Hsd3b6

Summary

Gene Symbol: Hsd3b6
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Alias: Hsd3b1, 3 beta-hydroxysteroid dehydrogenase 6, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV, 3-beta-HSD IV, Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase, hydroxysteroid dehydrogenase-6 delta<5>-3-beta
Species: rat

Top Publications

  1. ncbi Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase
    D Naville
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 5:1090-100. 1991
  2. ncbi Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary
    Laxmipriya P Nampoothiri
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara 390 002, Gujarat, India
    J Biochem Mol Toxicol 22:337-44. 2008
  3. ncbi Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis
    P J O'Shaughnessy
    Division of Cell Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:851-8. 2008
  4. ncbi Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
    M Szołtys
    Laboratory of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Fertil Dev 19:356-65. 2007
  5. ncbi Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells
    Shin Ichi Izumi
    Division of Oral Cytology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki 852 8588, Japan
    Acta Histochem 107:269-77. 2005
  6. ncbi Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal
    Julie R Murrell
    Medical Services, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Circulation 112:1301-8. 2005
  7. ncbi Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury
    Norio Hashimoto
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Neurosci Lett 340:45-8. 2003
  8. ncbi Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin
    J Couet
    Medical Research Council Group in Molecular Endocrinology, CHUL Research, Ste Foy, Quebec, Canada
    J Invest Dermatol 103:60-4. 1994
  9. ncbi Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin
    J Simard
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Biol Chem 268:19659-68. 1993
  10. ncbi Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
    Y Lachance
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 265:20469-75. 1990

Scientific Experts

  • M Szołtys
  • P J O'Shaughnessy
  • Shin Ichi Izumi
  • Perumal Elumalai
  • Laxmipriya P Nampoothiri
  • Julie R Murrell
  • Norio Hashimoto
  • Kandaswamy Selvakumar
  • Prabhu Venkataraman
  • Ramachandran Arunkumar
  • Gunasekaran Krishnamoorthy
  • Jagadeesan Arunakaran
  • Sarita Gupta
  • Ji-Liang Zhao
  • James Rosoff
  • Steven R Gullans
  • Roderick V Jensen
  • Jeffrey D Randall
  • Ji Liang Zhao
  • Garner T Haupert
  • Koichi Noguchi
  • Hiroki Yamanaka
  • Toshiyuki Mizushima
  • J Simard
  • J Couet
  • F Labrie
  • Y Labrie
  • C Martel
  • S Luo
  • R Sanchez
  • F Durocher
  • C Turgeon
  • N Breton
  • H F Zhao
  • Y de Launoit
  • Y Lachance
  • C Labrie
  • V Luu-The
  • D Naville
  • E Dupont
  • C Trudel
  • B A Murry
  • M Dumont
  • G Jenkin
  • G Pelletier
  • G Leblanc
  • S Guerin
  • D S Keeney
  • J R Head
  • J I Mason
  • E Rheaume

Detail Information

Publications12

  1. ncbi Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase
    D Naville
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 5:1090-100. 1991
    ..e. high apparent Km for dehydroepiandrosterone) and distinct from those of the high affinity gonadal type I 3 beta HSD.(ABSTRACT TRUNCATED AT 400 WORDS)..
  2. ncbi Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary
    Laxmipriya P Nampoothiri
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara 390 002, Gujarat, India
    J Biochem Mol Toxicol 22:337-44. 2008
    ..Biochemical effects are correlated with metals accumulated in blood, reproductive tissue such as placenta and ovary...
  3. ncbi Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis
    P J O'Shaughnessy
    Division of Cell Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:851-8. 2008
    ..enzymes cytochrome P450 11a1 (Cyp11a1), cytochrome P450 17a1 (Cyp17a1), 3beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1), 17beta-hydroxysteroid dehydrogenase type 3 (Hsd17b3) and the LH receptor...
  4. ncbi Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
    M Szołtys
    Laboratory of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Fertil Dev 19:356-65. 2007
    ..The present studies showed differences in AR and 3beta-HSD distribution within various generations of CLs and within particular regions of the same young CL...
  5. ncbi Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells
    Shin Ichi Izumi
    Division of Oral Cytology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki 852 8588, Japan
    Acta Histochem 107:269-77. 2005
    ..Our results indicate that immunostaining intensity of adrenodoxin in the mitochondria reflects the steroidogenic state in rat ovarian cells...
  6. ncbi Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal
    Julie R Murrell
    Medical Services, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Circulation 112:1301-8. 2005
    ..The objective of this study was to test the hypothesis that a biosynthetic pathway exists in mammalian tissues to produce a steroid derivative closely related to plant cardiac glycosides...
  7. ncbi Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury
    Norio Hashimoto
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Neurosci Lett 340:45-8. 2003
    ..Our results suggest that progesterone may have a role in the process against neuronal injury or in regeneration in the peripheral nervous system...
  8. ncbi Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin
    J Couet
    Medical Research Council Group in Molecular Endocrinology, CHUL Research, Ste Foy, Quebec, Canada
    J Invest Dermatol 103:60-4. 1994
    ..The present data demonstrate the multihormonal regulation of 3 beta-HSD/isomerase expression and activity in the rat skin...
  9. ncbi Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin
    J Simard
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Biol Chem 268:19659-68. 1993
    ....
  10. ncbi Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
    Y Lachance
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 265:20469-75. 1990
    ....
  11. ncbi Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues
    H F Zhao
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 266:583-93. 1991
    ..The present data indicate the existence of two mRNAs encoding rat 3 beta-HSD and their differential tissular distribution in both steroidogenic and peripheral tissues.(ABSTRACT TRUNCATED AT 400 WORDS)..
  12. ncbi Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats
    Perumal Elumalai
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 113, India
    Reprod Toxicol 27:41-5. 2009
    ..These results suggested that lycopene have ameliorative role against Aroclor 1254 induced Leydig cell dysfunction...