heat shock factor 2


Gene Symbol: heat shock factor 2
Description: heat shock transcription factor 2
Alias: heat shock factor protein 2, heat shock factor 2, heat shock transcription factor hsf2
Species: rat
Products:     heat shock factor 2

Top Publications

  1. Liu F, Xu Z, Qian X, Qiu W, Huang H. Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes. Mol Reprod Dev. 2011;78:283-91 pubmed publisher
    ..We present evidence suggesting that Hsf2 is also involved in germ cell removal in cryptorchid testis. ..
  2. Kubota H, Matsumoto S, Yokota S, Yanagi H, Yura T. Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2. FEBS Lett. 1999;461:125-9 pubmed
    ..These results suggest that HSF1 and/or HSF2 play a role in Cct gene expression. ..
  3. Kwong J, Lalezary M, Nguyen J, Yang C, Khattar A, Piri N, et al. Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells. Neurosci Lett. 2006;405:191-5 pubmed
    ..Our findings suggest that both heat shock transcription factors 1 and 2 are linked to the heat shock response in retinal ganglion cells. ..
  4. Prasad K, Taiyab A, Jyothi D, Srinivas U, Sreedhar A. Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma. J Biosci. 2007;32:585-93 pubmed
    ..We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells. ..
  5. Wilkerson D, Murphy L, Sarge K. Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol Reprod. 2008;79:283-8 pubmed publisher
    ..These results support a model in which the binding of HSF1, HSF2, and SP1 to the promoter of Hspa1b would allow the rapid formation of a transcription-competent state during the minor ZGA, thereby allowing Hspa1b expression. ..
  6. Chen J, Kuo C, Pai P, Ho T, Chen T, Tsai F, et al. Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity. J Cell Physiol. 2018;233:463-475 pubmed publisher
    ..Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo. ..
  7. Eriksson M, Jokinen E, Sistonen L, Leppa S. Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000;44:471-7 pubmed
    ..Taken together, our results indicate that HSF2 activation is associated with specific stages of heart formation but is not involved in the regulation of inducible heat shock gene expression. ..
  8. Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, et al. Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis. 2004;38:66-80 pubmed
    ..The findings suggest that additive or synergistic transcriptional activity of both hsf1 and hsf2 is required for normal mammalian spermatogenesis and male fertility. ..
  9. Min J, Han M, Lee S, Kim K, Park Y. Regulation of rat heat shock factor 2 expression during the early organogenic phase of embryogenesis. Biochim Biophys Acta. 2000;1494:256-62 pubmed
    ..To our knowledge, this is the first detailed report on the structure and regulation of the rat HSF2 during the early organogenic period of mammalian embryogenesis. ..

More Information


  1. Pai P, Kuo C, Ho T, Lin J, Lin D, Tsai F, et al. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure. Cell Death Dis. 2017;8:e2990 pubmed publisher
    ..However, the role of heat shock factor 2 (HSF2) in hypertension-induced cardiac hypertrophy is unknown...