Htr1a

Summary

Gene Symbol: Htr1a
Description: 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Alias: 5HT1A, RAT5HT1A, 5-HT-1A, 5-HT1A, 5-hydroxytryptamine receptor 1A, serotonin receptor 1A
Species: rat

Top Publications

  1. pmc Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
    L K Heisler
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Proc Natl Acad Sci U S A 95:15049-54. 1998
  2. doi Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety
    Esther Molina
    CIBERSAM, University of Granada, Section of Psychiatry, Institute of Neurosciences, Biomedical Research Centre CIBM, San Cecilio University Hospital, Granada
    Psychiatr Genet 21:195-201. 2011
  3. ncbi Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system
    Jérôme Bonnefont
    INSERM U766 Pharmacologie Fondamentale et Clinique de la Douleur, Facultes de Medecine et de Pharmacie, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Mol Pharmacol 71:407-15. 2007
  4. pmc Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress
    A H Iyo
    Department of Psychiatry and Human Behavior, Center for Psychiatric Neuroscience, University of Mississippi Medical Center, School of Medicine, Jackson, MS 39216, USA
    Neuroscience 163:1119-27. 2009
  5. pmc Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex
    Niamh Kieran
    Department of Psychiatry and Human Behavior and Center for Psychiatric Neuroscience, University of Mississippi Medical Center, School of Medicine, Jackson, MS 39216, USA
    Neurosci Lett 469:380-4. 2010
  6. pmc Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression
    Eduardo A Pineda
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Neuropsychopharmacology 36:1305-16. 2011
  7. pmc Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
    Hilda Ahnstedt
    Department of Clinical Sciences, Lund University, Sweden
    BMC Neurosci 12:5. 2011
  8. doi Activation of serotonin 1A receptors in ventrolateral orbital cortex depresses persistent nociception: a presynaptic inhibition mechanism
    Fu Quan Huo
    Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an, China
    Neurochem Int 57:749-55. 2010
  9. doi Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats
    K Zavitsanou
    Life Sciences, Australian Nuclear Science and Technology Organisation, Sydney, Australia Schizophrenia Research Institute, Sydney, Australia
    Neuroscience 169:315-24. 2010
  10. pmc Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons
    Y Yao
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Box 29, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Neuroscience 169:87-97. 2010

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. pmc Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
    L K Heisler
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Proc Natl Acad Sci U S A 95:15049-54. 1998
    ..5-HT1A receptor-null mutant mice have potential as a model for investigating mechanisms through which serotonergic systems modulate affective state and mediate the actions of psychiatric drugs...
  2. doi Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety
    Esther Molina
    CIBERSAM, University of Granada, Section of Psychiatry, Institute of Neurosciences, Biomedical Research Centre CIBM, San Cecilio University Hospital, Granada
    Psychiatr Genet 21:195-201. 2011
    ..Previous studies have yielded inconclusive results as to whether the 5-HT1A receptor gene (HTR1A) has a role in the aetiology of MD and no study up to date has analysed this polymorphism on either pure MD or MD ..
  3. ncbi Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system
    Jérôme Bonnefont
    INSERM U766 Pharmacologie Fondamentale et Clinique de la Douleur, Facultes de Medecine et de Pharmacie, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Mol Pharmacol 71:407-15. 2007
    ....
  4. pmc Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress
    A H Iyo
    Department of Psychiatry and Human Behavior, Center for Psychiatric Neuroscience, University of Mississippi Medical Center, School of Medicine, Jackson, MS 39216, USA
    Neuroscience 163:1119-27. 2009
    ....
  5. pmc Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex
    Niamh Kieran
    Department of Psychiatry and Human Behavior and Center for Psychiatric Neuroscience, University of Mississippi Medical Center, School of Medicine, Jackson, MS 39216, USA
    Neurosci Lett 469:380-4. 2010
    ....
  6. pmc Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression
    Eduardo A Pineda
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Neuropsychopharmacology 36:1305-16. 2011
    ..Downregulation of postsynaptic 5-HT1A receptors may further exacerbate the severity of epilepsy-associated depression...
  7. pmc Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
    Hilda Ahnstedt
    Department of Clinical Sciences, Lund University, Sweden
    BMC Neurosci 12:5. 2011
    ..Contractile properties were evaluated in a myograph and protein expression of the individual receptors and activated phosphorylated B-Raf (p-B-Raf) was evaluated immunohistochemically...
  8. doi Activation of serotonin 1A receptors in ventrolateral orbital cortex depresses persistent nociception: a presynaptic inhibition mechanism
    Fu Quan Huo
    Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an, China
    Neurochem Int 57:749-55. 2010
    ....
  9. doi Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats
    K Zavitsanou
    Life Sciences, Australian Nuclear Science and Technology Organisation, Sydney, Australia Schizophrenia Research Institute, Sydney, Australia
    Neuroscience 169:315-24. 2010
    ..In the present study, the effects of cannabinoid treatment on serotonin 5HT1A receptor density and mRNA expression were investigated in two age groups: Adolescent (postnatal day 35) and adult (..
  10. pmc Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons
    Y Yao
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Box 29, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Neuroscience 169:87-97. 2010
    ..The effect would be expected to have physiological consequences for 5-HT-mediated inhibitory post synaptic potentials and the Ca(2+) component of the action potentials of dr neurons...
  11. pmc Changes in 5-HT1A receptor expression in the oculomotor nucleus in a rat model of post-traumatic stress disorder
    Dongjuan Liu
    Department of Electron Microscopy, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, 110001, China
    J Mol Neurosci 49:360-8. 2013
    ..These results suggest that SPS can induce a change of the 5-HT1AR expression in the oculomotor nucleus, which may be one of the molecular mechanisms that lead to PTSD...
  12. ncbi Increase in the effectiveness of somatodendritic 5-HT-1A receptors in a rat model of tardive dyskinesia
    Noreen Samad
    Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory, University of Karachi, Karachi 75270, Pakistan
    Acta Neurobiol Exp (Wars) 67:389-97. 2007
    ..The 5-HT-1A agonist may help to alleviate neuroleptic-induced TD...
  13. ncbi 8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors
    I S Ebenezer
    Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, England, UK
    Methods Find Exp Clin Pharmacol 29:269-72. 2007
    ..3 mg/kg). The results of this study show that the acute dose-dependent depressant effect of 8-OH-DPAT on food intake in fasted rats is mediated by an action at 5-HT1A receptors...
  14. doi 5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission
    L Costa
    Department of Biomedical Sciences, Section of Physiology, University of Catania, Italy
    Hippocampus 22:790-801. 2012
    ..In this respect, we underline the need for new selective agonists of 5-HT(7) receptors...
  15. pmc Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Exp Neurol 229:288-99. 2011
    ..These findings indicate a novel anti-dyskinetic mechanism of action for 5-HT(1A)R agonists with implications for the improved treatment of Parkinson's disease...
  16. doi The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurosci 32:6295-303. 2012
    ..Similar results were reached with the FRET technique in HEK293T cells, where TM-V of the 5HT1A receptor was found to be part of the receptor interface...
  17. ncbi Binding thermodynamics of 5-HT1A receptor ligands
    A Dalpiaz
    Istituto di Farmacologia, Universita di Ferrara, Italy
    Eur J Pharmacol 312:107-14. 1996
    ..The results are discussed from a quantitative point of view with the aim of obtaining new details on the nature of the forces driving the 5-HT1A binding at a molecular level...
  18. doi 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity
    Kevin P Grace
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 32:1622-33. 2012
    ..These data indicate that 5-HT(1A) receptor-responsive PPTn neurons normally function to restrain REM sleep by elevating the drive threshold for REM sleep induction, and restrain the expression of respiratory rate and motor activities...
  19. pmc Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat
    N J Penington
    Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637
    J Physiol 469:387-405. 1993
    ..8. These results show that in acutely isolated adult DR neurones 5-HT activates an inwardly rectifying K+ current and this involves a PTX-sensitive G-protein in the transduction pathway which may interact with the K+ channel directly...
  20. ncbi Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors
    Inmaculada Bellido
    Department of Pharmacology and Clinical Therapeutics, School of Medicine, University of Malaga, MA 29071, Malaga, Spain
    Neuroreport 15:1457-9. 2004
    ..Glucocorticoids, by enhancing dorsal raphe 5-HT1A autoreceptor function, may therefore cause reduced 5-HT neuronal activity and thus lead to a depressive state...
  21. doi 5HT(1A) and 5HT(1B) receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats
    Jalal Solati
    Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran
    Neurosci Lett 504:325-9. 2011
    ..5, 1, and 2 μg/rat) into the MPFC showed no significant effect. In conclusion, these findings suggest that 5HT(1A) and 5HT(1B) receptors of the MPFC region modulate anxiogenic-like behaviors in rats...
  22. pmc Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model
    Yu Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore Street, MSTF Rm 8 22, Baltimore, MD 21201, USA
    Neurochem Res 36:1785-92. 2011
    ..These results show a correlation between EA anti-hyperalgesia and receptor expression. Collectively, the data show that EA activates supraspinal serotonin neurons to release 5-HT, which acts on spinal 5-HT1AR to inhibit hyperalgesia...
  23. doi 5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons
    Laia Lladó-Pelfort
    Department of Neurochemistry and Neuropharmacology, IIBB CSIC IDIBAPS, 08036 Barcelona, Spain
    Cereb Cortex 22:1487-97. 2012
    ..This results in pyramidal disinhibition and subsequent downstream excitations of subcortical structures reciprocally connected with PFC, such as midbrain dopaminergic neurons...
  24. doi Alterations in serotonin receptors and transporter immunoreactivities in the hippocampus in the rat unilateral hypoxic-induced epilepsy model
    Sung Jin An
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, Republic of Korea
    Cell Mol Neurobiol 31:1245-55. 2011
    ..These findings indicate that alteration of the 5-HT system results in a "diaschisis" pattern, and may contribute to neuronal death and the development of emotional disorders in epileptic patients accompanied by psychological stress...
  25. pmc 5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia
    Olga Dergacheva
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Respir Physiol Neurobiol 179:254-8. 2011
    ..This study examines the role of serotonergic 5HT1A receptors in modulating these excitatory neurotransmissions to CVNs during control conditions, H/H and recovery ..
  26. doi 5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning
    Elin Elvander-Tottie
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 19:1187-98. 2009
    ..It is proposed that NMDA receptor hypofunction in the septal area may unmask a negative effect of 5-HT(1A) receptor activation on memory, which may be clinically relevant...
  27. pmc Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation
    Chad K Otoshi
    Department of Physiological Science, University of California Los Angeles, Los Angeles, California 90095 1606, USA
    J Neurotrauma 26:575-84. 2009
    ..Combined, these data demonstrate that the upregulation in 5-HT(1A)R that occurs with spinal cord transection alone is dependent on the presence of sensory input...
  28. ncbi Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats
    M Valic
    Department of Neuroscience, University of Split School of Medicine, Split, Croatia
    J Physiol Pharmacol 59:17-25. 2008
    ..These results show that stimulation of 5-HT(1A) receptors by intravenous application of 8-OH-DPAT enhances phrenic nerve activity in spontaneously breathing rats...
  29. pmc The spleen is required for 5-HT1A receptor agonist-mediated increases in mean circulatory filling pressure during hemorrhagic shock in the rat
    Ruslan Tiniakov
    Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1392-401. 2009
    ..Moreover, blood mobilization stimulated by the spleen is required for the beneficial effects of 8-OH-DPAT...
  30. pmc Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system
    Kathryn G Commons
    Department of Anesthesiology, Perioperative, and Pain Medicine, Children s Hospital, Boston, MA 02115, USA
    Eur J Neurosci 27:2611-8. 2008
    ..swim). Moreover, they reveal that the effect of 5-HT-1A receptor blockade in each case is subregionally organized...
  31. pmc A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats
    Kyoko Nishi
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    Neurochem Int 54:299-307. 2009
    ..The data also suggest that there could be a different fraction of 5-HT(1A) receptors in high and low affinity states in these strains, as well as the possibility of different intracellular signalling...
  32. pmc Estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta
    Dania V Rossi
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    Psychoneuroendocrinology 35:1023-33. 2010
    ..Determining the mechanisms by which estrogens induce desensitization may aid in the development of better treatments for mood disorders...
  33. ncbi Serotonin(1A) receptor agonism in the expression of behavioral dopaminergic supersensitivity in subchronic haloperidol treated rats
    Farhat Batool
    Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 21:411-20. 2008
    ....
  34. doi Effects of prenatal ethanol exposure on regulation of basal hypothalamic-pituitary-adrenal activity and hippocampal 5-HT1A receptor mRNA levels in female rats across the estrous cycle
    J H Sliwowska
    Department of Cellular and Physiological Sciences, The University of the British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Psychoneuroendocrinology 33:1111-23. 2008
    ....
  35. doi Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584, CT, Utrecht, The Netherlands
    Psychopharmacology (Berl) 200:367-80. 2008
    ..While individual differences in vulnerability to psychostimulants have been largely attributed to dopaminergic neurotransmission, the role of serotonin is not fully understood...
  36. doi GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT 1A receptor activation-induced antinociception in the rat
    Fu Quan Huo
    Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an Yanta Street, W 76, Xi an, Shaanxi, China
    Pain 139:398-405. 2008
    ....
  37. doi Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats
    Patrícia de Souza Villa
    Department of Physiology, São Paulo State University at Araraquara, UNESP, Brazil
    Regul Pept 150:14-20. 2008
    ..We suggest that antidipsogenic and diuretic responses seem to be mediated via 5-HT(1A) receptors of the lateral-medial posterior magnocellular region of the PVN in water-deprived rats...
  38. doi Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
    ....
  39. ncbi Regional differences in 5-HT receptors in cerebral and testicular arterioles of the rat as revealed by Ca2+ imaging of real-time confocal microscopy: variances by artery size and organ specificity
    Kazuki Masu
    Department of Anatomy, School of Medicine, Iwate Medical University, Morioka, Japan
    Arch Histol Cytol 71:291-302. 2008
    ..Regional differences and the size-dependent manner of responses to 5-HT in cerebral blood vessels also indicate that the regulatory mechanism of blood circulation is highly differentiated in each region of the central nervous system...
  40. pmc Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal
    Robin Sperling
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Enders 307, Boston, MA 02115, USA
    Eur J Neurosci 33:1866-75. 2011
    ..The complementary patterns of activation and inhibition suggest that 5-HT1A receptors may help to shape distinct topographic patterns of activation within the DR...
  41. doi Activity of 5-HT1A receptor is involved in neuronal apoptosis of the amygdala in a rat model of post-traumatic stress disorder
    Hong Liu
    Department of Histology and Embryology, Basic Medical Sciences College, China Medical University, Shenyang 110001, P R China
    Mol Med Rep 4:291-5. 2011
    ..Our results indicate that SPS induces amygdala neuronal apoptosis, which was partially inhibited by WAY100635, and suggest that this apoptosis may be related to the activity of the 5-HT1A receptor...
  42. ncbi Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons
    Xiang Cai
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 277:36553-62. 2002
    ..This modulation demonstrates the critical role of CaMKII in serotonergic regulation of PFC neuronal activity, which may explain the neuropsychiatric behavioral phenotypes seen in CaMKII knockout mice...
  43. doi Spatial memory alterations by activation of septal 5HT 1A receptors: no implication of cholinergic septohippocampal neurons
    Julie Koenig
    Laboratoire d Imagerie et de Neurosciences Cognitives, FRE 3289, Universite de Strasbourg CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, 67000, Strasbourg, France
    Psychopharmacology (Berl) 214:437-54. 2011
    ..If so, selective damage of these neurons should mimic the effects of 8-OH-DPAT, or, at least, synergistically interfere with them...
  44. doi Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting
    Carolina Blaya
    Anxiety Disorders Program, Hospital de Clinicas de Porto Alegre, Post Graduate Program in Medical Sciences Psychiatry, Federal University of Rio Grande do Sul, Luiz Manoel Gonzaga, 630 11, 90470 280 Porto Alegre, RS, Brazil
    Neurosci Lett 485:11-5. 2010
    The aim of this study is to evaluate the association between HTR1A, HTR2A and the 5-HTTLPR in panic disorder (PD) patients and controls...
  45. pmc Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus
    Robert R Rozeske
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309 0354, USA
    J Neurosci 31:14107-15. 2011
    ..These data suggest that uncontrollable stressors produce a desensitization of DRN 5-HT(1A) autoreceptors and that this desensitization is responsible for the behavioral consequences of uncontrollable stress...
  46. ncbi Serotonergic modulation of respiratory rhythmogenesis and central chemoreception
    Matthew J Gdovin
    Department of Biology at the University of Texas at San Antonio, 78247, USA
    Ethn Dis 20:S1-39-44. 2010
    ..We examined the role of serotonin 5HT1A receptors in respiratory rhythmicity and central respiratory chemosensitivity in in vitro brainstem preparations ..
  47. doi Differential distribution of 5-HT 1A and 5-HT 1B-like immunoreactivities in rat central nucleus of the amygdala neurones projecting to the caudal dorsomedial medulla oblongata
    Sikha Saha
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine, University of Leeds, Leeds, LS2 9JT, UK
    Brain Res 1330:20-30. 2010
    ....
  48. pdf Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors
    M Victoria Puig
    Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
    J Neurosci 30:2211-22. 2010
    ..These results may provide insight into impaired serotonergic control of network activity in psychiatric illnesses such as schizophrenia and depression...
  49. doi Role of serotonergic 5-HT1A and oxytocinergic receptors of the lateral septal area in sodium intake regulation
    Gabriela Maria Pavan de Arruda Camargo
    Department of Clinical Analysis, Sao Paulo State University, UNESP, Brazil
    Behav Brain Res 209:260-6. 2010
    ..8% NaCl intake. These results show that 5-HT(1A) serotonergic receptors in the LSA, including some that interact with the oxytocinergic system, modulate sodium intake induced by sodium loss in rats...
  50. pmc Endogenous activation of spinal 5-hydroxytryptamine (5-HT) receptors contributes to the thermoregulatory activation of brown adipose tissue
    Christopher J Madden
    Oregon National Primate Research Center OHSU, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 298:R776-83. 2010
    ....
  51. doi Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins
    Sven Parkel
    Institute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia
    Neurotoxicology 32:25-30. 2011
    ....
  52. pmc Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress
    Nathalie M Goodfellow
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci 29:10094-103. 2009
    ..These data represent the first examination of functional 5-HT(1A) receptors in layer II/III of the prefrontal cortex during normal development as well as after stress...
  53. doi Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat
    Samantha L McLean
    Bradford School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Psychopharmacology (Berl) 206:403-14. 2009
    ..5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia...
  54. pmc Investigating the motivational mechanism of altered saline consumption following 5-HT(1A) manipulation
    Melissa L Caras
    Program in Neuroscience, Brandeis University, Waltham, MA 02454, USA
    Behav Neurosci 122:407-15. 2008
    ..Overall, the results suggest that 8-OH-DPAT-induced 5-HT hypofunction increases thirst without substantially affecting the palatability of NaCl...
  55. ncbi Immunohistochemical study of the serotonergic neuronal system in an animal model of the mood disorder
    Shuji Iritani
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    Exp Neurol 201:60-5. 2006
    ..issues, we immunohistochemically examined vesicle monoamine transporter 2 (VMAT2), serotonin receptor type 1a (5HT1a), and serotonin transporter (5HTT) in the hippocampal region of reserpine-treated rats, an animal model of ..
  56. ncbi SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test
    Kathryn R Starr
    Schizophrenia and Bipolar Research, Psychiatry Centre of Excellence in Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Essex CM19 5AW, UK
    Neuropsychopharmacology 32:2163-72. 2007
    ..In conclusion, SB-649915-B is acutely anxiolytic and reduces the latency to onset of anxiolytic behavior compared to paroxetine in the SI model...
  57. ncbi Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats
    Julia O Fedotova
    SV Anichkov Department of Neuropharmacology, Institute of Experimental Medicine of the Russian Academy of Medical Sciences, St Petersburg, Russia
    Acta Physiol Hung 91:185-96. 2004
    ..05) improved PAR in OVX rats and failed to normalize PAR in intact rats with proestrus and estrus. Results of the work specify the involvement of 5-HT1A receptors in the mechanisms of passive avoidance learning in OVX female rats...
  58. ncbi Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling
    Neena Kushwaha
    Ottawa Health Research Institute Neuroscience, and Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada, K1H 8M5
    Mol Pharmacol 69:1518-26. 2006
    ..Thus, the 5-HT1A receptor Ci2 domain determines Gbetagamma specificity and stabilizes Galphai-mediated signaling...
  59. pmc Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    Heidi E W Day
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Comp Neurol 474:364-78. 2004
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
  60. ncbi 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression
    Michal Shayit
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Brain Res 980:100-8. 2003
    ..This may contribute to a better understanding of the involvement of the serotonergic system in depression, and lead to pharmacological interventions aiming to modulate 5-HT regulation...
  61. ncbi Activation of 5-hydroxytryptamine 1A receptors suppresses the cardiovascular response evoked from the dorsomedial hypothalamic nucleus
    Jouji Horiuchi
    Department of Physiology, Institute for Biomedical Research, The University of Sydney, NSW 2006, Australia
    Hypertension 46:173-9. 2005
    ....
  62. ncbi Ontogeny of 5-HT1A receptor expression in the developing hippocampus
    Tushar D Patel
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Medical Science Research Building, Room 508, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 157:42-57. 2005
    ..In recent years, a number of pharmacological studies have suggested a role for the serotonin 1A (5HT1A) receptor subtype in mediating the developmental effects of 5-HT in the hippocampus...
  63. ncbi Acute and chronic administration of the selective 5-HT1A receptor antagonist WAY-405 significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Yoshio Minabe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, 431 3192 Shizuoka, Japan
    Synapse 50:181-90. 2003
    ..Overall, these results indicate that the antagonism of the 5-HT(1A) receptor significantly alters the activity of midbrain DA neurons in anesthetized rats...
  64. ncbi Decreased 5-HT1A receptor gene expression and 5-HT1A receptor protein in the cerebral cortex and brain stem during pancreatic regeneration in rats
    Valiya veettil Mohanan
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
    Neurochem Res 30:25-32. 2005
    ..Our results suggest that the brain 5-HT through 5-HT(1A) receptor has a functional role in the pancreatic regeneration through the sympathetic regulation...
  65. ncbi Calmodulin interacts with the third intracellular loop of the serotonin 5-hydroxytryptamine1A receptor at two distinct sites: putative role in receptor phosphorylation by protein kinase C
    Justin H Turner
    Medical and Research Services of the Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina, USA
    J Biol Chem 279:17027-37. 2004
    ..These data suggest that the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function...
  66. ncbi 5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels
    Morten Grunnet
    MFI, Panum Institute, Copenhagen University, Copenhagen, Denmark
    J Neurosci Res 78:845-54. 2004
    ..We conclude that the activity of SK channels is modulated by activation of serotonergic receptors...
  67. ncbi 5-HT1A, 5-HT2, and GABAB receptors interact to modulate neurotransmitter release probability in layer 2/3 somatosensory rat cortex as evaluated by the paired pulse protocol
    José L Torres-Escalante
    Departamento de Neurociencias, Centro de Investigaciones Regionales Dr Hideyo Noguchi de la Universidad Autónoma de Yucatán, Merida, Yucatan, Mexico
    J Neurosci Res 78:268-78. 2004
    ..When the effect of GABA(B) receptor activation is maximal, however, the influence of 5-HT changes to the opposite direction, inhibiting PP facilitation (increasing glutamate release) through activation of 5-HT(2) receptors...
  68. ncbi 5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes
    Telésfora Sempere
    Laboratorio de Neuroquimica, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Neuroimmunomodulation 11:307-15. 2004
    ..Furthermore, endogenous serotonin is relevant in displaying its stimulatory effect...
  69. ncbi Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene
    P R Albert
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 265:5825-32. 1990
    ..9, 3.6, and 3.3 kilobases). These studies represent the first characterization of receptor function and brain distribution of the cloned rat 5-HT1A receptor...
  70. ncbi Effect of neonatal handling on serotonin 1A sub-type receptors in the rat hippocampus
    A Stamatakis
    Department of Basic Sciences, Faculty of Nursing, School of Health Sciences, University of Athens, 123 Papadiamantopoulou str, 11527 Athens, Greece
    Neuroscience 140:1-11. 2006
    ....
  71. ncbi Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT
    Céline Faure
    Laboratory of Neuropharmacology and Neurochemistry, Faculty of Pharmacy, University of Claude Bernard Lyon I, France
    Neurosci Lett 404:122-6. 2006
    ..5 mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HT(1A) and 5-HT(7) receptors in core body temperature regulation...
  72. ncbi Activation of 5-HT(1A) receptors attenuates tachycardia induced by restraint stress in rats
    Sukonthar Ngampramuan
    Neuro Behavioural Biology Centre, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Nakron Pathom, Thailand
    Am J Physiol Regul Integr Comp Physiol 294:R132-41. 2008
    ..Activation of central 5-HT(1A) receptors attenuates this tachycardia by suppressing autonomic effects. At least some of the relevant receptors are located in the medullary raphe-parapyramidal area...
  73. ncbi Attenuating effects of prior oestradiol benzoate priming on 5-HT-mediated lordosis behavior in rats are dose-dependent
    A Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Acta Physiol Hung 94:209-21. 2007
    ..This offers a comparable effect on lordosis as a result of the two 5-HT agents used...
  74. ncbi Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus
    Gino Giannaccini
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, Pisa 56126, Italy
    Neurochem Int 51:496-506. 2007
    ..Therefore, our results encourage at extending the study of MDMA biochemical profiles, in the attempt to elucidate those amphetamine-induced pathways with a potential for neurotoxicity or psycho-stimulant activity...
  75. ncbi Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Mamm Genome 8:731-5. 1997
    ..Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker per 1.1 cM...
  76. ncbi Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration
    Julie G Hensler
    Department of Pharmacology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 26:565-73. 2002
    ....
  77. pmc Serotonin receptor 1A knockout: an animal model of anxiety-related disorder
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:14476-81. 1998
    ....
  78. ncbi Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex
    Noemí Santana
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cereb Cortex 14:1100-9. 2004
    ..These data help to clarify the role of 5-HT in prefrontal circuits and shed new light to the cellular elements involved in the action of atypical antipsychotics...
  79. ncbi Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain
    Clotilde Mannoury La Cour
    Unité Mixte de Recherche 677, Institut National de la Santé et de la Recherche Médicale INSERM Université Pierre et Marie Curie, Institut Fédératif 70 des Neurosciences, Facultéde Médecine Pierre et Marie Curie, Paris, France
    Mol Pharmacol 70:1013-21. 2006
    ..Such a disparity in G-protein coupling might explain regional differences in adaptive regulations of brain 5-HT1A receptors...
  80. ncbi Selective heterologous regulation of 5-HT1A receptor-stimulated 35S GTPgammaS binding in the anterior cingulate cortex as a result of 5-HT2 receptor activation
    M Valdez
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Brain Res 957:174-82. 2002
    ....
  81. ncbi Effects of isolation-rearing on serotonin-1A and M1-muscarinic receptor messenger RNA expression in the hipocampal formation of rats
    Elaine A Del-Bel
    Department of MEF Physiology, School of Odontology, Campus USP, Ribeirao Preto, SP 14040 904, Brazil
    Neurosci Lett 332:123-6. 2002
    ..No significant change on M1 mRNA expression was found. These results may reflect up-regulation of 5-HT1A gene transcription in response to deficits in hippocampal serotonin neurotransmission induced by social isolation...
  82. ncbi Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex
    Tatsuki Yoshino
    Department of Hospital Pharmacy, Jichi Medical School, 3311 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Neurochem Int 40:355-60. 2002
    ....
  83. ncbi Activation of 5-HT1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis
    Shaun F Morrison
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 286:R832-7. 2004
    ..These results contribute to our understanding of central neural substrates for the augmented energy expenditure stimulated by leptin...
  84. doi Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats
    Vanessa de Paula Soares
    Department of Pharmacology, School of Medicine, University of Sao Paulo, Av Bandeirantes 3900, CEP 14049 900 Ribeirao Preto, Brazil
    Behav Brain Res 197:178-85. 2009
    ..In conclusion, our data show that the activation of 5-HT1A and 5-HT2A receptors in the vlPAG affects defensive responses related to generalized anxiety, but not panic disorder...
  85. ncbi Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C
    Amy L Mize
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas School of Medicine, Kansas City, Kans, USA
    Neuroendocrinology 76:339-47. 2002
    ..These studies demonstrate that 17beta-estradiol acts on estrogen receptors locally within the hippocampus through nongenomic mechanisms to activate PKA and PKC, phosphorylate 5-HT(1A) receptors and uncouple them from their G proteins...
  86. ncbi Ovariectomy-induced increases in hypothalamic serotonin-1A receptor function in rats are prevented by estradiol
    Dani K Raap
    Center for Serotonin Disorders Research, Stritch School of Medicine, Loyola University Chicago, Maywood, Ill, USA
    Neuroendocrinology 76:348-56. 2002
    ..Results from the present study indicate a supersensitivity of 5-HT(1A) receptors after withdrawal of estradiol and suggest that estradiol suppresses 5-HT(1A) receptor signaling...
  87. ncbi Lamotrigine induced selective changes in 5-HT(1A) receptor mediated response in rat brain
    K Y Vinod
    Department of Neurochemistry, National Institute of Mental Health and Neurosciences, P B No 2900, Bangalore 560029, India
    Neurochem Int 40:315-9. 2002
    ..These results suggest that one mode of action of LTG may be by the downregulation of cortical 5-HT(1A) receptor-mediated AC response...
  88. pmc Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:17194-204. 2008
    ..These findings provide a framework for understanding the complex interactions between serotonin and NMDARs in PFC, which could be important for cognitive and emotional control in which both systems are highly involved...
  89. ncbi Peripheral 5-HT1A receptors are not essential for increased ventilation evoked by systemic 8-OH-DPAT challenge in anaesthetized rats
    Malgorzata Szereda-Przestaszewska
    Laboratory of Respiratory Reflexes, PAS Medical Research Center, 5 Pawinskiego Street, 02 106 Warsaw, Poland
    Exp Physiol 92:953-61. 2007
    ....
  90. ncbi A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies
    K Wedzony
    Institute of Pharmacology Polish Academy of Sciences, Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, 31 343 Krakow, Poland
    J Physiol Pharmacol 59:229-38. 2008
    ....
  91. doi Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is mediated by Yif1B
    Damien Carrel
    Faculte de Medecine Pierre et Marie Curie, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, Institut Fédératif de Recherche 70 des Neurosciences, Unité Mixte de Recherche 677, F 75013 Paris, France
    J Neurosci 28:8063-73. 2008
    ..This finding opens up new pathways for the study of 5-HT(1A)R regulation by partner proteins and for the development of novel antidepressant drugs...
  92. ncbi Activation of the external urethral sphincter central pattern generator by a 5-HT(1A) receptor agonist in rats with chronic spinal cord injury
    Paul C Dolber
    Department of Surgery, Veterans Affairs Medical Center, Durham, NC, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1699-706. 2007
    ..It remains to be determined when phasic relaxation is restored after spinal cord injury, and indeed whether it is ever truly lost or is only temporarily separated from excitatory input...
  93. ncbi Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action
    Llorenc Diaz-Mataix
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Neurosci 25:10831-43. 2005
    ..This mechanism may be involved in the elevation of extracellular DA produced by atypical antipsychotics...
  94. pmc Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats
    Chen Li Cheng
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Am J Physiol Renal Physiol 298:F771-8. 2010
    ....
  95. ncbi 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis
    Sietse F de Boer
    Department of Behavioral Physiology, Biological Center, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Eur J Pharmacol 526:125-39. 2005
    ....
  96. ncbi 5-HT1A receptor mRNA and immunoreactivity in the rat medial septum/diagonal band of Broca-relationships to GABAergic and cholinergic neurons
    M Luttgen
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Chem Neuroanat 29:93-111. 2005
    ..In addition, 5-HT may exert its effects in the MSDB via cells expressing both 5-HT1A and 5-HT2A receptors...
  97. doi Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats
    Jocelien D A Olivier
    Department Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Pharmacol 590:190-7. 2008
    ..It is concluded that the SERT knockout rat reveals that 5-HT(1A) receptors modulating stress-induced hyperthermia belong to a population of receptors that differs from that involved in hypothermia...
  98. doi Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation
    Jouji Horiuchi
    School of Medical Sciences Physiology and Bosch Institute, University of Sydney, NSW 2006, Australia
    Auton Neurosci 142:71-6. 2008
    ..These observations demonstrate that activation of 5-HT(1A) receptors within the lower brainstem, but not in the RVLM, can powerfully suppress the cardiovascular response evoked from the DMH...
  99. ncbi Role of 5-HT1A receptors in the control of food intake in obese Zucker rats of different ages
    J P Voigt
    Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Koserstr 20, D 14195 Berlin, Germany
    Pharmacol Biochem Behav 72:403-9. 2002
    ..The persistently different feeding responses to 8-OH-DPAT in obese Zucker rats and lean controls may be related to changes in brain 5-HT metabolism in the obese Zucker rats...
  100. ncbi Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats
    Shivani Mittra
    Department of Pharmacology, NDDR, Ranbaxy Research Laboratories, Plot No 20, Udyog Vihar Industrial Area, Sector 18, Gurgaon 122001, Haryana, India
    Eur J Pharmacol 561:189-93. 2007
    ..Taken together, these observations suggest the involvement of peripheral 5-HT(1A) receptors in detrusor over activity associated with bladder outlet obstruction in female rats...

Research Grants46

  1. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2010
    ....
  2. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun Morrison; Fiscal Year: 2007
    ..Understanding the pharmacology within this pathway driving the sympathetic responses during fever could provide a foundation for developing strategies to alter sympathetically-mediated increases in body temperature. ..
  3. CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT
    Shaun Morrison; Fiscal Year: 2005
    ..Understanding the neurotransmitter pharmacology within pathways determining BAT sympathetic outflow will be a foundation for development of strategies to alter energy balance in this model tissue. ..
  4. CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT
    Shaun Morrison; Fiscal Year: 2007
    ....
  5. Serotonin Receptor Subtypes: Regulation and Interaction
    JULIE HENSLER; Fiscal Year: 2007
    ..Studies of the regulation of 5-HT1A receptor function may have important implications for our understanding the role of this receptor in the therapeutic action of drugs used to treat mental illness ..
  6. 5HT transporter & 1A receptor function in BDNF mice
    JULIE HENSLER; Fiscal Year: 2007
    ..Region-specific and age-dependent changes in BDNF protein levels will be determined in selected brain regions of wild-type and BDNF () mice (Aim #3). ..
  7. CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT
    Shaun F Morrison; Fiscal Year: 2010
    ..abstract_text> ..
  8. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2010
    ....
  9. A STUDY OF STIMULANT-INDUCED CONDITIONED DRUG EFFECTS
    Robert Carey; Fiscal Year: 1993
    ..The results obtained can provide a basis for pharmacological treatment strategies for clinical control of craving and attendant relapse problems during drug abuse rehabilitation...
  10. Central Sympathetic Regulation of Thermogenesis
    Shaun Morrison; Fiscal Year: 2003
    ..Understanding the pharmacology within pathways determining BAT sympathetic outflow will be a foundation for developing strategies to alter sympathetically- mediated heat production. ..
  11. INTEROCEPTIVE DRUG CUE CONDITIONING OF COCAINE EFFECTS
    Robert Carey; Fiscal Year: 2002
    ..This research is important for the identification of the ways interoceptive drug cues can activate or inactivate cocaine conditioned stimuli. ..