Gene Symbol: Ifitm2
Description: interferon induced transmembrane protein 2
Alias: Ifitm3l, Ifitml, interferon-induced transmembrane protein 2, interferon induced transmembrane protein 2 (1-8D), interferon induced transmembrane protein, like, interferon-inducible protein 16
Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al
. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
Weidner J, Jiang D, Pan X, Chang J, Block T, Guo J. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646-57 pubmed publisher
..Collectively, our work sheds light on the mechanisms by which tetherin and IFITM3 restrict infection with rhabdoviruses and possibly other pathogenic viruses. ..
Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al
. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. ..
Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. ..
Daido H, Zhou M, Gomez Sanchez E, Gomez Sanchez C. Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells. Mol Cell Endocrinol. 2003;200:81-7 pubmed
..These results show that genes similar to the human 1-8 gene family are expressed in rat adrenal glomerulosa cells and VSMC, but their expression is not regulated by A-II. The function of these genes in VSMC and adrenal is unknown. ..
Lau S, Yuen M, Kou C, Au K, Zhou J, Tsui S. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes. J Cell Biochem. 2012;113:841-7 pubmed publisher
..The expression levels of three IFITM family members, IFITM1, IFITM2, and IFITM3 were investigated during Sprague-Dawley rat myocardial development and differentiation of H9C2 ..
Zhang Z, Liu J, Li M, Yang H, Zhang C. Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates. PLoS ONE. 2012;7:e49265 pubmed publisher
..Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity...
Li K, Markosyan R, Zheng Y, Golfetto O, Bungart B, Li M, et al
. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013;9:e1003124 pubmed publisher
..suppressed syncytia formation and cell-cell fusion induced by almost all viral fusion proteins examined; IFITM2 and IFITM3 also strongly inhibited their fusion, with efficiency somewhat dependent on cell types...