Hormad2

Summary

Gene Symbol: Hormad2
Description: HORMA domain containing 2
Alias: HORMA domain-containing protein 2
Species: rat
Products:     Hormad2

Top Publications

  1. Wojtasz L, Cloutier J, Baumann M, Daniel K, Varga J, Fu J, et al. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012;26:958-73 pubmed publisher
    ..We disrupted the meiosis-specific mouse HORMAD2 (Hop1, Rev7, and Mad2 domain 2) protein, which preferentially associates with unsynapsed chromosome axes...
  2. Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H. HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012;17:897-912 pubmed publisher
    ..In our present study, we generated mice lacking HORMAD2, a protein that localizes to unsynapsed meiotic chromosomes...
  3. Wojtasz L, Daniel K, Roig I, Bolcun Filas E, Xu H, Boonsanay V, et al. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet. 2009;5:e1000702 pubmed publisher
    ..examined the behavior of two previously uncharacterized meiosis-specific mouse HORMA-domain proteins--HORMAD1 and HORMAD2--in wild-type mice and in mutants defective in DSB processing or SC formation...