Hmgb1

Summary

Gene Symbol: Hmgb1
Description: high mobility group box 1
Alias: Ac2-008, Hmg1, high mobility group protein B1, Ac2-008-like, HMG-1, amphoterin, heparin-binding protein p30, high mobility group 1, high mobility group protein 1
Species: rat
Products:     Hmgb1

Top Publications

  1. Song J, Lu J, Liu L, Chen L, Durairajan S, Yue Z, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/?-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014;10:144-54 pubmed publisher
    ..Furthermore, we showed that SNCA binds to both cytosolic and nuclear high mobility group box 1 (HMGB1), impairs the cytosolic translocation of HMGB1, blocks HMGB1-BECN1 binding, and strengthens BECN1-BCL2 binding...
  2. Lei C, Lin S, Zhang C, Tao W, Dong W, Hao Z, et al. High-mobility group box1 protein promotes neuroinflammation after intracerebral hemorrhage in rats. Neuroscience. 2013;228:190-9 pubmed publisher
    High-mobility group box1 (HMGB1) protein is massively released into the cytoplasm and induces inflammation following various insults such as sepsis, acute cerebral ischemia, and pancreatitis...
  3. Taguchi A, Blood D, Del Toro G, Canet A, Lee D, Qu W, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature. 2000;405:354-60 pubmed
    ..RAGE is a central cell surface receptor for amphoterin, a polypeptide linked to outgrowth of cultured cortical neurons derived from developing brain...
  4. Kokkola R, Sundberg E, Ulfgren A, Palmblad K, Li J, Wang H, et al. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 2002;46:2598-603 pubmed
    ..These findings suggest a pathogenetic role for HMGB-1 in synovitis and indicate a new potential therapeutic target molecule. ..
  5. Liu K, Mori S, Takahashi H, Tomono Y, Wake H, Kanke T, et al. Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats. FASEB J. 2007;21:3904-16 pubmed
    The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space...
  6. Dumitriu I, Baruah P, Valentinis B, Voll R, Herrmann M, Nawroth P, et al. Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol. 2005;174:7506-15 pubmed
    High mobility group box 1 (HMGB1) is an abundant and conserved nuclear protein that is released by necrotic cells and acts in the extracellular environment as a primary proinflammatory signal...
  7. Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, et al. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine (Phila Pa 1976). 2010;35:1109-15 pubmed publisher
    ..culture and rat spinal cord injury (SCI) model were used to examine the expression of high mobility group box 1 (HMGB1), TNF-alpha, and Rage by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical ..
  8. El Gazzar M, Yoza B, Chen X, Garcia B, Young N, McCall C. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009;29:1959-71 pubmed publisher
    ..Here, we report the novel findings that intracellular high mobility group box 1 protein (HMGB1) and nucleosome linker histone H1 protein are necessary components of endotoxin-mediated silencing of TNF-alpha in ..
  9. Lange S, Mitchell D, Vasquez K. High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage. Proc Natl Acad Sci U S A. 2008;105:10320-5 pubmed publisher
    b>High mobility group protein B1 (HMGB1) is a multifunctional protein with roles in chromatin structure, transcriptional regulation, V(D)J recombination, and inflammation...

More Information

Publications62

  1. Prasad R, Liu Y, Deterding L, Poltoratsky V, Kedar P, Horton J, et al. HMGB1 is a cofactor in mammalian base excision repair. Mol Cell. 2007;27:829-41 pubmed
    ..Mass spectrometry identified the high-mobility group box 1 protein (HMGB1) as specifically interacting with the BER intermediate...
  2. Hreggvidsdottir H, Ostberg T, Wähämaa H, Schierbeck H, Aveberger A, Klevenvall L, et al. The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation. J Leukoc Biol. 2009;86:655-62 pubmed publisher
    The nuclear protein HMGB1 has previously been demonstrated to act as an alarmin and to promote inflammation upon extracellular release, yet its mode of action is still not well defined...
  3. Chung K, Park J, Kim Y. The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate. Transplant Proc. 2008;40:2136-8 pubmed publisher
    High mobility group box-1(HMGB1) was identified as a DNA-binding protein that functions as a cofactor for proper transcriptional regulation in somatic cells...
  4. Rauvala H, Merenmies J, Pihlaskari R, Korkolainen M, Huhtala M, Panula P. The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons. J Cell Biol. 1988;107:2293-305 pubmed
    ..A model summarizing the suggested interactions of p30 in cell adhesion and neurite growth is presented. ..
  5. Mohammad G, Siddiquei M, Othman A, Al Shabrawey M, Abu El Asrar A. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Exp Eye Res. 2013;107:101-9 pubmed publisher
    ..Our findings provide evidence that in the diabetic retina, HMGB-1 possibly interacts with RAGE and activates ERK(1/2) and NF-?B to generate an inflammatory response and disrupt retinal vascular barrier...
  6. Youn J, Kwak M, Wu J, Kim E, Ji Y, Min H, et al. Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model. Eur J Immunol. 2011;41:2753-62 pubmed publisher
    ..We have previously demonstrated that high mobility group box 1 (HMGB1) can bind to and transfer LPS, consequently increasing LPS-induced TNF-? production in human peripheral blood ..
  7. Arimura N, Ki i Y, Hashiguchi T, Kawahara K, Biswas K, Nakamura M, et al. Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Lab Invest. 2009;89:278-89 pubmed publisher
    High-mobility group box 1 (HMGB1) protein is a multifunctional protein, which is mainly present in the nucleus and is released extracellularly by dying cells and/or activated immune cells...
  8. Merenmies J, Pihlaskari R, Laitinen J, Wartiovaara J, Rauvala H. 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. J Biol Chem. 1991;266:16722-9 pubmed
    ..cDNA and peptide sequencing identified a dipolar sequence that has been previously found in studies of high mobility group 1 protein: the 184-amino acid cationic region is followed by a cluster of 30 anionic residues...
  9. Pallier C, Scaffidi P, Chopineau Proust S, Agresti A, Nordmann P, Bianchi M, et al. Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Mol Biol Cell. 2003;14:3414-26 pubmed
    ..Previous studies based on immunofluorescence analysis indicated that HMGB1 dissociates from chromosomes during mitosis...
  10. Jung Y, Lippard S. Nature of full-length HMGB1 binding to cisplatin-modified DNA. Biochemistry. 2003;42:2664-71 pubmed
    b>HMGB1, a highly conserved non-histone DNA-binding protein, interacts with specific DNA structural motifs such as those encountered at cisplatin damage, four-way junctions, and supercoils...
  11. Yang J, Shah R, Robling A, Templeton E, Yang H, Tracey K, et al. HMGB1 is a bone-active cytokine. J Cell Physiol. 2008;214:730-9 pubmed
    High mobility group box 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells...
  12. Takahashi K, Fukushima S, Yamahara K, Yashiro K, Shintani Y, Coppen S, et al. Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. Circulation. 2008;118:S106-14 pubmed publisher
    ..High-mobility group box 1 (HMGB1) is a nuclear protein, which has recently been uncovered to also act as a modifier of inflammation when released...
  13. Stros M, Ozaki T, Bacikova A, Kageyama H, Nakagawara A. HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J Biol Chem. 2002;277:7157-64 pubmed
    ..Previous reports have shown that architectural DNA-bending/looping chromosomal proteins HMGB1 and HMGB2 (formerly known as HMG1 and HMG2), which function in a number of biological processes including ..
  14. Susa Y, Masuda Y, Imaizumi H, Namiki A. Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. Crit Care Med. 2009;37:2619-24 pubmed publisher
    ..Extracellularly released high mobility group-box 1 can bind to cell surface receptors, such as receptor for advanced glycation end-products, eliciting inflammatory responses that lead to the development of sepsis...
  15. Pérez Carrión M, Ceña V. Knocking down HMGB1 using dendrimer-delivered siRNA unveils its key role in NMDA-induced autophagy in rat cortical neurons. Pharm Res. 2013;30:2584-95 pubmed publisher
    To explore the role of the High Mobility Group Box 1 (HMGB1) protein in NMDA-mediated excitotoxicity in rat cortical neurons. We knocked down HMGB1 using small-interfering RNA (siRNA) delivered into neurons by means of a dendrimer...
  16. Hayakawa K, Pham L, Katusic Z, Arai K, Lo E. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012;109:7505-10 pubmed publisher
    ..reactive astrocytes can release a damage-associated molecular-pattern molecule called high-mobility-group-box-1 (HMGB1) that promotes endothelial progenitor cell (EPC)-mediated neurovascular remodeling during stroke recovery...
  17. Paull T, Haykinson M, Johnson R. The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes Dev. 1993;7:1521-34 pubmed
    The mammalian high mobility group proteins HMG1 and HMG2 are abundant, chromatin-associated proteins whose cellular function is not known...
  18. Li J, Kokkola R, Tabibzadeh S, Yang R, Ochani M, Qiang X, et al. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med. 2003;9:37-45 pubmed
    ..b>HMGB1 is released by activated macrophages...
  19. Calogero S, Grassi F, Aguzzi A, Voigtlander T, Ferrier P, Ferrari S, et al. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet. 1999;22:276-80 pubmed
    b>High mobility group 1 (HMG1) protein is an abundant component of all mammalian nuclei, and related proteins exist in all eukaryotes...
  20. Feng Y, Yang Q, Xu J, Qian G, Liu Y. Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury. Exp Mol Pathol. 2008;85:214-22 pubmed publisher
    To observe the effects of intravenous injection of HMGB1 inhibitor sodium butyrate on changes in apoptosis of PMN during LPS-induced acute lung injury in rats and HMGB1 in vitro on human circulating PMN apoptosis, in order to clarify the ..
  21. Degryse B, Bonaldi T, Scaffidi P, Muller S, Resnati M, Sanvito F, et al. The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J Cell Biol. 2001;152:1197-206 pubmed
    HMG1 (high mobility group 1) is a ubiquitous and abundant chromatin component. However, HMG1 can be secreted by activated macrophages and monocytes, and can act as a mediator of inflammation and endotoxic lethality...
  22. Kokkola R, Andersson A, Mullins G, Ostberg T, Treutiger C, Arnold B, et al. RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand J Immunol. 2005;61:1-9 pubmed
    Abstract High-mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear functions and extracellular cytokine-like effects...
  23. Gao H, Zhou H, Zhang F, Wilson B, Kam W, Hong J. HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci. 2011;31:1081-92 pubmed publisher
    ..Mechanistic studies indicated that HMGB1 (high-mobility group box 1), released from inflamed microglia and/or degenerating neurons, bound to microglial ..
  24. Palumbo R, Sampaolesi M, De Marchis F, Tonlorenzi R, Colombetti S, Mondino A, et al. Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol. 2004;164:441-9 pubmed
    High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells...
  25. Tong W, Wang W, Huang J, Ren N, Wu S, Li Y. Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain. Biochem Biophys Res Commun. 2010;395:572-6 pubmed publisher
    ..Being first reported as a nonhistone chromosomal protein, high-mobility group box 1 (HMGB1) is now implicated as a mediator of inflammation...
  26. Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-61 pubmed
    ..NH2-terminal and internal protein sequence data for p23 matched that reported previously for amphoterin. Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and ..
  27. Yuan F, Gu L, Guo S, Wang C, Li G. Evidence for involvement of HMGB1 protein in human DNA mismatch repair. J Biol Chem. 2004;279:20935-40 pubmed
    ..The complementing activity was identified as HMGB1 (the high mobility group box 1 protein), a non-histone chromatin protein that facilitates protein-protein ..
  28. Kazama H, Ricci J, Herndon J, Hoppe G, Green D, Ferguson T. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity. 2008;29:21-32 pubmed publisher
    ..ROS oxidized the potential danger signal high-mobility group box-1 protein (HMGB1) released from dying cells and thereby neutralized its stimulatory activity...
  29. Hardman C, Broadhurst R, Raine A, Grasser K, Thomas J, Laue E. Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry. 1995;34:16596-607 pubmed
    b>HMG1 has two homologous, folded DNA-binding domains ("HMG boxes"), A and B, linked by a short basic region to an acidic C-terminal domain...
  30. Park J, Gamboni Robertson F, He Q, Svetkauskaite D, Kim J, Strassheim D, et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 2006;290:C917-24 pubmed
    High mobility group box 1 (HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses...
  31. Stros M, Cherny D, Jovin T. HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends. Eur J Biochem. 2000;267:4088-97 pubmed
    ..We demonstrate that HMG1 is able to enhance cohesive-end and blunt-end DNA ligation by T4 DNA ligase via its B domain...
  32. Pasheva E, Sarov M, Bidjekov K, Ugrinova I, Sarg B, Lindner H, et al. In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Biochemistry. 2004;43:2935-40 pubmed
    ..The alterations in the acetylation pattern of HMGB-1 and -2 upon removal of the C-terminal tail are regarded as a means by which the acidic domain modulates some properties of these proteins. ..
  33. Watson M, Stott K, Thomas J. Mapping intramolecular interactions between domains in HMGB1 using a tail-truncation approach. J Mol Biol. 2007;374:1286-97 pubmed
    The mechanism underlying negative regulation of HMGB1-DNA interaction by the acidic C-terminal tail is ill defined...
  34. Liu A, Dirsch O, Fang H, Sun J, Jin H, Dong W, et al. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Histochem Cell Biol. 2011;135:443-52 pubmed publisher
    High mobility group box 1 (HMGB1) acts as an early mediator in inflammation and organ injury. Ischemia reperfusion (I/R) injury induces HMGB1 translocation and expression in ischemic areas...
  35. Liu A, Dirsch O, Fang H, Dong W, Jin H, Huang H, et al. HMGB1 translocation and expression is caused by warm ischemia reperfusion injury, but not by partial hepatectomy in rats. Exp Mol Pathol. 2011;91:502-8 pubmed publisher
    Mechanical injury or ischemia/reperfusion (I/R) injury induces high mobility of group box 1 (HMGB1) translocation and release...
  36. Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, et al. Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Ann Neurol. 2012;72:373-84 pubmed publisher
    High mobility group box-1 (HMGB1) plays an important role in triggering inflammatory responses in many types of diseases...
  37. Yanai H, Ban T, Wang Z, Choi M, Kawamura T, Negishi H, et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 2009;462:99-103 pubmed publisher
    ..b>Hmgb1(-/-) and Hmgb2(-/-) mouse cells are defective in type-I interferon and inflammatory cytokine induction by DNA or ..
  38. Andersson U, Wang H, Palmblad K, Aveberger A, Bloom O, Erlandsson Harris H, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med. 2000;192:565-70 pubmed
    ..b>High mobility group 1 protein (HMG-1), a ubiquitous DNA-binding protein, was recently identified as a "late" mediator ..
  39. Wolf M, Lossdörfer S, Craveiro R, Gotz W, Jager A. Regulation of macrophage migration and activity by high-mobility group box 1 protein released from periodontal ligament cells during orthodontically induced periodontal repair: an in vitro and in vivo experimental study. J Orofac Orthop. 2013;74:420-34 pubmed publisher
    ..Hypothesizing that high-mobility group box 1 (HMGB1) protein is released by mechanically stressed PDL cells into the extracellular space and has a role in mediating ..
  40. Ge H, Roeder R. The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J Biol Chem. 1994;269:17136-40 pubmed
    ..The high mobility group 1 protein (HMG1) was previously demonstrated to be a nonhistone chromatin-associated protein, which ..
  41. Kim J, Lim C, Yu Y, Lee J. Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain. J Neurosci Res. 2008;86:1125-31 pubmed
    High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA-binding protein...
  42. Li J, Wang H, Mason J, Levine J, Yu M, Ulloa L, et al. Recombinant HMGB1 with cytokine-stimulating activity. J Immunol Methods. 2004;289:211-23 pubmed
    We describe methods for the isolation, purification, and characterization of full-length high-mobility group box 1 (HMGB1) and truncated mutants expressed in bacteria and in mammalian Chinese Hamster Ovary (CHO) cells...
  43. Scaffidi P, Misteli T, Bianchi M. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002;418:191-5 pubmed
    b>High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets...
  44. Ha T, Xia Y, Liu X, Lu C, Liu L, Kelley J, et al. Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-?B activation. Am J Physiol Heart Circ Physiol. 2011;301:H848-55 pubmed publisher
    ..High-mobility group box 1 (HMGB1) serves as a late mediator of lethality in sepsis...
  45. Tang D, Kang R, Livesey K, Cheh C, Farkas A, Loughran P, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010;190:881-92 pubmed publisher
    ..Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a ..
  46. Shibasaki M, Sasaki M, Miura M, Mizukoshi K, Ueno H, Hashimoto S, et al. Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury. Pain. 2010;149:514-21 pubmed publisher
    ..Blocking HMGB-1/RAGE signalling might thus be a promising therapeutic strategy for the management of neuropathic pain...
  47. Guazzi S, Strangio A, Franzi A, Bianchi M. HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain. Gene Expr Patterns. 2003;3:29-33 pubmed
    b>HMGB1 is an abundant chromatin component, so far considered ubiquitous...
  48. Huang S, Wang B, Zhang Z, Meng Z, Cao H, Lian Q, et al. [Effect of curcumin on the expression of high mobility group box 1 and apoptotic neurons in hippocampus after global cerebral ischemia reperfusion in rats]. Zhonghua Yi Xue Za Zhi. 2011;91:1340-3 pubmed
    To explore the effects of curcumin on the expression of high mobility group box 1 (HMGB1) and apoptotic neurons in hippocampus after global cerebral ischemia/reperfusion in SD rats...
  49. Hagiwara S, Iwasaka H, Shingu C, Matsumoto S, Uchida T, Noguchi T. High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Inflamm Res. 2010;59:511-8 pubmed publisher
    Systemic inflammatory mediators, including the high mobility group box 1 (HMGB1) protein, play important roles in the development of various inflammatory conditions...
  50. Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, et al. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015;7:78-101 pubmed publisher
    ..which causes spinocerebellar ataxia type 1 (SCA1), binds to and impairs the function of high-mobility group box 1 (HMGB1), a crucial nuclear protein that regulates DNA architectural changes essential for DNA damage repair and ..
  51. Xu M, Zhou G, Wang L, Zhu L, Liu J, Wang X, et al. Inhibiting High-Mobility Group Box 1 (HMGB1) Attenuates Inflammatory Cytokine Expression and Neurological Deficit in Ischemic Brain Injury Following Cardiac Arrest in Rats. Inflammation. 2016;39:1594-602 pubmed publisher
    ..Previous studies have indicated that high-mobility group box 1 (HMGB1), a nuclear protein implicated in several inflammatory disorders, is involved in the inflammatory processes ..
  52. Wang Y, Yao Y, Wang Q, Wang W. [Effect of "Xuebijing injection" on expression of high mobility group box-1 protein and acute liver injury in rats with scald injury]. Zhonghua Shao Shang Za Zhi. 2009;25:171-5 pubmed
    ..quot;Xuebijing injection" (Xuebijing in brief) on expression of hepatic high mobility group box-1 protein (HMGB1) and acute liver injury in rats with scald injury...
  53. Huang L, Yao Y, Zhang L, Dong N, Yu Y, Sheng Z. The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. Shock. 2009;31:322-9 pubmed publisher
    The aim of the present study was to investigate in vivo the effect of high-mobility group box 1 protein (HMGB1) on activity of regulatory T cells (Tregs) and the influence on T-cell-mediated immunity after thermal injury...