Gene Symbol: Ifitm5
Description: interferon induced transmembrane protein 5
Alias: interferon-induced transmembrane protein 5
Moffatt P, Gaumond M, Salois P, Sellin K, Bessette M, Godin E, et al
. Bril: a novel bone-specific modulator of mineralization. J Bone Miner Res. 2008;23:1497-508 pubmed publisher
..Although previously identified in silico as ifitm5, no localization or functional studies had been undertaken on this gene...
Hanagata N, Li X, Morita H, Takemura T, Li J, Minowa T. Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice. J Bone Miner Metab. 2011;29:279-90 pubmed publisher
Interferon-inducible transmembrane protein 5 (IFITM5) is an osteoblast-specific membrane protein whose expression peaks around the early mineralization stage during the osteoblast maturation process...
Hickford D, Frankenberg S, Shaw G, Renfree M. Evolution of vertebrate interferon inducible transmembrane proteins. BMC Genomics. 2012;13:155 pubmed publisher
..Only two IFITM genes, IFITM5 and IFITM10, have orthologues in both marsupials and eutherians...
Farber C, Reich A, Barnes A, Becerra P, Rauch F, Cabral W, et al
. A novel IFITM5 mutation in severe atypical osteogenesis imperfecta type VI impairs osteoblast production of pigment epithelium-derived factor. J Bone Miner Res. 2014;29:1402-11 pubmed
Osteogenesis imperfecta (OI) types V and VI are caused, respectively, by a unique dominant mutation in IFITM5, encoding BRIL, a transmembrane ifitm-like protein most strongly expressed in the skeletal system, and recessive null mutations ..