Ikzf1

Summary

Gene Symbol: Ikzf1
Description: IKAROS family zinc finger 1
Alias: RGD1562979, DNA-binding protein Ikaros
Species: rat
Products:     Ikzf1

Top Publications

  1. Molnar A, Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol. 1994;14:8292-303 pubmed
    ..The ability of the Ikaros gene to generate functionally diverse proteins that may participate in distinct regulatory pathways substantiates its role as a master regulator during lymphocyte development. ..
  2. Lopez R, Schoetz S, DeAngelis K, O NEILL D, Bank A. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc Natl Acad Sci U S A. 2002;99:602-7 pubmed
    ..These results indicate that Ikaros and PYR complex function together in vivo at many adult hematopoietic cell-specific genes and at intergenic sites, affecting their expression and leading to pleiotropic hematopoietic defects. ..
  3. Boggs S, Trevisan M, Patrene K, Geogopoulos K. Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant mice. Nat Immun. 1998;16:137-45 pubmed
    ..These data suggest that the deficiency of mature NK cells in Ikaros mutant mice is related to lack of functional precursors. ..
  4. Krentz S, Hof J, Mendioroz A, Vaggopoulou R, Dörge P, Lottaz C, et al. Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia. 2013;27:295-304 pubmed publisher
    ..The most common alterations were deletions of CDKN2A/2B, IKZF1, PAX5, ETV6, fusion of ETV6-RUNX1 and deletions and/or mutations of TP53...
  5. Dumortier A, Kirstetter P, Kastner P, Chan S. Ikaros regulates neutrophil differentiation. Blood. 2003;101:2219-26 pubmed
    ..3) Expression of the Gr-1 marker is delayed and repressed. In contrast, neutrophil function appears normal. These data demonstrate that Ikaros regulates early neutrophil differentiation but is dispensable in mature neutrophils. ..
  6. Ström L, Lundgren M, Severinson E. Binding of Ikaros to germline Ig heavy chain gamma1 and epsilon promoters. Mol Immunol. 2003;39:771-82 pubmed
    ..In spite of this, there was no effect on transcription or Ig class switching. The data are discussed in relation to the different hypotheses for the function of Ikaros. ..
  7. Bottardi S, Zmiri F, Bourgoin V, Ross J, Mavoungou L, Milot E. Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. Nucleic Acids Res. 2011;39:3505-19 pubmed publisher
    ..Our results show that Ikaros exerts dual functionality during gene activation, by promoting efficient transcription initiation and elongation. ..
  8. Ezzat S, Mader R, Yu S, Ning T, Poussier P, Asa S. Ikaros integrates endocrine and immune system development. J Clin Invest. 2005;115:1021-9 pubmed
    ..Given the established immunomodulatory properties of glucocorticoid hormones, these findings reveal a novel role for Ikaros in orchestrating immune-endocrine development and function. ..
  9. Georgopoulos K, Bigby M, Wang J, Molnar A, Wu P, Winandy S, et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 1994;79:143-56 pubmed
    ..In the absence of a functional Ikaros gene, these stem cells are exclusively diverted into the erythroid and myeloid lineages. ..

More Information

Publications21

  1. Dijon M, Bardin F, Murati A, Batoz M, Chabannon C, Tonnelle C. The role of Ikaros in human erythroid differentiation. Blood. 2008;111:1138-46 pubmed
    ..We conclude that Ikaros is involved in human adult or fetal erythroid differentiation as well as in the commitment between erythroid and myeloid cells. ..
  2. Ezzat S, Mader R, Fischer S, Yu S, Ackerley C, Asa S. An essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth. Proc Natl Acad Sci U S A. 2006;103:2214-9 pubmed
    ..These findings unmask a wider role for Ikaros in the neuroendocrine system, highlighting a critical contribution to the development of the hypothalamic-pituitary somatotrophic axis. ..
  3. Dorman K, Shen Z, Yang C, Ezzat S, Asa S. CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia. Mol Endocrinol. 2012;26:447-57 pubmed publisher
    ..These results identify putative oncogenic properties of CtBP1 and provide new insights into the overlapping functions of two members of the chromatin remodeling network in the response to hypoxic pituitary tumor cell drive. ..
  4. Elliott J, Jolicoeur C, Ramamurthy V, Cayouette M. Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron. 2008;60:26-39 pubmed publisher
  5. Yamauchi M, Kawai S, Kato T, Ooshima T, Amano A. Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors. Gene. 2008;426:81-90 pubmed publisher
    ..Several Runx2 and Ikzf1 binding sites were found in both mouse and human Osr1 promoters...
  6. Goldman F, Gurel Z, Al Zubeidi D, Fried A, Icardi M, Song C, et al. Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene. Pediatr Blood Cancer. 2012;58:591-7 pubmed publisher
    ..Our report describes a novel case of congenital pancytopenia associated with mutation of the IKAROS gene. Furthermore, these data suggest a critical role of IKAROS in human hematopoiesis and immune development. ..
  7. Li Z, Song C, Ouyang H, Lai L, Payne K, Dovat S. Cell cycle-specific function of Ikaros in human leukemia. Pediatr Blood Cancer. 2012;59:69-76 pubmed publisher
    ..The differences we observe in murine and human Ikaros function highlight the importance of using human cells in studies of ALL. These data identify the CK2 pathway as a target for therapies in ALL. ..
  8. Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, et al. Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett. 1999;447:76-80 pubmed
    ..These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue. ..
  9. Kelley C, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, et al. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol. 1998;8:508-15 pubmed
    ..The preferential expression of Helios in the earliest stages of hematopoiesis suggests that this gene functions predominantly in early progenitors. ..
  10. Uckun F, Ma H, Zhang J, Ozer Z, Dovat S, Mao C, et al. Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc Natl Acad Sci U S A. 2012;109:18072-7 pubmed publisher
    ..Mechanistically, we establish that SYK-induced Ikaros activation is essential for its nuclear localization and optimal transcription factor function. ..
  11. Westman B, Perdomo J, Matthews J, Crossley M, Mackay J. Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers. Biochemistry. 2004;43:13318-27 pubmed
    ..These studies provide the first structural insights into how EosC mediates protein-protein interactions and contributes to our understanding of why it does not exhibit high-affinity DNA binding. ..
  12. Mattar P, Ericson J, Blackshaw S, Cayouette M. A conserved regulatory logic controls temporal identity in mouse neural progenitors. Neuron. 2015;85:497-504 pubmed publisher
    ..castor lies downstream of the early temporal identity factor hunchback, we find that the hunchback ortholog Ikzf1 represses Casz1...