Gene Symbol: Il33
Description: interleukin 33
Alias: RGD1311155, interleukin-33, IL-33
Species: rat
Products:     Il33

Top Publications

  1. Kurowska Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan C, Ying S, et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol. 2009;183:6469-77 pubmed publisher
    ..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation. ..
  2. Masamune A, Watanabe T, Kikuta K, Satoh K, Kanno A, Shimosegawa T. Nuclear expression of interleukin-33 in pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G821-32 pubmed publisher
    ..Decreased IL-33 expression by small interfering RNA resulted in decreased proliferation in response to PDGF-BB. In conclusion, activated PSCs expressed IL-33 in the nucleus. IL-33 might regulate the PDGF-induced proliferation in PSCs. ..
  3. Demirtas L, Turkmen K, Kandemir F, Ozkaraca M, Kucukler S, Gürbüzel M, et al. The possible role of interleukin-33 as a new player in the pathogenesis of contrast-induced nephropathy in diabetic rats. Ren Fail. 2016;38:952-60 pubmed publisher
    ..This could be secondary to inactivation of IL-33 via increased caspase-3 activity. The release of IL-33 from necrotic cells might induce autophagy, which can further balance the effects of increased apoptosis secondary to CN in DKD. ..
  4. Luo H, Higuchi K, Matsumoto K, Mori M. An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats. Genes Immun. 2013;14:192-7 pubmed publisher
    ..In this study, we examined the interleukin-33 (Il33) gene as a candidate for the eos3 and found a missense nucleotide substitution in the gene, which resulted in a ..
  5. Hayakawa H, Hayakawa M, Kume A, Tominaga S. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem. 2007;282:26369-80 pubmed
    ..Our study provides a molecular mechanism wherein soluble ST2 modulates the biological activity of IL-33 in allergic airway inflammation. ..
  6. Seki K, Sanada S, Kudinova A, Steinhauser M, Handa V, Gannon J, et al. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ Heart Fail. 2009;2:684-91 pubmed publisher
    ..Finally, IL-33 improved survival after MI in wild-type but not in ST2(-/-) mice. IL-33 prevents cardiomyocyte apoptosis and improves cardiac function and survival after MI through ST2 signaling. ..
  7. Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, et al. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE. 2011;6:e18404 pubmed publisher
    ..Our findings suggest that LPS-mediated macrophage activation is accelerated by macrophage-derived paracrine IL-33 stimulation. ..
  8. Zhao J, Wei J, Mialki R, Mallampalli D, Chen B, Coon T, et al. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat Immunol. 2012;13:651-8 pubmed publisher
    The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression...
  9. Natarajan C, Yao S, Sriram S. TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair. PLoS ONE. 2016;11:e0152163 pubmed publisher
    ..Our studies suggest that poly-IC and IL-33 play a role in myelin repair by enhancing expression of myelin genes and are therefore attractive therapeutic agents for use as remyelinating agents in human demyelinating disease. ..

More Information


  1. Kempuraj D, Twait E, Williard D, Yuan Z, Meyerholz D, Samuel I. The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice. PLoS ONE. 2013;8:e56866 pubmed publisher
    ..IL-33 is induced in acute pancreatitis, activates acinar cell proinflammatory pathways and exacerbates acute pancreatic inflammation. ..
  2. Liang Y, Jie Z, Hou L, Aguilar Valenzuela R, Vu D, Soong L, et al. IL-33 induces nuocytes and modulates liver injury in viral hepatitis. J Immunol. 2013;190:5666-75 pubmed publisher
    ..Its direct immunoregulatory functions and ability to induce novel nuocytes further suggest to us that it may be a potentially promising therapeutic candidate for the management of viral hepatitis. ..
  3. Jiang Y, An Y, Jiang D, Wu B, Yang Y, Sun D. TNF-α Regulating Interleukin-33 Induces Acute Pancreatic Inflammation in Rats. Ann Clin Lab Sci. 2016;46:54-9 pubmed
    ..IL-33 is elevated at the early stage of AP and correlated with AP severity. TNF-α stimulated IL-33/sST2 and subsequent increase of IL-6 may be the mechanism of IL-33 in AP. ..
  4. Ruisong M, Xiaorong H, Gangying H, Chunfeng Y, Changjiang Z, Xuefei L, et al. The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway. PLoS ONE. 2015;10:e0143064 pubmed publisher
    ..These findings indicated that IL-33 protects against myocardial I/R injury by inhibiting inflammatory responses and myocardial apoptosis, which may be associated with the HMGB1 and P38 MAPK signaling pathways. ..
  5. Ragusa R, Cabiati M, Guzzardi M, D Amico A, Giannessi D, Del Ry S, et al. Effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver: study in the experimental model of Zucker rats. Exp Mol Pathol. 2017;102:354-359 pubmed publisher
    ..The strong relationships with NP systems and inflammatory mediators could suggest an involvement for IL-33/ST2 in molecular pathways leading to cardiac dysfunction and inflammation associated with obesity. ..
  6. Yang S, Lin J, Wu S, Huang K, Jung F, Ma M, et al. Membrane translocation of IL-33 receptor in ventilator induced lung injury. PLoS ONE. 2015;10:e0121391 pubmed publisher
    ..Moreover, IL-33/ST2 signaling activated by mechanically responsive lung injury may potentially serve as a new therapy target. ..
  7. Lax A, Sánchez Más J, Asensio Lopez M, Fernandez Del Palacio M, Caballero L, Garrido I, et al. Mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction. JACC Heart Fail. 2015;3:50-8 pubmed publisher
    ..MRAs play a pivotal role in the Gal-3 and IL-33/ST2 modulation in post-MI cardiac remodeling. ..
  8. Huang L, Li H, Sun Q, Liu M, Li W, Li S, et al. IL-33 expression in the cerebral cortex following experimental subarachnoid hemorrhage in rats. Cell Mol Neurobiol. 2015;35:493-501 pubmed publisher
    ..Moreover, a significant positive association was observed between IL-33 and IL-1β expression. These findings indicate that IL-33 might play an important role in the inflammatory response following SAH. ..
  9. Fang K, Yang C, Lin T, Chan T, Tzeng S. Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells. Neuro Oncol. 2014;16:552-66 pubmed publisher
  10. Barrett O, Yndestad A, Marshall A, Sugden P, Clerk A. The early transcriptomic response to interleukin 1? and interleukin 33 in rat neonatal cardiomyocytes. Cytokine. 2013;61:340-4 pubmed publisher
    ..cytokines including interleukin (IL) 1? are implicated in regulating adaptive and maladaptive changes, whereas IL33 negatively regulates cardiomyocyte hypertrophy and promotes cardioprotection...
  11. Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, et al. Production and functions of IL-33 in the central nervous system. Brain Res. 2011;1385:8-17 pubmed publisher
    ..It also enhances chemokines and nitric oxide production and phagocytosis by microglia. Thus, IL-33 produced in the CNS activates microglia and may function as a pro-inflammatory mediator in the pathophysiology of the CNS. ..
  12. Miller A, Xu D, Asquith D, Denby L, Li Y, Sattar N, et al. IL-33 reduces the development of atherosclerosis. J Exp Med. 2008;205:339-46 pubmed publisher
    ..In conclusion, IL-33 may play a protective role in the development of atherosclerosis via the induction of IL-5 and ox-LDL antibodies. ..