Gene Symbol: Hdac9
Description: histone deacetylase 9
Alias: RGD1310748, RGD1563092, histone deacetylase 9
Species: rat
Products:     Hdac9

Top Publications

  1. Zhou X, Marks P, Rifkind R, Richon V. Cloning and characterization of a histone deacetylase, HDAC9. Proc Natl Acad Sci U S A. 2001;98:10572-7 pubmed
    ..Here, we report the identification of a ninth member of the HDAC family, designated HDAC9. HDAC9 is a class II HDAC and its gene resides on human chromosome 7...
  2. Lemercier C, Verdel A, Galloo B, Curtet S, Brocard M, Khochbin S. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J Biol Chem. 2000;275:15594-9 pubmed
  3. Li B, Samanta A, Song X, Iacono K, Bembas K, Tao R, et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A. 2007;104:4571-6 pubmed
    ..histone acetyltransferase TIP60 (Tat-interactive protein, 60 kDa) and class II histone deacetylases HDAC7 and HDAC9. The N-terminal 106-190 aa of FOXP3 are required for TIP60-FOXP3, HDAC7-FOXP3 association, as well as for the ..
  4. Zhou X, Richon V, Rifkind R, Marks P. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000;97:1056-61 pubmed
    ..HDAC inhibitors do not reverse transcriptional repression mediated by Gal4-HDRP. Thus, HDRP is a transcriptional repressor and can repress transcription in the presence of HDAC inhibitors. ..
  5. Sugo N, Oshiro H, Takemura M, Kobayashi T, Kohno Y, Uesaka N, et al. Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons. Eur J Neurosci. 2010;31:1521-32 pubmed publisher
    ..Here, we investigated the role of histone deacetylase 9 (HDAC9), which regulates transcription by histone modification, in the development of neocortical neurons...
  6. Sucharov C, Dockstader K, McKinsey T. YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5. Mol Biol Cell. 2008;19:4141-53 pubmed publisher
    ..Our results strongly suggest that YY1 functions as an antihypertrophic factor by preventing HDAC5 nuclear export and that up-regulation of YY1 in human heart failure may be a protective mechanism against pathological hypertrophy. ..
  7. Bourgeois C, Satou R, Prieto M. HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference. Biol Sex Differ. 2017;8:18 pubmed publisher
    ..All histone deacetylase (HDAC) mRNA levels in the kidneys were determined using a PCR array. HDAC9 protein expression in the kidneys and cultured renal proximal tubular cells (PTC) was analyzed by Western blot ..
  8. Ajamian F, Suuronen T, Salminen A, Reeben M. Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Neurosci Lett. 2003;346:57-60 pubmed
    ..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation. ..
  9. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, et al. The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem. 2003;278:16059-72 pubmed
    ..We have now fully characterized a new member of the Class II HDAC family, HDAC9. The enzyme contains a conserved deacetylase domain, represses reporter activity when recruited to a promoter, and ..

More Information


  1. Urbich C, Rossig L, Kaluza D, Potente M, Boeckel J, Knau A, et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood. 2009;113:5669-79 pubmed publisher
    ..The derepression of angiogenic genes by HDAC5 inactivation may provide a useful therapeutic target for induction of angiogenesis. ..
  2. Harrison B, Huynh K, Lundgaard G, Helmke S, Perryman M, McKinsey T. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. FEBS Lett. 2010;584:1103-10 pubmed publisher
    ..HDAC7 and HDAC9 contain analogous sites that are phosphorylated by PRK, while HDAC4 harbors a non-phosphorylatable alanine residue ..
  3. Shang L, Tomasi T. The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem. 2006;281:1876-84 pubmed
    ..We conclude that JAK1/2 are client proteins of Hsp90 and that Hsp90 and CDC37 play a critical role in types I and II interferon pathways. ..
  4. Wong R, Chang I, Hudak C, Hyun S, Kwan H, Sul H. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell. 2009;136:1056-72 pubmed publisher
    ..Under fasting conditions, USF-1 is deacetylated by HDAC9, causing promoter inactivation...
  5. He M, Zhang B, Wei X, Wang Z, Fan B, Du P, et al. HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2013;17:531-42 pubmed publisher
  6. Dai Y, Xu J, Molkentin J. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005;25:9936-48 pubmed
    ..Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj. ..
  7. Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-67 pubmed
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases. ..
  8. Omonijo O, Wongprayoon P, Ladenheim B, McCoy M, Govitrapong P, Jayanthi S, et al. Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum. Neurotoxicology. 2014;45:178-84 pubmed publisher
    ..METH also decreased expression of HDAC6, HDAC9, and HDAC10 that are class II HDACs. The expression of the class IV HDAC, HDAC11, was also suppressed by METH...
  9. Zhang C, McKinsey T, Olson E. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol. 2002;22:7302-12 pubmed
    ..MEF2-interacting transcription repressor (MITR) is an amino-terminal splice variant of HDAC9 that also potently inhibits MEF2 transcriptional activity despite lacking a catalytic domain...
  10. Shi W, Wei X, Wang Z, Han H, Fu Y, Liu J, et al. HDAC9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2016;20:1139-49 pubmed publisher
    ..the development of ischaemic stroke and very recent genome-wide association studies have identified a variant in HDAC9 associated with large-vessel ischemic stroke, the molecular events by which HDAC9 induces cerebral injury keep ..
  11. Chang S, McKinsey T, Zhang C, Richardson J, Hill J, Olson E. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004;24:8467-76 pubmed
    ..We showed previously that histone deacetylase 9 (HDAC9) acts as a suppressor of cardiac hypertrophy and that mice lacking HDAC9 are sensitized to cardiac ..
  12. Han A, He J, Wu Y, Liu J, Chen L. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J Mol Biol. 2005;345:91-102 pubmed
    ..The crystal structure of a HDAC9/MEF2/DNA complex reveals that HDAC9 binds to a hydrophobic groove of the MEF2 dimer...
  13. Zhang C, McKinsey T, Olson E. The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis. Proc Natl Acad Sci U S A. 2001;98:7354-9 pubmed
    ..These results reveal a role for MITR as a signal-dependent regulator of muscle differentiation. ..
  14. Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..