Gene Symbol: ICAM
Description: intercellular adhesion molecule 1
Alias: CD54, ICAM, intercellular adhesion molecule 1, ICAM-1
Species: rat
Products:     ICAM

Top Publications

  1. Chen S, Chen W, Hayakawa S, Li P, Chien C. Acute urinary bladder distension triggers ICAM-1-mediated renal oxidative injury via the norepinephrine-renin-angiotensin II system in rats. J Formos Med Assoc. 2009;108:627-35 pubmed
    ..and end-organ damage via activation of angiotensin-II-receptor-mediated intercellular adhesion molecule-1 (ICAM-1) expression and leukocyte infiltration in the kidney...
  2. Joussen A, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand S, et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol. 2002;160:501-9 pubmed
    ..Previous work has shown that intercellular adhesion molecule-1 (ICAM-1) and CD18 are required for these processes...
  3. Ma J, Möllsten A, Prázný M, Falhammar H, Brismar K, Dahlquist G, et al. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy. Diabet Med. 2006;23:1093-9 pubmed
    The intercellular adhesion molecule-1 (ICAM-1) gene is located on chromosome 19p13, which is linked to Type 1 diabetes (T1D). ICAM-1 expression is related to development of T1D and diabetic nephropathy...
  4. Greenwood J, Amos C, Walters C, Couraud P, Lyck R, Engelhardt B, et al. Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol. 2003;171:2099-108 pubmed
    To examine the role of the ICAM-1 C-terminal domain in transendothelial T lymphocyte migration and ICAM-1-mediated signal transduction, mutant human (h)ICAM-1 molecules were expressed in rat brain microvascular endothelial cells...
  5. Masamune A, Sakai Y, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro. Pancreas. 2002;25:78-85 pubmed
    ..of PSCs in pancreatic inflammation by determining whether activated PSCs express intercellular adhesion molecule-1 (ICAM-1)...
  6. Barreiro O, Yanez Mo M, Serrador J, Montoya M, Vicente Manzanares M, Tejedor R, et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol. 2002;157:1233-45 pubmed
    ..spreading on the endothelium, whereas only moesin participated in TEM, following the same distribution pattern as ICAM-1...
  7. Kapsogeorgou E, Dimitriou I, Abu Helu R, Moutsopoulos H, Manoussakis M. Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells. Clin Exp Immunol. 2001;124:126-33 pubmed
    ICAM.1 (CD54) is a surface protein expressed on epithelial and other nonhematopoietic cells upon activation and is known to play an important role in the stimulation of T cells by the provision of cellular adhesion and costimulatory ..
  8. Milicevic N, Nohroudi K, Milicevic Z, Westermann J. Blood lymphocytes, monocytes and NK cells modulate their expression of CD44, ICAM-1, LFA-1 and MHC class II after arrival into lymphoid organs. Immunol Invest. 2004;33:439-52 pubmed
    ..The helper and cytotoxic subsets of T cells, as well as B cells, display the increased expression of CD44, ICAM-1 and LFA-1, whereas B cells additionally show the augmented expression of MHC class II...
  9. Kim D, Kim Y, Chang S, Lee H, Kim H, Kim H, et al. The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy. Eur J Heart Fail. 2010;12:1051-60 pubmed publisher
    ..analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-?, IL-1?, ICAM-1, and VCAM-1...

More Information


  1. Yang J, Gu Y, Huang X, Shen A, Cheng C. Dynamic changes of ICAM-1 expression in peripheral nervous system following sciatic nerve injury. Neurol Res. 2011;33:75-83 pubmed publisher
    ..Recent studies provide evidence that intercellular adhesion molecule-1 (ICAM-1) is involved not only in inflammation, but also in cell recruitment during Wallerian degeneration after ..
  2. Mahmoud M, Salem A, Rifaat M. Human giardiasis as an etiology of skin allergy: the role of adhesion molecules and interleukin-6. J Egypt Soc Parasitol. 2004;34:723-37 pubmed
    The role of adhesion molecules; the intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) as mediators in development of skin allergy caused by giardiasis and the controlling role of the cytokine ..
  3. Lu L, Zhang J, Ramires F, Sun Y. Molecular and cellular events at the site of myocardial infarction: from the perspective of rebuilding myocardial tissue. Biochem Biophys Res Commun. 2004;320:907-13 pubmed
    ..Requisite to these objectives is the expression of adhesion molecules (ICAM-1) and chemoattractant cytokines (MCP-1), matrix metalloproteinase (MMP) activity, a neovasculature, and fibrillar ..
  4. Kleinjan A, Willart M, van Nimwegen M, Leman K, Hoogsteden H, Hendriks R, et al. United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation. Clin Exp Allergy. 2010;40:494-504 pubmed publisher
    ..increased numbers of eosinophils in bronchoalveolar lavage fluid and increased inter-cellular adhesion molecule-1 (ICAM-1) expression on lung endothelium, when compared with OVA-sensitized controls...
  5. Wada J, Shikata K, Makino H, Morioka S, Hirata K, Ota K, et al. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Nephron. 1996;73:264-72 pubmed
    Intercellular adhesion molecule-1 (ICAM-1, CD54), an adhesion molecule of the immunoglobulin superfamily, is an endothelial cell surface ligand for such leukocyte integrins as lymphocyte-function-associated molecule 1 (LFA-1, CD11a/CD18), ..
  6. Collins K, White W. Intercellular adhesion molecule 1 (ICAM-1) and bcl-2 are differentially expressed in early evolving malignant melanoma. Am J Dermatopathol. 1995;17:429-38 pubmed
    The expression of intercellular adhesion molecule 1 (ICAM-1), a molecule pivotal in many inflammatory and immune paracrine interactions, has been highly correlated with malignant melanoma (MM) progression...
  7. Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher E, et al. Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol. 1995;7:1557-65 pubmed
    ..Our data suggest that HSA, in addition to the recently identified 160 kDa glycoprotein ligand on mouse neutrophils, belongs to a group of monospecific P-selectin ligands on myeloid cells. ..
  8. Yun Y, Hou L, Sang N. SO(2) inhalation modulates the expression of pro-inflammatory and pro-apoptotic genes in rat heart and lung. J Hazard Mater. 2011;185:482-8 pubmed publisher
    ..rats were treated with 7, 14 and 28 mg/m(3) SO(2) for 6h/day for 7 days, and the mRNA levels of TNF-?, IL-1?, iNOS, ICAM-1, Bax and Bcl-2 and subsequent insults were determined in the heart and lung...
  9. Lee W, Sonntag W, Lee Y. Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neurosci Lett. 2010;476:89-93 pubmed publisher
    ..factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), and matrix ..
  10. Tang C, Xue H, Bai C, Fu R, Wu A. The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. Phytomedicine. 2010;17:1145-9 pubmed publisher
    ..decreased BBB permeability to Evans blue, suppressed the expression of intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), inhibited the degradation of tight junction proteins zonula occludens-1 (ZO-..
  11. Martins J, Zanoni F, Martins D, Coimbra R, Krieger J, Jancar S, et al. Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats. Shock. 2009;31:404-9 pubmed publisher
    ..The goal of this study was to investigate whether insulin regulates transcription of cytokines and intercellular adhesion molecule 1 (ICAM-1) via nuclear factor-kappaB (NF-kappaB) signaling pathway in Escherichia coli LPS-induced ..
  12. Yang Q, Liu X, Liu M, Zhang L, Guan Y. Ulinastatin-mediated protection against zymosan-induced multiple organ dysfunction in rats. Biologicals. 2010;38:552-6 pubmed publisher
    ..In conclusion, ulinastatin is able to protect multiple organs from yeast polysaccharide-induced damage and function failure, at least partially, through a TLR4-dependent mechanism, suggesting a therapeutic potential against MODS. ..
  13. Machelska H, Mousa S, Brack A, Schopohl J, Rittner H, Schafer M, et al. Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J Neurosci. 2002;22:5588-96 pubmed
    ..Intercellular adhesion molecule-1 [ICAM-1 (or CD54)] is expressed by endothelium and mediates adhesion and extravasation of leukocytes...
  14. Straczkowski M, Lewczuk P, Dzienis Straczkowska S, Kowalska I, Stepien A, Kinalska I. Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity. Metabolism. 2002;51:75-8 pubmed
    Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear...
  15. Domagala Kulawik J, Maskey Warzechowska M, Krenke R, Chazan R. Role of bronchoalveolar lavage in the initial diagnosis of smoking-related interstitial lung diseases. J Physiol Pharmacol. 2008;59 Suppl 6:243-51 pubmed
    ..Mean proportion of CD14 positive macrophages was 6%, and of CD54 positive macrophages - 62%...
  16. Zhu H, Guo Y, Zhang J, Hu M, Tang J, Tian D, et al. Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft. Hepatobiliary Pancreat Dis Int. 2007;6:379-82 pubmed
    ..The present experiment was designed to study the expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) mRNA in liver graft and to elucidate the role of Kupffer cells and the sympathetic nerve of the liver in down-..
  17. Xie L, Galettis A, Morris J, Jackson C, Twigg S, Gallery E. Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes Metab Res Rev. 2008;24:294-300 pubmed
    ..from both normal and diabetic pregnancies, and to examine the involvement of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in regulation of such adhesion...
  18. Motojima K, Azuma K, Kitahara Y, Miura K, Mita T, Hirose T, et al. Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats. Endocr J. 2008;55:373-9 pubmed
    ..Consumption of high-fat diet resulted in overexpression of heme oxygenase-1, intercellular adhesion molecule-1 (ICAM-1), and connecting segment-1 fibronectin on the arterial wall, compared with standard diet...
  19. Hang C, Shi J, Li J, Li W, Yin H. Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats. World J Gastroenterol. 2005;11:1149-54 pubmed
    ..to critical illnesses, but it is not known if and how NF-kappaB is activated and intercellular adhesion molecule-1 (ICAM-1) expressed in the gut following traumatic brain injury (TBI)...
  20. Higano C, Schellhammer P, Small E, Burch P, Nemunaitis J, Yuh L, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer. 2009;115:3670-9 pubmed publisher
    ..support for the activity of sipuleucel-T is provided by the correlation between a measure of the product's potency, CD54 up-regulation, and overall survival...
  21. Mozaffari M, Abdelsayed R, Zakhary I, El Salanty M, Liu J, Wimborne H, et al. Submandibular gland and caries susceptibility in the obese Zucker rat. J Oral Pathol Med. 2011;40:194-200 pubmed publisher
    ..We also examined the potential impact of chromium picolinate (Cr(Pic)3), a nutritional supplement suggested to improve glycemic control, on the aforementioned parameters...
  22. Wilkinson Berka J, Heine R, Tan G, Cooper M, Hatzopoulos K, Fletcher E, et al. RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina. Hypertension. 2010;55:1454-60 pubmed publisher
  23. Ou J, Zhang X, Wu C, Wu D, Yan P. Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis. J Zhejiang Univ Sci B. 2012;13:919-31 pubmed publisher
    ..liver, kidneys, and lungs), toll-like receptor 4 (TLR-4) protein levels (only in the liver), intercellular adhesion molecule 1 (ICAM-1) protein levels (only in the lung), and terminal deoxynucleotidy transferase mediated ..
  24. Shinoda H, Huang C. Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. Eur Arch Otorhinolaryngol. 1995;252:385-90 pubmed
    Intercellular adhesion molecule-1 (ICAM-1) may have a role in acquired cholesteatoma, which is usually associated with an inflammatory reaction occurring in the middle ear cavity...
  25. Huang Y, Richardson J, Vitetta E. Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Cancer Res. 1995;55:610-6 pubmed
    Recent studies have suggested that ICAM-1 (CD54) is involved in the pathogenesis of human multiple myeloma. A monoclonal antihuman CD54 antibody has been generated by immunizing BALB/c mice with human myeloma cell lines...
  26. Schaper C, Gustavus B, Koch B, Ewert R, Hanf G, Kunkel G, et al. Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. J Investig Allergol Clin Immunol. 2009;19:459-64 pubmed
    ..The changes observed in the markers analyzed in both nasal secretions and serum are attributable to the anti-inflammatory effects of fexofenadine in vivo. ..
  27. Siu G, Hedrick S, Brian A. Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation. J Immunol. 1989;143:3813-20 pubmed
    ..One such molecule, intercellular adhesion molecule 1 (ICAM-1), is important in the function, aggregation, and adherence of leukocytes...
  28. Han F, An Y, Zhao C. [Alteration of cytokines and mucin in lower respiratory tract in allergic rhinitis model in rats]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:339-42 pubmed
    ..IL-4) in bronchial alveolus lavage fluid (BALF) and the expression of intercellular adhesion molecule-1 (ICAM-1) and MUC5AC in nasal and lung tissue, respectively...
  29. Pola R, Flex A, Gaetani E, Santoliquido A, Serricchio M, Pola P, et al. Intercellular adhesion molecule-1 K469E gene polymorphism and Alzheimer's disease. Neurobiol Aging. 2003;24:385-7 pubmed
    ..Intercellular adhesion molecule-1 (ICAM-1) is an important mediator of inflammatory response and immune cell activation, is expressed on cerebrovascular ..
  30. Lu S, Wang X, Wen L, Han Z, Tao T, Guan D. [Effect of superoxide dismutase on adhesion molecules expression in skeletal muscle ischemia/reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2002;82:840-3 pubmed
    To study the effect of SOD on the expression of CD11b/CD18 and ICAM-1 after skeletal muscle ischemia / reperfusion injury in rats. Establish the rat model of hind limb ischemia / reperfusion...
  31. Roh H, Yoo D, Ko S, Kim Y, Kim J. Bacteroides fragilis enterotoxin upregulates intercellular adhesion molecule-1 in endothelial cells via an aldose reductase-, MAPK-, and NF-?B-dependent pathway, leading to monocyte adhesion to endothelial cells. J Immunol. 2011;187:1931-41 pubmed publisher
    ..We investigated whether BFT affected the expression of ICAM-1 and monocytic adhesion to endothelial cells (ECs)...
  32. Hu X, Sun A, Xie X, Huang Z, Jia J, Yao R, et al. Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. J Cardiovasc Pharmacol Ther. 2013;18:162-76 pubmed publisher
    ..1 (SDF-1), chemokine motif CXC receptor 4 (CXCR-4), vascular endothelial growth factor (VEGF), and intercellular adhesion molecule 1 (ICAM-1) in peri-infarction region and nonischemic region at different time points were determined ..
  33. Atay S, Gercel Taylor C, Kesimer M, Taylor D. Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells. Exp Cell Res. 2011;317:1192-202 pubmed publisher
    ..This characterization is essential in furthering our understanding of "normal" early pregnancy. ..
  34. Whitcup S, Hikita N, Shirao M, Miyasaka M, Tamatani T, Mochizuki M, et al. Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis. Exp Eye Res. 1995;60:597-601 pubmed
    We studied the effect of monoclonal antibodies (mAbs) against CD54 (intercellular adhesion molecule-1; ICAM-1) and CD11a (lymphocyte function-associated antigen-1; LFA-1) on the prevention and treatment of endotoxin-induced uveitis (EIU)...
  35. Wu R, Zhou Q, Lin S, Ao X, Chen X, Yang J. [Effect of Cordceps Sinensis on the expression of ICAM-1 and VCAM-1 in the kidney of spontaneously hypertensive rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:152-8 pubmed publisher
    To observe the effect of Cordceps Sinensis (CS) on the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the kidney of spontaneously hypertensive rats(SHR), and to investigate the ..
  36. Ware L, Koyama T, Billheimer D, Wu W, Bernard G, Thompson B, et al. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010;137:288-96 pubmed publisher
    ..From a pathogenesis perspective, the degree of acute inflammation and alveolar epithelial injury are highly associated with the outcome of human ALI/ARDS. ..
  37. Heilman K, Zilmer M, Zilmer K, Tillmann V. Lower bone mineral density in children with type 1 diabetes is associated with poor glycemic control and higher serum ICAM-1 and urinary isoprostane levels. J Bone Miner Metab. 2009;27:598-604 pubmed publisher
    ..total mineral content adjusted for age and height (BMCadj), and measured plasma intercellular adhesion molecule-1 (ICAM-1), high sensitivity C-reactive protein (hs-CRP), and urinary 8-iso-prostaglandin F(2a) (F(2)-IsoPs)...
  38. Nordal R, Wong C. Intercellular adhesion molecule-1 and blood-spinal cord barrier disruption in central nervous system radiation injury. J Neuropathol Exp Neurol. 2004;63:474-83 pubmed
    ..Increased expression of intercellular adhesion molecule-1 (ICAM-1) accompanies and is believed to be important in BBB disruption in other CNS injuries...
  39. Hirose F, Kiryu J, Miyamoto K, Nishijima K, Miyahara S, Katsuta H, et al. In vivo evaluation of retinal injury after transient ischemia in hypertensive rats. Hypertension. 2004;43:1098-102 pubmed
    ..Intercellular adhesion molecule-1 (ICAM-1) mRNA expression was studied by semiquantitative polymerase chain reaction and ICAM-1 protein levels were studied ..
  40. Krauss K, Altevogt P. Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J Biol Chem. 1999;274:36921-7 pubmed
    ..We report here that LFA-1-mediated binding of mouse thymocytes or activated T lymphocytes to intercellular adhesion molecule 1 can be rapidly induced by clustering of membrane rafts using antibodies to the ..
  41. Limb G, Chignell A. Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy. Br J Ophthalmol. 1999;83:953-6 pubmed
    To investigate whether high vitreous levels of the soluble intercellular adhesion molecule 1 (sICAM-1) may be related to clinical risk factors of proliferative vitreoretinopathy (PVR) and whether their measurement may serve as an ..
  42. Friedrich V, Bi W, Sehba F. Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage. Neurol Res. 2015;37:1054-9 pubmed publisher
  43. Hattori T, Matsubara A, Taniguchi K, Ogura Y. Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. Curr Eye Res. 2010;35:146-54 pubmed publisher
    ..In this study, we investigated the effect of fidarestat on leukocyte-endothelial cell interactions in an in vivo experimental model for diabetic retina...
  44. Xiao X, Cheng C, Mruk D. Intercellular adhesion molecule-1 is a regulator of blood-testis barrier function. J Cell Sci. 2012;125:5677-89 pubmed publisher
    ..In the present study, we show that intercellular adhesion molecule-1 [ICAM-1, a Sertoli and germ cell adhesion protein having five immunoglobulin (Ig)-like domains, in addition to ..
  45. Lv X, Tan J, Liu D, Wu P, Cui X. Intratracheal administration of p38? short-hairpin RNA plasmid ameliorates lung ischemia-reperfusion injury in rats. J Heart Lung Transplant. 2012;31:655-62 pubmed publisher
    ..We determined the levels of inflammatory cytokines, the level of intercellular adhesion molecule 1 (ICAM-1), c-Myc mRNA expression, and ICAM-1 protein expression, and the presence of cell apoptosis...
  46. Howell C, Li J, Chen W. Role of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 during nonsuppurative destructive cholangitis in a mouse graft-versus-host disease model. Hepatology. 1999;29:766-76 pubmed
    Intercellular adhesion molecule-1 (ICAM-1) is expressed abnormally on the bile duct epithelium during the course of primary biliary cirrhosis (PBC), but the importance of ICAM-1 and its lymphocyte function-associated antigen-1 (LFA-1) ..
  47. Donadio A, Remedi M, Frede S, Bonacci G, Chiabrando G, Pistoresi Palencia M. Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo. Clin Exp Metastasis. 2002;19:437-44 pubmed
    ..from a spontaneous rat sarcoma revealed, by flow cytometry, a high frequency of intercellular adhesion molecule-1 (ICAM-1, 70.1 +/- 8.7%) and urokinase-type plaminogen activator receptor (uPAR, 51.2 +/- 5...
  48. Huang H, Pan Y, Ye Y, Gao M, Yin Z, Luo L. Dipyrithione attenuates oleic acid-induced acute lung injury. Pulm Pharmacol Ther. 2011;24:74-80 pubmed publisher
    ..Immunohistochemical observion displayed that PTS2 inhibited OA-induced enhanced expression of VCAM-1 and ICAM-1 in lung tissue...
  49. Leal E, Martins J, Voabil P, Liberal J, Chiavaroli C, Bauer J, et al. Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes. 2010;59:2637-45 pubmed publisher
    ..of tight junction proteins (occludin, claudin-5, and zonula occluden-1 [ZO-1]), intercellular adhesion molecule-1 (ICAM-1), and p38 mitogen-activated protein kinase (p38 MAPK) was evaluated by Western blotting and immunohistochemistry...
  50. Krauss T, Kuhn W, Lakoma C, Augustin H. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol. 1997;177:443-9 pubmed
    ..immunosorbent assay technique was used to quantitate concentrations of soluble intercellular adhesion molecule-1 (CD54), vascular cell adhesion molecule-1 (CD106), E-selectin (CD62E), platelet endothelial cell adhesion molecule (CD31),..
  51. Kurose I, Saito H, Miura S, Ebinuma H, Higuchi H, Watanabe N, et al. CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. J Clin Invest. 1997;99:867-78 pubmed
    ..Monoclonal antibodies directed against rat CD18 and ICAM-1, as well as TMB-8, a calcium inhibitor, prevented the calcium mobilization, active oxygen production, and NF-..
  52. Totoson P, Maguin Gaté K, Nappey M, Prati C, Wendling D, Demougeot C. Microvascular abnormalities in adjuvant-induced arthritis: relationship to macrovascular endothelial function and markers of endothelial activation. Arthritis Rheumatol. 2015;67:1203-13 pubmed publisher
    ..function was studied in aortic rings, and blood pressure, plasma levels of C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured at each time point...
  53. Wang H, Nawata J, Kakudo N, Sugimura K, Suzuki J, Sakuma M, et al. The upregulation of ICAM-1 and P-selectin requires high blood pressure but not circulating renin-angiotensin system in vivo. J Hypertens. 2004;22:1323-32 pubmed
    ..after constriction of the abdominal aortas of Wistar rats, the expressions of intercellular adhesion molecule-1 (ICAM-1), P-selectin, nuclear factor (NF) kappa B p65 subunit and monocytes were assessed at sites proximal and distal to ..