Gene Symbol: Hnrnpr
Description: heterogeneous nuclear ribonucleoprotein R
Alias: Hnrpr, heterogeneous nuclear ribonucleoprotein R
Rossoll W, Kröning A, Ohndorf U, Steegborn C, Jablonka S, Sendtner M. Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?. Hum Mol Genet. 2002;11:93-105 pubmed
..Interestingly, hnRNP-R is predominantly located in axons of motor neurons and co-localizes with Smn in this cellular compartment. Thus, this finding could provide a key to understand a motor neuron-specific Smn function in SMA. ..
Hassfeld W, Chan E, Mathison D, Portman D, Dreyfuss G, Steiner G, et al
. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. Nucleic Acids Res. 1998;26:439-45 pubmed
..Support for this notion comes from observations that concomitant or coupling of autoantibody responses to proteins which are associated with each other as components of subcellular particles are often found in autoimmune diseases. ..
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K. SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. J Biol Chem. 2000;275:9823-31 pubmed
..cDNA cloning of SYNCRIP cDNA revealed that the protein was highly homologous to heterogeneous nuclear ribonucleoprotein R (hnRNP R) recently identified...
Rossoll W, Jablonka S, Andreassi C, Kröning A, Karle K, Monani U, et al
. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol. 2003;163:801-12 pubmed
..Together, these data suggest that a complex of Smn with its binding partner hnRNP R interacts with beta-actin mRNA and translocates to axons and growth cones of motoneurons. ..
Kim T, Kim J, Kim J, Myung J, Chae H, Woo K, et al
. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Mol Cell Biol. 2005;25:3232-46 pubmed
..These proteins include heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L...
Huang J, Li S, Chen X, Han Y, Xu P. hnRNP-R regulates the PMA-induced c-fos expression in retinal cells. Cell Mol Biol Lett. 2008;13:303-11 pubmed publisher
..These findings indicate that hnRNP-R regulates the c-fos expression in retinal cells, and that the ARE of c-fos mRNAs contributes to this regulation. ..
Peng Z, Huang J, Lee S, Shi Y, Chen X, Xu P. The expression pattern of heterogeneous nuclear ribonucleoprotein R in rat retina. Neurochem Res. 2009;34:1083-8 pubmed publisher
..In addition, the hnRNP-R1 distribution is regulated in rat retina during circadian. The present investigation suggests that hnRNP-R may play roles in retinal development and light-elicited cellular activities. ..