Genomes and Genes
Gene Symbol: Hsd3b5
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Alias: Hsd1, Hsd3b, RATHSDI, 3 beta-hydroxysteroid dehydrogenase type 5, 3 beta-hydroxysteroid dehydrogenase 5, 3 beta-hydroxysteroid dehydrogenase type V, 3-beta-HSD V, 3-beta-hydroxy-5-ene steroid dehydrogenase, NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, progesterone reductase, steroid delta-isomerase, 3 beta
- Meffre D, Delespierre B, Gouézou M, Schumacher M, Stein D, Guennoun R. 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury. J Steroid Biochem Mol Biol. 2007;104:293-300 pubmed..This decrease has less impact in pseudopregnant females since they have high plasmatic and brain levels of PROG compared to males. ..
- Lewin Kowalik J, Sieron A, Barski J. [Recent views on the role of nerve growth factor and other molecules with well documented neuronotrophic action]. Postepy Hig Med Dosw. 1992;46:497-519 pubmed..The purpose of this article was also to discuss the possible role of these molecules in the pathogenesis of some neurological diseases and their potential therapeutic importance. ..
- Soma K, Sinchak K, Lakhter A, Schlinger B, Micevych P. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Endocrinology. 2005;146:4386-90 pubmed..These data support the hypothesis that PROG is a neurosteroid, produced locally in the hypothalamus from cholesterol, which functions in the estrogen positive-feedback mechanism driving the LH surge. ..