Gene Symbol: Ifitm1
Description: interferon induced transmembrane protein 1
Alias: interferon-induced transmembrane protein 1
Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al
. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
..We discovered that the interferon-inducible transmembrane proteins IFITM1, 2, and 3 restrict an early step in influenza A viral replication...
Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al
. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein...
Lickert H, Cox B, Wehrle C, Taketo M, Kemler R, Rossant J. Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005;132:2599-609 pubmed
..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets. ..
Zhang Z, Liu J, Li M, Yang H, Zhang C. Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates. PLoS ONE. 2012;7:e49265 pubmed publisher
..Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity...
Jia R, Ding S, Pan Q, Liu S, Qiao W, Liang C. The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity. PLoS ONE. 2015;10:e0118794 pubmed publisher
..We previously reported the inhibition of human immunodeficiency virus type 1 (HIV-1) strain BH10 by human IFITM1, 2 and 3...
Lau S, Yuen M, Kou C, Au K, Zhou J, Tsui S. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes. J Cell Biochem. 2012;113:841-7 pubmed publisher
..The expression levels of three IFITM family members, IFITM1, IFITM2, and IFITM3 were investigated during Sprague-Dawley rat myocardial development and differentiation of H9C2 ..