Gene Symbol: Hsd3b5
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Alias: Hsd1, Hsd3b, RATHSDI, 3 beta-hydroxysteroid dehydrogenase type 5, 3 beta-hydroxysteroid dehydrogenase 5, 3 beta-hydroxysteroid dehydrogenase type V, 3-beta-HSD V, 3-beta-hydroxy-5-ene steroid dehydrogenase, NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, progesterone reductase, steroid delta-isomerase, 3 beta
Species: rat

Top Publications

  1. Coirini H, Gouézou M, Liere P, Delespierre B, Pianos A, Eychenne B, et al. 3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cord. Neuroscience. 2002;113:883-91 pubmed
  2. Zhao H, Rheaume E, Trudel C, Couet J, Labrie F, Simard J. Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomerase. Endocrinology. 1990;127:3237-9 pubmed
  3. Kuhn N, Briley M. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Biochem J. 1970;117:193-201 pubmed
    ..This mechanism is super-imposed on the already declining rate of net Delta(4)-steroid release by the ovary. 5. A relationship of these pathways to subcellular compartments of luteal cells is proposed. ..
  4. Qujeq D. Development of a quantitative assay method for 3 beta-hydroxy-delta 5-steroid dehydrogenase in the rat testis. Steroids. 2002;67:1071-7 pubmed
    ..The activity of this enzyme ranged from 4.57+/-1.34 to 10.56+/-2.13 nmol/mg protein/min with a mean activity of 8.96+/-1.27 nmol/mg protein/min. The K(m) of the enzyme at an optimum pH of 7.25 was about 4.7+/-0.12 nM. ..
  5. Chen Y, Lee M, Yao H, Hsiao P, Ke F, Hwang J. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Endocrinology. 2008;149:4658-68 pubmed publisher
    ..MPP/ICI suppression of FSH +/- TGFbeta1 action is partly attributed to the reduced ERalpha-mediated expression of Hsd3b and Cyp11a1 genes, but not steroidogenic acute regulatory protein...
  6. Gordon M, Robertson W. The application of continuous monitoring microdensitometry to an analysis of NAD+ binding and 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in the regressing corpus luteum of the pro-oestrous rat ovary. Histochem J. 1986;18:41-4 pubmed
    ..The apparent Michaelis-Menten constant (Km) was 29 mumol/l and Vmax 0.63 mumol NAD+ reduced/min/cm3 corpora lutea. ..
  7. Deng A, Dene H, Rapp J. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest. 1994;94:431-6 pubmed
    ..The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance. ..
  8. Nagaya M, Arai M, Widmaier E. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Mol Cell Endocrinol. 1995;114:27-34 pubmed
    ..In addition, the combined decreased activities of these two enzymes can almost entirely account for the decreased steroidogenic output of rat adrenocortical cells on d1, but not during the later neonatal period. ..
  9. Lo M, Lee S. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Immunol Cell Biol. 2006;84:38-43 pubmed

Scientific Experts

More Information


  1. Meffre D, Delespierre B, Gouézou M, Schumacher M, Stein D, Guennoun R. 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury. J Steroid Biochem Mol Biol. 2007;104:293-300 pubmed
    ..This decrease has less impact in pseudopregnant females since they have high plasmatic and brain levels of PROG compared to males. ..
  2. Lewin Kowalik J, Sieron A, Barski J. [Recent views on the role of nerve growth factor and other molecules with well documented neuronotrophic action]. Postepy Hig Med Dosw. 1992;46:497-519 pubmed
    ..The purpose of this article was also to discuss the possible role of these molecules in the pathogenesis of some neurological diseases and their potential therapeutic importance. ..
  3. Soma K, Sinchak K, Lakhter A, Schlinger B, Micevych P. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Endocrinology. 2005;146:4386-90 pubmed
    ..These data support the hypothesis that PROG is a neurosteroid, produced locally in the hypothalamus from cholesterol, which functions in the estrogen positive-feedback mechanism driving the LH surge. ..