Hmgcr

Summary

Gene Symbol: Hmgcr
Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Alias: 3H3M, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase
Species: rat

Top Publications

  1. ncbi Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent
    Gene C Ness
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States
    FEBS Lett 579:3126-30. 2005
  2. ncbi Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2
    U Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neuroscience 134:901-6. 2005
  3. ncbi 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
  4. ncbi Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease
    Emile Levy
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Life Sci 80:1472-83. 2007
  5. pmc Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin
    Gene C Ness
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Biochem Biophys Res Commun 420:178-82. 2012
  6. doi Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro
    Jian Xu
    School of Pharmacy, Anhui Medical University, Hefei, China
    J Pharm Pharmacol 61:503-10. 2009
  7. ncbi Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin
    Pertti J Neuvonen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Pharmacokinet 47:463-74. 2008
  8. doi Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury
    Xiao Ru Chen
    Equipe de recherche Pharmacologie de la Circulation Cérébrale EA 2510, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    J Pharmacol Exp Ther 326:966-74. 2008
  9. doi Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression
    N Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 74:144-53. 2008
  10. doi Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion
    Carin Gustavsson
    Unit on Vascular Diabetic Complications, Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Retina 28:645-52. 2008

Research Grants

Scientific Experts

Detail Information

Publications67

  1. ncbi Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent
    Gene C Ness
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States
    FEBS Lett 579:3126-30. 2005
    ..The results indicate that in liver, neither the rate of reductase protein degradation nor the ubiquitin-proteasome system appear to play roles in mediating changes in HMG-CoA reductase protein levels in response to dietary cholesterol...
  2. ncbi Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2
    U Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neuroscience 134:901-6. 2005
    ..Our results indicate that rosuvastatin may have utility not only as stroke prophylaxis but also as acute therapy inhibiting executive cell death pathways...
  3. ncbi 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
    ..Monitoring of expression of the newly identified candidate genes and patterns of lymphocyte subpopulations might predict the responsiveness of multiple sclerosis patients to statin treatment...
  4. ncbi Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease
    Emile Levy
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Life Sci 80:1472-83. 2007
    ..Our data emphasize the crucial role of copper balance in hepatic sterol homeostasis and lipoprotein metabolism in LEC rats. Additional studies are needed to delineate the mechanisms of these disorders...
  5. pmc Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin
    Gene C Ness
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Biochem Biophys Res Commun 420:178-82. 2012
    ..In comparison, siRNA to AU RNA binding protein/enoyl coenzyme A hydratase (AUH) had no effect. These findings indicate a role for TTP in the insulin-mediated activation of hepatic HMGR transcription...
  6. doi Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro
    Jian Xu
    School of Pharmacy, Anhui Medical University, Hefei, China
    J Pharm Pharmacol 61:503-10. 2009
    ..Here, we demonstrate that Ang II-induced apoptosis is prevented by losartan and simvastatin in neonatal cardiomyocytes...
  7. ncbi Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin
    Pertti J Neuvonen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Pharmacokinet 47:463-74. 2008
    ..On the pharmacokinetic basis, fluvastatin and pravastatin can be better choices than simvastatin or lovastatin for an OTC statin...
  8. doi Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury
    Xiao Ru Chen
    Equipe de recherche Pharmacologie de la Circulation Cérébrale EA 2510, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    J Pharmacol Exp Ther 326:966-74. 2008
    ..Thus, these results may have important therapeutic significance for the treatment of TBI...
  9. doi Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression
    N Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 74:144-53. 2008
    ....
  10. doi Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion
    Carin Gustavsson
    Unit on Vascular Diabetic Complications, Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Retina 28:645-52. 2008
    ....
  11. ncbi Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin
    Minodora Dobreanu
    Department of Clinical Biochemistry Immunology, University of Medicine and Pharmacy, Targu Mures, Romania
    Rom J Intern Med 45:193-9. 2007
    ....
  12. ncbi Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation
    Valentina Pallottini
    Department of Biology, University of Rome Roma Tre, Viale Marconi 446, 00146 Rome, Italy
    Mech Ageing Dev 128:688-95. 2007
    ..Thus, in this work, we have performed a study of HMG-CoAR by analyzing the enzymes involved in its short-term regulation, namely, AMP-activated kinase (AMPK) and protein phosphatase 2A (PP2A)...
  13. ncbi Effect of ScrF I polymorphism in the 2nd intron of the HMGCR gene on lipid-lowering response to simvastatin in Chinese diabetic patients
    Su Ying
    Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    Biochem Biophys Res Commun 363:395-8. 2007
    To investigate whether ScrF I polymorphism in the 2nd intron of the HMG-COA reductase gene (HMGCR) influences serum lipid levels and whether this polymorphism affects the efficiency of the cholesterol lowering HMG-CoA reductase inhibitor,..
  14. ncbi Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    G Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Neurology 69:878-85. 2007
    ..We investigated whether antecedent statin exposure is associated with neuritic plaque (NP) or neurofibrillary tangle (NFT) burden in a population-based sample of human subjects...
  15. ncbi Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease
    Marta Valenza
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurobiol Dis 28:133-42. 2007
    ..The defect occurs early in these mice and generates lower levels of newly synthesized cholesterol and its intermediates, which may affect different aspects of the disease...
  16. pmc Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
    Benjamin Wolozin
    Boston University School of Medicine, Boston, MA, USA
    BMC Med 5:20. 2007
    ..We used a large database to compare the action of several different statins to investigate whether some statins might be differentially associated with a reduction in the incidence of dementia and Parkinson's disease...
  17. ncbi Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation
    William R Lagor
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Exp Biol Med (Maywood) 232:353-61. 2007
    ..We also conclude that in vivo electroporation is a convenient and powerful technique for the analysis of promoter elements in the livers of live animals...
  18. ncbi Lovastatin attenuates nerve injury in an animal model of Guillain-Barré syndrome
    Jason P Sarkey
    Research Service, Department of Veterans Affairs, Edward Hines Jr VA Hospital, Hines, Illinois 60141, USA
    J Neurochem 100:1265-77. 2007
    ..Together, these data demonstrate that a short-term course of lovastatin attenuates the development and progression of EAN in Lewis rats by limiting the proliferation and migration of autoreactive leukocytes...
  19. ncbi Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats
    N P Visavadiya
    Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India
    Clin Exp Pharmacol Physiol 34:244-9. 2007
    ..7. Administration of C. borivilianum root powder also increased the activities of anti-oxidant enzymes and vitamin C levels, which may have enhanced the anti-oxidant capacity of the liver...
  20. doi Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner
    Christopher Torrens
    Vascular Biology Group, Institute of Developmental Sciences 887, University of Southampton, School of Medicine, Southampton General Hospital, Tremona Rd, Southampton S016 6YD, United Kingdom
    Hypertension 53:661-7. 2009
    ..These data suggest that atorvastatin can restore endothelial function in this model, but its effects are gender specific and dependent on the vascular bed...
  21. doi Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction
    Milka Perovic
    Laboratory of Molecular Neurobiology, Department of Neurobiology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Bul D Stefana 142, 11060 Belgrade, Serbia
    Biogerontology 10:735-45. 2009
    ....
  22. doi Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells
    Donna H Wong
    Department of Obstetrics and Gynecology, School of Medicine, University of California Davis, Sacramento, California 95817, USA
    Fertil Steril 96:1252-8. 2011
    ..To examine the mechanisms of action of resveratrol and its interaction with simvastatin on growth and the mevalonate pathway in rat theca-interstitial cells...
  23. doi Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats
    Alper Ucak
    Department of Cardiovascular Surgery, Gulhane Military Medical Academy, Istanbul, Turkey
    Ann Vasc Surg 25:686-95. 2011
    ..We aimed to investigate the role of rosuvastatin (RSV) against ischemia/reperfusion injury in an experimental model of spinal cord ischemia in rats...
  24. pmc Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy
    ANDREW L MAMMEN
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 63:713-21. 2011
    ..The purpose of this study was to identify these molecules to help clarify the disease mechanism and facilitate diagnosis...
  25. pmc Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin
    Xian Wu Cheng
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Hypertens 29:542-52. 2011
    ..Statins improve renal remodeling and dysfunction in patients with proteinuric kidney diseases. We aimed to clarify the beneficial effects and mechanisms of action of statins in renal insufficiency...
  26. ncbi The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides
    Michiaki Abe
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai, Japan
    Drug Metab Pharmacokinet 25:274-82. 2010
    ..In addition, insulin secretion from isolated islets was enhanced by pravastatin. These data suggest that pravastatin has pleiotropic effects on islets through membrane transport under high fat/glucose conditions...
  27. doi Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA
    Mônica Testoni Cardozo
    Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508 900, Sao Paulo, SP, Brazil
    J Nutr Biochem 22:130-5. 2011
    ....
  28. doi Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation
    Laura Trapani
    Department of Biology, University Roma Tre, Viale Marconi, 446 00146 Rome, Italy
    J Cell Biochem 110:392-8. 2010
    ....
  29. doi The effect of statin therapy on allergic patients with asthma
    Marina Ostroukhova
    Department of Medicine, Rochester General Hospital, Rochester, New York, USA
    Ann Allergy Asthma Immunol 103:463-8. 2009
    ..They have anti-inflammatory and cholesterol-lowering effects. Statins alter the production of T(H)1 cytokines and thus promote a T(H)2 response. This immune alteration would promote allergic diseases such as asthma...
  30. doi Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat
    Keunsook Cho
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Republic of Korea
    J Med Food 12:1293-301. 2009
    ....
  31. doi Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat
    Zuoquan Xie
    State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PRC
    Metabolism 59:554-60. 2010
    ..These observations facilitated our understanding of the pathways involved in the development of NAFLD induced by HFD...
  32. doi Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats
    Laura Trapani
    Department of Biology, University Roma Tre, Viale Marconi 446, Rome, Italy
    Exp Gerontol 45:119-28. 2010
    ..These findings highlight the correlation between estrogen and HMGR short-term regulation, and suggest the presence of another mechanism underlying the protective role of estrogen in age-related diseases...
  33. doi Simvastatin improves wound strength after intestinal anastomosis in the rat
    G Karadeniz Cakmak
    Department of Surgery, The School of Medicine, Zonguldak Karaelmas University, Kozlu Zonguldak, Turkey
    J Gastrointest Surg 13:1707-16. 2009
    ..Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis...
  34. doi Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model
    Mizuki Mizukawa
    Department of Cardiorenal Cerebrovascular Medicine, Kagawa University Faculty of Medicine, Kagawa, Japan
    Hypertens Res 32:617-24. 2009
    ....
  35. doi 3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation
    Chiara Martini
    Department of Biology, University of Roma Tre, Rome, Italy
    J Cell Physiol 220:524-30. 2009
    ....
  36. ncbi Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells
    Hiroyuki Yamazaki
    Tokyo New Drug Research Laboratories I, Pharmaceutical Division, Kowa, Co Ltd, Japan
    J Atheroscler Thromb 13:295-307. 2006
    ..We found that cerivastatin showed the most potent cytotoxicity in HSkMCs and strongly lowered ubiquinone levels in the rat heart...
  37. ncbi Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells
    Antonio G Tristano
    Department of Pharmaceutical and Administrative Sciences, College of Pharmacy, Health Professions Division, Nova Southeastern University, Fort Lauderdale, FL 33328, USA
    Biochem Biophys Res Commun 353:11-7. 2007
    ..Our results suggest that statins modulate AII effects in VSMC, and that transient increases in AII effects mediated via the MAPK pathway may play a role in the vascular dysfunction associated with statin withdrawal...
  38. ncbi Reduced incidence of new-onset diabetes mellitus after renal transplantation with 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors (statins)
    G V Ramesh Prasad
    Division of Nephrology, Department of Medicine, University of Toronto, 61 Queen Street East, 9th Floor, Toronto, ON M5C 2T2, Canada
    Am J Transplant 4:1897-903. 2004
    ..02, HR 1.230[1.023-1.480]) and age > or =45 years (p = 0.01, HR 2.226[1.162-4.261]) were associated with increased diabetes. Statin use is associated with reduced new-onset diabetes development after renal transplantation...
  39. ncbi Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro
    Emilia Rung
    Department of Physiology and Pharmacology, Goteborg, Sweden
    Biol Reprod 72:538-45. 2005
    ..These results show that PR antagonists reduce cholesterol synthesis in periovulatory granulosa cells and that cholesterol synthesis is important for granulosa cell survival...
  40. ncbi Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model
    Yang Yu
    Second Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Japan
    J Am Coll Cardiol 44:904-13. 2004
    ....
  41. pmc Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes
    Shinsuke Miyahara
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Pathol 164:1697-706. 2004
    ..Simvastatin may thus be useful in the prevention of diabetic retinopathy...
  42. ncbi Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study
    S Floris
    Department of Molecular Cell Biology, VU Medical Center FdG, P O Box 7057, 1007 Mbyte Amsterdam, The Netherlands
    Brain 127:616-27. 2004
    ..These studies also implicate that USPIOs are a valuable tool to visualize monocyte infiltration in vivo and quantitatively assess the efficacy of new therapeutics like lovastatin...
  43. ncbi Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure
    Michal Chmielewski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Debinki, Poland
    Mol Cell Biochem 246:187-91. 2003
    ..The results also indicate that the physiological diurnal rhythm of HMG-CoA reductase activity is preserved in the course of experimental CRF...
  44. ncbi Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1830 E Monument, 5th Floor, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 285:H938-45. 2003
    ..Enhancement of lung eNOS expression does not appear to be involved in mediating this effect...
  45. ncbi Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
    Torgun Waehre
    Research Institute of Internal Medicine, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    J Am Coll Cardiol 41:1460-7. 2003
    ..We sought to investigate whether the activation of the chemokine network observed in patients with coronary artery disease (CAD) could be modified by treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins)...
  46. ncbi Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
    ..We investigated the effect of two statins on the proliferation rate and protein steady state levels of hepatic stellate cells (HSC)...
  47. ncbi The effect of statins on mortality in patients with bacteremia
    A P Liappis
    Division of Infectious Diseases, Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA
    Clin Infect Dis 33:1352-7. 2001
    ..008). These data suggest a potential clinical role of statins in bacteremic infection; however, the mechanism by which mortality is reduced remains undefined...
  48. ncbi Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism
    S D Gupta
    Department of Biochemistry and Molecular Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    J Lipid Res 40:1572-84. 1999
    ..Based on these observations, the significance and a possible regulatory model in the formation of isoprenoid end-products are discussed...
  49. pmc Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver
    P R Clarke
    Protein Phosphorylation Group, Department of Biochemistry, The University, Dundee, Scotland, UK
    EMBO J 9:2439-46. 1990
    ..We have also identified by amino acid sequencing the N-terminus of the catalytic fragment, which corresponds to residue 423 of the human enzyme...
  50. ncbi Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes
    J G Gillespie
    Department of Biochemistry, The University, Dundee, Scotland, UK
    FEBS Lett 306:59-62. 1992
    ....
  51. ncbi Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver
    Valentina Pallottini
    Department of Biology, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy
    Mech Ageing Dev 125:633-9. 2004
    ..These findings support the hypothesis that a different arrangement of the HMG-CoA reductase membrane domain in aged rats is a cause of reductase deregulation...
  52. pmc Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction
    Matthew E Gegg
    Division of Cellular Therapy, Institute of Ophthalmology, University College London, London, United Kingdom
    J Immunol 174:2327-35. 2005
    ..These data highlight the potential differential activity of statins in different inflammatory conditions and their possible therapeutic use for the treatment of human posterior uveitis...
  53. ncbi Effects of pravastatin in murine collagen-induced arthritis
    Toshiaki Yamagata
    Department of Nephrology and Rheumatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Rheumatol Int 27:631-9. 2007
    ..Meanwhile, adverse reactions of pravastatin, such as peritonitis, were not detected. Pravastatin may have good prospects for treating some anti-inflammatory effects on human rheumatoid arthritis...
  54. ncbi Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury
    Hong Wei Yao
    Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, Hangshou, People s Republic of China
    Clin Exp Pharmacol Physiol 33:793-7. 2006
    ..The inhibitory effect of pravastatin was associated with its effect in decreasing TNF-alpha...
  55. ncbi Defects of cholesterol biosynthesis
    Hans R Waterham
    Laboratory Genetic Metabolic Diseases, F0 224, Department of Pediatrics Emma Children s Hospital, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    FEBS Lett 580:5442-9. 2006
    ..The etiology of the underlying pathophysiology may involve multiple affected processes due to lowered cholesterol and/or the elevated, teratogenic levels of the intermediate sterol precursors...
  56. ncbi Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia
    Valentina Pallottini
    Department of Biology, University of Rome Roma Tre, Viale Marconi 446, 00146 Rome, Italy
    J Cell Biochem 98:1044-53. 2006
    ..The SREBP-2 in particular seems to be committed in multiple way to gene transcription. The obtained data represent a good contribution to explain the age-related hypercholesterolemia...
  57. ncbi A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes
    Chia Wen Chen
    Graduate Institute of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
    J Nutr 136:1472-6. 2006
    ..The high contents of gamma-oryzanol and gamma-tocotrienol in RBO can lead to increased fecal neutral sterol and bile acid excretion, via upregulation of cholesterol synthesis and catabolism...
  58. ncbi Selective compensatory induction of hepatic HMG-CoA reductase in response to inhibition of cholesterol absorption
    Gene C Ness
    Department of Biochemistry and Molecular Biology, College of Medicine, 12901 Bruce B Downs Boulevard, University of South Florida, Tampa, FL 33612, USA
    Exp Biol Med (Maywood) 231:559-65. 2006
    ..This indicates that ezetimibe should be most effective in lowering serum cholesterol levels in people with low rates of cholesterol synthesis/high rates of cholesterol absorption...
  59. pmc Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects
    H Yasuda
    Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, Bethesda, Maryland, USA
    Kidney Int 69:1535-42. 2006
    ..Simvastatin improved sepsis-induced AKI by direct effects on the renal vasculature, reversal of tubular hypoxia, and had a systemic anti-inflammatory effect...
  60. ncbi Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat
    Li Zhang
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA
    Circulation 112:3486-94. 2005
    ..We therefore investigated the neuroprotective effects of a combination of atorvastatin and delayed rht-PA treatment in a rat model of embolic stroke...
  61. ncbi White blood cell count predicts reduction in coronary heart disease mortality with pravastatin
    Ralph A H Stewart
    Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
    Circulation 111:1756-62. 2005
    ....
  62. ncbi Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemia
    R McPherson
    Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Clin Ther 14:276-91. 1992
    ..The frequency of overall side effects, including central nervous system-related symptoms and headache, was similar and low in all groups...
  63. ncbi Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content
    Valentina Pallottini
    Department of Biology, University of Rome Roma Tre, Viale Marconi 446, 00146 Rome, Italy
    J Hepatol 44:368-74. 2006
    ....
  64. pmc In vivo identification of promoter elements and transcription factors mediating activation of hepatic HMG-CoA reductase by T3
    Lindsey R Boone
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA
    Biochem Biophys Res Commun 385:466-71. 2009
    ..These data provide in vivo evidence for functional roles for USF-2, SREBP-2, and NF-Y in mediating the T3-induction of hepatic HMGR transcription...
  65. ncbi Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation
    P A Edwards
    J Biol Chem 260:10278-82. 1985
    ..The simplest interpretation of these results is that rat liver 3-hydroxy-3-methylglutaryl-CoA reductase in situ is a noncovalently linked dimer of the Mr = 97,200 enzyme subunit...
  66. ncbi Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
    Bao Liang Song
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 279:28798-806. 2004
    ....
  67. ncbi Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells
    M Carmen Garcia-Pelayo
    Department of Biochemistry and Molecular Biology, University of Granada, Polígono de Cartuja s n, 18071 Granada, Spain
    Exp Biol Med (Maywood) 229:781-6. 2004
    ..Results obtained with cycloheximide as a protein-synthesis inhibitor confirm these findings...

Research Grants28

  1. Exhaled Nitric Oxide and Oxidative Stress in Pulmonary Arterial Hypertention Asso
    Reda E Girgis; Fiscal Year: 2010
    ..This study aims to develop and validate novel, easily-obtained biomarkers in exhaled breath and urine that may ultimately improve clinical management of these patients and allow early detection of disease. (End of Abstract) ..
  2. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE NESS; Fiscal Year: 2009
    ....
  3. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  4. LRRK2 and Neurodegeneration
    Benjamin Wolozin; Fiscal Year: 2009
    ..elegans. This aim will elucidate whether wild type LRRK2 normally protects against pathophysiological changes associated with PD, and whether PD-related mutations in LRRK2 enhance these changes. ..
  5. LRRK2 and Neurodegeneration
    Benjamin L Wolozin; Fiscal Year: 2010
    ..elegans. This aim will elucidate whether wild type LRRK2 normally protects against pathophysiological changes associated with PD, and whether PD-related mutations in LRRK2 enhance these changes. ..
  6. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin L Wolozin; Fiscal Year: 2010
    ..Aim 3 will determine whether combined use of a mitochondrial complex II stimulant plus an apoptotic inhibitor or antioxidant protects neurons against degeneration in transgenic mice carrying the A53T alpha-synuclein transgene.. ..
  7. Effects of Simvastatin on CSF AD biomarkers in cognitively normal subjects
    Gail Li; Fiscal Year: 2010
    ..Simvastatin has been widely used for prevention of coronary artery disease. The findings of the proposed study may provide proof of concept in support of large scale primary prevention trials in persons at high risk for AD. ..
  8. LRRK2 and Neurodegeneration
    Benjamin Wolozin; Fiscal Year: 2009
    ..elegans. This aim will elucidate whether wild type LRRK2 normally protects against pathophysiological changes associated with PD, and whether PD-related mutations in LRRK2 enhance these changes. ..
  9. Regulation of APP Processing by Presenilins
    Benjamin Wolozin; Fiscal Year: 2004
    ..Identification of mutant forms of presenilin that inhibit beta- amyloid production could lead to novel strategies for therapeutic intervention in Alzheimer's disease. ..
  10. Ubiquitination/Receptor Signaling--Regulation by Parkin
    Benjamin Wolozin; Fiscal Year: 2004
    ..abstract_text> ..
  11. Vascular Risk Factors in Alzheimer's Disease
    Gail Li; Fiscal Year: 2006
    ..abstract_text> ..
  12. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  13. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin Wolozin; Fiscal Year: 2007
    ..Aim 3 will determine whether combined use of a mitochondrial complex II stimulant plus an apoptotic inhibitor or antioxidant protects neurons against degeneration in transgenic mice carrying the A53T alpha-synuclein transgene.. ..
  14. LRRK2 and Neurodegeneration
    Benjamin L Wolozin; Fiscal Year: 2010
    ..elegans. This aim will elucidate whether wild type LRRK2 normally protects against pathophysiological changes associated with PD, and whether PD-related mutations in LRRK2 enhance these changes. ..