Hsp90aa1

Summary

Gene Symbol: Hsp90aa1
Description: heat shock protein 90, alpha (cytosolic), class A member 1
Alias: Hsp86, Hsp90, Hspca, heat shock protein HSP 90-alpha, HSP 86, heat shock 86 kDa, heat shock protein 1, alpha, heat shock protein 86
Species: rat
Products:     Hsp90aa1

Top Publications

  1. Peng X, Guo X, Borkan S, Bharti A, Kuramochi Y, Calderwood S, et al. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005;280:13148-52 pubmed
    ..The chaperone activity of Hsp90 requires ATP, which binds with approximately 10-fold lower affinity than ADP...
  2. Whitesell L, Sutphin P, Pulcini E, Martinez J, Cook P. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol. 1998;18:1517-24 pubmed
    ..reported by others, but in addition, other well-recognized elements of the cellular chaperone machinery, including hsp90, cyclophilin 40, and p23, were detected...
  3. Cortés González C, Barrera Chimal J, Ibarra Sánchez M, Gilbert M, Gamba G, Zentella A, et al. Opposite effect of Hsp90? and Hsp90? on eNOS ability to produce nitric oxide or superoxide anion in human embryonic kidney cells. Cell Physiol Biochem. 2010;26:657-68 pubmed publisher
    Heat shock protein 90 subfamily is composed by two cytosolic isoforms known as Hsp90? and Hsp90?...
  4. Ramirez V, Uribe N, García Torres R, Castro C, Rubio J, Gamba G, et al. Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat. Cell Stress Chaperones. 2004;9:198-206 pubmed
    Two genes encoding isoforms heat shock protein (Hsp) 90alpha and Hsp90beta constitute the Hsp90 subfamily...
  5. Banh A, Deschamps P, Vijayan M, Sivak J, West Mays J. The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants. Mol Vis. 2007;13:2248-62 pubmed
    This study investigates the effects of heat shock treatment and the role of Hsp70 and Hsp90 on tranforming growth factor beta 2 (TGF-beta2)-induced epithelial-to-mesenchymal transition (EMT) in rat lens epithelial explants...
  6. Bergmayr C, Thurner P, Keuerleber S, Kudlacek O, Nanoff C, Freissmuth M, et al. Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. J Biol Chem. 2013;288:28831-44 pubmed publisher
    ..We identified molecular chaperones (heat-shock proteins HSP90? and HSP70-1A) that interact with and retain partially folded A2A receptor prior to ER exit...
  7. Noh H, Kim H, Yu M, Kim W, Kim J, Ryu J, et al. Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-? type II receptor. Lab Invest. 2012;92:1583-96 pubmed publisher
    ..The purpose of this study is to determine the therapeutic efficacy of Hsp90 inhibitor on renal fibrosis...
  8. Kaneta H, Ukai W, Tsujino H, Furuse K, Kigawa Y, Tayama M, et al. Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production. J Psychiatr Res. 2017;92:108-118 pubmed publisher
    ..The antipsychotics olanzapine, aripiprazole, and blonanserin, but not haloperidol increased HSP90 levels, which were reduced by the exposure to MK-801...
  9. Yamaguchi Y, Miyagi Y, Baba H. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. J Neurosci Res. 2008;86:766-75 pubmed

More Information

Publications87

  1. Cheng A, Zhang M, Gentry M, Worby C, Dixon J, Saltiel A. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007;21:2399-409 pubmed
    ..Taken together, these results indicate that binding to glycogen crucially regulates the stability of AGL and, further, that its ubiquitination may play an important role in the pathophysiology of both Lafora and Cori's disease. ..
  2. Kim Y, Kim K, Lee H, Han S, Lee Y, Choe J, et al. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur J Pharmacol. 2009;612:131-42 pubmed publisher
    ..a negative effect on FcepsilonRIbeta signaling by inhibiting the interaction between heat shock protein 90 (hsp90) and proteins, such as, FcepsilonRIbeta, Akt and PKCalpha...
  3. Park K, Choi K, Kim H, Kim K, Lee M, Lee J, et al. Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis. Exp Mol Med. 2009;41:371-81 pubmed publisher
    ..Accumulating findings reveal that heat shock protein 90 (HSP90) is a molecular chaperone and a component of the IgammaB kinase (IKK) complex that plays a central role in NF-..
  4. Lei H, Romeo G, Kazlauskas A. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res. 2004;94:902-9 pubmed
  5. Yun C, Boggon T, Li Y, Woo M, Greulich H, Meyerson M, et al. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 2007;11:217-27 pubmed
    ..Strikingly, direct binding measurements show that gefitinib binds 20-fold more tightly to the L858R mutant than to the wild-type enzyme. ..
  6. Park S, Suetsugu S, Takenawa T. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. EMBO J. 2005;24:1557-70 pubmed publisher
    ..Here, we show that heat shock protein 90 (HSP90) regulates N-WASP-induced actin polymerization in cooperation with phosphorylation of N-WASP...
  7. Yoshida M, Xia Y. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem. 2003;278:36953-8 pubmed
    ..Here we show that NO synthesis from iNOS can be profoundly modulated by heat shock protein 90 (hsp90) through protein-protein interaction...
  8. Dhar S, Thota A, Rao M. Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis. J Biol Chem. 2012;287:6387-405 pubmed publisher
    ..Thus, our results indicate this interaction to be a vital step in the chromatin remodeling process during mammalian spermiogenesis. ..
  9. Misa Agustiño M, Jorge Mora T, Jorge Barreiro F, Suárez Quintanilla J, Moreno Piquero E, Ares Pena F, et al. Exposure to non-ionizing radiation provokes changes in rat thyroid morphology and expression of HSP-90. Exp Biol Med (Maywood). 2015;240:1123-35 pubmed publisher
    ..Further research is needed to determine if the effect of this physical agent over time may cause disease in the human thyroid gland. ..
  10. Kim Y, Kim J, Ko A, Kang T. Reduction in heat shock protein 90 correlates to neuronal vulnerability in the rat piriform cortex following status epilepticus. Neuroscience. 2013;255:265-77 pubmed publisher
    In the present study, we addressed the question of whether the distinct patterns of heat shock protein (HSP) 70 and HSP90 expressions in the brain region represents the regional specific responses to status epilepsticus (SE) in an effort ..
  11. Fan A, Bhangoo M, Young J. Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import. J Biol Chem. 2006;281:33313-24 pubmed
    The Tom70 import receptor on the mitochondrial outer membrane specifically recognizes Hsp90 and Hsc70, a critical step for the import of mitochondrial preproteins, the targeting of which depends on these cytosolic chaperones...
  12. Elaković I, Brkljacic J, Matić G. Gender-related differences in the effects of antidepressant imipramine on glucocorticoid receptor binding properties and association with heat shock proteins in the rat liver and kidney. Eur J Pharmacol. 2009;608:7-13 pubmed publisher
    ..K(D), were determined by radioligand binding assay, the glucocorticoid receptor and heat shock proteins (Hsp70 and Hsp90) levels by quantitative immunoblotting, and the interaction of these proteins within glucocorticoid receptor ..
  13. Lappalainen J, Lappalainen Z, Oksala N, Laaksonen D, Khanna S, Sen C, et al. Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain. Cell Biochem Funct. 2010;28:644-50 pubmed publisher
    ..Diabetes increased constitutive HSC70 mRNA, and decreased HSP90 and glucose-regulated protein 75 (GRP75) mRNA without affecting protein levels...
  14. Datta R, Bansal T, Rana S, Datta K, Datta Chaudhuri R, Chawla Sarkar M, et al. Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy. Mol Cell Biol. 2017;37: pubmed publisher
    ..Our recent findings have identified heat shock protein 90 (Hsp90) to be a critical modulator of fibrotic signaling in cardiac fibroblasts in this disease milieu...
  15. Lee J, Chung I. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 2010;290:76-86 pubmed publisher
    The molecular chaperone complex Hsp90-p23 interacts with the rate-limiting catalytic subunit of telomerase, hTERT...
  16. Xiong L, Zhao T, Huang X, Liu Z, Zhao H, Li M, et al. Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells. Cell Stress Chaperones. 2009;14:183-92 pubmed publisher
    ..HIF-1 could be stabilized under hypoxic conditions, and heat shock protein 90 (HSP90) is an essential protein that controls the activity and stabilization of HIF-1alpha...
  17. Forner F, Furlan S, Salvatori S. Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK). Biochim Biophys Acta. 2010;1804:1334-41 pubmed publisher
    ..several putative DMPK-binding proteins, including several heat shock proteins such as HSP20/HSPB6, HSP60/CPN60, HSP70 and HSP90. We also obtained evidence of a direct interaction of DMPK with alphaB-crystallin/HSPB5 and HSP25/HSPB1.
  18. Gao F, Hu X, Xie X, Liu X, Wang J. Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K/Akt and ERK1/2 pathways. Cell Biochem Biophys. 2015;71:481-9 pubmed publisher
    The objective of this study was to determine the role of Hsp90α in regulating the migration of mesenchymal stem cells (MSCs) and to investigate the underlying mechanisms of this effect...
  19. Cliff M, Williams M, Brooke Smith J, Barford D, Ladbury J. Molecular recognition via coupled folding and binding in a TPR domain. J Mol Biol. 2005;346:717-32 pubmed
    ..by the TPR domain of protein phosphatase 5 (PP5), which binds to the C terminus of the chaperone protein Hsp90. Here, we report NMR and CD spectroscopic studies that reveal that this domain is largely unfolded at ..
  20. Newton A. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010;298:E395-402 pubmed publisher
    ..This review introduces the PKC family and then focuses on recent advances in understanding the cellular regulation of its diacylglycerol-regulated members. ..
  21. Ortiz P, Hong N, Garvin J. Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90. Am J Physiol Renal Physiol. 2004;287:F281-8 pubmed
    ..We next tested whether heat shock protein (Hsp)90 is involved in eNOS translocation. The Hsp90 inhibitor geldanamycin blocked flow-induced eNOS translocation to the apical membrane (n = 6)...
  22. Lee K, Jang Y, Chung J. Heat shock protein 90 regulates I?B kinase complex and NF-?B activation in angiotensin II-induced cardiac cell hypertrophy. Exp Mol Med. 2010;42:703-11 pubmed publisher
    Heat shock protein 90 (HSP90), one of the most abundant proteins in the cardiac cells is essential for cell survival. Previous studies have shown that angiotensin II induces cardiac cell hypertrophy...
  23. Venema R, Venema V, Ju H, Harris M, Snead C, Jilling T, et al. Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2003;285:H669-78 pubmed
    ..In this study, we demonstrate that sGC exists in a complex with eNOS and heat shock protein 90 (HSP90) in aortic endothelial cells...
  24. Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed
    ..In malignant cells, the capacity to buffer transformation has been attributed to heat-shock protein 90 (Hsp90)...
  25. Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan K. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999;19:5523-34 pubmed
    ..observe that murine KSR forms a multimolecular signaling complex in human embryonic kidney 293T cells composed of HSP90, HSP70, HSP68, p50(CDC37), MEK1, MEK2, 14-3-3, and several other, unidentified proteins...
  26. Cannino G, Ferruggia E, Rinaldi A. Proteins participating to the post-transcriptional regulation of the mitochondrial cytochrome c oxidase subunit IV via elements located in the 3'UTR. Mitochondrion. 2009;9:471-80 pubmed publisher
    ..We successfully isolated two main proteins of about 86 and 42kDa, whose sequences were highly attributable to Hsp90 and Actin...
  27. Islam A, Lv Y, Abdelnasir A, Rehana B, Liu Z, Zhang M, et al. The role of Hsp90? in heat-induced apoptosis and cell damage in primary myocardial cell cultures of neonatal rats. Genet Mol Res. 2013;12:6080-91 pubmed publisher
    ..among the heat-induced pathological changes and apoptosis and the variations in the levels of protective Hsp90? and its mRNA in the heat-stressed primary myocardial cells of neonatal rats in vitro were studied by ..
  28. Young J, Obermann W, Hartl F. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J Biol Chem. 1998;273:18007-10 pubmed
    The molecular chaperone hsp90 in the eukaryotic cytosol interacts with a variety of protein cofactors. Several of these cofactors have protein domains containing tetratricopeptide repeat (TPR) motifs, which mediate binding to hsp90...
  29. Ginsberg J, Labedz T, Brindley D. Phosphorylation of heat shock protein-90 by TSH in FRTL-5 thyroid cells. Thyroid. 2006;16:737-42 pubmed
    ..In summary, we have demonstrated that TSH action stimulates the phosphorylation of hsp-90 in FRTL-5 thyroid cells. Abnormalities of hsp-90 phosphorylation may be a mediator in the development of thyroid disease. ..
  30. Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett. 2003;548:17-20 pubmed
    ..In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex...
  31. Lee H, Sengupta N, Villagra A, Rezai Zadeh N, Seto E. Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. Mol Cell Biol. 2006;26:5259-69 pubmed
    ..Importantly, HDAC8 regulation of hEST1B protein stability modulates total telomerase enzymatic activity. Our findings reveal a novel mechanism by which HDAC8 contributes to tumorigenesis by regulating telomerase activity. ..
  32. Prescott J, Coetzee G. Molecular chaperones throughout the life cycle of the androgen receptor. Cancer Lett. 2006;231:12-9 pubmed
    ..Regardless of whether chaperones are involved in the causation of prostate carcinogenesis, molecular chaperones provide therapeutic targets for the treatment of prostate cancer. ..
  33. Gerges N, Tran I, Backos D, Harrell J, Chinkers M, Pratt W, et al. Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. J Neurosci. 2004;24:4758-66 pubmed
    ..Here, we evaluate the role of the molecular chaperone hsp90 (heat shock protein 90) in excitatory synaptic transmission in the hippocampus...
  34. Wang Y, Thuillier R, Culty M. Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes. Biol Reprod. 2004;71:1652-64 pubmed
    ..study, we found that purified gonocytes contained the mRNAs of estrogen receptor beta (ERbeta) and the chaperones Hsp90, p23, and Cyp40, but no inducible Hsp70...
  35. Cheng M, Zhang Y, Zhong X, Sutter B, Cao C, Chen X, et al. Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cell Signal. 2010;22:1206-13 pubmed publisher
    ..However, the activation of these kinases under heat shock requires the association of chaperone proteins of the Hsp90 family, in particular, the Hsp90beta under heat shock...
  36. Aguilà M, Bevilacqua D, McCulley C, Schwarz N, Athanasiou D, Kanuga N, et al. Hsp90 inhibition protects against inherited retinal degeneration. Hum Mol Genet. 2014;23:2164-75 pubmed publisher
    The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple indications in cancer...
  37. Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo A. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol. 2008;28:5747-63 pubmed publisher
    ..The two major chaperones related to CMA, hsc70 and hsp90, play critical roles in the functional dynamics of the LAMP-2A complexes at the lysosomal membrane...
  38. Simic I, Mitic M, Djordjevic J, Radojcic M, Adzic M. Chronic stress decreases availability of heat shock proteins to glucocorticoid receptor in response to novel acute stress in Wistar rat hypothalamus. Cell Mol Neurobiol. 2012;32:625-32 pubmed publisher
    ..GR), as a mediator of HPA axis feedback inhibition, and its chaperones, the heat shock proteins (HSPs), hsp70 and hsp90. The CPSI did not cause any changes in either GR or HSPs levels...
  39. Pratt W, Morishima Y, Murphy M, Harrell M. Chaperoning of glucocorticoid receptors. Handb Exp Pharmacol. 2006;:111-38 pubmed
    A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradle-to-grave' system for regulating the steroid binding, trafficking and turnover of the glucocorticoid receptor (GR)...
  40. Raffaniello R, Fedorova D, Ip D, Rafiq S. Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells. Cell Physiol Biochem. 2009;24:369-78 pubmed publisher
    ..It has recently been demonstrated that a Heat shock protein 90 (Hsp90) chaperone complex regulates the interactions between Rab proteins and Rab-GDI-1...
  41. Kanno Y, Miyama Y, Ando M, Inouye Y. Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor. Mol Pharmacol. 2010;77:311-6 pubmed publisher
    ..Taking these into consideration, PB-mediated nuclear translocation of rCAR might be dependent on the 90-kDa heat shock protein as well as the microtubule network. ..
  42. Zhang L, Ma J, Li Y, Guo L, Ran Y, Liu S, et al. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90. Life Sci. 2010;87:223-31 pubmed publisher
    ..As HSP90 is known to be involved in apoptosis in other tissues and cells, we aim to test whether anti-apoptotic effect of ..
  43. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..We conclude that GBP-1 is a downstream processor of IFN-? via which T cells regulate cytoskeleton-dependent cell functions. ..
  44. Yang J, Fuller P. Interactions of the mineralocorticoid receptor--within and without. Mol Cell Endocrinol. 2012;350:196-205 pubmed publisher
    ..This review will discuss the current understanding of interactions involving the MR and highlight their relevance to ligand- or tissue-specificity as well as their suitability as therapeutic targets. ..
  45. Eiam Ong S, Sinphitukkul K, Manotham K, Eiam Ong S. Rapid nongenomic action of aldosterone on protein expressions of Hsp90( ? and ? ) and pc-Src in rat kidney. Biomed Res Int. 2013;2013:346480 pubmed publisher
    ..epidermal growth factor receptor (EGFR) through activation of upstream signals, heat shock protein 90 ? (Hsp90 ? ), and cytosolic (c)-Src kinase...
  46. Yang F, Chen W, Zheng M, Yu G, Xu H, Shen Y, et al. Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts. J Heart Lung Transplant. 2011;30:928-34 pubmed publisher
    ..The present study investigated whether heat shock protein 90 (Hsp90) is important in the anti-apoptotic effect of diazoxide in hypothermic preservation rat hearts...
  47. Lo C, Chang Y, Chao C, Chang M, Chang K, Lai Y. Control mechanisms of differential translation of Hsp90 isoforms in 9L rat gliosarcoma cells. J Cell Biochem. 2009;107:418-27 pubmed publisher
    ..Hsp90alpha and Hsp90beta was extensively studied in many kinds of cells, the post-transcriptional regulation of Hsp90 isoforms remains unclear...
  48. Ai J, Yang Z, Qiu F. [Role of heat shock protein 90 in hyperdynamic circulation of portal hypertensive rats]. Zhonghua Yi Xue Za Zhi. 2004;84:9-13 pubmed
    ..05). However, GA did not affect the vasodilation of the ensothelium-neduded mesenteric artery in response to SNP. HSP90 is responsible for the hyperdynamic circulation in the portal hypertensive rats.
  49. Maselli J, Hales B, Robaire B. Paternal exposure to testis cancer chemotherapeutics alters sperm fertilizing capacity and affects gene expression in the eight-cell stage rat embryo. Andrology. 2014;2:259-66 pubmed publisher
    ..b>HSP90AA1, HSP90B1 and PDIA3, involved in spermatozoa-egg interactions, were overexpressed in BEP-exposed spermatozoa after ..
  50. Ramsey A, Russell L, Chinkers M. C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins. Biochem J. 2009;423:411-9 pubmed publisher
    ..repeat) proteins that bind to the maturation complex via the C-termini of hsp70 (heat-shock protein 70) and hsp90 (heat-shock protein 90)...
  51. Sakisaka T, Meerlo T, Matteson J, Plutner H, Balch W. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. EMBO J. 2002;21:6125-35 pubmed
    ..We have now identified a novel alphaGDI complex from synaptic membranes that contains three chaperone components: Hsp90, Hsc70 and cysteine string protein (CSP)...
  52. Tominaga M, Ohta M, Kai S, Iwaki K, Shibata K, Kitano S. Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. J Gastroenterol Hepatol. 2009;24:1136-41 pubmed publisher
    ..to investigate the relation between adaptive cytoprotection after exposure to ethanol and gastric expression of Hsp90 in PHT rats. Portal hypertension was induced in rats by staged portal vein occlusion...
  53. Carbone D, Doorn J, Kiebler Z, Ickes B, Petersen D. Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. J Pharmacol Exp Ther. 2005;315:8-15 pubmed
    ..The results revealed that essential 90-kDa heat shock protein (Hsp90) was consistently modified by 4-HNE in the alcohol-treated animals...
  54. Sidera K, Samiotaki M, Yfanti E, Panayotou G, Patsavoudi E. Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system. J Biol Chem. 2004;279:45379-88 pubmed
    Heat shock protein HSP90 plays important roles in cellular regulation, primarily as a chaperone for a number of key intracellular proteins...
  55. Boudeau J, Deak M, Lawlor M, Morrice N, Alessi D. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. Biochem J. 2003;370:849-57 pubmed
    ..In this study we have purified LKB1 from cells and establish that it is associated with the heat-shock protein 90 (Hsp90) chaperone and the Cdc37 kinase-specific targetting subunit for Hsp90...
  56. Langer T, Fasold H. Isolation and quantification of the heat shock protein 90 alpha and beta isoforms from rat liver. Protoplasma. 2001;218:54-6 pubmed
    Heat shock protein 90 (Hsp90) is an abundant cytosolic protein. In higher eukaryotes two isoforms of Hsp90 exist, Hsp90 alpha and Hsp90 beta...
  57. Arambasić J, Mihailovic M, Uskoković A, Dinić S, Grdovic N, Markovic J, et al. Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. Eur J Nutr. 2013;52:1461-73 pubmed publisher
    ..factor 2 (Nrf2), enhanced expression of heat shock proteins (HSPs) and by reduction in O-GlcNAcylation of HSP90, HSP70, and extracellular regulated kinase and p38...
  58. Zhong G, Tu R, Zeng Z, Li Q, Li S, He Y, et al. Novel functional role of heat shock protein 90 in protein kinase C-mediated ischemic postconditioning. J Surg Res. 2014;189:198-206 pubmed publisher
    Previous studies have shown that heat shock protein 90 (HSP90) plays a vital role in ischemic preconditioning...
  59. Liou S, Wang C. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Arch Biochem Biophys. 2005;435:253-63 pubmed
    ..In this study, we demonstrated that the TPR domain of SGT also interacted with Hsp90. Moreover, we investigated the functional significance of regions of SGT outside the TPR domain...
  60. Ko Y, Kang Y, Kim E, Park S, Kim S. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J Cell Biol. 2000;149:567-74 pubmed
    ..Thus, human MRS plays a role in the biogenesis of rRNA in nucleoli, while it is catalytically involved in protein synthesis in cytoplasm. ..
  61. Tortosa E, Santa Maria I, Moreno F, Lim F, Perez M, Avila J. Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein. J Alzheimers Dis. 2009;17:319-25 pubmed publisher
    ..changes could be regulated by chaperones such as heat shock proteins, since one of these, heat shock protein 90 (Hsp90), has already been described as a putative tau-binding protein...
  62. Kang C, Qin J, Osei W, Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochem Biophys Res Commun. 2017;482:1201-1206 pubmed publisher
    ..lower at the basal condition and in response to adenosine treatment, along with largely decreased mitochondrial HSP90 and TOM70 protein expression...
  63. Gao F, Hu X, Xie X, Xu Q, Wang Y, Liu X, et al. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. J Zhejiang Univ Sci B. 2010;11:608-17 pubmed publisher
    ..The aim of this study is to explore the cytoprotection of heat shock protein 90 (Hsp90) against hypoxia and serum deprivation-induced apoptosis and the possible mechanisms in rat MSCs...
  64. Yang S, Oh K, Park E, Chang H, Park J, Seong M, et al. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci. 2013;33:12728-38 pubmed publisher
    ..These results indicate that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. ..
  65. Franco M, Ricart K, Gonzalez A, Dennys C, Nelson P, Janes M, et al. Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism. J Biol Chem. 2015;290:19055-66 pubmed publisher
    ..Nitration of the pro-survival chaperone heat shock protein 90 (Hsp90) in position 33 and 56 induces motor neuron death through a toxic gain-of-function...
  66. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches. ..
  67. Yang Z, Yang C, Xiao L, Liao X, Lan A, Wang X, et al. Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia-induced injury in H9c2 cardiac myocytes. Int J Mol Med. 2011;28:397-403 pubmed publisher
    ..The aim of this study was to investigate the role of heat shock protein 90 (HSP90) in cardioprotection of H2S in H9c2 cells...
  68. Garcia Fuster M, Flagel S, Mahmood S, Watson S, Akil H. Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. PLoS ONE. 2012;7:e42092 pubmed publisher
    ..and corticosteroid receptors (GR, MR, MR/GR mRNA ratios) and expression of other stress-related molecules (HSP90AA1 and HSP90AB1 mRNA) were measured in hippocampal subfields using in situ hybridization...
  69. Quintá H, Maschi D, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010;115:716-34 pubmed publisher
    ..protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors...
  70. Zhu W, Guo W, Zhu J, Tang C, Fu Y, Lin Q, et al. Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury. Sci Rep. 2016;6:24498 pubmed publisher
    ..Heat shot protein 90 (Hsp90) aa1 mRNA expression was decreased post-I/R, and Hsp90aa1 protein level was decreased on day1 post-I/R, but was reversed on day 3 and day 7 post-I/R...
  71. Siebelt M, Jahr H, Groen H, Sandker M, Waarsing J, Kops N, et al. Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats. Arthritis Rheum. 2013;65:2102-12 pubmed publisher
    ..This study was undertaken to examine the roles of Hsp70 and Hsp90 in biomechanically induced OA, and the possibility of using Hsp90 inhibition as an intervention strategy for OA ..
  72. Tu R, Li Q, Huang Z, He Y, Meng J, Zheng H, et al. Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning. Cell Physiol Biochem. 2017;44:982-997 pubmed publisher
    Previous studies have shown that heat shock protein 90 (HSP90)-mediated mitochondrial import of connexin 43 (Cx43) is critical in preconditioning cardioprotection...
  73. Jiao J, Garg V, Yang B, Hu K. Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning. Cardiovasc Res. 2008;77:126-33 pubmed
    ..Further, our data showed that inhibiting heat shock protein 90 (HSP90) function with the HSP90 inhibitor geldanamycin or HSP90 expression with siRNA completely inhibited the protection ..
  74. Holt S, Aisner D, Baur J, Tesmer V, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999;13:817-26 pubmed
    ..We have identified the molecular chaperones p23 and Hsp90 as proteins that bind to the catalytic subunit of telomerase...
  75. Kharlamov E, Lepsveridze E, Meparishvili M, Solomonia R, Lu B, Miller E, et al. Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy. Epilepsy Res. 2011;95:20-34 pubmed publisher
    ..1, ?4, ?2, and ? subunits, NMDA (NR2B) and AMPA (GluR1) receptor subunits, and heat shock proteins (HSP70 and HSP90) in the hippocampus of Sprague-Dawley rats evaluated by Western blotting in controls, CCI-injured animals without ..
  76. Corso Díaz X, Krukoff T. nNOS alpha and nNOS beta localization to aggresome-like inclusions is dependent on HSP90 activity. J Neurochem. 2010;114:864-72 pubmed publisher
    ..Heat shock protein 90 (HSP90) regulates nNOSalpha activity by facilitating heme insertion into the nNOSalpha monomer, resulting in increased NO ..
  77. Chao C, Sun F, Wang C, Lo C, Chang Y, Chang K, et al. Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells. J Cell Biochem. 2008;104:1286-96 pubmed publisher
    b>HSP90 chaperones are transducer proteins of many signaling pathways in cells. Using a highly specific inhibitor, geldanamycin (GA), an increasing number of the HSP90 client proteins have been identified...
  78. Martínez Ruiz A, Villanueva L, González de Orduña C, Lopez Ferrer D, Higueras M, Tarin C, et al. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A. 2005;102:8525-30 pubmed
    ..a variety of methods (ozone chemiluminescence, biotin switch, and mass spectrometry) that the molecular chaperone Hsp90 is a target of S-nitrosylation and identify a susceptible cysteine residue in the region of the C-terminal domain ..