Gene Symbol: Hoxa11
Description: homeobox A11
Alias: Hoxa10, RGD1564605, RGD1566402, homeobox A11, homeobox protein Hox-A11, homeo box A10, homeobox protein A10, homeobox protein Hox-A11-like
Species: rat
Products:     Hoxa11

Top Publications

  1. Boulet A, Capecchi M. Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development. 2004;131:299-309 pubmed
    ..Targeted disruption of Hoxa11 and Hoxd11 or Hoxa10, Hoxc10 and Hoxd10 result in gross mispatterning of the radius and ulna or the femur, respectively...
  2. Davis A, Witte D, Hsieh Li H, Potter S, Capecchi M. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature. 1995;375:791-5 pubmed
    ..The appendicular skeleton defects suggest that paralogous Hox genes function together to specify limb outgrowth and patterning along the proximodistal axis. ..
  3. Raines A, Adam M, Magella B, Meyer S, Grimes H, Dey S, et al. Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development. 2013;140:2942-52 pubmed publisher
    ..a novel recombineering strategy to introduce simultaneous frameshift mutations into the flanking Hoxa9, Hoxa10 and Hoxa11 genes, as well as their paralogs on the HoxD cluster...
  4. Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS ONE. 2012;7:e43553 pubmed publisher
    ..Here we report a new function for Hoxa11 and Hoxd11 in regulating the early steps of chondrocyte differentiation...
  5. Varayoud J, Ramos J, Bosquiazzo V, Muñoz de Toro M, Luque E. Developmental exposure to Bisphenol a impairs the uterine response to ovarian steroids in the adult. Endocrinology. 2008;149:5848-60 pubmed publisher
    ..We investigated whether neonatal exposure to bisphenol A (BPA) alters Hoxa10 and Hoxa11 mRNA uterine expression shortly after treatment as well as in the adult...
  6. Seki T, Shimokawa N, Iizuka H, Takagishi K, Koibuchi N. Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats. Mol Cell Biochem. 2008;312:193-9 pubmed publisher
  7. Gong K, Yallowitz A, Sun H, Dressler G, Wellik D. A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol. 2007;27:7661-8 pubmed
    ..Thus, anterior-posterior-patterning Hox proteins interact with Pax2 and Eya1, factors important for nephrogenic mesoderm specification, to directly regulate the activation of downstream target genes during early kidney development. ..
  8. Thompson A, Nguyen L. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. Nat Genet. 2000;26:397-8 pubmed
  9. Hsieh Li H, Witte D, Weinstein M, Branford W, Li H, Small K, et al. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development. 1995;121:1373-85 pubmed
    ..In addition, the mutant testes fail to descend properly into the scrotum and, likely as a result, spermatogenesis is perturbed. ..

More Information


  1. Sakoyama Y, Mizuta I, Ogasawara N, Yoshikawa H. Cloning of rat homeobox genes. Biochem Genet. 1994;32:351-60 pubmed
    ..This His residue is not found in any of the previously published mammalian homeodomain sequences except mouse IPF1. ..
  2. Wellik D, Hawkes P, Capecchi M. Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 2002;16:1423-32 pubmed
    ..For example, mice individually mutant for Hoxa11 or Hoxd11 show no discernible kidney abnormalities...
  3. Wellik D, Capecchi M. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science. 2003;301:363-7 pubmed
    ..The redundancy among these paralogous family members is so great that this global aspect of Hox patterning is not apparent in mice that are mutant for five of the six paralogous alleles. ..
  4. Zhao Y, Potter S. Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Dev Biol. 2002;244:21-36 pubmed
    ..It is interesting that Hox homeoboxes are interchangeable in this process, but are functionally distinct in other aspects of development. ..
  5. Huang L, Pu Y, Hepps D, Danielpour D, Prins G. Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes. Endocrinology. 2007;148:1235-45 pubmed
    ..In contrast, Hoxa9 and Hoxa11 levels declined after morphogenesis suggesting a specific developmental role...
  6. Patterson L, Pembaur M, Potter S. Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development. 2001;128:2153-61 pubmed
    b>Hoxa11 and Hoxd11 are functionally redundant during kidney development. Mice with homozygous null mutation of either gene have normal kidneys, but double mutants have rudimentary, or in extreme cases, absent kidneys...
  7. Bao S, Sheng S, Peng Y, Lin Q. Effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin alpha v beta 3 in uterine epithelium of rats. Fertil Steril. 2009;91:244-8 pubmed publisher
    To compare the effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin alpha(v)beta(3) in the uterine epithelium in rats. Controlled prospective study. Teaching hospital and university research laboratory...
  8. Shen W, Montgomery J, Rozenfeld S, Moskow J, Lawrence H, Buchberg A, et al. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol. 1997;17:6448-58 pubmed
    ..DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with Meis1 alone, suggesting that Hox proteins stabilize the interactions of Meis1 proteins with their DNA targets. ..
  9. Hassan M, Saini S, Gordon J, Van Wijnen A, Montecino M, Stein J, et al. Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis. Cells Tissues Organs. 2009;189:122-5 pubmed publisher
    ..Our studies provide evidence for (1) selective association of HOXA10, MSX2, DLX3 and DLX5 homeodomain transcription factors on Runx2 and OC genes at stages of osteoblast maturation as ..
  10. Koyama E, Yasuda T, Minugh Purvis N, Kinumatsu T, Yallowitz A, Wellik D, et al. Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development. 2010;137:3795-800 pubmed publisher
    ..The re-emergence of such anatomical structures suggests that their genetic blueprint is still present in the mouse genome but is normally modified to the needs of the mammalian joint-formation program by distinct Hox11 function. ..