Gene Symbol: Hdac6
Description: histone deacetylase 6
Alias: histone deacetylase 6
Species: rat
Products:     Hdac6

Top Publications

  1. Kim C, Choi H, Jung E, Lee W, Oh S, Jeon N, et al. HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. PLoS ONE. 2012;7:e42983 pubmed publisher
    ..We found that inhibiting histone deacetylase 6 (HDAC6), which deacetylates ?-tubulin, significantly restored the velocity and motility of the ..
  2. Kim A, Puram S, Bilimoria P, Ikeuchi Y, Keough S, Wong M, et al. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009;136:322-36 pubmed publisher
    ..We also find that the centrosome-associated protein histone deacetylase 6 (HDAC6) promotes the polyubiquitination of Cdc20, stimulates the activity of centrosomal Cdc20-APC, and ..
  3. Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, Seigneurin Berny D, et al. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 2002;21:6820-31 pubmed
    ..A (TSA) inhibits all histone deacetylases (HDACs) of both class I and II, whereas trapoxin (TPX) cannot inhibit HDAC6, a cytoplasmic member of class II HDACs...
  4. Iwata A, Riley B, Johnston J, Kopito R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 2005;280:40282-92 pubmed
    ..inclusion bodies by a process requiring an intact microtubule cytoskeleton and the cytoplasmic deacetylase HDAC6. These data suggest that HDAC6-dependent retrograde transport on microtubules is used by cells to increase the ..
  5. Kawaguchi Y, Kovacs J, McLaurin A, Vance J, Ito A, Yao T. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell. 2003;115:727-38 pubmed
    ..We have discovered that HDAC6, a microtubule-associated deacetylase, is a component of the aggresome...
  6. Parmigiani R, Xu W, Venta Perez G, Erdjument Bromage H, Yaneva M, Tempst P, et al. HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A. 2008;105:9633-8 pubmed publisher
    ..Among zinc-dependent HDACs, HDAC6 is unique...
  7. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, et al. HDAC6 is a microtubule-associated deacetylase. Nature. 2002;417:455-8 pubmed
    ..Here we report that a member of the histone deacetylase family, HDAC6, functions as a tubulin deacetylase...
  8. Seigneurin Berny D, Verdel A, Curtet S, Lemercier C, Garin J, Rousseaux S, et al. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol. 2001;21:8035-44 pubmed
    The immunopurification of the endogenous cytoplasmic murine histone deacetylase 6 (mHDAC6), a member of the class II HDACs, from mouse testis cytosolic extracts allowed the identification of two associated proteins...
  9. Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer Klaucke W, et al. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 2006;25:3357-66 pubmed
    b>HDAC6 is a unique cytoplasmic deacetylase capable of interacting with ubiquitin...

More Information


  1. Ding H, Dolan P, Johnson G. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem. 2008;106:2119-30 pubmed publisher
    b>Histone deacetylase 6 (HDAC6), a unique cytoplasmic deacetylase, likely plays a role in neurodegeneration by coordinating cell responses to abnormal protein aggregation...
  2. Rivieccio M, Brochier C, Willis D, Walker B, D Annibale M, McLaughlin K, et al. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc Natl Acad Sci U S A. 2009;106:19599-604 pubmed publisher
    ..Real-time PCR revealed a robust and selective increase in HDAC6 expression due to injury in neurons...
  3. Southwood C, Peppi M, Dryden S, Tainsky M, Gow A. Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res. 2007;32:187-95 pubmed
    ..Herein, we analyze two microtubule regulatory alpha-tubulin deacetylases, histone deacetylase-6 (HDAC6) and SirT2. HDAC6 is expressed by most neurons but is abundant in cerebellar Purkinje cells...
  4. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007;21:2172-81 pubmed
    ..The cytoplasmic deacetylase HDAC6 (histone deacetylase 6) was previously shown to be a key element in this response by coordinating the clearance of protein ..
  5. North B, Marshall B, Borra M, Denu J, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell. 2003;11:437-44 pubmed
    ..Knockdown of SIRT2 via siRNA results in tubulin hyperacetylation. SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase...
  6. Zhang Y, Li N, Caron C, Matthias G, Hess D, Khochbin S, et al. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 2003;22:1168-79 pubmed
  7. Verdel A, Khochbin S. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999;274:2440-5 pubmed
    ..We postulate the existence of a regulatory mechanism, commanding a coordinate expression of a group of genes involved in the remodeling of chromatin not only during cell differentiation but also after abnormal histone acetylation. ..
  8. Shimizu E, Selvamurugan N, Westendorf J, Olson E, Partridge N. HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. J Biol Chem. 2010;285:9616-26 pubmed publisher
    ..Thus, HDAC4 is a basal repressor of MMP-13 transcription, and PTH regulates HDAC4 to control MMP-13 promoter activity. These data identify a novel and discrete mechanism of regulating HDAC4 levels and, subsequently, gene expression. ..
  9. Lin Z, Bazzaro M, WANG M, Chan K, Peng S, Roden R. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin Cancer Res. 2009;15:570-7 pubmed publisher
    ..A combination of proteasome and HDAC inhibitors, including bortezomib and vorinostat, respectively, warrants exploration for the treatment of cervical cancer. ..
  10. Vishwakarma S, Iyer L, Muley M, Singh P, Shastry A, Saxena A, et al. Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects. Int Immunopharmacol. 2013;16:72-8 pubmed publisher
    ..b>HDAC6, a member of the HDAC family, whose major substrate is ?-tubulin, is being increasingly implicated in the ..
  11. Balasubramanian A, Kawahara G, Gupta V, Rozkalne A, Beauvais A, Kunkel L, et al. Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J. 2014;28:2955-69 pubmed publisher
    ..Fam65b binds to HDAC6 and dysferlin, the protein mutated in limb girdle muscular dystrophy 2B...
  12. Wickström S, Masoumi K, Khochbin S, Fassler R, Massoumi R. CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 2010;29:131-44 pubmed publisher
    ..to the perinuclear region of the cell is achieved by an inhibitory interaction of CYLD with histone deacetylase-6 (HDAC6) leading to an increase in the levels of acetylated alpha-tubulin around the nucleus...
  13. Lee J, Nagano Y, Taylor J, Lim K, Yao T. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol. 2010;189:671-9 pubmed publisher
    ..by catalyzing mitochondrial ubiquitination, which in turn recruits ubiquitin-binding autophagic components, HDAC6 and p62, leading to mitochondrial clearance...
  14. Gradilone S, Radtke B, Bogert P, Huang B, Gajdos G, Larusso N. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013;73:2259-70 pubmed publisher
    ..as a model, we found that primary cilia are reduced in cholangiocarcinoma by a mechanism involving histone deacetylase 6 (HDAC6)...
  15. Kee H, Bae E, Park S, Lee K, Suh S, Kim S, et al. HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity. Kidney Blood Press Res. 2013;37:229-39 pubmed publisher
    ..We show that expression of GATA6 and HDAC6 is upregulated in DOCA-salt hypertension...
  16. Alamdari N, Smith I, Aversa Z, Hasselgren P. Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010;299:R509-20 pubmed publisher
    ..Sepsis in rats upregulated p300 mRNA and protein levels, stimulated HAT activity, and reduced HDAC6 expression and HDAC activity...
  17. Lemon D, Horn T, Cavasin M, Jeong M, Haubold K, Long C, et al. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol. 2011;51:41-50 pubmed publisher
    ..In contrast, catalytic activity of the class IIb HDAC, HDAC6, was consistently increased in stressed myocardium, but not in a model of physiologic hypertrophy...
  18. Kang H, Lee M, Kang H, Kim S, Ahn J, Na H, et al. Differential regulation of estrogen receptor ? expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 2014;74:1484-94 pubmed publisher
  19. Bicaku E, Marchion D, Schmitt M, Munster P. Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 2008;68:1513-9 pubmed publisher
    ..Selective inhibition of HDAC2, but not HDAC1 or HDAC6, was sufficient to potentiate tamoxifen-induced apoptosis in ER/PR-positive cells...
  20. Ageta Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, et al. Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun. 2013;4:2532 pubmed publisher
    ..The phenotypic similarity between SEPT7 depletion and the pharmacological inhibition of ?-tubulin deacetylase HDAC6 reveals that HDAC6 requires SEPT7 not for its enzymatic activity, but to associate with acetylated ?-tubulin...
  21. Gal J, Chen J, Barnett K, Yang L, Brumley E, Zhu H. HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation. J Biol Chem. 2013;288:15035-45 pubmed publisher
    b>Histone deacetylase 6 (HDAC6) is a tubulin deacetylase that regulates protein aggregation and turnover...
  22. Kaliszczak M, Trousil S, Aberg O, Perumal M, Nguyen Q, Aboagye E. A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer. 2013;108:342-50 pubmed publisher
    This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours.
  23. Gao L, Cueto M, Asselbergs F, Atadja P. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem. 2002;277:25748-55 pubmed
    ..Co-immunoprecipitation experiments indicate that HDAC11 may be present in protein complexes that also contain HDAC6. These results indicate that HDAC11 is a novel and unique member of the histone deacetylase family and it may have ..
  24. Kekatpure V, Dannenberg A, Subbaramaiah K. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem. 2009;284:7436-45 pubmed publisher
    ..Silencing HDAC6 or treatment with tubacin, a pharmacological inhibitor of HDAC6, also suppressed the induction of CYP1A1 and ..
  25. Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher
    ..is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6)...
  26. Tao H, Yang J, Hu W, Shi K, Li J. HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression. Cardiology. 2016;133:18-26 pubmed publisher
    ..b>HDAC6 is a transcriptional regulator of the histone deacetylase family, subfamily 2...
  27. Li Y, Zhang X, Polakiewicz R, Yao T, Comb M. HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem. 2008;283:12686-90 pubmed publisher
    ..report that EGF-induced beta-catenin nuclear localization and activation of c-myc are dependent on the deacetylase HDAC6. We show that EGF induces HDAC6 translocation to the caveolae membrane and association with beta-catenin...
  28. Gradilone S, Habringer S, Masyuk T, Howard B, Masyuk A, Larusso N. HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis. Am J Pathol. 2014;184:600-8 pubmed publisher
    ..Because histone deacetylase 6 (HDAC6) plays an important role in both cell cycle regulation and ciliary disassembly, we examined the ..
  29. Kim J, Kwon O, Kim M. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Differentiation. 2007;75:147-57 pubmed
    ..Of 11 known genes, seven (Atp5g3, TOM22, INrf2, Slc25a4, Hdac6, Tpm1, and Sv2b) were up and three (Podxl, Myh1, and Surf1) were down-regulated following immobilization...
  30. Ajamian F, Suuronen T, Salminen A, Reeben M. Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Neurosci Lett. 2003;346:57-60 pubmed
    ..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation. ..
  31. Zhou J, Vos C, Gjyrezi A, Yoshida M, Khuri F, Tamanoi F, et al. The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem. 2009;284:9648-55 pubmed publisher
    The cytoplasmic deacetylase HDAC6 is an important regulator of cellular pathways that include response to stress, protein folding, microtubule stability, and cell migration, thus representing an attractive target for cancer chemotherapy...
  32. Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011;31:10249-61 pubmed publisher
    ..These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy. ..
  33. Zhang Y, Liu C, Cao X, Zang Y, Zhou Y, Li J. Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation. Biochem Biophys Res Commun. 2014;450:433-9 pubmed publisher
    b>HDAC6 is a major cytoplasmic deacetylase. XBP1s is a basic-region leucine zipper (bZIP) transcriptional factor...
  34. Omonijo O, Wongprayoon P, Ladenheim B, McCoy M, Govitrapong P, Jayanthi S, et al. Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum. Neurotoxicology. 2014;45:178-84 pubmed publisher
    ..METH also decreased expression of HDAC6, HDAC9, and HDAC10 that are class II HDACs...
  35. Parab S, Shetty O, Gaonkar R, Balasinor N, Khole V, Parte P. HDAC6 deacetylates alpha tubulin in sperm and modulates sperm motility in Holtzman rat. Cell Tissue Res. 2015;359:665-678 pubmed publisher
    b>Histone deacetylase 6 (HDAC6) is an alpha (α)-tubulin deacetylase and its over-expression has been demonstrated to promote chemotactic cell movement...
  36. Schoepflin Z, Shapiro I, Risbud M. Class I and IIa HDACs Mediate HIF-1? Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1? Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. J Bone Miner Res. 2016;31:1287-99 pubmed publisher
    ..Noteworthy, selective inhibition of HDAC6 and not of class I and IIa HDACs decreased HIF-1-mediated transcription under hypoxia to a similar extent as lower-..
  37. Cook C, Carlomagno Y, Gendron T, Dunmore J, Scheffel K, Stetler C, et al. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum Mol Genet. 2014;23:104-16 pubmed publisher
    ..Furthermore, we identify histone deacetylase 6 (HDAC6) as the enzyme responsible for the deacetylation of these residues, and provide proof of concept ..
  38. Kovacs J, Murphy P, Gaillard S, Zhao X, Wu J, Nicchitta C, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005;18:601-7 pubmed
    ..evidence that Hsp90 chaperone activity is regulated by reversible acetylation and controlled by the deacetylase HDAC6. We show that HDAC6 functions as an Hsp90 deacetylase...
  39. Noack M, Leyk J, Richter Landsberg C. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. Glia. 2014;62:535-47 pubmed publisher
    b>Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family. It is localized within the cytoplasm and has unique substrate specificities for nonhistone proteins, such as ?-tubulin...
  40. Lee J, Wei J, Liu W, Cheng J, Feng J, Yan Z. Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. J Physiol. 2012;590:1535-46 pubmed publisher
    ..To identify the key regulators of stress responses, we examined the role of histone deacetylase 6 (HDAC6), a unique member of the HDAC family that could regulate the GR chaperone protein heat shock ..
  41. Tao H, Yang J, Shi K, Li J. Epigenetic factors MeCP2 and HDAC6 control α-tubulin acetylation in cardiac fibroblast proliferation and fibrosis. Inflamm Res. 2016;65:415-26 pubmed publisher
    ..observed a reduction in acetylated α-tubulin and an increase in the α-tubulin-specific deacetylase, histone deacetylase 6 (HDAC6)...