Gene Symbol: Hdac7
Description: histone deacetylase 7
Alias: Hdac7a, histone deacetylase 7, HD7, HD7a, histone deacetylase 7A
Species: rat
Products:     Hdac7

Top Publications

  1. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  2. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. HDAC7 modulates TNF-α-mediated suppression of Leydig cell steroidogenesis. Mol Cell Biochem. 2015;406:83-90 pubmed publisher
    ..In the present study, we demonstrate that TNF-α activates histone deacetylases 7 (HDAC7), which regulates the expression of steroidogenic enzyme genes in Leydig cells...
  3. Jensen E, Schroeder T, Bailey J, Gopalakrishnan R, Westendorf J. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res. 2008;23:361-72 pubmed
    b>HDAC7 associates with Runx2 and represses Runx2 transcriptional activity in a deacetylase-independent manner. HDAC7 suppression accelerates osteoblast maturation...
  4. Dequiedt F, Martin M, von Blume J, Vertommen D, Lecomte E, Mari N, et al. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol. 2006;26:7086-102 pubmed
    ..Using HDAC7 as a paradigm, we extend these findings by demonstrating that signal-independent phosphorylation of the most N-..
  5. Dai Y, Xu J, Molkentin J. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005;25:9936-48 pubmed
    ..Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj. ..
  6. Winnay J, Hammer G. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol. 2006;20:147-66 pubmed
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  7. Harrison B, Huynh K, Lundgaard G, Helmke S, Perryman M, McKinsey T. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. FEBS Lett. 2010;584:1103-10 pubmed publisher
    ..b>HDAC7 and HDAC9 contain analogous sites that are phosphorylated by PRK, while HDAC4 harbors a non-phosphorylatable ..
  8. Ma C, D Mello S. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem. 2011;286:4819-28 pubmed publisher
    ..Although some of the HDAC proteins have been shown to regulate neuronal survival and death, whether HDAC7 has a similar role is not known. In this study, we show that HDAC7 protects neurons from apoptosis...
  9. Stypula Cyrus Y, Damania D, Kunte D, Cruz M, Subramanian H, Roy H, et al. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PLoS ONE. 2013;8:e64600 pubmed publisher
    ..We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC...

More Information


  1. Zhao X, Hsu K, Lim J, Bruggeman L, Kao H. α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J Biol Chem. 2015;290:338-49 pubmed publisher
    ..Taken together, our data identify ACTN4 as a novel coactivator for NF-κB transcription factors in podocytes. Importantly, this nuclear function of ACTN4 is independent of its actin binding activity in the cytoplasm. ..
  2. Li B, Samanta A, Song X, Iacono K, Bembas K, Tao R, et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A. 2007;104:4571-6 pubmed
    ..that includes histone acetyltransferase TIP60 (Tat-interactive protein, 60 kDa) and class II histone deacetylases HDAC7 and HDAC9...
  3. Ajamian F, Suuronen T, Salminen A, Reeben M. Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Neurosci Lett. 2003;346:57-60 pubmed
    ..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation. ..
  4. Yan Z, Yao Q, Zhang M, Qi Y, Guo Z, Shen B, et al. Histone deacetylases modulate vascular smooth muscle cell migration induced by cyclic mechanical strain. J Biomech. 2009;42:945-8 pubmed publisher
    ..The cyclic strain upregulated the levels of acetylased histone H3 and HDAC7 while downregulated the level of HDAC3/4 in VSMCs...
  5. Chang S, Young B, Li S, Qi X, Richardson J, Olson E. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006;126:321-34 pubmed
    ..We show that histone deacetylase 7 (HDAC7) is specifically expressed in the vascular endothelium during early embryogenesis, where it ..
  6. Urbich C, Rossig L, Kaluza D, Potente M, Boeckel J, Knau A, et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood. 2009;113:5669-79 pubmed publisher
    ..The derepression of angiogenic genes by HDAC5 inactivation may provide a useful therapeutic target for induction of angiogenesis. ..
  7. Aude Garcia C, Collin Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C. Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression. Biochem J. 2010;430:237-44 pubmed publisher
    ..We show that MEF2A/D dimers strongly interact with HDAC1, and to a lesser extent with HDAC7 in macrophages, whereas low levels of MEF2A/D-HDAC1 complexes are found in undifferentiated cells or in monocytes...
  8. Zhao M, Liang G, Wu X, Wang S, Zhang P, Su Y, et al. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Br J Dermatol. 2012;166:226-73 pubmed publisher
    ..MLL), SET7/9 (SETD7), G9A (EHMT2), JMJD2C (KDM4C) and JARID1A (KDM5A) expression, as well as reduced HDAC2, HDAC7, LSD1 (KDM1A), JMJD2A (KDM4A) and JMJD2B (KDM4B) expression...
  9. Kao H, Downes M, Ordentlich P, Evans R. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000;14:55-66 pubmed
    ..SMRT-interacting proteins resulted in the isolation of the recently described HDAC5 and a new family member termed HDAC7. Molecular and biochemical results indicate that this interaction is direct and in vivo evidence colocalizes SMRT, ..