Ikbke

Summary

Gene Symbol: Ikbke
Description: inhibitor of nuclear factor kappa B kinase subunit epsilon
Alias: inhibitor of nuclear factor kappa-B kinase subunit epsilon, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, inhibitor of kappaB kinase epsilon
Species: rat
Products:     Ikbke

Top Publications

  1. Renner F, Moreno R, Schmitz M. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell. 2010;37:503-15 pubmed publisher
    ..SUMO modification of IKKepsilon is required to trigger phosphorylation of nuclear substrates including NF-kappaB p65, thereby contributing to the antiapoptotic function of NF-kappaB in response to DNA damage. ..
  2. Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, et al. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol. 1999;11:1357-62 pubmed
    ..These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response. ..
  3. Hiscott J, Lacoste J, Lin R. Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Biochem Pharmacol. 2006;72:1477-84 pubmed
    ..These observations provide an outline of the mechanism by which HCV evades the IFN antiviral response. ..
  4. Peters R, Liao S, Maniatis T. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell. 2000;5:513-22 pubmed
    ..These observations indicate that the activation of NF-kappaB requires multiple distinct IkappaB kinase complexes, which respond to both overlapping and discrete signaling pathways. ..
  5. Cao C, Zhu Y, Chen W, Li L, Qi Y, Wang X, et al. IKK? knockout prevents high fat diet induced arterial atherosclerosis and NF-?B signaling in mice. PLoS ONE. 2013;8:e64930 pubmed publisher

Detail Information

Publications5

  1. Renner F, Moreno R, Schmitz M. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell. 2010;37:503-15 pubmed publisher
    ..SUMO modification of IKKepsilon is required to trigger phosphorylation of nuclear substrates including NF-kappaB p65, thereby contributing to the antiapoptotic function of NF-kappaB in response to DNA damage. ..
  2. Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, et al. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol. 1999;11:1357-62 pubmed
    ..These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response. ..
  3. Hiscott J, Lacoste J, Lin R. Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Biochem Pharmacol. 2006;72:1477-84 pubmed
    ..These observations provide an outline of the mechanism by which HCV evades the IFN antiviral response. ..
  4. Peters R, Liao S, Maniatis T. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell. 2000;5:513-22 pubmed
    ..These observations indicate that the activation of NF-kappaB requires multiple distinct IkappaB kinase complexes, which respond to both overlapping and discrete signaling pathways. ..
  5. Cao C, Zhu Y, Chen W, Li L, Qi Y, Wang X, et al. IKK? knockout prevents high fat diet induced arterial atherosclerosis and NF-?B signaling in mice. PLoS ONE. 2013;8:e64930 pubmed publisher