Hsd11b2

Summary

Gene Symbol: Hsd11b2
Description: hydroxysteroid 11-beta dehydrogenase 2
Alias: 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type 2, Hydroxysteroid dehydrogenase, 11 beta type 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 2
Species: rat

Top Publications

  1. doi Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta
    Zuzana Vackova
    Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    Reprod Toxicol 28:46-51. 2009
  2. ncbi Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Endocrinol 146:553-8. 2002
  3. ncbi 11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate
    Ren Shan Ge
    The Population Council, 1230 York Avenue, New York, New York 10021, USA
    Endocrinology 146:2657-64. 2005
  4. ncbi Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
    Christina Jang
    Department of Endocrinology and Diabetes, St Vincent s Hospital, Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    J Clin Endocrinol Metab 92:3314-20. 2007
  5. doi Uninephrectomy reduces 11β-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats
    M Lauterburg
    Department of Nephrology and Hypertension, University Hospital Bern, Inselspital, Freiburgstrasse 15, 3010 Bern, Switzerland
    J Endocrinol 214:373-80. 2012
  6. doi Tissue-specific programming expression of glucocorticoid receptors and 11 beta-HSDs by maternal perinatal undernutrition in the HPA axis of adult male rats
    I Dutriez-Casteloot
    Neurosciences et Neurophysiologie Adaptatives, Equipe Stress Périnatal, Universite de Lille I, Villeneuve d Ascq, France
    Horm Metab Res 40:257-61. 2008
  7. ncbi 11beta-hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats
    Yvetta Koeva
    Department of Anatomy and Histology, Medical University, Plovdiv, Bulgaria
    Folia Histochem Cytobiol 45:381-6. 2007
  8. ncbi Increased renal expression of aquaporin-3 in rats inhibited type 2 11beta-hydroxysteroid dehydrogenase
    Seong Kwon Ma
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Kidney Blood Press Res 30:8-14. 2007
  9. pmc DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
    Zoltan Balazs
    Institute of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Am Soc Nephrol 19:92-101. 2008
  10. ncbi Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat
    Man Chen
    Department of Pharmacology, Basic Medical School of Wuhan University, Donghu Road 115 Hubei Province Wuhan 430071, China
    Exp Toxicol Pathol 59:245-51. 2007

Scientific Experts

  • Hui Bao Gao
  • Yoshiyu Takeda
  • ARTHUR LOEWY
  • Mariana Baserga
  • Y J Liu
  • P J Lucassen
  • K E Sheppard
  • Brendan J Waddell
  • Elise P Gomez-Sanchez
  • Satoshi Suzuki
  • Christina Jang
  • J Takaya
  • Jiri Pacha
  • T Remer
  • Peter J Mark
  • Akinobu Konishi
  • Marisa Laura Zallocchi
  • Erin E Kershaw
  • Elise Gomez Sanchez
  • Ren Shan Ge
  • Joel C Geerling
  • Soo Wan Kim
  • Yvetta Koeva
  • Dianne O Hardy
  • Ivan Miksik
  • Jørgen Frøkiaer
  • Søren Nielsen
  • Mark A Knepper
  • M Lauterburg
  • Janine Schmid
  • Binghai Zhao
  • Iris Ostreicher
  • Zuzana Vackova
  • Bing Bing Chen
  • Petra Klusonova
  • Karla Vagnerova
  • Qian Wang
  • I Dutriez-Casteloot
  • Mariana Bakalska
  • K Vagnerova
  • Zoltan Balazs
  • Nina Atanassova
  • Katerina Georgieva
  • Michail Davidoff
  • F J Frey
  • Mitsuo Takeda
  • Fermin I Milagro
  • B Dick
  • Chunling Li
  • Man Chen
  • Seong Kwon Ma
  • JongUn Lee
  • Felix J Frey
  • Ghislaine Groyer
  • Mitsuhiro Kawata
  • Sophie de Seigneux
  • David J Morris
  • Chantal M Sottas
  • Qiang Dong
  • Karla Mazancova
  • Syed A Latif
  • Shun Sato
  • Bing Yao
  • Matthew P Hardy
  • Rasoul Alikhani-Koopaei
  • Rikke Nørregaard
  • A Audigé
  • Gareth G Lavery
  • D Ackermann
  • G Escher
  • Julio Licinio
  • Xiao Kun Li
  • Norman L Block
  • Stefan R Bornstein
  • Anja Steffen
  • Charmaine J Simeonovic
  • Monika Ehrhart-Bornstein
  • Mathias D Brendel
  • Barbara Ludwig
  • Andrew V Schally
  • QingQuan Lian
  • Christian G Ziegler
  • Yassemi Koutmani
  • Yanhui Chu
  • Katia P Karalis
  • Jorg Dotsch
  • Manfred Rauh
  • Jorge Reis Almeida
  • Valentina Campean
  • Kerstin Amann

Detail Information

Publications53

  1. doi Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta
    Zuzana Vackova
    Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    Reprod Toxicol 28:46-51. 2009
    ....
  2. ncbi Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Endocrinol 146:553-8. 2002
    Mutations in the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2) explain the syndrome of apparent mineralocorticoid excess where cortisol acts as a mineralocorticoid...
  3. ncbi 11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate
    Ren Shan Ge
    The Population Council, 1230 York Avenue, New York, New York 10021, USA
    Endocrinology 146:2657-64. 2005
    ..These data suggest that both types I and II 11beta HSD in Leydig cells play a protective role, opposing the adverse effects of excessive CORT on testosterone production...
  4. ncbi Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
    Christina Jang
    Department of Endocrinology and Diabetes, St Vincent s Hospital, Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    J Clin Endocrinol Metab 92:3314-20. 2007
    ..There is little information regarding the regulation of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes in skeletal muscle in the setting of type 2 diabetes...
  5. doi Uninephrectomy reduces 11β-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats
    M Lauterburg
    Department of Nephrology and Hypertension, University Hospital Bern, Inselspital, Freiburgstrasse 15, 3010 Bern, Switzerland
    J Endocrinol 214:373-80. 2012
    ..Both 11β-HSD1 and 11β-HSD2 are downregulated after UNX in rats, a constellation considered to induce hypertension...
  6. doi Tissue-specific programming expression of glucocorticoid receptors and 11 beta-HSDs by maternal perinatal undernutrition in the HPA axis of adult male rats
    I Dutriez-Casteloot
    Neurosciences et Neurophysiologie Adaptatives, Equipe Stress Périnatal, Universite de Lille I, Villeneuve d Ascq, France
    Horm Metab Res 40:257-61. 2008
    ....
  7. ncbi 11beta-hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats
    Yvetta Koeva
    Department of Anatomy and Histology, Medical University, Plovdiv, Bulgaria
    Folia Histochem Cytobiol 45:381-6. 2007
    ....
  8. ncbi Increased renal expression of aquaporin-3 in rats inhibited type 2 11beta-hydroxysteroid dehydrogenase
    Seong Kwon Ma
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Kidney Blood Press Res 30:8-14. 2007
    ..To investigate whether the regulation of aquaporin (AQP) channels is altered by inhibition of type 2 11beta-hydroxysteroid dehydrogenase (11betaHSD2)...
  9. pmc DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
    Zoltan Balazs
    Institute of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Am Soc Nephrol 19:92-101. 2008
    ..It was found that CCAAT/enhancer-binding protein-alpha (C/EBP-alpha) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/..
  10. ncbi Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat
    Man Chen
    Department of Pharmacology, Basic Medical School of Wuhan University, Donghu Road 115 Hubei Province Wuhan 430071, China
    Exp Toxicol Pathol 59:245-51. 2007
    ....
  11. ncbi Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension
    Mariana Baserga
    Univ of Utah School of Medicine, Dept of Pediatrics, Division of Neonatology, Salt Lake City, UT 84158, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1943-55. 2007
    ..We conclude that in our animal model, UPI decreases fetal COX-2 expression during a period of active nephrogenesis in the IUGR rat, which is also characterized by decreased nephron number and adult-onset hypertension...
  12. ncbi Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 504:379-403. 2007
    ..These findings offer new perspectives on the roles of sensory information from the brainstem in the regulation of sodium appetite...
  13. ncbi Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts
    Mitsuo Takeda
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    Hypertens Res 30:427-37. 2007
    ....
  14. ncbi Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated
    Ren Shan Ge
    Population Council, New York, NY 10021, USA
    Mol Cell Endocrinol 243:35-42. 2005
    ..We conclude that Leydig cells express MRs and that testosterone production is subject to regulation by aldosterone...
  15. ncbi Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, University of Aarhus, DK 8230 Aarhus N, Denmark
    Am J Physiol Renal Physiol 293:F333-41. 2007
    ..These results suggest that altered expression of alpha-, beta-, and gamma-ENaC may contribute to impaired renal sodium and water handling in response to ureteral obstruction...
  16. pmc Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cardiovasc Res 81:140-7. 2009
    ..We studied the transcriptional and biochemical mechanisms that mediate or modulate the suppression of eNOS expression by glucocorticoids...
  17. doi Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation
    K Vagnerova
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Reprod Sci 15:921-31. 2008
    ..The objective of this study was to investigate the role of 11beta-hydroxysteroid dehydrogenases (11HSD1 and 11HSD2) in determining the fetal concentration of glucocorticoids...
  18. doi Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2
    P J Lucassen
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 29:97-103. 2009
    ..Hence, stress-induced placental 11beta-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis...
  19. pmc Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase
    Janine Schmid
    Department of Medicine III, University Hospital Carl Gustav Carus, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 108:13722-7. 2011
    ..Agonists of CRHR1 and GHRH-receptor, therefore, may play an important role as novel therapeutic tools in the treatment of diabetes mellitus...
  20. ncbi Magnesium deficiency in pregnant rats alters methylation of specific cytosines in the hepatic hydroxysteroid dehydrogenase-2 promoter of the offspring
    Junji Takaya
    Department of Pediatrics, Kansai Medical University, Osaka, Japan
    Epigenetics 6:573-8. 2011
    ..receptor α (Ppara), glucocorticoid receptor (Nr3c1) and 11β-hydroxysteroid dehydrogenase-2 (Hsd11b2) promoters in the liver were measured by pyrosequencing...
  21. doi The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances
    Binghai Zhao
    Heilongjiang Key Laboratory of Anti fibrosis Biotherapy, Mudanjiang Medical University, Heilongjiang 157011, PR China
    J Steroid Biochem Mol Biol 125:143-7. 2011
    ..PFASs showed competitive inhibition of both human and rat 11β-HSD2 activities. This observation indicates that PFOS is a potent endocrine disruptor for glucocorticoid metabolism. Article from the Special issue on Targeted Inhibitors...
  22. doi Changes in 11beta-hydroxysteroid dehydrogenase type 2 expression in a low-protein rat model of intrauterine growth restriction
    Iris Ostreicher
    Department of Pediatrics and Adolescent Medicine, University Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 25:3195-203. 2010
    ....
  23. doi Age-related changes in the expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells
    Yvetta Koeva
    Department of Anatomy and Histology, Medical University, Plovdiv, Bulgaria
    Folia Histochem Cytobiol 47:281-7. 2009
    ..The observed reduction in 11beta-HSD type 2 expression in aging LCs reflects the decline in their protection ability, opposing the suppressive effect of glucocorticoids on testosterone production...
  24. doi Chronic intermittent hypoxia induces 11beta-hydroxysteroid dehydrogenase in rat heart
    Petra Klusonova
    Institute of Physiology, Czech Academy of Sciences, 142 20 Prague 4, Krc, Czech Republic
    Endocrinology 150:4270-7. 2009
    ..These findings suggest that myocardial remodeling induced by CIH is associated with the up-regulation of cardiac 11HSD2. Consequently, local metabolism of glucocorticoids could indeed play a role in cardiac hypertrophy and fibrosis...
  25. pmc Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells
    Qian Wang
    Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chong Qing Road, Shanghai 200025, PR China
    Reprod Biol Endocrinol 7:39. 2009
    ..capability of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and type 2 (11beta-HSD2; encoded by gene Hsd11b2 in rats) in Leydig cells...
  26. pmc Changes in the placental glucocorticoid barrier during rat pregnancy: impact on placental corticosterone levels and regulation by progesterone
    Peter J Mark
    School of Anatomy and Human Biology, The University of Western Australia, Western Australia, Australia
    Biol Reprod 80:1209-15. 2009
    ..This study determined expression of genes encoding the two HSD11B isoforms (Hsd11b1 and Hsd11b2), the two ABCB1 isoforms (Abcb1a and Abcb1b), and Nr3c1 in the junctional and labyrinth zones of rat placentas at ..
  27. doi The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2
    Bing Bing Chen
    School of Pharmacy, Zhejiang, PR China
    J Steroid Biochem Mol Biol 113:177-81. 2009
    ..The potency of gossypol to inhibit 11betaHSD1 was far less; the IC(50) was > or =100 microM for racemic gossypol. The gossypol-induced hypokalemia is likely associated with its potent inhibition of kidney 11betaHSD2...
  28. ncbi 11-Beta hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity
    Fermin I Milagro
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea s n, 31008 Pamplona, Spain
    J Steroid Biochem Mol Biol 104:81-4. 2007
    ..Thus, 11betaHSD2 is expressed in adipose tissue by both adipocytes and stromal-vascular cells, which suggests that this enzyme may play an important role in preventing fat accumulation in adipose tissue...
  29. ncbi Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells
    Ghislaine Groyer
    Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale and University Paris Sud 11, 94276 Le Kremlin Bicetre, France
    Endocrinology 147:4339-50. 2006
    ..These data support a physiological role for HSD2 regulation of glucocorticosteroid concentrations in nerve SC...
  30. ncbi The possible roles of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the spontaneously hypertensive rat
    Akinobu Konishi
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Steroid Biochem Mol Biol 85:439-42. 2003
    ..Findings from the present study appear to demonstrate that MR and 11beta-HSD2 mRNA significantly rise in the left ventricle of M-SHRSP and increase of these mRNA is one of the cause of cardiac fibrosis...
  31. ncbi Stimulation of 11-beta-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake
    Rikke Nørregaard
    Department of Physiology and Pharmacology, University of Southern Denmark, Winsloewparken 21, 3 DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 285:F348-58. 2003
    ..These data indicate that mineralocorticoid selectivity is physiologically regulated by NaCl intake at the level of 11betaHSD-2 expression and tissue distribution in the distal colon, but not in the kidney...
  32. ncbi Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract
    Brendan J Waddell
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
    Endocrinology 144:3101-6. 2003
    ....
  33. ncbi Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
    Elise P Gomez-Sanchez
    Endocrine Section and Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA
    Am J Physiol Endocrinol Metab 285:E272-9. 2003
    ..NAD+-dependent enzymatic activity in the absence or presence of a reducing agent demonstrated that the increase in 11betaHSD2 protein was not associated with an increase in in vitro activity unless the dimers were reduced to monomers...
  34. ncbi Glucocorticoids and 11 beta-hydroxysteroid dehydrogenase type 2 gene expression in the aging kidney
    A Audigé
    Division of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Eur J Clin Invest 32:411-20. 2002
    ..We hypothesized therefore that 11 beta-HSD2 gene expression and/or activity increase with age in male WAG/Rij rats, a strain without increased blood pressure with age or senescence-related obesity or kidney disease...
  35. ncbi Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase
    M Y Zhou
    Department of Internal Medicine, University of Missouri, Harry S Truman Memorial Veterans Hospital, Columbia 65201, USA
    Endocrinology 136:3729-34. 1995
    ..1 +/- 2.1 nM. In conclusion, we have cloned a rat NAD(+)-dependent 11 beta HSD with tissue distribution and kinetic characteristics suggesting that it could play a significant role in mineralocorticoid receptor selectivity...
  36. ncbi Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine
    Jiri Pacha
    Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4 Krc, Prague, Czech Republic
    Steroids 67:119-26. 2002
    ....
  37. ncbi 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart
    Karen E Sheppard
    Baker Medical Research Institute, P O Box 6492, St Kilda Road, Melbourne, Victoria, Australia 8008
    Endocrinology 143:198-204. 2002
    ....
  38. ncbi Effects of spironolactone on systolic blood pressure in experimental diabetic rats
    Y J Liu
    Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Kidney Int 57:2064-71. 2000
    ....
  39. pmc Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess
    A Li
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Am J Hum Genet 63:370-9. 1998
    ..Hypertensive populations should be screened to identify the prevalence of milder defects in 11beta-HSD2 in patients currently labeled as having "essential" hypertension...
  40. ncbi Pathophysiological roles of vascular 11beta-hydroxysteroid dehydrogenase and aldosterone
    Yoshiyu Takeda
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, 13 1 Takara machi, Kanazawa University, Kanazawa 920 8641, Japan
    J Steroid Biochem Mol Biol 85:443-7. 2003
    ..Both the local renin-angiotensin-aldosterone system (RAAS) and the vascular 11beta-HSDII level are critically important in the pathophysiology of cardiovascular disorders...
  41. ncbi Adrenal gland involvement in the regulation of renal 11beta-hydroxysteroid dehydrogenase 2
    Marisa Laura Zallocchi
    Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and PRHOM CONICET, Buenos Aires, Argentina
    J Cell Biochem 92:591-602. 2004
    ....
  42. pmc Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression
    Rasoul Alikhani-Koopaei
    Department of Nephrology and Hypertension, University Hospital of Berne, Berne UNK 3010, Switzerland
    J Clin Invest 114:1146-57. 2004
    The enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD2) is selectively expressed in aldosterone target tissues, where it confers aldosterone selectivity for the mineralocorticoid receptor by inactivating 11 beta-..
  43. ncbi Exaggerated adrenarche and altered cortisol metabolism in Type 1 diabetic children
    Thomas Remer
    Department of Nutrition and Health, Research Institute of Child Nutrition, Dortmund, Germany
    Steroids 71:591-8. 2006
    ..Whether the elevated urinary 6beta-hydroxycortisol and cortisone excretion, observed in the patients, are also present in other forms of hypercortisolism and may thus serve as non-invasive clinical stress markers deserves further study...
  44. ncbi Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:411-7. 2006
    ..These unique aldosterone target neurons may represent a previously unrecognized central convergence point at which hormonal and neural signals can be integrated to drive sodium appetite...
  45. ncbi Aldosterone-sensitive neurons in the rat central nervous system
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 494:515-27. 2006
    ..The HSD2 neurons in the NTS may represent an important target for aldosterone action in the brain...
  46. ncbi Inflammatory mediators down-regulate 11beta-hydroxysteroid dehydrogenase type 2 in a human lung epithelial cell line BEAS-2B and the rat lung
    Satoshi Suzuki
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 207:293-301. 2005
    ..We conclude that lung inflammation reduces local glucocorticoid breakdown and augments glucocorticoid action in the lung by down-regulating 11beta-HSD2 via multiple mechanisms...
  47. ncbi Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis
    Soo Wan Kim
    The Water and Salt Research Center, University of Aarhus, Aarhus, Denmark DK 8000
    J Am Soc Nephrol 16:3196-210. 2005
    ..In conclusion, increased apical targeting of ENaC subunits combined with diminished abundance of 11betaHSD2 in the DCT2, CNT, and cortical collecting duct is likely to play a role in the sodium retaining stage of liver cirrhosis...
  48. ncbi Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats
    Soo Wan Kim
    The Water and Salt Research Center, Bldg 233 234, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 290:F674-87. 2006
    ..The decreased abundance of NHE3, NKCC2, NCC, and Na-K-ATPase may play a compensatory role in promoting sodium excretion...
  49. ncbi 11beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats
    Karla Mazancova
    Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
    J Steroid Biochem Mol Biol 94:273-7. 2005
    ..These results show that the heart is able to metabolize glucocorticoids and that this metabolism is strain-dependent but do not support the notion of association between cardiac hypertrophy and changes of 11HSD1 and 11HSD2 expression...
  50. pmc Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 54:1023-31. 2005
    ..These data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome...
  51. ncbi Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney
    Bing Yao
    George O Brien Center for Kidney and Urologic Diseases and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 4794, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1767-73. 2005
    ....
  52. ncbi Induction of 11beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism are essential for enhanced sodium absorption after total colectomy in rats
    Shun Sato
    Departments of Surgery and Pathology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 9574, Japan
    Surgery 137:75-84. 2005
    ..Analysis of the intestinal adaptation after total colectomy may lead to developing novel therapies for postoperative diarrhea...
  53. ncbi Gene expression of 11beta-hydroxysteroid dehydrogenase type 1 and type 2 in the kidneys of insulin-dependent diabetic rats
    Y J Liu
    Department of Pediatrics, Hamamatsu University School of Medicine, Japan
    Hypertension 31:885-9. 1998
    ..These results indicate that alteration of renal 11beta-HSD2 activity and gene expression may be primarily responsible for the changes in blood pressure of STZ-diabetic rats after early treatment with insulin...

Research Grants33

  1. CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROL
    ARTHUR LOEWY; Fiscal Year: 2007
    ....
  2. Adrenal decommissioning and hypertension
    Elise Gomez Sanchez; Fiscal Year: 2007
    ..Using similar protocols as those in Aim 1, we will study and compare the process of adrenal decommissioning between SHR-SP and regular SHR rats with emphasis of the ZG genes identified as important in Aim 1. ..
  3. Adipocyte-specific glucocorticoid metabolism: 11betaHSDs
    ERIN KERSHAW; Fiscal Year: 2007
    ..The ultimate goal is for the applicant to become an independent investigator. ..
  4. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2007
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. ..
  5. ALDOSTERONE, HYPERTENSION AND THE BRAIN
    Elise Gomez Sanchez; Fiscal Year: 2003
    ..4) Study of the metabolism of aldosterone and corticosterone and the regulation of the synthesis of low polarity derivatives in the brain, including the identification of the sites of formation of aldosterone acyl esters. ..
  6. CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROL
    ARTHUR LOEWY; Fiscal Year: 2003
    ..In addition, they may provide insights into the underlying CNS mechanisms of certain clinical conditions, such as stress-induced cardiovascular changes and essential hypertension. ..
  7. CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROL
    Arthur D Loewy; Fiscal Year: 2010
    ..The studies presented here deal with the brain circuits controlling salt intake, and will provide new insights into the brain pathways which control sodium balance and ultimately, central regulation of the cardiovascular system. ..