Genomes and Genes
Gene Symbol: Hrg
Description: histidine-rich glycoprotein
Alias: HPRG, HRG1, histidine-rich glycoprotein, histidine-proline-rich glycoprotein, histidine-rich glycoprotein 1
- Roberts A, Campa M, Gottlin E, Jiang C, Owzar K, Kindler H, et al. Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303). Cancer. 2012;118:571-8 pubmed publisher..protein, alpha 1-antichymotrypsin (AACT), and 2 putative predictive proteins, histidine-rich glycoprotein (HRG) and complement factor H (CFH), for validation by ELISA...
- Macquarrie J, Stafford A, Yau J, Leslie B, Vu T, Fredenburgh J, et al. Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation. Blood. 2011;117:4134-41 pubmed publisherHistidine-rich glycoprotein (HRG) circulates in plasma at a concentration of 2?M and binds plasminogen, fibrinogen, and thrombospondin. Despite these interactions, the physiologic role of HRG is unknown...
- Rydengård V, Shannon O, Lundqvist K, Kacprzyk L, Chalupka A, Olsson A, et al. Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathog. 2008;4:e1000116 pubmed publisher..further by the present investigation, demonstrating a novel antifungal role of histidine-rich glycoprotein (HRG), an abundant and multimodular plasma protein...
- Lijnen H, Van Hoef B, Collen D. Histidine-rich glycoprotein modulates the anticoagulant activity of heparin in human plasma. Thromb Haemost. 1984;51:266-8 pubmed..69). It is concluded that the level of histidine-rich glycoprotein modulates the anticoagulant activity of heparin in human plasma to an extent which appears to be pharmacologically and possibly clinically relevant. ..
- White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher..Here, we show that the mammalian homolog of HRG1, a transmembrane heme permease in C...
- Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell. 2011;19:31-44 pubmed publisher..We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy...
- Dixelius J, Olsson A, Thulin A, Lee C, Johansson I, Claesson Welsh L. Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. Cancer Res. 2006;66:2089-97 pubmed..In conclusion, HRGP330, which we define as the minimal antiangiogenic domain of HRGP, exerts its effects through signal transduction targeting focal adhesions, thereby interrupting VEGF-induced endothelial cell motility. ..
- Jones A, Hulett M, Parish C. Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation. J Biol Chem. 2004;279:30114-22 pubmedHistidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline...
- Morgan W. Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands. Biochim Biophys Acta. 1978;535:319-33 pubmed
- Vanwildemeersch M, Olsson A, Gottfridsson E, Claesson Welsh L, Lindahl U, Spillmann D. The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner. J Biol Chem. 2006;281:10298-304 pubmed