Gene Symbol: Hspa5
Description: heat shock protein family A member 5
Alias: BIP, GRP 78, GRP78, endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, GRP-78, HSP70 family protein 5, binding-immunoglobulin protein, heat shock 70 kDa protein 5, heat shock 70kD protein 5, heat shock 70kDa protein 5 (glucose-regulated protein), heat shock protein 5, heat shock protein 70 family protein 5, immunoglobulin heavy chain-binding protein, steroidogenesis-activator polypeptide
Species: rat
Products:     Hspa5

Top Publications

  1. Kogure K, Nakamura K, Ikeda S, Kitahara Y, Nishimura T, Iwamune M, et al. Glucose-regulated protein, 78-kilodalton is a modulator of luteinizing hormone receptor expression in luteinizing granulosa cells in rats. Biol Reprod. 2013;88:8 pubmed publisher
    Glucose-regulated protein, 78-kilodalton (GRP78) is a molecular chaperone that exists in the endoplasmic reticulum and is involved in the assembly, transportation, and folding of proteins...
  2. Liu Y, Zhou Z, Chen K, Zhou B, Yang L, Yan H, et al. The ER chaperone GRP78 is associated with the severity of cerulein-induced pancreatic inflammation via regulating apoptosis of pancreatic acinar cells. Hepatogastroenterology. 2012;59:1670-6 pubmed publisher
    To study the potential role of the 78kDa glucose regulated protein (GRP78) in the pathogenesis of acute pancreatitis (AP) in vitro. AR42J cells were stimulated by cerulein or cerulein plus lipoplysaccharide (LPS)...
  3. Lee J, Beebe K, Nangle L, Jang J, Longo Guess C, Cook S, et al. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443:50-5 pubmed
    ..These findings demonstrate that disruption of translational fidelity in terminally differentiated neurons leads to the accumulation of misfolded proteins and cell death, and provide a novel mechanism underlying neurodegeneration. ..
  4. Rao R, Peel A, Logvinova A, Del Rio G, Hermel E, Yokota T, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002;514:122-8 pubmed
    ..Glucose-regulated protein (GRP) 78 (Bip) is an ER lumen protein whose expression is induced during ER stress. GRP78 is involved in polypeptide translocation across the ER membrane, and also acts as an apoptotic regulator by ..
  5. Suyama K, Watanabe M, Sakabe K, Okada Y, Matsuyama D, Kuroiwa M, et al. Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress. Neurosci Lett. 2011;504:271-6 pubmed publisher
    ..The 78-kDa glucose-regulated protein (GRP78) is an ER chaperone that regulates protein folding in the ER and has been suggested to contribute to cell survival...
  6. Sun F, Wei S, Li C, Chang Y, Chao C, Lai Y. Localization of GRP78 to mitochondria under the unfolded protein response. Biochem J. 2006;396:31-9 pubmed
    The ubiquitously expressed molecular chaperone GRP78 (78 kDa glucose-regulated protein) generally localizes to the ER (endoplasmic reticulum)...
  7. Kammoun H, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest. 2009;119:1201-15 pubmed publisher
    ..activation and thus contributes to lipogenesis, we overexpressed the chaperone glucose-regulated protein 78 (GRP78) in the livers of ob/ob mice using an adenoviral vector...
  8. Reddy R, Mao C, Baumeister P, Austin R, Kaufman R, Lee A. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 2003;278:20915-24 pubmed
    ..We report here that without the use of endoplasmic reticulum (ER) stress inducers, specific overexpression of GRP78 results in reduced apoptosis and higher colony survival when challenged with topoisomerase II inhibitors, ..
  9. Shani G, Fischer W, Justice N, Kelber J, Vale W, Gray P. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77 pubmed
    ..This screen led to our identification of glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) chaperone that is also expressed at the surfaces of tumor cells...

Scientific Experts

More Information


  1. Petrova K, Oyadomari S, Hendershot L, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J. 2008;27:2862-72 pubmed publisher
    ..protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly...
  2. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, et al. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010;17:488-98 pubmed publisher
    ..In this study we report the creation of a novel mouse model in which GRP78/BiP, a major ER chaperone and master regulator of UPR, is specifically eliminated in Purkinje cells (PCs)...
  3. Sun H, Sun L, Li Y, Shao M, Cheng X, Ge N, et al. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Exp Clin Endocrinol Diabetes. 2009;117:336-44 pubmed publisher
    ..Endoplasmic reticulum stress associated proteins expression of glucose-regulated protein-78 (GRP78/BiP), phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), phospho-pancreatic ER kinase (PERK) and caspase-..
  4. Zhang L, Lai E, Teodoro T, Volchuk A. GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells. J Biol Chem. 2009;284:5289-98 pubmed publisher
    ..Overexpressing the ER chaperone GRP78 partially rescued high glucose-induced suppression of proinsulin levels and improved glucose-stimulated insulin ..
  5. Chang S, Wooden S, Nakaki T, Kim Y, Lin A, Kung L, et al. Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression. Proc Natl Acad Sci U S A. 1987;84:680-4 pubmed
    The 78-kDa glucose-regulated protein GRP78 is a stress-inducible protein ubiquitously expressed in animal cells...
  6. Urban P, Bilecová Rabajdová M, Marekova M, Vesela J. Progression of apoptic signaling from mesenteric ischemia-reperfusion injury to lungs: correlation in the level of ER chaperones expression. Mol Cell Biochem. 2012;362:133-40 pubmed publisher
    ..We analyzed changes in mRNA levels of pro-apoptotic genes Gadd153 (Chop) and anti-apoptotic genes Grp78 (Bip) in the small intestine wall and lung parenchyma...
  7. Zhao Q, Hu X, Shao L, Wu G, Du J, Xia J. LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats. Heart Vessels. 2014;29:667-78 pubmed publisher
    ..LXA4 downregulates the mRNA and protein expression of GRP-78 and caspase-12. LXA4 could play a role in myocardial protection via a mechanism related to downregulation of GRP-78 and caspase-12, and inhibition of apoptosis. ..
  8. Gupta M, Tahrir F, Knezevic T, White M, Gordon J, Cheung J, et al. GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis. J Cell Biochem. 2016;117:1813-21 pubmed publisher
    ..that Bag5 protein expression is significantly increased in the ER during ER stress and that this in turn modulates GRP78 protein stability and reduces ER stress...
  9. Kuznetsov G, Chen L, Nigam S. Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem. 1997;272:3057-63 pubmed
    ..Biol. Chem. 269, 22990-22995). By coimmunoprecipitation in rat thyroid cells, we were able to demonstrate that BiP, grp94, ERp72, and grp170, four proteins believed to function as specific molecular chaperones, complex with Tg ..
  10. Fu Q, Zhou Z, Li X, Guo H, Fan X, Chen J, et al. [Protective effect of adenosine preconditioning against spinal cord ischemia-reperfusion injury in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34:92-5 pubmed
    ..01) and decreased caspase-12 expression (P<0.01). Adenosine can up-regulate GRP-78 expression and down-regulate caspase-12 expression, and protects the spinal cord against ischemia-reperfusion injury by inhibiting cell apoptosis. ..
  11. Lemaire K, Moura R, Granvik M, Igoillo Esteve M, Hohmeier H, Hendrickx N, et al. Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS ONE. 2011;6:e18517 pubmed publisher
    ..Together, our data suggest that UFM1-UFBP1 participate in preventing ER stress-induced apoptosis in protein secretory cells. ..
  12. Xie J, Luo L, Xue Q, Li X, Gong S. [Endoplasmic reticulum molecular chaperone involved in the impairment of inner ear consistent with the mimetic aging rats]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24:28-32 pubmed
    To explore the involvement of endoplasmic reticulum molecular chaperone GRP78 in the impairment of inner ear consistent with the mimetic aging model. Twenty-four Wistar rats were randomly divided into two groups...
  13. Cunnea P, Miranda Vizuete A, Bertoli G, Simmen T, Damdimopoulos A, Hermann S, et al. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem. 2003;278:1059-66 pubmed
    ..In vitro experiments demonstrated that ERdj5 interacts via its DnaJ domain with BiP in an ATP-dependent manner...
  14. Faure J, Hattingh S, Stein D, Daniels W. Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment. Metab Brain Dis. 2009;24:685-700 pubmed publisher
    ..ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), beta-synuclein, 78 kDa glucose-regulated protein (GRP 78), gamma-enolase, dihydropyrimidase-related protein 2 (DRP 2), complexin 2 and synapsin II...
  15. Xu B, Wang F, Wu S, Deng Y, Liu W, Feng S, et al. ?-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Mol Neurobiol. 2014;49:399-412 pubmed publisher
    ..Moreover, there was a dose-dependent increase in the protein expression of 78, 94-kDa glucose-regulated protein (GRP78/94), C/EBP homologous protein (CHOP), and caspase-12...
  16. Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, et al. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol. 2005;7:186-94 pubmed
    ..Furthermore, overexpression of OASIS resulted in induction of BiP and suppression of ER-stress-induced cell death, whereas knockdown partially reduced BiP levels and led to ER ..
  17. Sukumaran V, Veeraveedu P, Gurusamy N, Yamaguchi K, Lakshmanan A, Ma M, et al. Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. Int J Biol Sci. 2011;7:1077-92 pubmed
  18. Deuring J, de Haar C, Koelewijn C, Kuipers E, Peppelenbosch M, van der Woude C. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem J. 2012;441:87-93 pubmed publisher
    ..To this end, we correlated expression of ABCG2 and the unfolded protein response marker GRP78 (glucose-regulated protein of 78 kDa) in colon biopsies from healthy individuals (n=9) and patients with inactive ..
  19. Valkova C, Albrizio M, Röder I, Schwake M, Betto R, Rudolf R, et al. Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc Natl Acad Sci U S A. 2011;108:621-5 pubmed publisher
    ..Our data show that Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled ?-subunits to the early secretory pathway. ..
  20. Liu Z, Fu Z, Song J, Zhang J, Wei Y, Chu J, et al. Bip enhanced the association of GSK-3? with tau during ER stress both in vivo and in vitro. J Alzheimers Dis. 2012;29:727-40 pubmed publisher
    ..Endoplasmic reticulum (ER) stress has been indicated in AD pathogenesis and the increased level of binding immunoglobulin protein (Bip), an important ER associated chaperon, is increased in AD brain...
  21. Pan Y, Ren A, Zheng J, Rong W, Chen H, Yan X, et al. Delayed cytoprotection induced by hypoxic preconditioning in cultured neonatal rat cardiomyocytes: role of GRP78. Life Sci. 2007;81:1042-9 pubmed
    ..Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic preconditioning...
  22. Evensen N, Kuscu C, Nguyen H, Zarrabi K, Dufour A, Kadam P, et al. Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration. J Natl Cancer Inst. 2013;105:1402-16 pubmed publisher
    ..KIAA1199 has been shown to be upregulated in human cancers, yet its role in cancer progression was hitherto unknown...
  23. Kim C, Leung A, Huh Y, Yang E, Kim D, LeBlanc P, et al. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. J Biol Chem. 2011;286:9196-204 pubmed publisher
    ..mutant DBH induces an ER stress response, exogenous expression of mutant DBH dramatically induced expression of BiP, a master ER chaperone...
  24. Penas C, Font Nieves M, Fores J, Petegnief V, Planas A, Navarro X, et al. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Cell Death Differ. 2011;18:1617-27 pubmed publisher
    ..of the spliced isoform of Xbp1 and accumulation of ATF4 in their nucleus, two branches of the UPR, and late BiP downregulation in association with cytoskeletal and organelle disorganization...
  25. Falahatpisheh H, Nanez A, Montoya Durango D, Qian Y, Tiffany Castiglioni E, Ramos K. Activation profiles of HSPA5 during the glomerular mesangial cell stress response to chemical injury. Cell Stress Chaperones. 2007;12:209-18 pubmed
    ..of the unfolded protein response, proteasomal degradation of proteins, and induction of HSPA5, also known as GRP78 or BiP...
  26. Satoh T, Furuta K, Tomokiyo K, Nakatsuka D, Tanikawa M, Nakanishi M, et al. Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor. J Neurochem. 2000;75:1092-102 pubmed
    ..investigated the intracellular mechanism of the promotion by NEPPs and obtained evidence that immunoglobulin heavy chain binding protein/glucose-regulated protein 78 (BiP/GRP78) plays a role in the promotion, based on the following ..
  27. Munro S, Pelham H. An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell. 1986;46:291-300 pubmed
    ..We show that it is identical with two previously described proteins: GRP78, whose synthesis is induced by glucose starvation, and BiP, which is found bound to immunoglobulin heavy chains in ..
  28. Srinivasan K, Sharma S. 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. Life Sci. 2012;90:154-60 pubmed publisher
    ..blotting methods were employed for the detection and expression of ER stress/apoptosis markers [78 kDa glucose regulated protein (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP)]...
  29. Ravindran S, Narayanan K, Eapen A, Hao J, Ramachandran A, Blond S, et al. Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. J Biol Chem. 2008;283:29658-70 pubmed publisher
    ..Therefore, binding of DMP1 with GRP-78 receptor might be an important mechanism by which DMP1 is internalized and transported to the nucleus during bone and tooth development. ..
  30. Cheng Y, Cong X, Dai D, Zhang Y, Dai Y. Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats. J Pharm Pharmacol. 2013;65:94-101 pubmed publisher
    ..the abnormalities of nitric oxide synthase (NOS), p66Shc and immunoglobulin heavy-chain binding protein (Bip), in the corpus cavernosum (CC). SD rats were randomly divided into six groups...
  31. Zhang X, Yan X, Zhang B, Yang Q, Ye M, Cao W, et al. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Cell Res. 2015;25:818-36 pubmed publisher
    ..In this study, we demonstrated that Bip, an endoplasmic reticulum (ER) chaperone, selectively interacted with GluN2A and mediated the neuronal activity-..
  32. Li H, Zhu X, Fang F, Jiang D, Tang L. Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury. Neurosci Lett. 2014;575:68-73 pubmed publisher
    ..The transcriptional expression of ER stress-associated molecules, glucose-regulated protein-78 (GRP78) and C/EBP-homologous protein (CHOP) were significantly increased in I/R retinas in a time-dependent manner...
  33. Ohri S, Maddie M, Zhang Y, Shields C, Hetman M, Whittemore S. Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury. J Neurotrauma. 2012;29:579-88 pubmed publisher
    ..Confocal images of phosphorylated EIF2?, GRP78, CHOP, ATF4, and GADD34 localized the activation of the ERSR in neurons and oligodendrocytes at the injury ..
  34. Ijuin T, Hatano N, Hosooka T, Takenawa T. Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78. Biochim Biophys Acta. 2015;1853:3192-201 pubmed publisher
    ..SKIP), a phosphatidylinositol-3,4,5-trisphosphate (PIP3) phosphatase, and glucose-regulated protein 78 (GRP78) are implicated in the inhibition of insulin-dependent PI 3-kinase signaling in skeletal muscle...
  35. Cho Y, Jang Y, Jang Y, Chung S, Kim H, Lee J, et al. Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Exp Mol Med. 2009;41:440-52 pubmed publisher
    ..BIP/GRP78 protein expression was time-dependently increased, and three branches of UPR were all activated...
  36. Jakobsson M, Moen A, Bousset L, Egge Jacobsen W, Kernstock S, Melki R, et al. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J Biol Chem. 2013;288:27752-63 pubmed publisher
    ..Finally, we show that trimethylation of HSPA8 (Hsc70) has functional consequences, as it alters the affinity of the chaperone for both the monomeric and fibrillar forms of the Parkinson disease-associated protein ?-synuclein. ..
  37. Croci S, Recktenwald C, Lichtenfels R, Nicoletti G, Dressler S, De Giovanni C, et al. Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system. Proteomics. 2010;10:3835-53 pubmed publisher
    ..The distinct expression patterns for annexin A6 and GRP78 during tumour progression were further verified by western blot and/or immunoprecipitation...
  38. Chouchani E, Hurd T, Nadtochiy S, Brookes P, Fearnley I, Lilley K, et al. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochem J. 2010;430:49-59 pubmed publisher
    ..More generally, the development of SNO-DIGE facilitates robust investigation of protein S-nitrosation across the proteome. ..
  39. Wang W, Yeh S, Chang Y, Hsiao S, Lian W, Lin C, et al. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem. 2003;278:37705-12 pubmed
    ..These findings indicate a previously unidentified role for PICK1 in anchoring PKCalpha to mitochondria in a ligand-specific manner. ..
  40. Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, et al. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest Ophthalmol Vis Sci. 2009;50:334-44 pubmed publisher
    The effect of a preferential inducer of 78 kDa glucose-regulated protein (GRP78)/immunoglobulin heavy-chain binding protein (BiP; BiP inducer X, BIX) against tunicamycin-induced cell death in RGC-5 (a rat ganglion cell line), and also ..
  41. Zhang H, Lu M, Qi H, Zhang J. [Up-regulation of glucose regulated protein 78 induced by 2-deoxyglucose plays a protective role for fetal rat cerebral neuron following intrauterine distress]. Zhonghua Fu Chan Ke Za Zhi. 2008;43:356-60 pubmed
    To evaluate the influence of up-regulation of glucose regulated protein 78 (GRP 78) induced by 2-deoxyglucose (2DG) on fetal rat cerebral neuron apoptosis following intrauterine distress and the unification of endoplasmic reticulum and ..
  42. Sevilla L, Comstock S, Swier K, Miller J. Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. J Immunol. 2004;173:2586-93 pubmed
    ..These results suggest that the ERAD machinery can induce subunit disassembly, specifically targeting misfolded subunits to degradation and sparing properly folded subunits for reassembly and/or export. ..
  43. Kharenko O, Polichuk D, Nelson K, Abrams S, Loewen M. Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members. J Biochem. 2013;154:383-91 pubmed publisher
    ..and embryonic cells, leading to the identification of heat shock protein 70 (HSP70) family members, (including GRP78 and HSP70-2) as putative human ABA-binding proteins...
  44. Bernal Bayard J, Cardenal Muñoz E, Ramos Morales F. The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. J Biol Chem. 2010;285:16360-8 pubmed publisher
  45. Takeda K, Inoue H, Tanizawa Y, Matsuzaki Y, Oba J, Watanabe Y, et al. WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Hum Mol Genet. 2001;10:477-84 pubmed
    ..These studies represent a first step toward the characterization of WFS1 protein, which presumably functions to maintain certain populations of neuronal and endocrine cells. ..
  46. Sato Y, Hatta M, Karim M, Sawa T, Wei F, Sato S, et al. Anks4b, a novel target of HNF4? protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic ?-cells. J Biol Chem. 2012;287:23236-45 pubmed publisher
    ..Anks4b bound to glucose-regulated protein 78 (GRP78), a major endoplasmic reticulum (ER) chaperone protein, and overexpression of Anks4b enhanced the ER stress ..
  47. Yamaguchi A, Taniguchi M, Hori O, Ogawa S, Tojo N, Matsuoka N, et al. Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia. J Biol Chem. 2002;277:623-9 pubmed
    ..These results suggest that Peg3/Pw1 is involved in the p53-mediated cell death pathway as a downstream effector of p53 in brain ischemia/hypoxia. ..
  48. Vera P, Wang X, BUCALA R, Meyer Siegler K. Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat. PLoS ONE. 2009;4:e5835 pubmed publisher
    ..to alpha1-inhibitor III (A1-I3; a member of the alpha2-macroglubulin family) and glucose regulated protein 78 (GRP78) is a receptor for A1-I3 the goals of this study were to determine if substance P elicits urothelial cell-surface ..
  49. Zhang X, Wang Y, Li H, Zhang W, Wu D, Mi H. The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration. FEBS Lett. 2004;559:57-60 pubmed
    ..By high concentration of Ca(2+) this binding cannot be detected. Furthermore, the Ca(2+)-regulated binding of mFKBP23 and mBiP in ER can be detected by means of co-immunoprecipitation. ..
  50. Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, et al. Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes. 2012;61:2823-32 pubmed publisher
    ..adipose tissue-derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from ER to plasma membrane under ER stress...
  51. Liu Y, Yang L, Chen K, Zhou B, Yan H, Zhou Z, et al. Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and LPS induced pancreatic inflammation. PLoS ONE. 2014;9:e92389 pubmed publisher
    ..The endoplasmic reticulum (ER) chaperone protein GRP78 has anti-apoptotic properties, in addition to modulating ER stress responses...
  52. Zhang H, Lv M, Zhao Z, Jia J, Zhang L, Xiao P, et al. Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome. Gene. 2014;545:156-62 pubmed publisher
    This study is to investigate the role of glucose-regulated protein 78 (GRP78) in the pulmonary microvascular remodeling during hepatopulmonary syndrome (HPS) development. ..
  53. Torres Gonzalez E, Bueno M, Tanaka A, Krug L, Cheng D, Polosukhin V, et al. Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. Am J Respir Cell Mol Biol. 2012;46:748-56 pubmed publisher
    ..cells in aging lungs was accompanied by up-regulation of endoplasmic reticulum stress marker, binding immunoglobulin protein, and splicing of X-box-binding protein 1...