Gene Symbol: Il23a
Description: interleukin 23 subunit alpha
Alias: interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, IL-23p19, Interleukin 23, alpha subunit p19, interleukin-23 subunit p19
Species: rat
Products:     Il23a

Top Publications

  1. Oppmann B, Lesley R, Blom B, Timans J, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-25 pubmed
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. ..
  2. van de Wetering D, de Paus R, van Dissel J, van de Vosse E. IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int Immunol. 2009;21:145-53 pubmed publisher
  3. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168:5699-708 pubmed
    ..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2. ..
  4. Aggarwal S, Ghilardi N, Xie M, De Sauvage F, Gurney A. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278:1910-4 pubmed
    ..These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles. ..
  5. Pirhonen J, Matikainen S, Julkunen I. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol. 2002;169:5673-8 pubmed
    ..IFN-gamma, in contrast, up-regulates the p19 and p40 mRNA expression in Sendai virus infection. Thus, IL-4 and IFN-gamma serve as opposing factors in the regulation of IFN-gamma-inducing cytokines, including IL-23, in macrophages. ..
  6. Tanaka H, Terada Y, Okado T, Inoshita S, Kuwahara M, Sasaki S. Role of the E2F1-p19-p53 pathway in ischemic acute renal failure. Nephron Physiol. 2005;101:p27-34 pubmed
    ..These data support the hypothesis that the E2F1-p19(ARF)-p53 pathway forms a negative feedback loop to regulate the cell cycle of renal tubular cells in the ischemic ARF. ..
  7. Wang M, Zhong D, Zheng Y, Li H, Chen H, Ma S, et al. Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor. Neuroscience. 2015;289:406-16 pubmed publisher
    ..These results not only help us better understand the role of IL-23/IL-23R in brain ischemia, but also provide a potential therapeutic target in stroke. ..
  8. Hoeve M, Savage N, De Boer T, Langenberg D, de Waal Malefyt R, Ottenhoff T, et al. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol. 2006;36:661-70 pubmed
  9. Peng J, Yang X, Chang S, Yang J, Dong C. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res. 2010;20:62-71 pubmed publisher
    ..Conversely, in the absence of this signal, Th2 cell differentiation was partially inhibited. Therefore, IL-23 signaling may regulate allergic asthma through modulation of Th2 cell differentiation. ..

More Information


  1. Morishima N, Mizoguchi I, Takeda K, Mizuguchi J, Yoshimoto T. TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem Biophys Res Commun. 2009;386:105-10 pubmed publisher
    ..These results suggest that the induction of IL-23R and Th17 differentiation by IL-6 and IL-23 is mediated through endogenously produced TGF-beta. ..
  2. Smits H, van Beelen A, Hessle C, Westland R, De Jong E, Soeteman E, et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol. 2004;34:1371-80 pubmed
    ..Importantly, this study gives indications that the expression of the different IL-12 family members is dictated by different priming conditions of immature DC. ..
  3. van de Wetering D, de Paus R, van Dissel J, van de Vosse E. Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE. 2009;4:e8396 pubmed publisher
    ..The IL-23 induced cytokines allow for the subsequent production of IL-12 and amplify the IFN-gamma production in the type-1 cytokine pathway. ..
  4. DeLay M, Turner M, Klenk E, Smith J, Sowders D, Colbert R. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum. 2009;60:2633-43 pubmed publisher
    ..These results suggest a possible link between HLA-B27 misfolding and immune dysregulation in this animal model, with implications for human disease. ..
  5. Hu X, Ma R, Lu J, Zhang K, Xu W, Jiang H, et al. IL-23 Promotes Myocardial I/R Injury by Increasing the Inflammatory Responses and Oxidative Stress Reactions. Cell Physiol Biochem. 2016;38:2163-72 pubmed publisher
    ..05). All these effects were abolished by anti-IL-23 administration. The present study suggested that IL-23 may promote myocardial I/R injury by increasing the inflammatory responses and oxidative stress reaction. ..
  6. Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
    ..We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs. ..
  7. Yago T, Nanke Y, Kawamoto M, Furuya T, Kobashigawa T, Kamatani N, et al. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther. 2007;9:R96 pubmed
    ..Thus, controlling IL-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis. ..
  8. Ha S, Kim D, Baek K, Yun Y, Sung Y. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol. 2004;172:525-31 pubmed
    ..These data suggest that IL-23, particularly IL-23N220L, would be an effective adjuvant of DNA vaccine for the induction of durable Ag-specific T cell immunity. ..
  9. Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed
    ..Our results demonstrate that an abnormal Th1 bias in DCs from MS patients related to IL-23 exists, and that antisense oligonucleotides specific to IL-23 can be used for immune modulation by targeting DC gene expression. ..
  10. Wolf R, Mascia F, Dharamsi A, Howard O, Cataisson C, Bliskovski V, et al. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90 pubmed publisher
    ..This study provides a pathogenetic psoriasis model using a psoriasis candidate gene to link the epidermis and innate immune system in inflammation priming, highlighting the S100A7A15-RAGE axis as a potential therapeutic target. ..
  11. Doi T, Hara H, Kajita M, Kamiya T, Adachi T. Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2α/ATF4 axis in HAPI cells. Biometals. 2015;28:891-902 pubmed publisher
    ..Taken together, these findings suggest that Zn(2+) up-regulates expression of the IL-23 p19 gene via the eIF2α/ATF4 axis in HAPI cells. ..
  12. Liang S, Tan X, Luxenberg D, Karim R, Dunussi Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-9 pubmed
    ..Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity. ..
  13. Wassink L, Vieira P, Smits H, Kingsbury G, Coyle A, Kapsenberg M, et al. ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells. J Immunol. 2004;173:1779-86 pubmed