrane glycoprotein, gp130, which is the IL-6 signal transducing molecule...
  45. Moran D, Mayes N, Koniaris L, Cahill P, McKillop I. Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Liver Int. 2005;25:445-57 pubmed
    ..HCC specimens demonstrated decreased IL-6Ralpha/gp130 expression as compared with the normal liver...
  46. Nakashima K, Yanagisawa M, Arakawa H, Taga T. Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett. 1999;457:43-6 pubmed
    ..This spontaneous astrocyte differentiation is completely impaired when neuroepithelial cells deficient for gp130, a signal transducing receptor component for LIF, are used...
  47. Fujio Y, Matsuda T, Oshima Y, Maeda M, Mohri T, Ito T, et al. Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. FEBS Lett. 2004;573:202-6 pubmed
    Glycoprotein 130 (gp130), a common receptor of IL-6 family cytokines, plays critical roles in cardiac functions...