Il6

Summary

Gene Symbol: Il6
Description: interleukin 6
Alias: ILg6, Ifnb2, IL-6, Interleukin 6 (interferon, beta 2), interleukin-6
Species: rat

Top Publications

  1. doi Habitual physical exercise improves macrophage IL-6 and TNF-α deregulated release in the obese zucker rat model of the metabolic syndrome
    Leticia Martín-Cordero
    Departamento de Fisiologia, Grupo de Investigación de Inmunofisiología, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Espana
    Neuroimmunomodulation 18:123-30. 2011
  2. pmc Mitigation of isolation-associated adipocyte interleukin-6 secretion following rapid dissociation of adipose tissue
    Airlia C S Thompson
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA
    J Lipid Res 53:2797-805. 2012
  3. pmc Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6
    Sheng Chu Zhang
    Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
    World J Gastroenterol 18:3696-704. 2012
  4. pmc Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate
    Youngchul Kim
    Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Liver Int 32:1008-17. 2012
  5. ncbi [Changes of alveolar macrophage phagocytosis and TNF-alpha, IL-6 of rats with Pneumocystis pneumonia]
    Zhi min Lu
    Department of Parasitology, Hebei North University, Zhangjiakou 075000, China
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:428-30. 2011
  6. doi Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions
    Cecilia Valeria Pérez
    Instituto de Investigaciones Biomedicas, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biol Reprod 87:122. 2012
  7. doi [Effects of Quyu Jiedu Granule on expressions of tumor necrosis factor-alpha and interleukin-6 mRNAs in ovarian granulosa cells of endometriosis rats]
    Xin Ling Li
    Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250014, China
    Zhong Xi Yi Jie He Xue Bao 6:960-3. 2008
  8. pmc Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes
    Asha Jacob
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research Manhasset, NY 11030, USA
    Int J Clin Exp Med 1:22-31. 2008
  9. doi The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
  10. pmc alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    Dianne M Perez
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Pharmacol 76:144-52. 2009

Research Grants

  1. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2007
  2. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2003
  3. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
  4. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2003
  5. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
  7. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
  8. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2009
  9. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
  10. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010

Detail Information

Publications106 found, 100 shown here

  1. doi Habitual physical exercise improves macrophage IL-6 and TNF-α deregulated release in the obese zucker rat model of the metabolic syndrome
    Leticia Martín-Cordero
    Departamento de Fisiologia, Grupo de Investigación de Inmunofisiología, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Espana
    Neuroimmunomodulation 18:123-30. 2011
    ..The second purpose was to evaluate in the obese rats the effects of habitual exercise and of a bout of acute exercise on the observed MS-associated deregulation in the release of TNF-α and IL-6 by peritoneal macrophages...
  2. pmc Mitigation of isolation-associated adipocyte interleukin-6 secretion following rapid dissociation of adipose tissue
    Airlia C S Thompson
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA
    J Lipid Res 53:2797-805. 2012
    ....
  3. pmc Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6
    Sheng Chu Zhang
    Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
    World J Gastroenterol 18:3696-704. 2012
    ..To investigate the mechanism of interleukin (IL)-6 secretion through blocking the IL-17A/IL-17A receptor (IL-17RA) signaling pathway with a short hairpin RNA (shRNA) in hepatic stellate cells (HSCs) in vitro...
  4. pmc Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate
    Youngchul Kim
    Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Liver Int 32:1008-17. 2012
    ..The hepatic stellate cell (HSC) is a key target of anti-fibrotic therapies. Imatinib mesylate is a small molecule receptor tyrosine kinase inhibitor indicated for treatment of chronic myelogenous leukaemia and GI stromal tumours...
  5. ncbi [Changes of alveolar macrophage phagocytosis and TNF-alpha, IL-6 of rats with Pneumocystis pneumonia]
    Zhi min Lu
    Department of Parasitology, Hebei North University, Zhangjiakou 075000, China
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:428-30. 2011
    ..To observe the changes of alveolar macrophage (AM) phagocytosis and the levels of TNF-alpha and IL-6 in AM supernatants and bronchoalveolar lavage fluid (BALF) of rats with Pneumocystis pneumonia (PCP)...
  6. doi Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions
    Cecilia Valeria Pérez
    Instituto de Investigaciones Biomedicas, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biol Reprod 87:122. 2012
    ..The role of IL6 as modulator of tight junction dynamics was also evaluated because intratesticular content of this cytokine is ..
  7. doi [Effects of Quyu Jiedu Granule on expressions of tumor necrosis factor-alpha and interleukin-6 mRNAs in ovarian granulosa cells of endometriosis rats]
    Xin Ling Li
    Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250014, China
    Zhong Xi Yi Jie He Xue Bao 6:960-3. 2008
    ....
  8. pmc Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes
    Asha Jacob
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research Manhasset, NY 11030, USA
    Int J Clin Exp Med 1:22-31. 2008
    ..These studies suggest that sepsis-induced inflammation is exacerbated in an animal model of Type 2 diabetes...
  9. doi The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
    ..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes...
  10. pmc alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    Dianne M Perez
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Pharmacol 76:144-52. 2009
    ..Our results indicate that alpha(1)-ARs stimulated IL-6 expression and secretion through regulating both mRNA transcription and stability, involving p38 MAPK and NF-kappaB pathways...
  11. doi Pre-existing lipopolysaccharide may increase the risk of heatstroke in rats
    Xiao Jing Lin
    Department of Nursing, Nanfang Hospital, Southern University, Guangzhou, Guangdong, China
    Am J Med Sci 337:265-70. 2009
    ..We attempted to ascertain whether pre-existing inflammatory state [caused by exogenous administration of lipopolysaccharide (LPS)] exacerbated multiorgan dysfunction in experimental heatstroke...
  12. doi Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes
    Anna Ryden
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 25:335-43. 2009
    ..Further, to follow the immune response from onset to 2 years duration, the study focused on spontaneous as well as autoantigen-induced immune profile...
  13. doi Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells
    Juan Fan
    Institute of Neurosciences, Fourth Military Medical University, Xi an, Shaanxi, China
    J Neurosci Res 87:2757-62. 2009
    ..Our experiments provide further evidence for the responsiveness of the CB to proinflammatory cytokines and indicate that the CB might play a role in inflammation sensing and transmission of such information to the brain...
  14. doi Particle-induced cytokine responses in cardiac cell cultures--the effect of particles versus soluble mediators released by particle-exposed lung cells
    Annike I Totlandsdal
    Department of Air Pollution and Noise, Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Toxicol Sci 106:233-41. 2008
    ..These in vitro findings lend support to the hypothesis that particle-induced cardiac inflammation and disease may involve lung-derived mediators...
  15. pmc Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells
    Joseph D Roach
    Department of Chemistry, University of Nevada, Las Vegas, Nevada 89154 4003, USA
    Neuroimmunomodulation 15:117-24. 2008
    ..We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)...
  16. ncbi HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell
    Kuy Sook Lee
    Center for Biomedical Sciences, Division of Cardiovascular Diseases, National Institute of Health, Seoul, Korea
    Biochim Biophys Acta 1773:1637-44. 2007
    ..In conclusion, IL-6 plays an important role in the delayed activation of STAT3 and VSMC proliferation induced by HB-EGF...
  17. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
    ..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury...
  18. ncbi [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers]
    Hyun Ho Joo
    Department of Surgery, Inje University Pusan Paik Hospital, Inje University College of Medicine, Busanjin Gu, Busan, Korea
    Korean J Gastroenterol 50:370-8. 2007
    ..We aimed to analyze the expressions of each marker and their relationships with clinicopathologic factors...
  19. doi TNFalpha antagonist upregulates interleukin-6 in rats with hypertensive heart failure
    Espen Haugen
    Department of Molecular and Clinical Medicine and Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Sweden
    Int J Cardiol 130:64-8. 2008
    ..Hypertension is one of most common causes to chronic heart failure in humans...
  20. doi Interleukin-6, TNF-alpha and interleukin-1 beta levels in blood and tissue in severely burned rats
    Diane Agay
    Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP87, 38702 La Tronche Cedex, France
    Eur Cytokine Netw 19:1-7. 2008
    ....
  21. pmc Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice
    Huihua Li
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Anesthesiology 113:619-29. 2010
    ..The role of TLR4-MyD88 signaling in ventilator-induced lung injury remains incompletely understood...
  22. doi Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6
    Cristina Nogueira-Silva
    Life and Health Sciences Research Institute, ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Pediatr Pulmonol 43:680-9. 2008
    ....
  23. doi Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats
    Min Zhao
    Department of Naval Medicine, Second Military Medical University, 800 Xiangxin Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 373:90-3. 2008
    ..These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage...
  24. doi Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study
    M Jacobs
    Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Invest 39:437-44. 2009
    ..The aim was to study whether the association between the metabolic syndrome and CAD or the severity of PAD can be explained by low-grade inflammation...
  25. doi Post-ischemic hypothermia for 24h in P7 rats rescues hippocampal neuron: association with decreased astrocyte activation and inflammatory cytokine expression
    Man Xiong
    Key Laboratory of Neonatal Diseases, Ministry of Health, Children s Hospital, Fudan University, 399 Wanyuan Road, Shanghai 201102, China
    Brain Res Bull 79:351-7. 2009
    ..The present findings highlight an apparent association between inhibition of hippocampal neuron loss by hypothermia and decreased astrocytosis and inflammatory cytokine release after hypoxia-ischemia in the developing brain...
  26. doi High weight differences between donor and recipient affect early kidney graft function--a role for enhanced IL-6 signaling
    W Gong
    Institute of Medical Immunology, Charite University Medicine, Campus Mitte, Berlin, Germany
    Am J Transplant 9:1742-51. 2009
    ..These findings have strong clinical implication as anti-IL6R treatment of patients receiving grafts from lower-weight donors could be used to improve primary graft function...
  27. doi Spatiotemporal nuclear factor interleukin-6 expression in the rat brain during lipopolysaccharide-induced fever is linked to sustained hypothalamic inflammatory target gene induction
    Jelena Damm
    Department of Veterinary Physiology, Justus Liebig University Giessen, Germany
    J Comp Neurol 519:480-505. 2011
    ..To investigate whether NF-IL6 might be another important transcription factor implicated in this kind of immune-to-brain signaling, rats were ..
  28. pmc CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease
    Anthony Joetham
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 186:113-20. 2011
    ..These data identify the critical role of CD8-T regulatory cell interactions in regulating the suppressive phenotype of nTregs through control of IL-6 production...
  29. doi Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
    Martina Skurlova
    Department of Normal, Pathological, and Clinical Physiology, Charles University in Prague, 120 00 Prague, Czech Republic
    Neurosci Lett 487:250-4. 2011
    ....
  30. doi Differences in the relative involvement of peripherally released interleukin (IL)-6, brain IL-1β and prostanoids in mediating lipopolysaccharide-induced fever and sickness behavior
    Lois M Harden
    School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    Psychoneuroendocrinology 36:608-22. 2011
    ....
  31. doi Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis
    Shang Ju Yang
    Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 5, Fushing Street, Kweishan Shiang, Taoyuan 333, Taiwan
    Injury 42:638-42. 2011
    ..The aim of this study is to elucidate whether Akt plays any role in 17β-estradiol (E2)-mediated attenuation of lung injury after acute pancreatitis (AP)...
  32. doi Quantification of circulating cell-free DNA in the serum of patients with obstructive sleep apnea-hypopnea syndrome
    Liang Ye
    Department of Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Ruijin Second Road, Shanghai 200025, China
    Lung 188:469-74. 2010
    ..05). The increasing concentration of serum DNA in patients with OSAHS was positively correlated with disease severity. Serum DNA may become an important parameter for monitoring the severity of OSAHS and effectiveness of therapy...
  33. pmc Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, USA
    Am J Respir Crit Care Med 182:1305-14. 2010
    ..Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immune-mediated rather than being driven by viral load...
  34. ncbi [The role of p38 mitogen-activated protein kinase in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells]
    Yu Feng Chu
    Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:291-4. 2010
    ..To investigate the regulation mechanism of p38 mitogen-activated protein kinase (p38MAPK) in interleukin-6 (IL-6) expression of vascular smooth muscle cell (VSMC) induced by lipopolysaccharide (LPS)...
  35. ncbi [Effects of reduced glutathione on plasma level of cytokines and pulmonary ultrastructure in rats with sepsis]
    Xiu yu Liao
    Intensive Care Unit, First Hospital Affiliated of Fujian Medical University, Fuzhou 350005, Fujian, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:282-4. 2010
    ..To investigate the protection mechanism of reduced glutathione (GSH) in acute lung injury in rats with sepsis...
  36. pmc Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis
    Kai Wang
    Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi an Avenue, Changchun 130062, Jilin Province, China
    World J Gastroenterol 16:2252-9. 2010
    To characterise expression of interleukin 6 (IL-6), a potent proinflammatory cytokine, in the occurrence and development of inflammatory bowel disease (IBD) and investigate its effect on neuroimmunomodulation and immune homeostasis ..
  37. doi Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury
    K J Whitehead
    Pain Signalling Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Brain Behav Immun 24:569-76. 2010
    ..Moreover, our studies demonstrate the ability of a neurone-glia signaling mechanism to dynamically modulate this release and support a role of spinal IL-1beta in the phasic transmission of abnormal pain signals...
  38. doi IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats
    Miwa Takagishi
    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Am J Physiol Regul Integr Comp Physiol 298:R183-90. 2010
    ..Whether the abnormal gene expression of IL-6 in the NTS is associated in a causal way with hypertension remains to be resolved...
  39. pmc Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection
    Jun Chen
    Laboratory of Infectious Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 3203, USA
    J Virol 84:1289-301. 2010
    ..Our findings provide new insights into the pathogenesis of SARS, demonstrating the important role of CD4(+) but not CD8(+) T cells in primary SARS-CoV infection in this model...
  40. ncbi Activation of hypothalamic NPY, AgRP, MC4R, AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity
    A Stofkova
    Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Ke Karlovu 4, 120 00 Prague, Czech Republic
    Endocr Regul 43:99-106. 2009
    ..The aim of this work was to study the early-life diet-induced obesity in Lewis rats which are known to be highly susceptible to autoimmunity...
  41. doi Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis
    Miguel A Sánchez-Garrido
    Reina Sofia University Hospital, Cordoba, Spain
    Innate Immun 15:337-49. 2009
    ..Furthermore, PC is identified as a new survival agent that reverses several TNFalpha-inducible responses that are likely to promote steatosis and necrosis...
  42. pmc Salvianolate inhibits cytokine gene expression in small intestine of cirrhotic rats
    Dan Hong Yang
    Department of Infection, Zhejiang Provincial People s Hospital, Hangzhou 310014, Zhejiang Province, China
    World J Gastroenterol 17:1903-9. 2011
    ..To study the effect of salvianolate on expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 mRNA in small intestine of cirrhotic rats...
  43. ncbi IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching
    Cristina Nogueira-Silva
    Fetal and Neonatal Physiology, Life and Health Sciences Research Institute ICVS, University of Minho, 4709 057 Braga, Portugal
    Pediatr Res 60:530-6. 2006
    ..IL-6 enhanced p38-MAPK phosphorylation without changing MEK1/2 and JNK pathways. The present study suggests a physiological role for IL-6 on pulmonary branching mechanisms most likely involving p38-MAPK intracellular signalling pathway...
  44. ncbi Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF
    F Liu
    INSERM U403, Hopital E Herriot, Lyon, France
    Bone 31:212-9. 2002
    ....
  45. ncbi Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    A L Carey
    Department of Physiology, The University of Melbourne, Parkville 3010, Vic, Australia
    Biochem Biophys Res Commun 302:837-40. 2003
    ..It is likely that the differences observed when comparing healthy with insulin resistant muscle are due to the differential activation of insulin sensitive signalling proteins responsible for activating IL-6...
  46. ncbi The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
    H Ashdown
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Montreal, Quebec, Canada H4H 1R3
    Mol Psychiatry 11:47-55. 2006
    ..Collectively, these data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta...
  47. ncbi Interleukin-6 in neurons of the pterygopalatine ganglion of the rat
    I G Charyeva
    Department of Morphology, Russian State Medical University, Moscow
    Neurosci Behav Physiol 35:465-7. 2005
    ....
  48. pmc Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    Peter C Heinrich
    Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 374:1-20. 2003
    ..Also the cross-talk between the JAK/STAT pathway with other signalling cascades is discussed...
  49. ncbi Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
    ..Collectively these data indicate that skeletal muscle possesses many of the components of the innate immune system, including increases in both early- and late-phase cytokines and the presence of toll-like receptors...
  50. pmc Fibre-type specificity of interleukin-6 gene transcription during muscle contraction in rat: association with calcineurin activity
    Sébastien Banzet
    Department of Human Factors, Centre de Recherches du Service de Sante des Armees, BP 87, 38702 La Tronche Cedex, France
    J Physiol 566:839-47. 2005
    ..Our data clearly suggest that IL-6 gene transcription was mainly observed in early recruited myofibres and that contraction-induced IL-6 transcription could be associated with enhanced calcineurin activity...
  51. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
    ..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant...
  52. ncbi AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway
    Roser Gorina
    Departament de Farmacologia i Toxicologia, IIBB CSIC, IDIBAPS, Rossello 161, Planta 6, 08036 Barcelona, Spain
    J Neurochem 92:505-18. 2005
    ....
  53. ncbi Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants
    Hiromi An
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Am J Obstet Gynecol 191:1649-54. 2004
    ..In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study...
  54. ncbi Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function
    Shaolong Yang
    Center for Surgical Research, The Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 287:H2183-91. 2004
    ..Thus there is an inverse correlation between cardiomyocyte IL-6 levels and cardiac function after T-H. The salutary effects of E2 on cardiac function after T-H may be due in part to decreased IL-6 synthesis in cardiomyocytes...
  55. ncbi Diagnostic role of serum interleukin 6 and CA 19-9 in patients with cholangiocarcinoma
    Pisit Tangkijvanich
    Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Hepatogastroenterology 51:15-9. 2004
    ..The first marker represents the commonly used serum marker in cholangiocarcinoma and the second marker is a multi-functional cytokine associated with cancer development...
  56. ncbi Interleukin-6: a cytokine to forget
    D Balschun
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    FASEB J 18:1788-90. 2004
    ..In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage...
  57. ncbi Depolarization-induced slow Ca2+ transients stimulate transcription of IL-6 gene in skeletal muscle cells
    Nevenka Juretic
    Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70086 Santiago 7, Santiago, Chile
    Am J Physiol Cell Physiol 290:C1428-36. 2006
    ..Our results provide evidence for involvement of IP(3)-mediated Ca(2+) signals on IL-6 transcription in skeletal muscle cells...
  58. ncbi The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity
    Ping Wang
    Research Institute of General Surgery, Jinling Hospital, 305 Zhong Shan East Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 8:531-6. 2002
    ..The objective of this current study was to investigate the role of endotoxin, TNF-alpha and IL-6 in inducing the growth hormone insensitivity at the receptor and post-receptor levels...
  59. ncbi Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation
    K Abeyama
    Department of Laboratory Medicine, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 364:298-300. 1995
    ..Increases in the DNA binding activity of nuclear factor kappa B (NF-kappa B) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy...
  60. ncbi Contraction-induced interleukin-6 transcription in rat slow-type muscle is partly dependent on calcineurin activation
    Sébastien Banzet
    Department of Human Factors, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Cell Physiol 210:596-601. 2007
    ..Taken together, these results demonstrate that in addition to p38 MAPK, increased calcineurin activity is one of the signalling events involved in IL-6 gene transcription...
  61. ncbi Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: association with reduction of oxidative stress
    Lorenza Tacchini
    Institute of General Pathology, University of Milano, Via Mangiagalli 31, 20133, Milano, Italy
    Free Radic Res 40:1206-17. 2006
    ..In conclusion, IP modulates the activity of transcription factors and triggers IL-6 production; this may prevent hepatic I/R damage in a oxidative stress-dependent way, particularly in fatty livers...
  62. ncbi Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis
    Susan E Malley
    University of Vermont, College of Medicine, Department of Neurology, Burlington, Vermont 05405, USA
    Physiol Genomics 9:5-13. 2002
    ..Increased cytokine expression after CYP-induced cystitis, alone or in combination with other inflammatory mediators or growth factors, may contribute to altered lower urinary tract function after cystitis...
  63. ncbi Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium
    Emiliano A Palmieri
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, L Califano Facoltà di Medcina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H926-34. 2002
    ..Such findings may have potential implications with regard to compensatory hypertrophy and failure...
  64. ncbi Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...
  65. ncbi Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage
    Koji Osuka
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Res 1072:1-7. 2006
    ..These results indicate that SAH produces the proinflammatory cytokine IL-6 in the CSF, which activates the JAK-STAT signaling pathway in the basilar artery and induces transcription of immediate early genes...
  66. ncbi The systemic inflammatory response to exercise in adults with cystic fibrosis
    Alina A Ionescu
    Respiratory Medicine, Cardiff University, Academic Centre, Llandough Hospital, Cardiff, CF64 2XX, United Kingdom
    J Cyst Fibros 5:105-12. 2006
    ..We report greater increments in circulating concentrations of some cytokines with moderate exercise in adults with cystic fibrosis compared to healthy subjects...
  67. doi Roles of plasma interleukin-6 and tumor necrosis factor-alpha and FFA and TG in the development of insulin resistance induced by high-fat diet
    Kai Jiao
    Department of Endocrinology, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Street, Xi an 710038, China
    Cytokine 42:161-9. 2008
    ....
  68. pmc Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa
    Fei Yue Li
    Department of Digestive Diseases, Central Hospital of Daqing Youtian, Daqing, Heilongjiang Province, China
    World J Gastroenterol 15:3621-30. 2009
    ....
  69. ncbi Effects of histamine and the h2 receptor antagonist ranitidine on ischemia-induced acute renal failure: involvement of IL-6 and vascular endothelial growth factor
    Adam Vannay
    First Department of Pediatrics and Research Laboratory of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
    Kidney Blood Press Res 27:105-13. 2004
    ..The effects of histamine and the H2 receptor antagonist ranitidine on renal VEGF and IL-6 synthesis were investigated in a well-established rat model of renal ischemia/reperfusion injury...
  70. ncbi Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices
    Marina Pizzi
    Department of Biomedical Sciences and Biotechnologies, University of Brescia, 25123 Brescia, Italy
    Mol Cell Neurosci 25:301-11. 2004
    ..Our results suggest that IL-6 and IL6RIL6 may prove to be valuable in treating neurodegenerative and demyelinating diseases...
  71. ncbi Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6
    P J Simons
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    Endocrinology 139:3148-56. 1998
    ....
  72. pmc Leptin induces an inflammatory phenotype in lean Wistar rats
    Monique Allman
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Mediators Inflamm 2009:738620. 2009
    ..These findings support the hypothesis that leptin directly initiates inflammation in the local environment of mesenteric adipose tissue as well as systemically...
  73. ncbi Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 286:G942-6. 2004
    ..These results indicate that IL-10 production by Kupffer cells early after T-H may play a pivotal role in attenuating the proinflammatory cytokine environment, possibly in an autocrine/paracrine manner...
  74. ncbi L-Buthionine-(S,R)-sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an IkappaB-alpha/NF-kappaB insensitive pathway
    J J Haddad
    Neuroscience Research Laboratory, University of California at San Francisco, CA 94143 0542, USA corrected
    Eur Cytokine Netw 12:614-24. 2001
    ....
  75. ncbi Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis
    Niels C Riedemann
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    FASEB J 18:370-2. 2004
    ..Accordingly, we suggest that induction of IL-6 after CLP is neutrophil and C5a/C5aR dependent, likely due to the ability of C5a to cause activation of ERK1/2 and p38 MAPK signaling pathways...
  76. ncbi Parathyroid hormone induces interleukin-6 gene expression in bone stromal cells of young rats
    Shuichi Chiba
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA 02114, USA
    J Vet Med Sci 64:641-4. 2002
    ..Since IL-6 is a known activator of osteoclasts, these results are consistent with the hypothesis that PTH stimulates the local IL-6 synthesis in stromal cells to indirectly activate osteoclasts...
  77. ncbi Retinoic acid enhances leukemia inhibitory factor expression in OLN-93 oligodendrocytes
    Jörg Mey
    Institut fur Biologie II, RWTH Aachen, Kopernikusstrasse 16, 52074 Aachen, Germany
    Cell Tissue Res 310:155-61. 2002
    ..1 ( P<0.01). In contrast, RA had no significant effect on the expression of CNTF. The results suggest RA as a possible regulator of cytokine signaling in the CNS...
  78. doi Sequential expression of TLR4 and its effects on the myocardium of rats with myocardial ischemia-reperfusion injury
    Jun Yang
    Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China
    Inflammation 31:304-12. 2008
    ..728 and 0.676, P<0.01). Myocardial TLR4 expression was elevated at the early stage of myocardial ischemia reperfusion. Activated TLR4 may play a role in MI/RI by increasing TNF-alpha and IL-6 expression...
  79. ncbi IL-6 a key cytokine in in vitro and in vivo response of Sertoli cells to external gamma irradiation
    F Legue
    UPRES EA 2231, Universite de Rennes I, Centre Eugene Marquis, CS 44229, 35042 Rennes Cedex, France
    Cytokine 16:232-8. 2001
    ..In conclusion, IL-6 seems to constitute a good marker of exposure to gamma irradiation, both at low and high doses. In addition, we showed that IL-1 and IL-6 have a radioprotective effect at testicular level...
  80. doi Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis
    Kyung Suk Park
    Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea
    Ann N Y Acad Sci 1171:421-7. 2009
    ..In conclusion, omega-3 fatty acids may be beneficial for preventing oxidative stress-induced pancreatic inflammation and apoptosis by inhibiting inflammatory cytokine and apoptotic gene expression of pancreatic acinar cells...
  81. ncbi Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock
    Balazs Toth
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 97:2184-9. 2004
    ..Thus IL-6 plays a significant role in the induction of hepatic dysfunction and liver injury after T-H that appears to be in part mediated by increased thromboxane A(2) levels...
  82. pmc Cytokine mRNA expression in painful radiculopathy
    Sarah M Rothman
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Pain 10:90-9. 2009
    ....
  83. ncbi A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion
    Sumiko Abe
    Department of Legal Medicine, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan
    Neuroreport 16:1889-92. 2005
    ..The induction of interleukin-6 expression is likely to play a role in the protection of injured neurons perhaps related to growth of their axons. Glycoprotein 130 might also account for the inhibitory effects following nerve injury...
  84. doi Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats
    Alban Latremoliere
    Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, Institut Fédératif de Recherche 70 des Neurosciences, Unité Mixte de Recherche S677, F 75013 Paris, France
    J Neurosci 28:8489-501. 2008
    ..Our data further support the idea that different pathophysiological mechanisms contribute to the development of cephalic versus extracephalic neuropathic pain...
  85. ncbi Glucagon-stimulated but not isoproterenol-stimulated glucose formation inhibition by interleukin-6 in primary cultured rat hepatocytes
    M Quaas
    Institute of Biochemistry and Molecular Cell Biology, Georg August University, Gottingen, Germany
    Horm Metab Res 37:666-71. 2005
    ....
  86. ncbi Interleukin-6 has no effect on surfactant or lung function in different lung insults
    Tomoo Nakamura
    Department of Perinatal Medicine and Maternal Care, National Center for Children Health and Development, Tokyo, Japan
    Exp Lung Res 32:27-42. 2006
    ..These results suggest that IL-6 may have a limited role in the surfactant alterations observed in acute lung injury...
  87. ncbi PACAP stimulates the release of interleukin-6 in cultured rat Müller cells
    T Seki
    Ophthalmology, Kozawa Eye Hospital Eye Research Center, 2 2 11 Gokencho, Mito, Ibaraki 310 0063, Japan
    Ann N Y Acad Sci 1070:535-9. 2006
    ..These data suggest that Müller cells are one of the target cells for PACAP, stimulating the release of IL-6, and providing a mechanism whereby PACAP exerts a significant neuroprotective effect in the retina...
  88. ncbi The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats
    H Zivna
    Department of Physiology, Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic
    Adv Clin Path 5:147-53. 2001
    ..Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats...
  89. ncbi Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS
    Mazen Kurdi
    The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    J Cell Physiol 212:424-31. 2007
    ..The finding that signaling by the IL-6-type cytokine may be redox-sensitive defines a novel mechanism of regulation that has implications for exploiting their therapeutic potential...
  90. pmc Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration
    Jan Peter Sowa
    Department of Gastroenterology and Hepatology, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    World J Gastroenterol 14:7093-100. 2008
    ..To investigate the molecular events involved in liver regeneration following subtotal hepatectomy (SH) as previous studies have largely focused on partial hepatectomy (PH)...
  91. ncbi Influence of age on susceptibility to Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in Long-Evans rats
    Hsiao Li Chuang
    Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    J Vet Med Sci 71:163-9. 2009
    ..These data suggest that inflammatory cytokines play an important role in age-related differences in PEA-induced hepatotoxicity. Moreover, these cytokines might correlate with different patterns histopathologic features at various ages...
  92. doi Prophylactic maternal n-acetylcysteine before lipopolysaccharide suppresses fetal inflammatory cytokine responses
    Ron Beloosesky
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
    Am J Obstet Gynecol 200:665.e1-5. 2009
    ..We sought to determine whether prophylactic n-acetylcysteine (NAC), a known antiinflammatory, may modulate the fetal cytokine response to maternal lipopolysaccharide (LPS)...
  93. ncbi Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes
    Chinnasamy Thirunavukkarasu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Cell Physiol 204:654-65. 2005
    ..They also indicate that other factors, in addition to NO, TGF-beta, TNF-alpha, IL-1beta, and IL-6 are involved in the mechanisms of the growth inhibitory effects of qHSCs on hepatocytes...
  94. ncbi Inflammatory cytokine levels in paw tissues during development of rat collagen-induced arthritis: effect of FK506, an inhibitor of T cell activation
    K Magari
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, 532 8514 Yodogawa ku, Osaka, Japan
    Inflamm Res 53:469-74. 2004
    ....
  95. pmc Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
    H Xue
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada
    Br J Cancer 100:1581-8. 2009
    ..Taken together, Cipro prevented infectious challenges associated with immune hypo-responsiveness in systemic immune compartments, and it may also alleviate excessive pro-inflammatory responses mediating local gut injury...
  96. pmc LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB
    Karol Dokladny
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Cell Stress Chaperones 15:153-63. 2010
    ..We conclude that the effects of heat stress-induced increase in HSP70 protein expression on LPS-induced cytokine elaboration in whole animals can be reproduced by the actions of a single gene product...
  97. ncbi Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?
    Eugenio Mocchegiani
    Immunology Centre Section Nutrition, Immunity and Ageing, Res Dept INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Brain Res Bull 63:133-42. 2004
    ..As a consequence, compensatory phenomena between MT isoforms may not occur in the old hippocampus due to chronic stress-like condition elicited by high persistent levels of interleukin-6...
  98. pmc Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat
    A Bottger
    Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, The Netherlands
    J Clin Invest 98:856-62. 1996
    ..These findings provide support for the hypothesis that blood pressure and certain lipid subfractions can be modulated by linked genes or perhaps even the same genes...
  99. pmc The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10
    Maria K Dahle
    Institute for Surgical Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Infect Immun 72:5704-11. 2004
    ....
  100. ncbi Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors
    Sophie Flood
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Arthritis Rheum 56:2523-34. 2007
    ..This study was undertaken to determine whether glutamate receptors are expressed in the synovial joint, and to determine whether activation of glutamate receptors on human synoviocytes contributes to RA disease pathology...

Research Grants57

  1. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2007
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  2. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2003
    ..These experiments will provide the first morphological and functional evidence of the existence of a multisynaptic neural pathway between the testes and the CNS, that is influenced by alcohol. ..
  3. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  4. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2003
    ..abstract_text> ..
  5. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  7. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  8. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2009
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  9. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  10. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  11. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  12. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  13. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2010
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  14. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2004
    ....
  15. Neurotransmitter Regulation of Glial Cytokine Expression
    BRYAN SPANGELO; Fiscal Year: 2006
    ..Understanding molecular mechanisms by which neurotransmitters can prevent such toxic glial activation will provide new strategies for pharmacological abrogation of glia-mediated neuronal injury. ..
  16. CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITY
    ANBUKILI CHETTY; Fiscal Year: 2006
    ..This mentored work will provide extensive education and technical experience in Molecular Biology and the development of a model of hyperoxic lung injury. ..
  17. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  18. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  19. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  20. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2007
    ....
  21. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2007
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  22. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..