Gene Symbol: Hsf1
Description: heat shock transcription factor 1
Alias: heat shock factor protein 1
Species: rat
Products:     Hsf1

Top Publications

  1. Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, et al. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res. 2006;99:1411-8 pubmed
    ..Here, we showed a critical role of heat shock transcription factor 1 (HSF1), an important transcription factor for heat shock proteins, in the adaptive mechanism of cardiac hypertrophy...
  2. Zuo J, Baler R, Dahl G, Voellmy R. Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure. Mol Cell Biol. 1994;14:7557-68 pubmed
  3. Wang X, Grammatikakis N, Siganou A, Calderwood S. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003;23:6013-26 pubmed
    Heat shock factor 1 (HSF1) regulates the transcription of molecular chaperone hsp genes. However, the cellular control mechanisms that regulate HSF1 activity are not well understood...
  4. Jiang Y, Wang X, Cao X, Ye Z, Li L, Cai W. Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease. Brain Res. 2013;1519:105-11 pubmed publisher
    ..Furthermore, heat shock factor 1 (HSF1), a key transcription factor for the expression of HSP genes, was found to be greatly decreased in the cerebella of ..
  5. Hietakangas V, Ahlskog J, Jakobsson A, Hellesuo M, Sahlberg N, Holmberg C, et al. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol. 2003;23:2953-68 pubmed
    ..Hsp induction is mainly regulated at transcriptional level by stress-inducible heat shock factor 1 (HSF1)...
  6. Green M, Schuetz T, Sullivan E, Kingston R. A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol. 1995;15:3354-62 pubmed
    Human heat shock factor 1 (HSF1) stimulates transcription from heat shock protein genes following stress...
  7. Wang X, Khaleque M, Zhao M, Zhong R, Gaestel M, Calderwood S. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 2006;281:782-91 pubmed
    Heat shock transcription factor 1 (HSF1) monitors the structural integrity of intracellular proteins and its regulation is essential for the health and longevity of eukaryotic organisms...
  8. Chen C, Xie Y, Stevenson M, Auron P, Calderwood S. Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene. J Biol Chem. 1997;272:26803-6 pubmed
  9. Murshid A, Chou S, Prince T, Zhang Y, Bharti A, Calderwood S. Protein kinase A binds and activates heat shock factor 1. PLoS ONE. 2010;5:e13830 pubmed publisher
    ..We have studied such regulation of Heat Shock Factor 1 (HSF1), a key protein in control of the heat shock response, and a participant in carcinogenisis, neurological health and ..

More Information


  1. Sun X, Crawford R, Liu C, Luo T, Hu B. Development-dependent regulation of molecular chaperones after hypoxia-ischemia. Neurobiol Dis. 2015;82:123-131 pubmed publisher
    ..Nuclear accumulation of heat-shock transcription factor-1 (HSF1) and expression of molecular chaperone proteins and mRNAs were analyzed by in situ hybridization, Western blotting ..
  2. Ma H, Gong H, Chen Z, Liang Y, Yuan J, Zhang G, et al. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J Mol Cell Cardiol. 2012;52:1282-90 pubmed publisher
    ..Heat shock transcription factor 1 (HSF1), a definite endogenous protective protein in cardiomyocytes, may interact with Stat family under stress conditions...
  3. Iwashita Y, Sakiyama T, Musch M, Ropeleski M, Tsubouchi H, Chang E. Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011;301:G181-7 pubmed publisher
    ..These results indicate that polyamines play a critical role in the glutamine-dependent induction of the intestinal epithelial heat shock response through facilitation of HSF-1 binding to HSE. ..
  4. Xing H, Mayhew C, Cullen K, Park Sarge O, Sarge K. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. J Biol Chem. 2004;279:10551-5 pubmed
    Induction of heat shock protein (HSP) gene expression by stress is initiated by binding of HSF1 to HSP gene promoters to increase their transcription...
  5. Fairfield D, Kanicki A, Lomax M, Altschuler R. Expression and localization of heat shock factor (Hsf) 1 in the rodent cochlea. Hear Res. 2002;173:109-18 pubmed
    ..reaction (RT-PCR), Western blot and immunocytochemistry were used to examine the expression and localization of Hsf1, the stress-responsive member of the Hsf family, in the rat and mouse cochlea...
  6. Akcetin Z, Pregla R, Darmer D, Bromme H, Holtz J. During ischemia-reperfusion in rat kidneys, heat shock response is not regulated by expressional changes of heat shock factor 1. Transpl Int. 2000;13:297-302 pubmed
    ..the 70 kDa heat shock protein HSP70i (or HSP72) mainly via rapid activation of heat shock transcription factor 1 (HSF1). However, little is known about the regulation of the HSF1 gene...
  7. Kwong J, Lalezary M, Nguyen J, Yang C, Khattar A, Piri N, et al. Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells. Neurosci Lett. 2006;405:191-5 pubmed
    ..heat shock protein transcriptional mechanisms, we examined the cellular expression of heat shock factors 1 (HSF1) and 2 (HSF2) in the unstressed adult rat retina...
  8. Wilkerson D, Murphy L, Sarge K. Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol Reprod. 2008;79:283-8 pubmed publisher
    ..In this report, we investigated the role of HSF1 and HSF2 in bookmarking Hspa1b during late spermatogenesis...
  9. Lee Y, Park H, Koh S, Choi N, Lee K. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011;119:1262-70 pubmed publisher
    ..Our results indicate that AB and AC exert similar neuroprotective effects by reducing oxidative stress, enhancing survival signals, and inhibiting death signals. ..
  10. Wu L, Hu C, Huang M, Jiang M, Lu L, Tang J. Heat shock transcription factor 1 attenuates TNF?-induced cardiomyocyte death through suppression of NF?B pathway. Gene. 2013;527:89-94 pubmed publisher
    Heat shock transcription factor 1 (HSF1), which has been identified as an endogenous cardioprotective factor, possesses potent anti-inflammatory effects. However, the underlying mechanisms have not been fully understood yet...
  11. Tagawa K, Marubuchi S, Qi M, Enokido Y, Tamura T, Inagaki R, et al. The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes. J Neurosci. 2007;27:868-80 pubmed
    ..Surprisingly, however, heat shock factor 1 was not activated in granule cells by mutant htt. Collectively, different levels of hsp70 among neuronal subtypes might be involved in selective neuronal death in the HD pathology. ..
  12. Maheshwari M, Bhutani S, Das A, Mukherjee R, Sharma A, Kino Y, et al. Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease. Hum Mol Genet. 2014;23:2737-51 pubmed publisher
    ..Here we demonstrate that the defective HSR in the brain is due to the down-regulation of heat shock factor 1 (HSF1) in both mice and fly models of HD...
  13. Thakur P, Nehru B. Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology. Neurochem Int. 2014;75:1-10 pubmed publisher
    ..Our results indicate that besides being a known free radical scavenger and anti-inflammatory compound, SS can provide neuroprotection by differently upregulating the HSPs and reducing the protein aggregation burden. ..
  14. Gwag T, Park K, Park J, Lee J, Nikawa T, Choi I. Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation. J Physiol Pharmacol. 2015;66:273-83 pubmed
    ..These results suggest that CEL-mediated overexpression of HSP72 overcomes the atrophic effect of HSP72 gene silencing via both enhancement of FoxO3 phosphorylation and activation of Akt1-ERK1/2 signaling pathway. ..
  15. Petry Ã, Cruzat V, Heck T, Homem de Bittencourt P, Tirapegui J. L-glutamine supplementations enhance liver glutamine-glutathione axis and heat shock factor-1 expression in endurance-exercise trained rats. Int J Sport Nutr Exerc Metab. 2015;25:188-97 pubmed publisher
    ..liver glutamine-glutathione (GSH) axis, and 70 kDa heat shock proteins (HSP70)/heat shock transcription factor 1 (HSF1) expressions. Adult male Wistar rats were 8-week trained (60 min/day, 5 days/week) on a treadmill...
  16. Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, et al. Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Mol Cell Biol. 2011;31:3410-23 pubmed publisher
    Heat shock factor 1 (HSF1), while recognized as the major regulator of the heat shock transcriptional response, also exerts important functions during mammalian embryonic development and gametogenesis...
  17. Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
    ..b>HSF1 and HSF2 are required for some developmental processes, but it is unclear how they regulate these processes...
  18. Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt W, Toft D, et al. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem. 2001;276:45791-9 pubmed
    ..This repression mechanism may be required for a proportional transcriptional response to stress. Formation of the heterocomplex may also represent the first step toward returning the hHSF1 to its unactivated form. ..
  19. Yuan Z, Peng Y, Li X, Huang Y, Yang Z. [Expression of heat shock protein 70 in intestinal mucosa during the early stage after severe burns and its significance]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17:264-7 pubmed
    ..surface area (TBSA) full-thickness burned rats, the expression and distribution of HSP70 and heat shock factor-1 (HSF1) in intestinal mucosal were determined by reverse transcription-polymerase chain reaction (RT-PCR), Western blot ..
  20. Qin L, Zhang T, Jia Y, Zhang Y, Zhang Y, Wang H. Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha. Genet Mol Res. 2015;14:11771-9 pubmed publisher
    ..RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock factor-1 (HSF1) protein, respectively, in glioma cells...
  21. Syam A, Simadibrata M, Wanandi S, Hernowo B, Sadikin M, Rani A. Gastric ulcers induced by systemic hypoxia. Acta Med Indones. 2011;43:243-8 pubmed
    ..This development of gastric lesions was in line with the expression pattern of HSF-1 HIF-1 and HSP-70. ..
  22. Tang S, Chen H, Cheng Y, Nasir M, Kemper N, Bao E. The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress. Int J Mol Med. 2016;37:56-62 pubmed publisher
    Heat shock factor 1 (HSF1) is a heat shock transcription factor that rapidly induces heat shock gene transcription following thermal stress...
  23. Zou J, Guo Y, Guettouche T, Smith D, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 1998;94:471-80 pubmed
    ..In a novel in vitro system, in which human HSF1 can be activated by nonnative protein, heat, and geldanamycin, addition of Hsp90 inhibits activation...
  24. Zingarelli B, Hake P, Mangeshkar P, O Connor M, Burroughs T, Piraino G, et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. Shock. 2007;28:554-63 pubmed
    ..In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms. ..
  25. Kang G, Kim E, Lee H, Gil N, Cha H, Lee Y. Heat shock factor 1, an inhibitor of non-homologous end joining repair. Oncotarget. 2015;6:29712-24 pubmed publisher
    A novel role for HSF1 as an inhibitor of non-homologous end joining (NHEJ) repair activity was identified...
  26. Kaija H, Pakanen L, Kortelainen M, Porvari K. Hypothermia and rewarming induce gene expression and multiplication of cells in healthy rat prostate tissue. PLoS ONE. 2015;10:e0127854 pubmed publisher
    ..form of the prostatic acid phosphatase (PAcP), thrombomodulin (TM) and heat shock transcription factor 1 (HSF1) in rat ventral prostate were quantified in mild (2 or 4.5 h at room temperature) and severe (2 or 4...
  27. Kobba S, Kim S, Chen L, Kim E, Tran A, Knuefermann P, et al. The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock. 2011;35:478-84 pubmed publisher
    ..We conclude that the HS paradox occurs in adult cardiac myocytes, that HSP60 is increased as part of the HS paradox, and that HSF-1 activation contributes to injury. ..
  28. Qu M, Deng Z, Zhou Z, Wei A, Chen C, Yu Z, et al. [Effect of microwave irradiation on expression of heat shock proteins family in primary cultured rat hippocampal neurons]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010;28:909-13 pubmed
    ..Western blot was used to determine the expression of HSP27, HSP70, HSP90 and heat shock factor 1 (HSF1) at 0, 3, 6, 12 and 24 hour respectively. Real-time RT-PCR was used to determine the mRNA expression of HSF1...
  29. Baler R, Zou J, Voellmy R. Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chaperones. 1996;1:33-9 pubmed
    ..insults (stress) cause unfolding of proteins, triggering the activation of heat shock transcription factor HSF (HSF1 in vertebrates) that, in higher eukaryotes, involves trimerization of the factor and acquisition of heat shock ..
  30. Wang Y, Lam K, Cheng P, Lee Y. Celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats. J Ethnopharmacol. 2015;162:168-75 pubmed publisher
    ..Anti-inflammatory and anti-oxidant effects of celastrol contribute to prevent circulatory failure in sepsis. Induction of HO-1 and HSP70 by celastrol participates in these beneficial effects. ..
  31. Melhem H, Hansmannel F, Bressenot A, Battaglia Hsu S, Billioud V, Alberto J, et al. Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress. Gut. 2016;65:595-606 pubmed publisher
    ..The unfolded protein response (UPR), chaperones proteins, heat shock factor protein 1 (HSF1) and SIRT1 were examined in rats with MDD and dextran sulfate sodium (DSS)-induced colitis in a ..
  32. Gómez A, Córdova G, Munita R, Parada G, Barrios Ã, Cancino G, et al. Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response. PLoS ONE. 2015;10:e0129329 pubmed publisher
    ..inquire into the mechanisms regulating Hsp70 expression in neurons, we studied the activity of Heat Shock Factor 1 (HSF1) and histone posttranslational modifications (PTMs) at the hsp70 promoter in rat cortical neurons...
  33. Jung A, Fitzsimons H, Bland R, During M, Young D. HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity. Mol Ther. 2008;16:1048-55 pubmed publisher
    ..Our results suggest that a comparatively modest upregulation of multiple HSPs may be an effective approach for achieving significant neuroprotection in PD. ..
  34. Niederlechner S, Klawitter J, Baird C, Kallweit A, Christians U, Wischmeyer P. Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PLoS ONE. 2012;7:e50185 pubmed publisher
    ..GLN's signaling via the FN-Integrin pathway is associated with HSP induction via ERK1/2 and HSF-1 activation leading to reduced apoptosis after gut injury. ..
  35. Xue H, Slavov D, Wischmeyer P. Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. J Biol Chem. 2012;287:40400-13 pubmed publisher
    Regulation of transcriptional activity of heat shock factor-1 (HSF1) is widely thought to be the main point of control for heat shock protein (Hsp) expression...
  36. Liu Y, Sakamoto H, Adachi M, Zhao S, Ukai W, Hashimoto E, et al. Heat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats. Mol Biol Rep. 2012;39:3987-93 pubmed publisher
    ..Heat exposure also activated ER stress signals in primary cortical neurons. Since HSF1 knockdown enhanced heat-induced ER stress and subsequent cell death, HSR inhibition in turn augments ER stress, ..
  37. Chiang M, Chen H, Lai H, Chen H, Chou S, Chen C, et al. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system. Hum Mol Genet. 2009;18:2929-42 pubmed publisher
    ..By suppressing aggregate formation, CGS slowed the hijacking of a crucial transcription factor (HSF1) and two protein chaperons (Hsp27 and Hsp70) into hepatic Htt aggregates...
  38. Mazurek B, Haupt H, Klapp B, Szczepek A, Olze H. Exposure of Wistar rats to 24-h psycho-social stress alters gene expression in the inferior colliculus. Neurosci Lett. 2012;527:40-5 pubmed publisher
    ..iNos; superoxide dismutase 2, Sod2), neuroprotection (nerve growth factor beta, Ngfb; heat shock factor 1, Hsf1; heat shock protein 70, Hsp70) and inflammation (tumor necrosis factor alpha, Tnfa; tumor necrosis factor alpha ..
  39. Liu A, Mathur R, Mei N, Langhammer C, Babiarz B, Firestein B. Neuroprotective drug riluzole amplifies the heat shock factor 1 (HSF1)- and glutamate transporter 1 (GLT1)-dependent cytoprotective mechanisms for neuronal survival. J Biol Chem. 2011;286:2785-94 pubmed publisher
    Heat shock factor 1 (HSF1) mediates the cellular response to stress to increase the production of heat shock protein (HSP) chaperones for proper protein folding, trafficking, and degradation; failure of this homeostatic mechanism likely ..
  40. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007;21:2172-81 pubmed
    ..induces the expression of major cellular chaperones by triggering the dissociation of a repressive HDAC6/HSF1 (heat-shock factor 1)/HSP90 (heat-shock protein 90) complex and a subsequent HSF1 activation...
  41. Eriksson M, Jokinen E, Sistonen L, Leppa S. Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000;44:471-7 pubmed
    Two members of the heat shock transcription factor family, HSF1 and HSF2, have been identified as activators of mammalian heat shock gene expression...
  42. Jeong K, Seong J. Neonatal capsaicin treatment in rats affects TRPV1-related noxious heat sensation and circadian body temperature rhythm. J Neurol Sci. 2014;341:58-63 pubmed publisher
    ..Circadian body temperature and locomotion were recorded by biotelemetry. Expression of Per1, Per2, Bmal1 and Hsf1 (clock genes) was also investigated...
  43. Wang X, Cattaneo F, Ryno L, Hulleman J, Reixach N, Buxbaum J. The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice. J Neurosci. 2014;34:7253-65 pubmed publisher
    ..primary hippocampal neurons and the hippocampus of APP23 mice, is significantly enhanced by heat shock factor 1 (HSF1)...
  44. Paroo Z, Meredith M, Locke M, Haist J, Karmazyn M, Noble E. Redox signaling of cardiac HSF1 DNA binding. Am J Physiol Cell Physiol. 2002;283:C404-11 pubmed
    ..generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein (hsp) genes are the result of oxidation and/or ..
  45. Jin Y, Ahn S, Kim S. BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. Biochem Biophys Res Commun. 2015;464:561-7 pubmed publisher
    ..In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells...
  46. Budzyński M, Puustinen M, Joutsen J, Sistonen L. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation. Mol Cell Biol. 2015;35:2530-40 pubmed publisher
    ..expression of genes encoding heat shock proteins is under the control of the heat shock transcription factor 1 (HSF1)...
  47. Lee F, Peng S, Lin K, Chen R, Ho T, Tsai F, et al. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy. J Cell Physiol. 2018;233:979-989 pubmed publisher
    ..ERK activation subsequently phosphorylates HSF1 at serine 307, leading to a secondary phosphorylation by glycogen synthase kinase III (GSK3) at serine 303...
  48. Yu J, Jiang Z, Ning L, Zhao Z, Yang N, Chen L, et al. Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1. Biol Pharm Bull. 2015;38:1564-72 pubmed publisher
    ..Importantly, Z-ligustilide induced HSP70 expression both in vitro and in vivo. Although heat-shock factor 1 (HSF1) nuclear translocation was promoted by Z-ligustilide, HSP70-based heat-shock element (HSE)-binding luciferase ..
  49. Mercier P, Winegarden N, Westwood J. Human heat shock factor 1 is predominantly a nuclear protein before and after heat stress. J Cell Sci. 1999;112 ( Pt 16):2765-74 pubmed
    ..in eukaryotes by heat and other forms of stress is mediated by a transcription factor known as heat shock factor 1 (HSF1)...
  50. Kim K, Suh G, Kwon W, Lee H, Jeong K, Jung S, et al. The effect of glutamine on cerebral ischaemic injury after cardiac arrest. Resuscitation. 2013;84:1285-90 pubmed publisher
    ..Glutamine attenuates cerebral ischaemic injury in cardiac arrest model of rats and this is associated with the enhancement of Hsp-25 and Hsp-72 expressions. ..
  51. Li Q, Martinez J. P53 is transported into the nucleus via an Hsf1-dependent nuclear localization mechanism. Mol Carcinog. 2011;50:143-52 pubmed publisher
    ..We also show, for the first time, that the heat shock transcription factor (Hsf1), is required for establishment of the microtubule network in cells and for nuclear localization of p53...
  52. Lawler J, Kwak H, Kim J, Lee Y, Hord J, Martinez D. Biphasic stress response in the soleus during reloading after hind limb unloading. Med Sci Sports Exerc. 2012;44:600-9 pubmed publisher
    ..We conclude that the reloading phenotype in skeletal muscle is expressed in two distinct phases related to (a) pro-inflammatory signaling and (b) muscle mass recovery. ..
  53. Cybulsky A, Guillemette J, Papillon J. Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway. Biochim Biophys Acta. 2016;1863:2147-55 pubmed publisher
    ..We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway. Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity...
  54. Xie J, Zhao J, Xiao C, Xu Y, Yang S, Ni W. Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease. Exp Lung Res. 2010;36:219-26 pubmed publisher
    ..of rats to cigarette smoke/air mixture led to increased expression of Hsp70 and heat shock transcription factor (Hsf1) in ASM as compared to controls, whereas 3-month exposure caused dramatically reduced Hsp70 and Hsf1 than control ..
  55. Fiorenza M, Bevilacqua A, Canterini S, Torcia S, Pontecorvi M, Mangia F. Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol Reprod. 2004;70:1606-13 pubmed
    ..We found that one-cell mouse embryos respond to the osmotic shock of in vitro isolation with migration of HSF1, the canonical stress activator of mammalian heat shock genes, to pronuclei and by transient transcription of the ..
  56. Chen Y, Wang B, Liu D, Li J, Xue Y, Sakata K, et al. Hsp90 chaperone inhibitor 17-AAG attenuates A?-induced synaptic toxicity and memory impairment. J Neurosci. 2014;34:2464-70 pubmed publisher
    ..activated synaptic protein expression via transcriptional mechanisms through the heat shock transcription factor HSF1. Together, our findings identify a novel function of Hsp90 inhibition in regulating synaptic plasticity, in ..
  57. Csont T, Murlasits Z, Ménesi D, Kelemen J, Bencsik P, Pipicz M, et al. Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance. J Cardiovasc Pharmacol. 2015;65:485-93 pubmed publisher
    ..Lrn3, Lifr; decreased: Ihh, Fgfr1, Cryge, Krt9, Agrn, C4bpb, Fcer1a, Csf3, Hsd17b11, Hsd11b2, Ctnnbl1, Prpg1, Hsf1), only 14 genes were altered in the aorta (increased: Tas2r119, Ihh, Rrad, Npm1, Snai1; decreased: Tubb2b, Usp15, ..
  58. Fan xin M, Li mei S, Bei S, Xin Q, Yu Y, Yu C. Heat shock factor 1 regulates the expression of the TRPV1 gene in the rat preoptic-anterior hypothalamus area during lipopolysaccharide-induced fever. Exp Physiol. 2012;97:730-40 pubmed publisher
    ..Heat shock factor 1 (HSF1) is a ubiquitous heat-sensitive transcription factor that co-ordinates the genomic response to noxious heat, but it ..
  59. Xiao X, Zuo X, Davis A, McMillan D, Curry B, Richardson J, et al. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 1999;18:5943-52 pubmed
    b>HSF1 is the major heat shock transcriptional factor that binds heat shock element (HSE) in the promoter of heat shock proteins (Hsps) and controls rapid Hsp induction in cells subjected to various environmental stresses...
  60. Baler R, Dahl G, Voellmy R. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol. 1993;13:2486-96 pubmed
    ..To date genes for two human factors, HSF1 and HSF2, have been isolated...
  61. Cohen J, Dorai T, Ding C, Batinic Haberle I, Grasso M. The administration of renoprotective agents extends warm ischemia in a rat model. J Endourol. 2013;27:343-8 pubmed publisher
    ..Our cocktail minimized oxidative stress in an ischemic kidney rat model while at the same time protecting the global parenchymal function during extended periods of ischemia. ..
  62. Moura C, Lollo P, Morato P, Nisishima L, Carneiro E, Amaya Farfan J. Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats. PLoS ONE. 2014;9:e83437 pubmed publisher
    ..Co-chaperone Aha1 and p-HSF1 were also increased in the exercised animals fed with WPH in comparison with WP or CAS, consistent with enhanced ..
  63. Yu Y, Liu M, Zhang L, Cao Q, Zhang P, Jiang H, et al. Heat shock transcription factor 1 inhibits H?O?-induced cardiomyocyte death through suppression of high-mobility group box 1. Mol Cell Biochem. 2012;364:263-9 pubmed publisher
    Heat shock transcription factor 1 (HSF1), which has been identified as an endogenous cardioprotective factor, possesses considerable anti-inflammatory effects and the ability against oxidative stress...
  64. Hong Y, Rogers R, Matunis M, Mayhew C, Goodson M, Park Sarge O, et al. Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J Biol Chem. 2001;276:40263-7 pubmed
    Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein gene expression in cells exposed to elevated temperature and other stress conditions...
  65. Cahill C, Waterman W, Xie Y, Auron P, Calderwood S. Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1. J Biol Chem. 1996;271:24874-9 pubmed
    ..This is the first demonstration of heat shock factor 1 as a transcriptional repressor and suggests a role for the factor in the counter-regulation of cytokine gene transcription. ..
  66. Zhao R, Ren S, Moghadasain M, Rempel J, Shen G. Involvement of fibrinolytic regulators in adhesion of monocytes to vascular endothelial cells induced by glycated LDL and to aorta from diabetic mice. J Leukoc Biol. 2014;95:941-9 pubmed publisher
    ..Elevated levels of glyLDL were common in diabetic patients. Our previous studies indicated that HSF1 and p22-phox (a subunit of the NOX complex) were involved in glyLDL-induced up-regulation of PAI-1 in vascular EC...
  67. Zhang Y, Murshid A, Prince T, Calderwood S. Protein kinase A regulates molecular chaperone transcription and protein aggregation. PLoS ONE. 2011;6:e28950 pubmed publisher
    Heat shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essential for deterrence of protein-folding disorders, particularly in neuronal cells...
  68. Marunouchi T, Araki M, Murata M, Takagi N, Tanonaka K. Possible involvement of HSP90-HSF1 multichaperone complex in impairment of HSP72 induction in the failing heart following myocardial infarction in rats. J Pharmacol Sci. 2013;123:336-46 pubmed
    ..In the present study, we examined the involvement in heat-shock factor 1 (HSF1), a transcription factor of HSPs, in decreased ability for HSP72 induction in the failing rat heart following MI...
  69. Jain K, Suryakumar G, Ganju L, Singh S. Differential hypoxic tolerance is mediated by activation of heat shock response and nitric oxide pathway. Cell Stress Chaperones. 2014;19:801-12 pubmed publisher
    ..The heat shock response, through the action of chaperones and enhanced NO generation thus contributes substantially to the ability to sustain survival under acute sub lethal hypoxia. ..
  70. Shamovsky I, Ivannikov M, Kandel E, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006;440:556-60 pubmed
    The heat-shock transcription factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expression of heat-shock proteins (HSPs) and other cytoprotective proteins...
  71. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, et al. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun. 2003;303:700-6 pubmed
    ..As HSF1 is activated by heat shock simultaneously with the nuclear translocation of the protein kinase CK2, we have ..
  72. Xu T, Zhang B, Yang F, Cai C, Wang G, Han Q, et al. HSF1 and NF-κB p65 participate in the process of exercise preconditioning attenuating pressure overload-induced pathological cardiac hypertrophy. Biochem Biophys Res Commun. 2015;460:622-7 pubmed publisher
    ..05). Furthermore, EP treatment upregulated the expression of HSF1 and HSP70, increased the HSF1 levels in the nuclear fraction, inhibited the expression of the NF-κB p65 subunit, ..
  73. Gong J, Jing L. Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1. Minerva Anestesiol. 2011;77:488-95 pubmed
    ..The molecular mechanism of Gln-induced HSP70 expression appears to be mediated via enhancement of O-GlcNAc modification and subsequently to increase levels of endonuclear HSF-1 expression and HSF-1 transcription activity. ..
  74. Papasozomenos S, Papasozomenos H. The activation of heat shock transcription factor 1 is differentially regulated in the brain of estrogen- and testosterone-treated heat-shocked rats. J Alzheimers Dis. 2008;15:375-90 pubmed
    ..Heat shock transcription factor 1 (HSF1) also accumulated in the nuclei of neurons in TP-treated and exit the nuclei in EB-treated rats...
  75. Ahn J, Piri N, Caprioli J, Munemasa Y, Kim S, Kwong J. Expression of heat shock transcription factors and heat shock protein 72 in rat retina after intravitreal injection of low dose N-methyl-D-aspartate. Neurosci Lett. 2008;433:11-6 pubmed publisher
    ..To understand the regulatory mechanisms of HSP under stress, we examined the expression of Hsp72, HSF1 and HSF2 in the adult rat retina after intravitreal injection of NMDA...
  76. Skaggs H, Xing H, Wilkerson D, Murphy L, Hong Y, Mayhew C, et al. HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA. J Biol Chem. 2007;282:33902-7 pubmed
    ..How HSP mRNAs bypass this stress-associated export inhibition was not known. Here, we show that HSF1, the transcription factor that binds HSP promoters after stress to induce their transcription, interacts with the ..
  77. Staib J, Quindry J, French J, Criswell D, Powers S. Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart. Am J Physiol Regul Integr Comp Physiol. 2007;292:R432-9 pubmed
    ..heat shock protein 72 (HSP72) postexercise is initiated by the activation of heat shock transcription factor 1 (HSF1). However, it remains unknown which physiological stimuli govern myocardial HSF1 activation during exercise...
  78. Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, et al. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016;6:19174 pubmed publisher
    The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development...
  79. Buriro R, Lv Y, Ali I, Tang S, Liu Z, Zhang M, et al. Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress. Genet Mol Res. 2013;12:3003-16 pubmed publisher
    ..hsf-1 mRNA levels were significantly increased from 10 min of heat stress; however, HSF-1 protein levels did not simultaneously increase, indicating that HSF-1 is not the sole regulator of Hsp60 expression. ..