Hp

Summary

Gene Symbol: Hp
Description: haptoglobin
Alias: Ba1-647, haptoglobin, liver regeneration-related protein LRRG173, zonulin
Species: rat
Products:     Hp

Top Publications

  1. Chiellini C, Santini F, Marsili A, Berti P, Bertacca A, Pelosini C, et al. Serum haptoglobin: a novel marker of adiposity in humans. J Clin Endocrinol Metab. 2004;89:2678-83 pubmed
    b>Haptoglobin (Hp) is a glycoprotein involved in the acute phase response to inflammation...
  2. Zhao X, Song S, Sun G, Strong R, Zhang J, Grotta J, et al. Neuroprotective role of haptoglobin after intracerebral hemorrhage. J Neurosci. 2009;29:15819-27 pubmed publisher
    ..Our study indicates that haptoglobin (Hp), an acute-phase response protein primarily synthesized in the liver and known to bind and neutralize Hb in ..
  3. Giffen P, Turton J, Andrews C, Barrett P, Clarke C, Fung K, et al. Markers of experimental acute inflammation in the Wistar Han rat with particular reference to haptoglobin and C-reactive protein. Arch Toxicol. 2003;77:392-402 pubmed
    C-reactive protein (CRP), haptoglobin (Hp) and fibrinogen (Fbgn) are acute phase reactants (APRs), the blood levels of which increase during acute inflammation...
  4. Jubelirer S. Primary pulmonary hypertension. Its association with microangiopathic hemolytic anemia and thrombocytopenia. Arch Intern Med. 1991;151:1221-3 pubmed
    ..laboratory and clinical features of these patients were the following: mild anemia, reticulocytosis, low serum haptoglobin value, microangiopathic red blood cell changes on peripheral blood smear, mild to moderate thrombocytopenia, ..
  5. Hanley J, Haugen T, Heath E. Biosynthesis and processing of rat haptoglobin. J Biol Chem. 1983;258:7858-69 pubmed
    Native rat haptoglobin is an heterotetramer consisting of two alpha-subunits (Mr = approximately 9,500) and two glycosylated beta-subunits (Mr = approximately 38,000) joined by interchain disulfide bonds...
  6. Delanghe J, Duprez D, De Buyzere M, Bergez B, Callens B, Leroux Roels G, et al. Haptoglobin polymorphism and complications in established essential arterial hypertension. J Hypertens. 1993;11:861-7 pubmed
    Salt sensitivity and the magnitude of systolic blood pressure have been linked to haptoglobin (Hp) polymorphism in normotensives...
  7. Engstrom G, Lind P, Hedblad B, Stavenow L, Janzon L, Lindgarde F. Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke. Stroke. 2002;33:2744-9 pubmed
    ..BP and 5 ISPs (fibrinogen, alpha1-antitrypsin, haptoglobin, ceruloplasmin, orosomucoid) were assessed in 6071 healthy men 28 to 61 years of age...
  8. Chen R, Vendrell I, Chen C, Cash D, O Toole K, Williams S, et al. Proteomic analysis of rat plasma following transient focal cerebral ischemia. Biomark Med. 2011;5:837-46 pubmed publisher
    ..Six of them (?2-macroglobulin, complement C3, inter-?- trypsin inhibitor heavy chain H3, serum albumin, haptoglobin and transthyretin), which are a class of acute-phase proteins, changed significantly...
  9. Pors S, Chadfield M, Sørensen D, Offenberg H, Heegaard P, Bisgaard M, et al. Pathology, tissue metalloproteinase transcription and haptoglobin responses in mice after experimental challenge with different isolates of Pasteurella multocida obtained from cases of porcine pneumonia. J Comp Pathol. 2011;145:251-60 pubmed publisher
    ..9 (MMP9) and tissue inhibitor of metalloproteinase 1 (TIMP1) in lung tissue and quantification of serum haptoglobin concentration were performed. P. multocida was found in the lung and spleen...

More Information

Publications62

  1. Kim J, Lee S, In K, Kim J, You S, Kang K, et al. Increase in serum haptoglobin and apolipoprotein M in patients with obstructive sleep apnoea. J Sleep Res. 2009;18:313-20 pubmed publisher
    ..Three of these nine proteins, haptoglobin, paraoxonase-1 and apolipoprotein M, were quantified by using enzyme-linked immunosorbent assays, kinetic ..
  2. Dash S, Das K. Serum haptoglobin concentrations in "pure" iron-deficiency anemia. Clin Chem. 1978;24:839-40 pubmed
  3. Russell J, Kelly S, Diane A, Wang Y, Mangat R, Novak S, et al. Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome. Am J Physiol Gastrointest Liver Physiol. 2010;299:G507-16 pubmed publisher
    ..fasting plasma triglyceride and reduced plasma plasminogen activator inhibitor-1 and acute phase protein haptoglobin in cp/cp rats...
  4. Yang S, Ma Y, Liu Y, Que H, Zhu C, Liu S. Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver. J Neurosci Res. 2013;91:230-9 pubmed publisher
    b>Haptoglobin (Hp), an acute-phase response protein, is typically increased in the serum of adults after acute tissue injury. It is an antioxidant and may function as an injury-induced neuroprotective protein...
  5. Verrills N, Irwin J, He X, Wood L, Powell H, Simpson J, et al. Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183:1633-43 pubmed publisher
    ..A panel of four biomarkers (?(2)-macroglobulin, haptoglobin, ceruloplasmin, and hemopexin) was able to discriminate with statistical significance between the clinical ..
  6. Flisinski M, Brymora A, Elminowska Wenda G, Bogucka J, Walasik K, Stefanska A, et al. Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation. Ren Fail. 2008;30:443-51 pubmed publisher
    ..Blood pressure and serum creatinine, haptoglobin, MCP-1, VEGF, and PDGF were measured. There were significant differences (p < 0...
  7. Snyder S, Coodley E, Durham B, Pennock R. Serum glycoproteins in coronary artery disease. Circulation. 1977;56:359-62 pubmed
    ..increased in the coronary group, significantly higher levels were found in only five of 16 glycoproteins--C3c haptoglobin, GC-globulin, alpha1-acid glycoprotein, and C3 activator--with no change in 10 other glycoproteins and ..
  8. Chiellini C, Bertacca A, Novelli S, Gorgun C, Ciccarone A, Giordano A, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol. 2002;190:251-8 pubmed
    ..genetically obese db/db mice compared to their lean littermates, we performed RNA fingerprinting and identified haptoglobin (Hp), which is significantly upregulated in the obese animals...
  9. Kino K, Tsunoo H, Higa Y, Takami M, Nakajima H. Kinetic aspects of hemoglobin.haptoglobin-receptor interaction in rat liver plasma membranes, isolated liver cells, and liver cells in primary culture. J Biol Chem. 1982;257:4828-33 pubmed
    125I-Hemoglobin.haptoglobin injected intravenously into rats was incorporated into liver parenchymal cells as evidenced by a cell separation technique...
  10. Engstrom G, Hedblad B, Janzon L, Lindgarde F. Fatality of acute coronary events in relation to hypertension and low-grade inflammation: a population-based cohort study. J Hum Hypertens. 2006;20:581-6 pubmed
    ..BP) and five inflammation-sensitive plasma proteins (ISPs, fibrinogen, orosomucoid, alpha 1-antitrypsin, haptoglobin and ceruloplasmin) were determined in 6071 healthy men...
  11. Li M, Ye B, Zhang Y, Chen H, Xia D, Liu M, et al. Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene. J Biomed Biotechnol. 2009;2009:397910 pubmed publisher
    ..Changes of haptoglobin, transthyretin, and TNF superfamily member 8 (TNFRS8) were confirmed in sera from lung cancer by MALDI-TOF-MS...
  12. Gianazza E, Veber D, Eberini I, Buccellato F, Mutti E, Sironi L, et al. Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. Biochem J. 2003;374:239-46 pubmed
    ..4 months after TG in the spots corresponding to alpha1-antitrypsin and the de novo presence of thiostatin and haptoglobin beta. Cbl-replacement treatment in 4-month-TGX rats corrected these alterations in the CSF proteome...
  13. Lee M, Kim S, Choi J, Lee I, Choi Y, Jin J, et al. Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats. J Cereb Blood Flow Metab. 2002;22:1176-80 pubmed
    Immunohistochemistry for haptoglobin (Hp) in the postischemic hippocampus demonstrated an immunoreactivity visible one day after reperfusion and continuing to increase until 14 days after ischemia...
  14. Kline J, Marchick M, Hogg M. Reduction in plasma haptoglobin in humans with acute pulmonary embolism causing tricuspid regurgitation. J Thromb Haemost. 2009;7:1597-9 pubmed publisher
  15. Fernandez V, Castillo I, Tapia G, Romanque P, Uribe Echevarría S, Uribe M, et al. Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat. Hepatology. 2007;45:170-7 pubmed
    ..transcription 3 (STAT3) (53%) (electromobility shift assay), with 50% diminution in the protein expression of haptoglobin (Western blot), changes that were normalized by T(3) preconditioning...
  16. Keith J, Albert L, Leathurby Y, Follettie M, Wang L, Borges Marcucci L, et al. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Arthritis Res Ther. 2005;7:R427-38 pubmed
    ..rat adjuvant model, WAY-169916 markedly suppresses the adjuvant induction of three serum acute phase proteins: haptoglobin, alpha1-acid glycoprotein (alpha1-AGP), and C-reactive protein (CRP)...
  17. Hanson M, Piknova B, Keszler A, Diers A, Wang X, Gladwin M, et al. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Br J Haematol. 2011;154:502-11 pubmed publisher
    Normally, cell free haemoglobin is bound by haptoglobin and efficiently cleared...
  18. Atkinson S, Rockett K, Sirugo G, Bejon P, Fulford A, O Connell M, et al. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. PLoS Med. 2006;3:e172 pubmed
    Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma protein haptoglobin (Hp) binds avidly to free haemoglobin released following malaria-induced haemolysis...
  19. Uskoković A, Arambasić J, Bogojevic D, Ivanovic Matic S, Mihailovic M, Dinic S, et al. Differences between molecular mechanisms involved in the regulation of haptoglobin gene expression during the acute phase response and dietary restriction. Folia Biol (Praha). 2009;55:107-15 pubmed
    b>Haptoglobin is a glycoprotein involved in the acute phase response. Previously we reported that haptoglobin gene expression was up-regulated during dietary restriction in young female rats...
  20. Zhang J, Zhang Y, Li N, Liu Z, Xiong C, Ni X, et al. Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension. Respir Med. 2009;103:1801-6 pubmed publisher
    ..Nine proteins and their isoforms, including leucine-rich alpha-2-glycoprotein (LRG), haptoglobin precursor, albumin isoform 2, transferrin variant, C3 complement, hydroxypyruvate reductase isoform 1, RAF1, ..
  21. Levy A, Levy J, Kalet Litman S, Miller Lotan R, Levy N, Asaf R, et al. Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Arterioscler Thromb Vasc Biol. 2007;27:134-40 pubmed
    ..The haptoglobin (Hp) protein is critical for protection against Hb-induced injury...
  22. Ngai H, Sit W, Jiang P, Thongboonkerd V, Wan J. Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach. J Proteome Res. 2007;6:3313-20 pubmed
    ..the increase in urinary preprohaptoglobin has particularly drawn our attention because of its byproduct, haptoglobin (Hp), which is involved in the protection of tissue damage from hemoglobin-induced oxidative stress...
  23. Nielsen S, Grøfte T, Tygstrup N, Vilstrup H. Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. Comp Hepatol. 2006;5:3 pubmed
    ..The BDL-model itself increased the serum concentration of alpha1-acid glycoprotein (alpha1AGP) and haptoglobin. LPS was lethal to 25% of the cirrhotic animals and to none of the controls...
  24. Ngure R, Eckersall P, Burke J, Karori S, Mwangi W, Wachira F, et al. Endotoxin-like effects in acute phase response to Trypanosoma brucei brucei infection are not due to gastrointestinal leakage. Parasitol Int. 2009;58:325-9 pubmed publisher
    ..and the observed acute phase response was due to an increase in the levels of acute phase proteins SAP and haptoglobin. Therefore trypanosomes are responsible for the elevated plasma endotoxin-like activity levels and the ..
  25. Zheng S, Wu H, Yu S, Ren J, Duo W, Ma Z, et al. Shenfu Injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Chin J Integr Med. 2015;21:22-8 pubmed publisher
    ..05). The results of the MALDI-TOF MS indicated that haptoglobin (HP), pentraxin 3 (PTX3) and alpha-1-antitrypsin were up-regulated, while serum albumin and 40S ribosomal ..
  26. González Marrero I, Castaneyra Ruiz L, González Toledo J, Castañeyra Ruiz A, de Paz Carmona H, Castro R, et al. High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats. Int J Hypertens. 2013;2013:164653 pubmed publisher
    ..SHR and WKY, that ?-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin and ?-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin, ?-2-HS-..
  27. Sevaljevic L, MacVanin M, Zakula Z, Kanazir D, Ribarac Septić N. Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. J Steroid Biochem Mol Biol. 1998;66:347-53 pubmed
    ..requirements for full hepatic expression of alpha2-macroglobulin (alpha2M), alpha1-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA...
  28. Saso L, Tommasino P, Italiano G, Grippa E, Leone M, Gatto M, et al. Changes of acute-phase proteins in streptozotocin-induced diabetic rats. Physiol Res. 2000;49:403-9 pubmed
    ..05) and an increase of the beta chain of haptoglobin (beta-Hp, p<0.05) in both D and Y rats (n=3) compared with control animals...
  29. Visser J, Lammers K, Hoogendijk A, Boer M, Brugman S, Beijer Liefers S, et al. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia. 2010;53:2621-8 pubmed publisher
    ..Levels of serum zonulin, a physiological tight junction modulator, were measured by ELISA...
  30. Spagnuolo M, Maresca B, Mollica M, Cavaliere G, Cefaliello C, Trinchese G, et al. Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein E mediated cholesterol trafficking in neuroblastoma cell lines. Front Cell Neurosci. 2014;8:212 pubmed publisher
    ..We previously reported that the acute-phase protein Haptoglobin (Hpt) binds ApoE, and influences its function in blood cholesterol homeostasis...
  31. Trutic N, Magic Z, Urosevic N, Krtolica K. Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy. Comp Biochem Physiol C Toxicol Pharmacol. 2002;133:461-70 pubmed
    ..acute-phase reactants including cysteine protease inhibitor, alpha(1)-acid glycoprotein, fibrinogen and haptoglobin, and albumin as a negative reactant were monitored by Northern blot and slot-blot hybridizations using ..
  32. Ivanovic Matic S, Dinić S, Mihailovic M, Grigorov I, Bogojevic D, Poznanovic G. Acute-phase protein expression in DMSO-intoxicated rats. Toxicol Lett. 2004;147:153-9 pubmed
    ..about 710%, alpha1-acid glycoprotein (AGP) 630%, alpha1-macroglobulin (MG) 510%, gamma fibrinogen (Fb) 420%, haptoglobin (Hp) 280%, whereas the relative concentration of albumin, a "negative" AP reactant, decreased to 93%...
  33. Soler García A, Johnson D, Hathout Y, Ray P. Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases. Clin J Am Soc Nephrol. 2009;4:763-71 pubmed publisher
    ..In addition, we found elevated urine levels of iron and the iron-related proteins, transferrin, hemopexin, haptoglobin, lactoferrin, and neutrophil gelatinase-associated lipocalin (NGAL), in children with HIVAN and HIV-HUS...
  34. Bonkovsky H, Lincoln B, Healey J, Ou L, Sinclair P, Muller Eberhard U. Hepatic heme and drug metabolism in rats with chronic mountain sickness. Am J Physiol. 1986;251:G467-74 pubmed
    ..control Hct 43%], plasma hemoglobinemia, depletion of plasma haptoglobin, and decreased hemopexin concentrations...
  35. Delanghe J, Duprez D, De Buyzere M, Bergez B, Claeys L, Leroux Roels G, et al. Refractory hypertension is associated with the haptoglobin 2-2 phenotype. J Cardiovasc Risk. 1995;2:131-6 pubmed
    Many cases of refractory hypertension cannot be attributed to specific identifiable factors. Haptoglobin polymorphism has been suggested as a candidate genetic marker in essential hypertension...
  36. Strnad M, Radojicic C, Marinkovic D, Magic Z. Variability of haptoglobin and alpha 2-macroglobulin in Albino Oxford and Dark Augustin inbred strains of rats before and after trauma. Vojnosanit Pregl. 2000;57:381-6 pubmed
    ..b>Haptoglobin (Hp) and alpha 2-macroglobulin (alpha 2-M) are among the most important APP in rats...
  37. Forte A, Finicelli M, De Luca P, Quarto C, Onorati F, Sante P, et al. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. J Cell Mol Med. 2008;12:1956-73 pubmed publisher
    ..and extended the microrarray data, revealing time-dependent post-translational modifications of Hsp27, haptoglobin and contrapsin-like protease inhibitor 6, and the differential expression of proteins mainly involved in ..
  38. Depypere H, Langlois M, Delanghe J, Temmerman M, Dhont M. Haptoglobin polymorphism in patients with preeclampsia. Clin Chem Lab Med. 2006;44:924-8 pubmed
    b>Haptoglobin (Hp) polymorphism has been associated with blood pressure regulation and essential hypertension. We investigated Hp polymorphism in patients with preeclampsia...
  39. Beyea J, Olson D, Harvey S. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Dev Dyn. 2005;234:404-12 pubmed
    ..In contrast, the lung concentrations of haptoglobin and major acute phase alpha-1 protein were reduced by adenoviral expression of mouse GH...
  40. Shirpoor A, Norouzi L, Khadem Ansari M, Ilkhanizadeh B, Gharaaghaji R. Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall. Int Immunopharmacol. 2013;16:498-504 pubmed publisher
    ..the aortic and coronary wall changes, vascular endothelial growth factor (VEGF), alpha-1 glycoprotein and haptoglobin amounts in plasma, C-reactive protein levels(CRP), as well as the amount of aortic IL-6 were evaluated...
  41. Imrie H, Fowkes F, Michon P, Tavul L, Hume J, Piper K, et al. Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area. Am J Trop Med Hyg. 2006;74:965-71 pubmed
    b>Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites...
  42. Smeets M, Fontijn J, Kavelaars A, Pasterkamp G, de Kleijn D. The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. Int J Exp Pathol. 2003;84:69-74 pubmed
    b>Haptoglobin is an acute phase protein known to be highly expressed in the liver...
  43. Wallberg Jonsson S, Johansson H, Ohman M, Rantapaa Dahlqvist S. Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis. A retrospective cohort study from disease onset. J Rheumatol. 1999;26:2562-71 pubmed
    ..In multiple Cox regression analysis, male sex, high age at disease onset, hypertension, higher haptoglobin level at disease onset, and corticosteroid treatment early in disease increased risk of CVD...
  44. Sampietro T, Neglia D, Bionda A, Dal Pino B, Bigazzi F, Puntoni M, et al. Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy. Am J Cardiol. 2005;96:1718-20 pubmed
    ..fractions, soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1, haptoglobin, and ceruloplasmin...
  45. Galleano M, Tapia G, Puntarulo S, Varela P, Videla L, Fernandez V. Liver preconditioning induced by iron in a rat model of ischemia/reperfusion. Life Sci. 2011;89:221-8 pubmed publisher
    ..liver glutathione content and the redox-sensitive NF-?B signaling pathway (EMSA) and western blot analysis of haptoglobin. Significant hepatoprotection against IR injury, underlying transient oxidative stress and enhancement in the ..
  46. Bons J, Drent M, Bouwman F, Mariman E, van Dieijen Visser M, Wodzig W. Potential biomarkers for diagnosis of sarcoidosis using proteomics in serum. Respir Med. 2007;101:1687-95 pubmed
    ..Identification of the peak at m/z 17,377 resulted in the alpha-2chain of haptoglobin. This study acts as a proof-of-principle for the use of SELDI-TOF-MS in the detection of new biomarkers for ..
  47. Arumugam T, Shiels I, Woodruff T, Reid R, Fairlie D, Taylor S. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. J Surg Res. 2002;103:260-7 pubmed
    ..with tissue injury were assessed by neutropenia, intestinal edema, serum tumor necrosis factor-alpha, serum haptoglobin, plasma aspartate aminotransferase, and histopathology...
  48. Watts J, Lee Y, Gellar M, Fulkerson M, Hwang S, Kline J. Proteomics of microparticles after experimental pulmonary embolism. Thromb Res. 2012;130:122-8 pubmed publisher
    ..Consistent with recent observations of hemolysis in PE, haptoglobin precursor protein, a major protein of hemoglobin clearance, decreased significantly in the PE animals...
  49. Bogojevic D, Petrović M, Mihailovic M. p53-like protein binding affinity to the hormone responsive element of the haptoglobin gene in fetal rat livers. Cell Biol Int. 2002;26:217-24 pubmed
    In order to identify nucleoproteins involved in transcriptional regulation of the haptoglobin (Hp) gene, fetal rat livers of dams exposed to inflammation on day 19 of pregnancy were used...
  50. Turgeon N, Valiquette C, Blais M, Routhier S, Seidman E, Asselin C. Regulation of C/EBPdelta-dependent transactivation by histone deacetylases in intestinal epithelial cells. J Cell Biochem. 2008;103:1573-83 pubmed
    ..Our aim was to examine the effect of HDACs on C/EBPdelta-dependent regulation of haptoglobin, an acute phase protein induced in intestinal epithelial cells in response to pro-inflammatory cytokines...
  51. Brandslund I, Petersen P, Brinkløv M, Andersen P, Parlev E. Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies. Scand J Clin Lab Invest. 1982;42:521-7 pubmed
    The catabolism of haemoglobin-haptoglobin complexes was studied in four patients with increased vascular haemolysis as part of acute or subacute haemolytic uraemic syndromes...
  52. Nishimura K, Shima K, Asakura M, Ohnishi Y, Yamasaki S. Effects of heparin administration on Trypanosoma brucei gambiense infection in rats. J Parasitol. 2005;91:219-22 pubmed
    ..increased lipoprotein lipase activity, high-density lipoprotein (HDL) concentration in the blood, and haptoglobin messenger RNA content of the liver...
  53. Kapralov A, Vlasova I, Feng W, Maeda A, Walson K, Tyurin V, et al. Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages. J Biol Chem. 2009;284:30395-407 pubmed publisher
    ..The latter can be converted into H(2)O(2) and feed Hb peroxidase activity. Haptoglobins (Hp) bind with extracellular Hb and reportedly weaken Hb peroxidase activity...