Hspa8

Summary

Gene Symbol: Hspa8
Description: heat shock protein family A (Hsp70) member 8
Alias: Hsc70, heat shock cognate 71 kDa protein, Heat shock cognate protein 70, heat shock 70kD protein 8, heat shock 70kDa protein 8, heat shock protein 8, heat shock protein A8
Species: rat
Products:     Hspa8

Top Publications

  1. Amor Mahjoub M, Gomez Vrielyunck N, Suppini J, Fouchaq B, Benaroudj N, Ladjimi M. Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties. Protein Pept Lett. 2007;14:761-5 pubmed
    ..linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
  2. Dokladny K, Lobb R, Wharton W, Ma T, Moseley P. LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB. Cell Stress Chaperones. 2010;15:153-63 pubmed publisher
    ..We conclude that the effects of heat stress-induced increase in HSP70 protein expression on LPS-induced cytokine elaboration in whole animals can be reproduced by the actions of a single gene product. ..
  3. Alberti S, Böhse K, Arndt V, Schmitz A, Hohfeld J. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2004;15:4003-10 pubmed
    ..CHIP associates with the chaperones Hsc70 and Hsp90 during the regulation of signaling pathways and during protein quality control, and directs chaperone-..
  4. Suzuki T, Usuda N, Murata S, Nakazawa A, Ohtsuka K, Takagi H. Presence of molecular chaperones, heat shock cognate (Hsc) 70 and heat shock proteins (Hsp) 40, in the postsynaptic structures of rat brain. Brain Res. 1999;816:99-110 pubmed
    The synaptic localization of molecular chaperones, heat shock cognate protein 70 (Hsc70) and Hsp40, was investigated immunohistochemically in the normal rat brain...
  5. Yamagishi N, Ishihara K, Saito Y, Hatayama T. Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP. FEBS Lett. 2003;555:390-6 pubmed
    ..In contrast, Hsc70/Hsp40 suppressed the aggregation of heat-denatured protein in the presence of ATP rather than ADP...
  6. Hishiya A, Salman M, Carra S, Kampinga H, Takayama S. BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity. PLoS ONE. 2011;6:e16828 pubmed publisher
    ..Our findings indicate a novel function for BAG3 in inhibiting protein aggregation caused by the genetic mutation of CRYAB responsible for human myofibrillar myopathy. ..
  7. Yahata T, de Caestecker M, Lechleider R, Andriole S, Roberts A, Isselbacher K, et al. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000;275:8825-34 pubmed
    ..We also found that the Hsc70 heat-shock cognate protein also forms complex with MSG1 in vivo, suppressing both binding of MSG1 to p300/CBP and ..
  8. Yamada M, Kiuchi Y, Nara K, Kanda Y, Morinobu S, Momose K, et al. Identification of a novel splice variant of heat shock cognate protein 70 after chronic antidepressant treatment in rat frontal cortex. Biochem Biophys Res Commun. 1999;261:541-5 pubmed
    In this study, we identified a novel splice variant of 70-kDa heat shock cognate protein (HSC70), while screening differentially expressed molecules in rat brain after chronic antidepressant treatment...
  9. Komatsuda A, Wakui H, Ohtani H, Imai H, Miura A, Itoh H. Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis. Pathol Int. 1999;49:513-8 pubmed
    ..Our findings demonstrated that HSP73 and HSP90 chaperone proteins specifically accumulated within lysosomes of proximal tubular epithelial cells during the course of PDGA-induced acute lysosomal thesaurismosis. ..

More Information

Publications62

  1. Cvoro A, Korac A, Matić G. Intracellular localization of constitutive and inducible heat shock protein 70 in rat liver after in vivo heat stress. Mol Cell Biochem. 2004;265:27-35 pubmed
    ..redistribution of the two nucleo-cytoplasmic members of 70 kDa heat shock protein family (constitutive, Hsc70 or Hsp73, and inducible, Hsp72) were studied in rat liver during a 24-h period after exposure of the animals to 41 ..
  2. Kocsis J, Madaras B, Tóth E, Fust G, Prohaszka Z. Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Cell Stress Chaperones. 2010;15:143-51 pubmed publisher
    ..These novel findings indicate that the serum level of soluble HSP70 might prove a useful, stage-independent prognostic marker in colorectal cancer without distant metastasis. ..
  3. Koga H, Martinez Vicente M, Arias E, Kaushik S, Sulzer D, Cuervo A. Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease. J Neurosci. 2011;31:18492-505 pubmed publisher
    ..Components of CMA, namely the lysosome-associated membrane protein type 2A (LAMP-2A) and lysosomal-hsc70, are markedly increased in HD models...
  4. Saheki Y, De Camilli P. Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol. 2012;4:a005645 pubmed publisher
  5. Melville M, Tan S, Wambach M, Song J, Morimoto R, Katze M. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem. 1999;274:3797-803 pubmed
    ..The PKR pathway is even more complex as we show in this report that the molecular chaperone, hsp/Hsc70, was a component of a trimeric complex with hsp40 and P58(IPK)...
  6. Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, et al. Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 2013;8:e65280 pubmed publisher
    ..In this study we used mass spectrometry to identify novel interactors of NF-?B p65 within the brain. Hsc70 was identified as a novel neuronal interactor of NF-?B p65...
  7. Cuervo A, Dice J, Knecht E. A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem. 1997;272:5606-15 pubmed
    ..The increased stability of hsc73 in one population of lysosomes is primarily a consequence of this lysosomal population's more acidic pH. ..
  8. Lässer C, Alikhani V, Ekström K, Eldh M, Paredes P, Bossios A, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med. 2011;9:9 pubmed publisher
    ..Breast milk exosomes were further analysed for the presence of Hsc70, CD81 and calnexin by Western blot...
  9. Mashukova A, Wald F, SALAS P. Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mol Cell Biol. 2011;31:756-65 pubmed publisher
    ..These effects, including ZO-1 downregulation, were rescued by overexpression of constitutively active aPKC. We conclude that this novel mechanism is a complementary effector pathway for TNF-? signaling. ..
  10. Lederman M, Weiss A, Chowers I. Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells. Invest Ophthalmol Vis Sci. 2010;51:53-8 pubmed publisher
    ..0029). QPCR confirmed increased expression (1.6- to 4.3-fold) of four genes (HSPA8, IGHG1, ANXA5, VKORC1) in association with NVAMD (P = 0.02-0.0002)...
  11. Lee M, Stephenson D, Groves M, Sweeney M, Davis M, An S, et al. Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene. Hum Mol Genet. 2003;12:1917-25 pubmed
    ..This is the first report of a mutation in a molecular chaperonin causing a hereditary neuropathy and raises the possibility that mis-folding proteins may be a cause of this group of neuropathies. ..
  12. Jakobsson M, Moen A, Bousset L, Egge Jacobsen W, Kernstock S, Melki R, et al. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J Biol Chem. 2013;288:27752-63 pubmed publisher
    ..Finally, we show that trimethylation of HSPA8 (Hsc70) has functional consequences, as it alters the affinity of the chaperone for both the monomeric and ..
  13. Hung J, Cheng T, Chang M, Chen K, Huang H, Lai Y. Involvement of heat shock elements and basal transcription elements in the differential induction of the 70-kDa heat shock protein and its cognate by cadmium chloride in 9L rat brain tumor cells. J Cell Biochem. 1998;71:21-35 pubmed
    ..We have demonstrated that induction of the 70-kDa HSP (HSP70) and enhanced expression of its cognate (HSC70) by cadmium are concentration dependent and that the induction kinetics of these HSP70s are different...
  14. Yang S, Oh K, Park E, Chang H, Park J, Seong M, et al. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci. 2013;33:12728-38 pubmed publisher
    ..These results indicate that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. ..
  15. Voisin P, Pardue S, Macouillard F, Yehia G, Labouesse J, Morrison Bogorad M. Differential expression of heat shock 70 proteins in primary cultures from rat cerebellum. Brain Res. 1996;739:215-34 pubmed
    ..of the inducible heat shock 70 (hsp70) proteins and the constitutively synthesized members of the family (hsc70) in neurons and glia...
  16. Aquino D, Lopez C, Farooq M. Antisense oligonucleotide to the 70-kDa heat shock cognate protein inhibits synthesis of myelin basic protein. Neurochem Res. 1996;21:417-22 pubmed
    ..complementary to the mRNA encoding the initial ten amino acids of the rat 70-kDa heat shock cognate protein (HSC70) resulted in a rapid (within 24 h) and significant reduction in HSC70 synthesis (69% of control cells transfected ..
  17. Morita K, Wakui H, Komatsuda A, Ohtani H, Miura A, Itoh H, et al. Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys after ischemia. Ren Fail. 1995;17:405-19 pubmed
  18. Ferreira J, Fôfo H, Bejarano E, Bento C, Ramalho J, Girao H, et al. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy. 2013;9:1349-66 pubmed publisher
    ..has been identified in all CMA substrates, is required to mediate the interaction between HIF1A and the chaperone HSPA8. Moreover, mutations in the KFERQ-like motif of HIF1A preclude the interaction with the CMA receptor LAMP2A, thus ..
  19. Xilouri M, Stefanis L. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Mol Cell Neurosci. 2015;66:29-36 pubmed publisher
    ..This article is part of Special Issue entitled "Neuronal Protein". ..
  20. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, et al. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017;216:2059-2074 pubmed publisher
    ..MS data indicate that synapsin is part of a multiprotein complex enriched in chaperones/cochaperones including Hsc70. Axonal synapsin-Hsc70 coclusters are also visualized by two-color superresolution microscopy...
  21. Chiba S, Yokota S, Yonekura K, Tanaka S, Furuyama H, Kubota H, et al. Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis. J Neurol Sci. 2006;241:39-43 pubmed
    ..HSPs (HSP27, alphaA and alphaB crystallins, HSP60, CCT, Mycobacterium bovis HSP65, Escherichia coli GroEL, HSP70, HSC70 and HSP90) in CSF from 30 patients with MS, and 25 patients with motor neuron diseases (MND)...
  22. Carr V, Menco B, Yankova M, Morimoto R, Farbman A. Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa. J Comp Neurol. 2001;432:425-39 pubmed
    ..Odorant exposure led to transient, selective induction of HSP70, HSC70, HSP25, and ubiquitin immunoreactivities (IRs) in supporting cells and subepithelial Bowman's gland acinar cells, ..
  23. Sarrió S, Casado V, Escriche M, Ciruela F, Mallol J, Canela E, et al. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Mol Cell Biol. 2000;20:5164-74 pubmed
    ..These results open the interesting possibility that signaling via G protein-coupled receptors may be regulated by heat shock proteins. ..
  24. Hu B, Park M, Martone M, Fischer W, Ellisman M, Zivin J. Assembly of proteins to postsynaptic densities after transient cerebral ischemia. J Neurosci. 1998;18:625-33 pubmed
  25. Demand J, Lüders J, Hohfeld J. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Mol Cell Biol. 1998;18:2023-8 pubmed
    The modulation of the chaperone activity of the heat shock cognate Hsc70 protein in mammalian cells involves cooperation with chaperone cofactors, such as Hsp40; BAG-1; the Hsc70-interacting protein, Hip; and the Hsc70-Hsp90-organizing ..
  26. Chanarat S, Sträßer K. Splicing and beyond: the many faces of the Prp19 complex. Biochim Biophys Acta. 2013;1833:2126-34 pubmed publisher
    ..Thus, many important questions about the functions of this interesting complex remain to be investigated. In this review we discuss the different functions of NTC/Prp19C focusing on the novel and emerging ones as well as open questions. ..
  27. Lomnytska M, Becker S, Hellman K, Hellström A, Souchelnytskyi S, Mints M, et al. Diagnostic protein marker patterns in squamous cervical cancer. Proteomics Clin Appl. 2010;4:17-31 pubmed publisher
    ..for SVC it was OE cathepsin D, ?-catenin, RAB2A, for both cancers it was OE apolipoprotein E, tropomyosin 3, HSPA8, and underexpressed cytokeratin 13, osteoglycin...
  28. Maher Laporte M, Berthiaume F, Moreau M, Julien L, Lapointe G, Mourez M, et al. Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain. PLoS ONE. 2010;5:e11350 pubmed publisher
    ..The proteomic approach identified mRNA-binding proteins (PABPC1, hnRNP H1, YB1 and hsc70), proteins of the cytoskeleton (alpha- and beta-tubulin) and RUFY3 a poorly characterized protein...
  29. Liu F, Wu S, Hu S, Hsiao C, Wang C. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. J Biol Chem. 1999;274:34425-32 pubmed
    Using a yeast two-hybrid system with the 70-kDa heat shock cognate protein (hsc70) or its C-terminal 30-kDa domain as baits, we isolated several proteins interacting with hsc70, including Hip/p48 and p60/Hop...
  30. Nilsson A, Sköld K, Sjögren B, Svensson M, Pierson J, Zhang X, et al. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. J Proteome Res. 2007;6:3952-61 pubmed
    ..In conclusion, these data strongly suggests that FKBP-12 is altered in an experimental model of PD. ..
  31. Green L, Liem R. Beta-internexin is a microtubule-associated protein identical to the 70-kDa heat-shock cognate protein and the clathrin uncoating ATPase. J Biol Chem. 1989;264:15210-5 pubmed
    ..S., Chin, S. S. M., and Liem, R. K. H. (1985) J. Cell Biol. 101, 1323-1331) to heat-shock cognate 70 (hsc70), the major constitutive member of the mammalian heat-shock protein 70 (hsp70) family of stress proteins...
  32. Rothermel E, Detzler E, Walter L, Levan G, Gunther E. Characterization and mapping of a highly conserved processed pseudogene and an intron-carrying gene of the heat shock cognate protein 70 (Hsc70) gene family in the rat. Mamm Genome. 1995;6:602-6 pubmed
    A processed pseudogene of the rat Hsc70 gene, Hsc70-ps1, is described, which still presents the open reading frame of the original gene. The pseudogene does not appear to be expressed. It maps to rat Chromosome (Chr) 2...
  33. Yamamoto Y, Takase K, Kishino J, Fujita M, Okamura N, Sakaeda T, et al. Proteomic identification of protein targets for 15-deoxy-?(12,14)-prostaglandin J2 in neuronal plasma membrane. PLoS ONE. 2011;6:e17552 pubmed publisher
    ..pyruvate kinase M1 (PKM1) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH)), molecular chaperones (heat shock protein 8 and T-complex protein 1 subunit ?), cytoskeletal proteins (Actin ?, F-actin-capping protein, Tubulin ? and ..
  34. Sahu R, Kaushik S, Clement C, Cannizzo E, Scharf B, Follenzi A, et al. Microautophagy of cytosolic proteins by late endosomes. Dev Cell. 2011;20:131-9 pubmed publisher
    ..Protein cargo selection is mediated by the chaperone hsc70 and requires the cationic domain of hsc70 for electrostatic interactions with the endosomal membrane...
  35. Tessari P, Puricelli L, Iori E, Arrigoni G, Vedovato M, James P, et al. Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy. J Proteome Res. 2007;6:976-86 pubmed
    ..These changes of chaperone-like proteins in fibroblasts may highlight those of the kidney and be patho-physiologically related to the development of nephropathy in T1DM. ..
  36. Geminard C, Nault F, Johnstone R, Vidal M. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. J Biol Chem. 2001;276:9910-6 pubmed
    ..The heat shock cognate 70-kDa protein (Hsc70) has been demonstrated to interact with the cytosolic domain of the TfR and could thus trigger the receptor toward ..
  37. Goral J, Mathews H, Clancy J. Expression of 70-kDa heat-shock protein during acute graft-versus-host disease. Clin Immunol Immunopathol. 1998;86:252-8 pubmed
    ..Elevated levels of hsp70 in lymphoid organs during GVHD suggest an involvement of hsp70 in the pathology of the disease. ..
  38. Salinas E, Byrum S, Moreland L, Mackintosh S, Tackett A, Forrest J. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016;90:1397-413 pubmed publisher
    ..Among the top prioritized mLANA-binding proteins was a cellular chaperone, heat shock cognate protein 70 (Hsc70)...
  39. Brown J, Zeiger S, Hettinger J, Brooks J, Holt B, Morrow J, et al. Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning. J Neurosci. 2010;30:5242-52 pubmed publisher
    ..The constitutively expressed chaperone HSC70 relocalized to autophagosomes...
  40. Oh hashi K, Naruse Y, Amaya F, Shimosato G, Tanaka M. Cloning and characterization of a novel GRP78-binding protein in the rat brain. J Biol Chem. 2003;278:10531-7 pubmed
    ..These results suggest that GBP would have a relevant functional role in embryonic and postnatal development of the brain. ..
  41. Singh D, Lampe P. Identification of connexin-43 interacting proteins. Cell Commun Adhes. 2003;10:215-20 pubmed
    ..Further in vitro/in vivo analysis of these interacting proteins will help in our understanding of the global role of connexins in regulating development, cell metabolism and growth. ..
  42. Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, et al. Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Biochem Biophys Res Commun. 2009;378:433-8 pubmed publisher
    ..Given the important role of exosomes as intercellular messengers, the discovery of PPARgamma as a component of human plasma exosomes identifies a potential new pathway for the paracrine transfer of nuclear receptors. ..
  43. Hirasaka K, Tokuoka K, Nakao R, Yamada C, Oarada M, Imagawa T, et al. Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells. J Physiol Sci. 2008;58:105-11 pubmed publisher
    ..C propeptide interacted with proteins with a molecular mass of approximately 70 kDa, including IAP and heat shock cognate protein 70. Our present results suggest that the propeptide of cathepsin C may stimulate the sorting to the ..
  44. Unno K, Asakura H, Shibuya Y, Kaiho M, Okada S, Oku N. Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain. J Gerontol A Biol Sci Med Sci. 2000;55:B329-35 pubmed
    ..We found that the basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70), in 24-month-old Wistar rats was significantly higher in some parts of the brain than that in 6-month-old rats...
  45. Yim Y, Sun T, Wu L, Raimondi A, De Camilli P, Eisenberg E, et al. Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci U S A. 2010;107:4412-7 pubmed publisher
    ..expressed cyclin-G-dependent kinase (GAK) are homologous proteins that act as cochaperones to support the Hsc70-dependent clathrin uncoating of clathrin-coated vesicles...
  46. Kawano F, Oke Y, Nomura S, Fujita R, Ohira T, Nakai N, et al. Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats. J Physiol Sci. 2011;61:445-56 pubmed publisher
    ..The level of 70 kDa heat shock cognate (HSC70) expression was greater in the diencephalon of the 3 ppm Fe group...
  47. Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo A. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol. 2008;28:5747-63 pubmed publisher
    ..The two major chaperones related to CMA, hsc70 and hsp90, play critical roles in the functional dynamics of the LAMP-2A complexes at the lysosomal membrane...
  48. Hu S, Wang C. Involvement of the 10-kDa C-terminal fragment of hsc70 in complexing with unfolded protein. Arch Biochem Biophys. 1996;332:163-9 pubmed
    Using native gel electrophoresis, we demonstrate that both bovine brain hsc70 and recombinant rat hsc70 form a tightly associated complex with bovine S-carboxymethyl alpha-lactalbumin (CMLA)...
  49. Oguri M, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, et al. Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease. Mol Med Rep. 2009;2:205-11 pubmed publisher
    ..31) and -110A?C of the heat shock 70-kDa protein 8 gene (HSPA8; odds ratio in recessive model, 0.72) were significantly (P<0...
  50. Hfaiedh N, Allagui M, el Feki A, Gaubin Y, Murat J, Soleilhavoup J, et al. Effects of nickel poisoning on expression pattern of the 72/73 and 94 kDa stress proteins in rat organs and in the COS-7, HepG2, and A549 cell lines. J Biochem Mol Toxicol. 2005;19:12-8 pubmed
    ..No significant effect on HSP expression was observed. ..
  51. Zou N, Ao L, Cleveland J, Yang X, Su X, Cai G, et al. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008;294:H2805-13 pubmed publisher
    ..In the present study, we examined 1) whether heat shock cognate protein 70 (HSC70), which is constitutively expressed in the myocardium, is released during ischemia-reperfusion; ..
  52. Cheng K, Ren D, Yi J, Zhou X, Yang W, Chen Y, et al. Pulsed electromagnetic wave exposure induces ultrastructural damage and upregulated expression of heat shock protein 70 in the rat adenohypophysis. Mol Med Rep. 2015;12:2175-80 pubmed publisher
    ..These findings suggested that PEMW induced ultrastructural damages in the rat adenohypophysis and that HSP70 may have contributed to the PEMW-induced adenohypophyseal damage. ..
  53. Zhang F, Liu C, Hu B. Irreversible aggregation of protein synthesis machinery after focal brain ischemia. J Neurochem. 2006;98:102-12 pubmed
    ..eukaryotic initiation factors 2alpha, 4E and 3eta, and co-translational chaperone heat-shock cognate protein 70 (HSC70) and co-chaperone Hdj1, were all irreversibly clumped into large abnormal protein aggregates after ischemia...