Gene Symbol: Hdac1
Description: histone deacetylase 1
Alias: histone deacetylase 1, HD1
Species: rat
Products:     Hdac1

Top Publications

  1. Zhu L, Li H, Tang J, Zhu J, Zhang Y. Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. Pediatr Pulmonol. 2012;47:264-74 pubmed publisher
    ..Our results showed that hyperoxia exposure led to a suppression of the HDAC1/HDAC2 expression and activity, and the overall HDAC activity, as well as arrest of alveolarization, and an ..
  2. DiTacchio L, Le H, Vollmers C, Hatori M, Witcher M, Secombe J, et al. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011;333:1881-5 pubmed publisher
    ..JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner...
  3. Duong H, Robles M, Knutti D, Weitz C. A molecular mechanism for circadian clock negative feedback. Science. 2011;332:1436-9 pubmed publisher
    ..These findings provide a function for the PER complex and a molecular mechanism for circadian clock negative feedback. ..
  4. Duong H, Weitz C. Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014;21:126-32 pubmed publisher
    ..HP1?-Suv39h was recruited to the Per1 and Per2 promoters ~4 h after recruitment of HDAC1, a PER-associated protein previously implicated in clock function and H3K9 deacetylation at the Per1 promoter...
  5. Waltregny D, North B, Van Mellaert F, de Leval J, Verdin E, Castronovo V. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. Eur J Histochem. 2004;48:273-90 pubmed
    ..To test this possibility, we have sought to screen the expression profiles of several class I and class II HDACs (HDAC1-8) in DU-145, PC-3 and LNCaP human prostate cancer cell lines as well as in matched malignant and non-malignant ..
  6. Halkidou K, Gaughan L, Cook S, Leung H, Neal D, Robson C. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate. 2004;59:177-89 pubmed
    b>Histone deacetylase 1 (HDAC1) is a co-repressor involved in differentiation and proliferation control. It is upregulated in malignant compared to benign tissue, and targets a number of transcription factors including p53...
  7. Wang J, Liu N, Liu Z, Li Y, Song C, Yuan H, et al. The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Biochim Biophys Acta. 2008;1783:224-36 pubmed
    ..This de-repression effect depended on acetylation of Rev-erbbeta at its RXKK motif by Tip60. In addition, histone deacetylase 1 (HDAC1) interacted with Rev-erbbeta and was recruited to the apoCIII promoter by Rev-erbbeta to antagonize ..
  8. Aude Garcia C, Collin Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C. Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression. Biochem J. 2010;430:237-44 pubmed publisher
    ..We show that MEF2A/D dimers strongly interact with HDAC1, and to a lesser extent with HDAC7 in macrophages, whereas low levels of MEF2A/D-HDAC1 complexes are found in ..
  9. Fuks F, Burgers W, Brehm A, Hughes Davies L, Kouzarides T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet. 2000;24:88-91 pubmed
    ..Consistent with this association, we find that one of the known histone deacetylases, HDAC1, has the ability to bind Dnmt1 and can purify methyltransferase activity from nuclear extracts...

More Information


  1. Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009;28:2763-76 pubmed publisher
    ..These findings may shed new light on the EGFR-related breast carcinogenesis and might offer a potential new target for breast cancer therapy. ..
  2. Vecera J, Bartova E, Krejci J, Legartova S, Komůrková D, Ruda Kucerova J, et al. HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals. J Cell Physiol. 2018;233:530-548 pubmed publisher
    ..embryonic brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3...
  3. Huang Y, Myers S, Dingledine R. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat Neurosci. 1999;2:867-72 pubmed
    ..These results identify a general mechanism for controlling the neuronal expression pattern of a specific set of genes via the RE1 silencer element. ..
  4. Toffolo E, Rusconi F, Paganini L, Tortorici M, Pilotto S, Heise C, et al. Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2. J Neurochem. 2014;128:603-16 pubmed publisher
    ..forming a stable core complex with the corepressors corepressor of REST (CoREST) and histone deacetylases (HDAC1/2)...
  5. Wang W, Gao J, Man X, Li Z, Gong Y. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Oncol Rep. 2009;21:1439-47 pubmed
    ..to examine expression levels of two critical enzymes, DNA methyltransferase-1 (DNMT1) and histone deacetylase-1 (HDAC1), by immunohistochemistry (IHC) in human pancreatic cancer and precancerous lesions: 20 foci containing normal ..
  6. Blaze J, Roth T. Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex. Int J Dev Neurosci. 2013;31:804-10 pubmed publisher
    ..levels of several genes important in regulating DNA methylation patterns (Dnmt1, Dnmt3a, MeCP2, Gadd45b, and Hdac1)...
  7. Zhang H, Muders M, Li J, Rinaldo F, Tindall D, Datta K. Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer. Cancer Res. 2008;68:8770-8 pubmed publisher
    ..1 led to increased VEGF-C expression. Histone deacetylase 1 acted as a corepressor of VEGF-C expression along with NKX3.1...
  8. Winnay J, Hammer G. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol. 2006;20:147-66 pubmed
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  9. Kim J, Shen S, Dietz K, He Y, Howell O, Reynolds R, et al. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci. 2010;13:180-9 pubmed publisher
    b>Histone deacetylase 1 (HDAC1) is a nuclear enzyme involved in transcriptional repression...
  10. Cai R, Yan Neale Y, Cueto M, Xu H, Cohen D. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. J Biol Chem. 2000;275:27909-16 pubmed
    b>HDAC1 is a member of the histone deacetylase family, which plays an important role in modulating the eukaryotic chromatin structure. Numerous studies have demonstrated its involvement in transcription and in tumorigenesis...
  11. Renthal W, Carle T, Maze I, Covington H, Truong H, Alibhai I, et al. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci. 2008;28:7344-9 pubmed publisher
    ..DeltaFosB desensitizes c-fos expression by recruiting histone deacetylase 1 (HDAC1) to the c-fos gene promoter, which, in turn, deacetylates surrounding histones and attenuates gene ..
  12. Ping J, Wang J, Liu L, Yan Y, Liu F, Lei Y, et al. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Toxicology. 2014;321:53-61 pubmed publisher
    ..These effects may contribute to the inhibition of the expression of SF-1 and its associated steroidogenic enzymes and the production of corticosterone during fetal development. ..
  13. Zhao M, Liang G, Wu X, Wang S, Zhang P, Su Y, et al. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Br J Dermatol. 2012;166:226-73 pubmed publisher
    ..These changes were accompanied by increased p300 (EP300), histone deacetylase 1 (HDAC1), myeloid/lymphoid or mixed lineage leukemia (MLL), SET7/9 (SETD7), G9A (EHMT2), JMJD2C (KDM4C) and ..
  14. Lee C, Gyorgy A, Maric D, Sadri N, Schneider R, Barker J, et al. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. Cereb Cortex. 2008;18:2909-19 pubmed publisher
    ..Moreover, AUF1 is coexpressed with histone deacetylase 1 (HDAC1) and metastasis-associated protein 2 (MTA2), members of the nucleosome remodeling and histone ..
  15. Yang W, Inouye C, Zeng Y, Bearss D, Seto E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996;93:12845-50 pubmed
    ..These data suggest that YY1 negatively regulates transcription by tethering RPD3 to DNA as a cofactor and that this transcriptional mechanism is highly conserved from yeast to human. ..
  16. Khabele D, Son D, Parl A, Goldberg G, Augenlicht L, Mariadason J, et al. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther. 2007;6:795-801 pubmed
    ..Taken together, the present studies offer several novel findings that have direct relevance for the strategic use of inhibitors that target Class I HDACs, particularly HDAC3, in the treatment of ovarian cancer. ..
  17. Sharma D, Bhave S, Gregg E, UHT R. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Mol Endocrinol. 2013;27:1142-52 pubmed publisher
    ..Dexamethasone (Dex)-repressed crh expression is associated with glucocorticoid receptor (GR) and histone deacetylase 1 (HDAC1) recruitment to the region of the crh promoter...
  18. Weichert W, Denkert C, Noske A, Darb Esfahani S, Dietel M, Kalloger S, et al. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Neoplasia. 2008;10:1021-7 pubmed
    ..Therefore, we tested the hypothesis whether high-level expression of class 1 HDACs (HDAC1, 2, and 3) is associated with clinically distinct subsets of ovarian and endometrial carcinomas...
  19. Lu J, McKinsey T, Zhang C, Olson E. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol Cell. 2000;6:233-44 pubmed
    ..These findings reveal central roles for HDACs in chromatin remodeling during myogenesis and as intranuclear targets for signaling pathways controlled by IGF and CaM kinase. ..
  20. Shaw J, Zhang T, Rzeszutek M, Yurkova N, Baetz D, Davie J, et al. Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes. Circ Res. 2006;99:1347-54 pubmed
    ..BNIP3 is transcriptionally silenced by NF-kappaB through a mechanism that involves the cooperative actions of HDAC1. Activation of the NF-kappaB signaling pathway in ventricular myocytes suppressed basal and hypoxia-inducible ..
  21. Stypula Cyrus Y, Damania D, Kunte D, Cruz M, Subramanian H, Roy H, et al. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PLoS ONE. 2013;8:e64600 pubmed publisher
    ..However, the role of HDAC proteins in early colorectal carcinogenesis has not been previously reported. We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC...
  22. Horike S, Cai S, Miyano M, Cheng J, Kohwi Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet. 2005;37:31-40 pubmed
    ..Mecp2 targeted histone deacetylase 1 to a sharply defined, approximately 1-kb region at the Dlx5-Dlx6 locus and promoted repressive histone ..
  23. Kochetkova E, Bykova T, Zubova S, Pospelova T. [Role of MEK/ERK pathway in the regulation of HDACI-induced senescence of transformed rat embryo fibroblasts]. Tsitologiia. 2014;56:581-90 pubmed
  24. Kuyama H, Morine Y, Shimada M, Saito Y, Utsunomiya T, Ishibashi H, et al. Carcinogenic Potential of Biliary Epithelium of Congenital Choledochal Cyst Model in Rats: A Special Reference to HDAC Expression. Hepatogastroenterology. 2014;61:795-801 pubmed
    ..to clarify the carcinogenic potential of the epithelium of choledochal cyst particularly by paying attention of HDAC1 and COX-2 expressions...
  25. Mahon P, Hirota K, Semenza G. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001;15:2675-86 pubmed
    ..Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration. ..
  26. Xuan C, Wang Q, Han X, Duan Y, Li L, Shi L, et al. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene. 2013;32:3711-21 pubmed publisher
    ..Significantly, we showed that RBB suppresses cell proliferation and sensitizes cells to DNA damage-induced apoptosis. Our data indicate that RBB is a novel transcriptional repressor and an important regulator of p53 pathway. ..
  27. Bartl S, Taplick J, Lagger G, Khier H, Kuchler K, Seiser C. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol Cell Biol. 1997;17:5033-43 pubmed
    ..By using differential mRNA display, we have identified a mouse histone deacetylase gene, HD1, as an interleukin-2-inducible gene in murine T cells...
  28. Yamaguchi H, Ding Y, Lee J, Zhang M, Pal A, Bornmann W, et al. Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol Carcinog. 2008;47:739-43 pubmed publisher
    ..Histone deacetylase (HDAC) inhibitors, but not DNA methyltransferase inhibitor upregulated maspin, and HDAC1 inhibited the transactivation of maspin promoter...
  29. Kim H, Leeds P, Chuang D. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009;110:1226-40 pubmed publisher
  30. LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein J, Olson E, et al. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010;19:807-18 pubmed publisher
    ..We find that deletion of ectodermal Hdac1 and Hdac2 results in dramatic failure of hair follicle specification and epidermal proliferation and ..
  31. Saleque S, Kim J, Rooke H, Orkin S. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007;27:562-72 pubmed
    ..Lineage-restricted deployment of these cofactors through interaction with Gfi proteins controls hematopoietic differentiation. ..
  32. Gupta M, Samant S, Smith S, Shroff S. HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. J Biol Chem. 2008;283:10135-46 pubmed publisher
    ..These studies provide the first evidence that HATs and HDACs play a role in regulation of muscle contraction. ..
  33. Nusinzon I, Horvath C. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol. 2006;26:3106-13 pubmed
    ..RNA interference indicated that several deacetylase enzymes, including histone deacetylase 1 (HDAC1), HDAC8, and HDAC6, influence IFN-beta gene expression with opposing effects...
  34. Wang J, An H, Mayo M, Baldwin A, Yarbrough W. LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell. 2007;12:239-51 pubmed
    ..In aggregate, these data support a role of LZAP in NF-kappaB regulation and tumor suppression. ..
  35. Noh H, Oh E, Seo J, Yu M, Kim Y, Ha H, et al. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Am J Physiol Renal Physiol. 2009;297:F729-39 pubmed publisher
    ..These findings suggest that HDAC-2 plays an important role in the development of ECM accumulation and EMT in diabetic kidney and that ROS mediate TGF-beta1-induced activation of HDAC-2. ..
  36. Lin Z, Bazzaro M, WANG M, Chan K, Peng S, Roden R. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin Cancer Res. 2009;15:570-7 pubmed publisher
    ..The expression of HDAC1/HDAC2 in situ was examined in cervical cancer, its precursors, and normal epithelium...
  37. Liu D, Nath N, Chellappan S, Greene L. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev. 2005;19:719-32 pubmed
    ..for repression of pro-apoptotic genes is E2F4, and that the p130-E2F4 complex recruits the chromatin modifiers HDAC1 and Suv39H1 to promote gene silencing and neuron survival...
  38. Liberatore R, Goff S, Nunes I. NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. Proc Natl Acad Sci U S A. 2009;106:17823-8 pubmed publisher
    ..They do, however, show reduced levels of the histone deacetylase HDAC1, a negative regulator of basal NF-kappaB activity...
  39. Yamada T, Yang Y, Hemberg M, Yoshida T, Cho H, Murphy J, et al. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron. 2014;83:122-34 pubmed publisher
    ..Our findings define NuRD-dependent promoter decommissioning as a developmentally regulated programming mechanism that drives synaptic connectivity in the mammalian brain...
  40. Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, et al. Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell. 2007;18:755-67 pubmed
    ..DACH1 coprecipitated the histone deacetylase proteins (HDAC1, HDAC2, and NCoR), providing a mechanism by which DACH1 represses c-Jun activity through the conserved delta ..
  41. Zhang P, Zhu X, Wu Y, Hu R, Li D, Du J, et al. Histone deacetylase inhibitors reduce WB-F344 oval cell viability and migration capability by suppressing AKT/mTOR signaling in vitro. Arch Biochem Biophys. 2016;590:1-9 pubmed publisher
    ..In conclusion, this study demonstrates that HDAC inhibitors affect oval cells by suppressing AKT/mTOR signaling. ..
  42. Contreras A, Mebratu Y, Delgado M, Montaño G, Hu C, Ryter S, et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol. 2013;201:427-37 pubmed publisher
    ..IFN-?-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53's proline-rich ..
  43. Huang H, Lin S, Chen W, Li K, Kuo J, Wang M. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3? and histone deacetylase. Neurobiol Aging. 2011;32:1662-77 pubmed publisher
    ..These results suggest that dopaminergic neuron-derived UCN might be involved in an autocrine protective signaling mechanism. ..
  44. Hong C, Gong E, Kim K, Suh J, Ko H, Lee H, et al. Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol Endocrinol. 2005;19:2245-57 pubmed
    ..Overexpression of HDAC1 further inhibits the Pod-1-mediated repressions and Pod-1 directly interacts with HDAC1...
  45. Kwintkiewicz J, Padilla Banks E, Jefferson W, Jacobs I, Wade P, Williams C. Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells. Biol Reprod. 2012;86:1-8 pubmed publisher
    ..In the ovary, MTA3 interacted with NuRD proteins CHD4 and HDAC1 and the core cohesin complex protein RAD21...
  46. Derwish R, Paterno G, Gillespie L. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. PLoS ONE. 2017;12:e0169338 pubmed publisher
    ..has been well characterized and is known to function in transcriptional repression through its ability to recruit HDAC1 and 2...
  47. Tsai R, Wang J, Chou K, Wong C, Cherng C. Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression. J Formos Med Assoc. 2016;115:445-54 pubmed publisher
    ..To examine the effects on spinal cord expression of histone deacetylase 1 (HDAC1), the inflammatory cytokine tumor necrosis factor-α (TNF-α), and TNF receptor (TNFR) 1 and ..
  48. Kiefer S, McDill B, Yang J, Rauchman M. Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J Biol Chem. 2002;277:14869-76 pubmed
    ..protein that are required for repression physically interact with components of chromatin remodeling complexes, HDAC1, HDAC2, RbAp46/48, MTA-1, and MTA-2...
  49. Cho K, Choi W, Crane C, Park C. Pubertal supplementation of lipotropes in female rats reduces mammary cancer risk by suppressing histone deacetylase 1. Eur J Nutr. 2014;53:1139-43 pubmed publisher
    ..Interestingly, quantitative RT-PCR revealed significantly decreased expression of histone deacetylase 1 (Hdac1) and DNA methyltransferase 1 (Dnmt1) genes in tumor tissues of the rats supplemented with lipotrope-..
  50. Pang M, Ma L, Liu N, Ponnusamy M, Zhao T, Yan H, et al. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J Cell Biochem. 2011;112:2138-48 pubmed publisher
    ..In this study, we further examined the role of HDACs, in particular, HDAC1 and HDAC2, in proliferation of cultured rat renal interstitial fibroblasts (NRK-49F) and expression of cell cycle ..
  51. Ye F, Chen Y, Hoang T, Montgomery R, Zhao X, Bu H, et al. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci. 2009;12:829-38 pubmed publisher
    ..We found that two histone-modifying enzymes, HDAC1 and HDAC2, were required for oligodendrocyte formation...
  52. Liu Q, Merkler K, Zhang X, McLean M. Prostaglandin F2alpha suppresses rat steroidogenic acute regulatory protein expression via induction of Yin Yang 1 protein and recruitment of histone deacetylase 1 protein. Endocrinology. 2007;148:5209-19 pubmed
    ..The StAR promoter region bound by YY1 was also associated with histone deacetylase 1 (HDAC1)...
  53. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, et al. The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem. 2003;278:16059-72 pubmed
    ..These results suggest that HDAC9 plays a role in hematopoiesis; its deregulated expression may be associated with some human cancers. ..
  54. Montgomery R, Hsieh J, Barbosa A, Richardson J, Olson E. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A. 2009;106:7876-81 pubmed publisher
    ..We show that HDAC1 and HDAC2 redundantly control neuronal development and are required for neuronal specification...
  55. Bicaku E, Marchion D, Schmitt M, Munster P. Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 2008;68:1513-9 pubmed publisher
    ..Selective inhibition of HDAC2, but not HDAC1 or HDAC6, was sufficient to potentiate tamoxifen-induced apoptosis in ER/PR-positive cells...
  56. Zhang Z, Yamashita H, Toyama T, Sugiura H, Ando Y, Mita K, et al. Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. Breast Cancer Res Treat. 2005;94:11-6 pubmed
    ..The aim of this study was to determine the expression of the HDAC1 gene in malignant human breast tissue and to correlate our observations with available clinical information...
  57. Lu D, Wang Y, Su Z, Zeng Z, Xing X, He Z, et al. Knockdown of the HDAC1 promotes the directed differentiation of bone mesenchymal stem cells into cardiomyocytes. PLoS ONE. 2014;9:e92179 pubmed publisher
    ..Our recent study has demonstrated that the expression of histone deacetylase 1 (HDAC1) is decreased in bone mesenchymal stem cells (BMSCs) during their differentiation into ..
  58. Matsuoka Y, Fukamachi K, Uehara N, Tsuda H, Tsubura A. Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis. Cancer Sci. 2008;99:309-15 pubmed publisher
    ..parous mammary glands coincided with the upregulation of Mnt, a Myc-suppressor, and the formation of histone deacetylase 1/Mnt/Max complexes that unexpectedly contained c-Myc...
  59. Bardai F, Price V, Zaayman M, Wang L, D Mello S. Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. J Biol Chem. 2012;287:35444-53 pubmed publisher
    Both neuroprotective and neurotoxic roles have previously been described for histone deacetylase-1 (HDAC1)...
  60. Basta J, Rauchman M. The nucleosome remodeling and deacetylase complex in development and disease. Transl Res. 2015;165:36-47 pubmed publisher
    ..Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer. ..
  61. Shimazu T, Horinouchi S, Yoshida M. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J Biol Chem. 2007;282:4470-8 pubmed
    ..Whereas CBP acetylated these proteins, HDAC1, HDAC3, HDAC10, SIRT1, and SIRT2 were involved in in vivo deacetylation...
  62. Cherng C, Lee K, Chien C, Chou K, Cheng Y, Hsin S, et al. Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats. J Formos Med Assoc. 2014;113:513-20 pubmed publisher
    ..In the present study, we examined the effect of baicalin on the antinociceptive effect of morphine and histone deacetylase 1 (HDAC1) expression in the spinal cord dorsal horn in neuropathic pain rats...
  63. Zhong N, Kim C, Rizzu P, Geula C, Porter D, Pothos E, et al. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem. 2006;281:20940-8 pubmed
    ..TH expression by inhibiting the sumoylation of PSF and preventing its sumoylation-dependent recruitment of histone deacetylase 1. Furthermore, siRNA silencing of DJ-1 decreases the acetylation of TH promoter-bound histones, and histone ..
  64. Lundh M, Christensen D, Damgaard Nielsen M, Richardson S, Dahllöf M, Skovgaard T, et al. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia. 2012;55:2421-31 pubmed publisher
    ..All 11 classical HDACs (HDAC1-11) are found in the pancreatic beta cell, and HDAC inhibitors (HDACi) protect beta cells from inflammatory ..
  65. Marinova Z, Ren M, Wendland J, Leng Y, Liang M, Yasuda S, et al. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. J Neurochem. 2009;111:976-87 pubmed publisher
  66. Wang R, Zhang Y, Qing H, Liu M, Yang P. The extinction of morphine-induced conditioned place preference by histone deacetylase inhibition. Neurosci Lett. 2010;483:137-42 pubmed publisher
    ..Our increasing understanding of these epigenetic mechanisms will provide key answers to basic processes in drug addiction and hopefully provide insight into designing improved treatments for drug addiction. ..
  67. Kruse J, Gu W. Modes of p53 regulation. Cell. 2009;137:609-22 pubmed publisher
    ..To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53. ..
  68. Shen Y, Lee G, Choe Y, Zoltewicz J, Peterson A. Functional architecture of atrophins. J Biol Chem. 2007;282:5037-44 pubmed
    ..Atrophin-1 and the short form of Atrophin-2, on the other hand, can act as potent and evolutionarily conserved transcriptional activators. ..
  69. He Z, Cai J, Lim J, KROLL K, Ma L. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J Biol Chem. 2011;286:7279-89 pubmed publisher
    ..ZNF431 is a nuclear transcriptional repressor whose repressive activity depends on its association with HDAC1 and -2...
  70. Qiu Y, Zhao Y, Becker M, John S, Parekh B, Huang S, et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell. 2006;22:669-79 pubmed
    Although histone deacetylases (HDACs) are generally viewed as corepressors, we show that HDAC1 serves as a coactivator for the glucocorticoid receptor (GR)...
  71. Zhao L, Chen C, Hajji N, Oliver E, Cotroneo E, Wharton J, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012;126:455-67 pubmed publisher
    ..b>HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs ..
  72. Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen Kaesbach G, et al. The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications. Nucleic Acids Res. 2008;36:6450-8 pubmed publisher
    ..Our data are the first to indicate a molecular and functional connection of NIPBL with chromatin-remodeling processes via the direct interaction with histone deacetylases. ..
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    ..Thus, HDAC4 could be a useful target for new anti-cancer therapies based on selective inhibition of specific HDACs. ..
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    ..Identifying the cell types and developmental stages that express HDAC1 and HDAC2 within the brain is important for determining the therapeutic mode of action of HDAC inhibitors, and ..
  75. Ishii S, Kurasawa Y, Wong J, Yu Lee L. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc Natl Acad Sci U S A. 2008;105:4179-84 pubmed publisher
    ..Taken together, our studies raise the interesting possibility that acetylation-deacetylation of mitotic spindle components may be essential for mitotic spindle function. ..
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    ..Despite these differences, caloric, fat, and protein content were similar in breast milk from Con and IUGR dams. We conclude that IUGR results in postnatal changes in cerebral chromatin structure and that these changes are sex specific. ..
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    ..Pharmacological treatment or silencing of histone deacetylase 1 (Hdac1) or histone deacetylase 2 (Hdac2) in OPCs did not affect BMP4-dependent astrogliogenesis, while it ..
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    ..These findings define unique roles for class I HDACs and DUSP5 as integral components of a regulatory signaling circuit that controls cardiac hypertrophy. ..
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    ..IUGR state was characterized by loss of USF-1 binding at the proximal promoter of Pdx1, recruitment of the histone deacetylase 1 (HDAC1) and the corepressor Sin3A, and deacetylation of histones H3 and H4...
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    ..The striking correlation of Hr expression with brain regions, cell types, and developmental stages influenced by TH, together with its function as a corepressor, suggests Hr is a key mediator of TH action in developing brain. ..
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    ..Further, K39 of C/EBPbeta can be deacetylated by HDAC1, and HDAC1 may decrease C/EBPbeta-mediated transcription, suggesting that acetylation of C/EBPbeta at K39 is ..