Gene Symbol: Hspb6
Description: heat shock protein family B (small) member 6
Alias: Hsp20, p20, heat shock protein beta-6, heat shock 20 kDa-like protein p20, heat shock 20-kDa protein, heat shock protein family B (small) member B6, heat shock protein, alpha-crystallin-related, B6
Species: rat
Products:     Hspb6

Top Publications

  1. Wang X, Zingarelli B, O Connor M, Zhang P, Adeyemo A, Kranias E, et al. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. J Mol Cell Cardiol. 2009;47:382-90 pubmed publisher
    ..Heat shock protein 20 (Hsp20) has been shown to enhance myocardial contractile function and protect against doxorubicin-induced cardiotoxicity...
  2. Fan G, Zhou X, Wang X, Song G, Qian J, Nicolaou P, et al. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circ Res. 2008;103:1270-9 pubmed publisher
    ..However, it is not clear whether Hsp20 would exert similar protective effects against DOX-induced cardiac injury...
  3. Fan G, Chu G, Mitton B, Song Q, Yuan Q, Kranias E. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circ Res. 2004;94:1474-82 pubmed
    ..is associated with transient increases in expression and phosphorylation of a small heat-shock protein, Hsp20. To determine the functional significance of Hsp20, we overexpressed this protein and its constitutively ..
  4. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. 2009;27:3021-31 pubmed publisher
    ..In this study, we genetically engineered rat MSCs with Hsp20 gene (Hsp20-MSCs) and examined cell survival, revascularization, and functional improvement in rat left anterior ..
  5. Inaguma Y, Hasegawa K, Kato K, Nishida Y. cDNA cloning of a 20-kDa protein (p20) highly homologous to small heat shock proteins: developmental and physiological changes in rat hindlimb muscles. Gene. 1996;178:145-50 pubmed
    A cDNA clone encoding p20, a novel member of the small heat-shock protein family in mammals, was isolated from a rat soleus cDNA library. The clone contained an insert of 1...
  6. Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye M, et al. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. J Biol Chem. 2000;275:1095-104 pubmed
    ..extensive characterization of five of the six sHSPs so far identified, that is, HSP27, alphaB-crystallin, p20, MKBP/HSPB2, and HSPB3, omitting lens-specific alphaA-crystallin...
  7. Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T. Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. J Biol Chem. 1994;269:15302-9 pubmed
    A 20-kDa protein (p20) that had internal amino acid sequences highly similar to those of alpha B crystallin was purified from rat and human skeletal muscle...
  8. Sin Y, Baillie G. Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1). Cell Biochem Funct. 2015;33:421-6 pubmed publisher
    Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1...
  9. Sin Y, Martin T, Wills L, Currie S, Baillie G. Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Commun Signal. 2015;13:16 pubmed publisher
    ..We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective...

More Information


  1. Bagneris C, Bateman O, Naylor C, Cronin N, Boelens W, Keep N, et al. Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20. J Mol Biol. 2009;392:1242-52 pubmed publisher
    ..Here, crystal structures of excised alpha-crystallin domain from rat Hsp20 and that from human alphaB-crystallin show that they form homodimers with a shared groove at the interface by ..
  2. Nefedova V, Sudnitsyna M, Strelkov S, Gusev N. Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy. Arch Biochem Biophys. 2013;538:16-24 pubmed publisher
    ..Both mutants weakly interact with HspB6 forming small heterooligomers and being unable to form large heterooligomers characteristic for the wild type ..
  3. Pipkin W, Johnson J, Creazzo T, Burch J, Komalavilas P, Brophy C. Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart. Circulation. 2003;107:469-76 pubmed
    The small heat shock proteins HSP20, HSP25, alphaB-crystallin, and myotonic dystrophy kinase binding protein (MKBP) may regulate dynamic changes in the cytoskeleton...
  4. Bukach O, Seit Nebi A, Marston S, Gusev N. Some properties of human small heat shock protein Hsp20 (HspB6). Eur J Biochem. 2004;271:291-302 pubmed
    Human heat shock protein of apparent molecular mass 20 kDa (Hsp20) and its mutant, S16D, mimicking phosphorylation by cyclic nucleotide-dependent protein kinases, were cloned and expressed in Escherichia coli...
  5. Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J. 2009;425:245-55 pubmed publisher
    ..In addition, we show that Bag3 can bind to the molecular chaperone HspB6. The interaction between HspB6 and Bag3 requires the same regions that are involved in the HspB8-Bag3 association ..
  6. Zhang X, Wang X, Zhu H, Kranias E, Tang Y, Peng T, et al. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS ONE. 2012;7:e32765 pubmed publisher
    ..Recent studies have indicated that Hsp20 (HspB6), a small heat shock protein, was increased in blood from cardiomyopathic hamsters...
  7. Shimizu M, Tanaka M, Atomi Y. Small Heat Shock Protein ?B-Crystallin Controls Shape and Adhesion of Glioma and Myoblast Cells in the Absence of Stress. PLoS ONE. 2016;11:e0168136 pubmed publisher
    ..These results indicate that the small HSP ?B-crystallin has important roles for cell adhesion, and thus microtubule dynamics are necessary for persistent adhesion. ..
  8. Vos M, Kanon B, Kampinga H. HSPB7 is a SC35 speckle resident small heat shock protein. Biochim Biophys Acta. 2009;1793:1343-53 pubmed publisher
    ..The functional divergence between HSPB members seems larger than previously expected and also includes non-canonical members lacking classical chaperone-like functions. ..
  9. Huey K, Thresher J, Brophy C, Roy R. Inactivity-induced modulation of Hsp20 and Hsp25 content in rat hindlimb muscles. Muscle Nerve. 2004;30:95-101 pubmed
    ..Spinal cord isolation (SI) is a model of inactivity with an intact neuromuscular connection. After 7 days of SI, Hsp20 and Hsp25 levels in the soleus, plantaris, and adductor longus muscles were lower than in control rats, whereas ..
  10. Chen X, Zhang H, Pavlish K, Benoit J. Effects of chronic portal hypertension on small heat-shock proteins in mesenteric arteries. Am J Physiol Gastrointest Liver Physiol. 2005;288:G616-20 pubmed
    ..Recent data have implicated two small heat-shock proteins (HSP), namely HSP20 and HSP27, in the regulation of vascular tone...