Gene Symbol: Hyou1
Description: hypoxia up-regulated 1
Alias: Cab140, Orp150, hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, ORP-150, oxygen regulated protein (150kD)
Species: rat
Products:     Hyou1

Top Publications

  1. Kitao Y, Hashimoto K, Matsuyama T, Iso H, Tamatani T, Hori O, et al. ORP150/HSP12A regulates Purkinje cell survival: a role for endoplasmic reticulum stress in cerebellar development. J Neurosci. 2004;24:1486-96 pubmed
    ..b>ORP150 (oxygen-regulated protein 150)/HSP12A (heat shock protein 12A), a novel stress protein located in the ER, was ..
  2. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, et al. ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med. 2001;7:317-23 pubmed
    Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia...
  3. Aleshin A, Sawa Y, Kitagawa Sakakida S, Bando Y, Ono M, Memon I, et al. 150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart. J Mol Cell Cardiol. 2005;38:517-25 pubmed
    ..Here, we found that 24 h of hypoxia and 1 h of reoxygenation induced the expression of the chaperone ORP150 in cultured rat cardiomyocytes...
  4. Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O, et al. 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Am J Physiol Cell Physiol. 2000;278:C1172-82 pubmed
    To assess the participation of the 150-kDa oxygen-regulated protein (ORP150) in protein transport, its function in Madin-Darby canine kidney (MDCK) cells was studied...
  5. Wei H, Wang F, Wang X, Yang J, Li Z, Cong X, et al. Lysophosphatidic acid promotes secretion of VEGF by increasing expression of 150-kD Oxygen-regulated protein (ORP150) in mesenchymal stem cells. Biochim Biophys Acta. 2013;1831:1426-34 pubmed publisher
    ..LPA also increased ORP150 protein expression. Inhibition of ORP150 upregulation by siRNA knockdown attenuated LPA-induced VEGF secretion...
  6. Cunningham C, He K, Arunagiri A, Paton A, Paton J, Arvan P, et al. Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes. 2017;66:741-753 pubmed publisher
    ..In principle, selective destruction of mutant proinsulin offers a rational approach to rectify the insulin secretion problem in MIDY. ..
  7. Kuwabara K, Matsumoto M, Ikeda J, Hori O, Ogawa S, Maeda Y, et al. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem. 1996;271:5025-32 pubmed
    ..b>ORP150 expression in hypoxic astrocytes resulted from de novo protein synthesis, as shown by inhibition in the presence ..
  8. Kuznetsov G, Chen L, Nigam S. Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem. 1997;272:3057-63 pubmed
    ..We therefore propose that these ER chaperones complex together with a variety of large oligomeric secretory glycoproteins as they fold and assemble in the ER. ..
  9. Kitao Y, Imai Y, Ozawa K, Kataoka A, Ikeda T, Soda M, et al. Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet. 2007;16:50-60 pubmed
    ..by their decreased survival in mice deficient in the ubiquitin-protein ligase Parkin and the ER chaperone ORP150 (150 kDa oxygen-regulated protein)...

More Information


  1. Arrington D, Schnellmann R. Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress. Am J Physiol Cell Physiol. 2008;294:C641-50 pubmed
    Oxygen-regulated protein 150 (ORP150) is an inducible endoplasmic reticulum (ER) chaperone molecule that is upregulated after numerous cellular insults and has a cytoprotective role in renal, neural, and cardiac models of ischemia-..
  2. Deng W, Chen C, Wang W, Yu J, Li J, Liu L. Effects of ORP150 on appearance and function of pancreatic beta cells following acute necrotizing pancreatitis. Pathol Res Pract. 2011;207:370-6 pubmed publisher
    ..The 150kD oxygen-regulated protein (ORP150) took part in the process of endoplasmic reticulum stress...
  3. Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M, et al. Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun. 1997;230:94-9 pubmed
    We have cloned a cDNA encoding the human 150 kDa oxygen-regulated protein (ORP150) from hypoxia-treated astrocytoma U373 cDNA library...
  4. Matsushita K, Matsuyama T, Nishimura H, Takaoka T, Kuwabara K, Tsukamoto Y, et al. Marked, sustained expression of a novel 150-kDa oxygen-regulated stress protein, in severely ischemic mouse neurons. Brain Res Mol Brain Res. 1998;60:98-106 pubmed
    The 150-kDa oxygen-regulated protein (ORP150) first was described with reference to the central nervous system in cultured astrocytes subjected to dense hypoxia...
  5. Ozawa K, Kuwabara K, Tamatani M, Takatsuji K, Tsukamoto Y, Kaneda S, et al. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. J Biol Chem. 1999;274:6397-404 pubmed
    To determine the contribution of 150-kDa oxygen-regulated protein (ORP150) to cellular processes underlying adaptation to hypoxia, a cell line stably transfected to overexpress ORP150 antisense RNA was created...
  6. Ohse T, Inagi R, Tanaka T, Ota T, Miyata T, Kojima I, et al. Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells. Kidney Int. 2006;70:1447-55 pubmed
    ..7- and 4.6-fold (glucose-regulated protein 78 (GRP78) and oxygen-regulated protein 150 (ORP150), respectively) as compared to control...
  7. Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher