Genomes and Genes
Gene Symbol: Hmga1
Description: high mobility group AT-hook 1
Alias: Hmgi, Hmgiy, high mobility group protein HMG-I/HMG-Y, HMG-I(Y), high mobility group AT-hook protein 1, high mobility group protein A1
- Camós S, Gubern C, Sobrado M, Rodriguez R, Romera V, Moro M, et al. The high-mobility group I-Y transcription factor is involved in cerebral ischemia and modulates the expression of angiogenic proteins. Neuroscience. 2014;269:112-30 pubmed publisher..High-mobility group I-Y protein (HMGIY) TF characterization in a rat permanent focal cerebral ischemia model was performed by quantitative real time ..
- Bussemakers M, Van de Ven W, Debruyne F, Schalken J. Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis. Cancer Res. 1991;51:606-11 pubmed..The overexpression of high mobility group protein I(Y) correlates rather with metastatic ability than with growth rate; hence it may serve as a valuable marker to identify progressionally advanced prostate cancer cells. ..
- Berlingieri M, Pierantoni G, Giancotti V, Santoro M, Fusco A. Thyroid cell transformation requires the expression of the HMGA1 proteins. Oncogene. 2002;21:2971-80 pubmedElevated expression of HMGA1 and HMGA2 proteins is correlated with a highly malignant phenotype in several human tumors...
- Shlapobersky M, Sanders R, Clark C, Spector D. Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. J Virol. 2006;80:9951-61 pubmed
- De Martino I, Visone R, Wierinckx A, Palmieri D, Ferraro A, Cappabianca P, et al. HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res. 2009;69:1844-50 pubmed publisher..We have recently reported that transgenic mice carrying the Hmga1 or Hmga2 genes under transcriptional control of the cytomegalovirus promoter develop pituitary adenomas secreting ..
- Kitchen M, Yacqub Usman K, Emes R, Richardson A, Clayton R, Farrell W. Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. Pituitary. 2015;18:674-84 pubmed publisherTransgenic mice overexpressing the high mobility group A (HMGA) genes, Hmga1 or Hmga2 develop pituitary tumours and their overexpression is also a frequent finding in human pituitary adenomas...
- Hommura F, Katabami M, Leaner V, Donninger H, Sumter T, Resar L, et al. HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells. Mol Cancer Res. 2004;2:305-14 pubmed..Taken together, these results suggest that HMG-I/Y is a direct transcriptional target of c-Jun necessary for c-Jun-induced anchorage-independent growth in Rat1a cells. ..
- Bianconcini A, Lupo A, Capone S, Quadro L, Monti M, Zurlo D, et al. Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54 nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1). Int J Biochem Cell Biol. 2009;41:2189-203 pubmed publisher..This latter region contains several binding sites for the structural HMGA1 proteins, which are important to promoter regulation...