Hcn1

Summary

Gene Symbol: Hcn1
Description: hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
Alias: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Species: rat
Products:     Hcn1

Top Publications

  1. Shin M, Brager D, JARAMILLO T, Johnston D, Chetkovich D. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Neurobiol Dis. 2008;32:26-36 pubmed publisher
    ..These results implicate h channel localization as a molecular mechanism influencing CA1 excitability in TLE. ..
  2. Notomi T, Shigemoto R. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. J Comp Neurol. 2004;471:241-76 pubmed
    ..Four subunits of the Hyperpolarization-activated and Cyclic-Nucleotide-gated nonselective cation channels (HCN1-4), which generate I(h), have been cloned recently...
  3. Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, et al. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007;27:4697-706 pubmed
    ..we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of ..
  4. Shin M, Chetkovich D. Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons. J Biol Chem. 2007;282:33168-80 pubmed
    ..h channels comprised primarily of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel subunits, HCN1 and HCN2...
  5. Santoro B, Wainger B, Siegelbaum S. Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. J Neurosci. 2004;24:10750-62 pubmed
    Hyperpolarization-activated cation currents (I(h)) are carried by channels encoded by a family of four genes (HCN1-4) that are differentially expressed within the brain in specific cellular and subcellular compartments...
  6. Lorincz A, Notomi T, Tamas G, Shigemoto R, Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci. 2002;5:1185-93 pubmed
    ..the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain...
  7. Noam Y, Zha Q, Phan L, Wu R, Chetkovich D, Wadman W, et al. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem. 2010;285:14724-36 pubmed publisher
    ..b>HCN1-green fluorescence protein (HCN1-GFP) channels resided in vesicle-like organelles that moved in distinct patterns ..
  8. Bender R, Soleymani S, Brewster A, Nguyen S, Beck H, Mathern G, et al. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003;23:6826-36 pubmed
    ..Therefore, we determined whether HCN isoform expression was modified in hippocampi of individuals with TLE. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi from three ..
  9. Brewster A, Chen Y, Bender R, Yeh A, Shigemoto R, Baram T. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex. 2007;17:702-12 pubmed
    ..HCN) cation channels, we tested the hypothesis that understanding the quantitative developmental profiles of HCN1, HCN2, and HCN4 expression, and the isoform- and age-specific progression of their subcellular distribution, should ..

More Information

Publications77

  1. Atkinson S, Williams S. Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons. J Neurophysiol. 2009;102:735-51 pubmed publisher
    ..nucleotide (HCN)-gated channels found in cell-attached patches or by immunostaining for the HCN channel isoform HCN1. Thus an age-dependent increase in apical dendritic HCN channel density ensures that L5 pyramidal neurons develop ..
  2. Battefeld A, Bierwirth C, Li Y, Barthel L, Velmans T, Strauss U. I(h) "run-up" in rat neocortical neurons and transiently rat or human HCN1-expressing HEK293 cells. J Neurosci Res. 2010;88:3067-78 pubmed publisher
    ..For a closer investigation of this I(h) increase, we overexpressed the predominant layer 5 rat subunit HCN1 in HEK293 cells. We characterized the resulting I(h) in the cell-attached and whole-cell configurations...
  3. Park K, Yi J, Kim H, Choi K, Kang S, Shin K. HCN channel activity-dependent modulation of inhibitory synaptic transmission in the rat basolateral amygdala. Biochem Biophys Res Commun. 2011;404:952-7 pubmed publisher
    ..Our results suggest that HCN channel activity can modulate the GABAergic synaptic transmission in the BLA, which in turn control the amygdala-related emotional behaviors such as anxiety. ..
  4. Lolicato M, Nardini M, Gazzarrini S, Möller S, Bertinetti D, Herberg F, et al. Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem. 2011;286:44811-20 pubmed publisher
    ..respond differently to cAMP; binding of cAMP shifts activation of HCN2 and HCN4 by 17 mV but shifts that of HCN1 by only 2-4 mV...
  5. Li S, He Z, Guo L, Huang L, Wang J, He W. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. 2010;165:654-61 pubmed publisher
    ..and reverse transcriptase-polymerase chain reaction (RT-PCR) assays were used to investigate whether and how HCN1 mRNA may be altered in global incomplete chronic cerebral ischemic rat model...
  6. Wilkars W, Liu Z, Lewis A, Stoub T, Ramos E, Brandt N, et al. Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. PLoS ONE. 2012;7:e32181 pubmed publisher
    ..In the medial perforant path, which normally contains HCN1 channels in axon terminals in immature but not in adult rodents, we found axonal HCN1 significantly increased in ..
  7. Luo P, Lu Y, Li C, Zhou M, Chen C, Lu Q, et al. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiol Learn Mem. 2015;123:72-83 pubmed publisher
    ..Expression of NeuN, HCN1 and HCN2 in hippocampal CA1, DG and CA3 areas was quantified by immunohistochemistry and western blotting...
  8. Oh Y, Na J, Jeong J, Park D, Park K, Ko J, et al. Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus. BMB Rep. 2012;45:635-40 pubmed
    ..Although HCN1 immunoreactivity was observed in the hippocampus, its immunoreactivities were enhanced at 12 hrs following SE...
  9. Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, et al. Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations. Cereb Cortex. 2014;24:199-210 pubmed publisher
    ..directly exposed to type I IFNs, the hyperpolarization-activated cyclic nucleotide (HCN)-gated channel subunit HCN1 was specifically affected. The effect required an intact type I receptor (IFNAR) signaling cascade...
  10. Xu X, Guo F, Cai X, Yang J, Zhao J, Min D, et al. Aberrant changes of somatostatin and neuropeptide Y in brain of a genetic rat model for epilepsy: tremor rat. Acta Neurobiol Exp (Wars). 2016;76:165-75 pubmed
    ..In conclusion, our results discovered the aberrant changes of SST and NPY in several TRM brain regions, suggesting that the peptidergic system might be involved in TRM epileptiform activity. ..
  11. Ding W, You Z, Shen S, Chen L, Zhu S, Mao J. Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats. Neurosci Lett. 2016;631:97-103 pubmed publisher
    ..In the thalamus, immunoreactivity of both HCN1 and HCN2 subunits was increased in both rat models...
  12. Huang X, Yang P, Yang Z, Zhang H, Ma A. Age-associated expression of HCN channel isoforms in rat sinoatrial node. Exp Biol Med (Maywood). 2016;241:331-9 pubmed publisher
    ..We investigated the protein expressions of HCN channel isoforms, HCN1-HCN4, in the sinoatrial nodes (SANs) from young (1-month-old), adult (4-month-old), and aged (30-month-old) rats...
  13. Ango F, Di Cristo G, Higashiyama H, Bennett V, Wu P, Huang Z. Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell. 2004;119:257-72 pubmed
    ..Disruption of NF186-ankyrinG interactions at AIS reduced pinceau synapse formation. These results implicate ankyrin-based localization of L1CAMs in subcellular organization of GABAergic synapses. ..
  14. Stevens D, Seifert R, Bufe B, Muller F, Kremmer E, Gauss R, et al. Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature. 2001;413:631-5 pubmed
    ..We show by in situ hybridization and immunohistochemistry that HCN1 and HCN4 are expressed in a subset of taste cells...
  15. Chan C, Shigemoto R, Mercer J, Surmeier D. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. J Neurosci. 2004;24:9921-32 pubmed
    ..and immunohistochemical approaches revealed robust expression of HCN2 subunits as well as significant levels of HCN1 subunits in GABAergic GP neurons...
  16. Wells J, Rowland K, Proctor E. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth. Int Endod J. 2007;40:715-21 pubmed
    To use immunocytochemistry for determining the expression of HCN1, HCN2 and HCN3 (three subunits of the hyperpolarization-activated cyclic nucleotide-gated current channel) in rodent trigeminal ganglia (TG) that innervate healthy teeth ..
  17. Powell K, Ng C, O Brien T, Xu S, Williams D, Foote S, et al. Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats. Epilepsia. 2008;49:1686-95 pubmed publisher
    ..Here HCN1 and HCN2 mRNA expression was quantitatively measured at different time points during epileptogenesis in two ..
  18. Poolos N, Bullis J, Roth M. Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase. J Neurosci. 2006;26:7995-8003 pubmed
    ..by the HCN2 isoform is regulated by cAMP, there is little known about kinase modulation of I(h), especially for the HCN1 isoform predominant in pyramidal neurons...
  19. Pavlov I, Scimemi A, Savtchenko L, Kullmann D, Walker M. I(h)-mediated depolarization enhances the temporal precision of neuronal integration. Nat Commun. 2011;2:199 pubmed publisher
  20. Hablitz J, Yang J. Abnormal pyramidal cell morphology and HCN channel expression in cortical dysplasia. Epilepsia. 2010;51 Suppl 3:52-5 pubmed publisher
    ..Immunocytochemical HCN1 staining, typically seen in the apical dendrites of layer V pyramidal cells in normal cortex, was greatly reduced ..
  21. Shi W, Wymore R, Yu H, Wu J, Wymore R, Pan Z, et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res. 1999;85:e1-6 pubmed
    ..In the rabbit SA node, the dominant HCN transcript is HCN4, representing >81% of the total HCN message. HCN1 is also expressed, representing >18% of the total HCN mRNA...
  22. Schridde U, Strauss U, Bräuer A, van Luijtelaar G. Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life. Eur J Neurosci. 2006;23:3346-58 pubmed
    ..might be correlated with changes in Ih and its channel subunits hyperpolarization-activated cation channel HCN1, 2 and 4...
  23. Cho Y, Kim Y, Moozhayil S, Yang E, Bae Y. The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, and dental pulp. Neuroscience. 2015;291:15-25 pubmed publisher
    Hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and 2 (HCN2) are abundantly expressed in primary sensory neurons and contribute to neuronal excitability and pathological pain...
  24. Kim C, Chang P, Johnston D. Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors. Neuron. 2012;75:503-16 pubmed publisher
    ..TRIP8b knockout mice lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have been shown to display antidepressant-like behaviors...
  25. Yeh J, Kim B, Peresie J, Page C. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Reprod Sci. 2009;16:986-94 pubmed publisher
    ..of the 4 hyperpolarization-activated cation (hyperpolarization-activated, cyclic nucleotide-gated [HCN]) channels (HCN1-4), channels associated with rhythmic electrical bursting, varies in the different cells of the ovary...
  26. Cho H, Staikopoulos V, Furness J, Jennings E. Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Neuroscience. 2009;162:453-61 pubmed publisher
    ..b>HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion ..
  27. Li Y, Tran T, Muelleman R, Schultz H. Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel. Cardiovasc Res. 2008;79:715-21 pubmed publisher
    ..Immunofluorescent and western blot analyses demonstrated that the expression of HCN1 and HCN2 channel protein in the NG from the T1D rats was higher than that from the sham rats...
  28. Lujan R, Albasanz J, Shigemoto R, Juiz J. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. Eur J Neurosci. 2005;21:2073-82 pubmed
    ..and immunohistochemical techniques to reveal the developmental expression and subcellular distribution of the HCN1 subunit in the cerebellar cortex...
  29. Muller F, Scholten A, Ivanova E, Haverkamp S, Kremmer E, Kaupp U. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Eur J Neurosci. 2003;17:2084-96 pubmed
    ..All four HCN channel isoforms (HCN1-4) are expressed differentially in the retina...
  30. Ramakrishnan N, Drescher M, Khan K, Hatfield J, Drescher D. HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J Biol Chem. 2012;287:37628-46 pubmed publisher
    A unique coupling between HCN1 and stereociliary tip-link protein protocadherin 15 has been described for a teleost vestibular hair-cell model and mammalian organ of Corti (OC) (Ramakrishnan, N. A., Drescher, M. J., Barretto, R. L...
  31. Fyk Kolodziej B, Pourcho R. Differential distribution of hyperpolarization-activated and cyclic nucleotide-gated channels in cone bipolar cells of the rat retina. J Comp Neurol. 2007;501:891-903 pubmed
    The hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel isoforms HCN1, HCN2, and HCN4 were localized by immunofluorescence in the rat retina...
  32. Han Y, Noam Y, Lewis A, Gallagher J, Wadman W, Baram T, et al. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. J Biol Chem. 2011;286:20823-34 pubmed publisher
    ..Interaction with the last three amino acids of the HCN1 C terminus governed the effect of TRIP8b on channel trafficking, whereas TRIP8b interaction with the HCN1 cyclic ..
  33. Xue L, Li Y, Han X, Yao L, Yuan J, Qin W, et al. Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder. Urology. 2012;80:224.e13-8 pubmed publisher
    ..First, the immunoreactivity of HCN1, HCN2, HCN3, and HCN4 isoforms was detected in the ICCs of lamina propria using immunofluorescence...
  34. Ramakrishnan N, Drescher M, Barretto R, Beisel K, Hatfield J, Drescher D. Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3. J Biol Chem. 2009;284:3227-38 pubmed publisher
    The cytoplasmic amino terminus of HCN1, the primary full-length HCN isoform expressed in trout saccular hair cells, was found by yeast two-hybrid protocols to bind the cytoplasmic carboxyl-terminal domain of a protocadherin 15a-like ..
  35. Milligan C, Edwards I, Deuchars J. HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata. Brain Res. 2006;1081:79-91 pubmed
    ..Here, we examined the distribution of HCN1 channel subunits in the brainstem and spinal cord using immunohistochemistry...
  36. Jung S, Warner L, Pitsch J, Becker A, Poolos N. Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J Neurosci. 2011;31:14291-5 pubmed publisher
    ..of CA1 hippocampal pyramidal neurons after pilocarpine-induced status epilepticus (SE), accompanied by loss of HCN1 channel protein expression...
  37. McClelland S, Flynn C, Dube C, Richichi C, Zha Q, Ghestem A, et al. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol. 2011;70:454-64 pubmed publisher
    ..and function of the ion channel hyperpolarization-activated cyclic adenosine monophosphate gated channel type 1 (HCN1) occurs in temporal lobe epilepsy (TLE)...
  38. Doan T, Stephans K, Ramirez A, Glazebrook P, Andresen M, Kunze D. Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers. J Neurosci. 2004;24:3335-43 pubmed
    ..demonstrated a differential distribution of hyperpolarization-activated cyclic nucleotide-gated (HCN) protein (HCN1, HCN2, HCN4) in sensory neurons and peripheral terminals...
  39. Tu H, Zhang L, Tran T, Muelleman R, Li Y. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Neuroscience. 2010;165:39-52 pubmed publisher
    ..In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber ..
  40. Boychuk J, Farrell J, Palmer L, Singleton A, Pittman Q, Teskey G. HCN channels segregate stimulation-evoked movement responses in neocortex and allow for coordinated forelimb movements in rodents. J Physiol. 2017;595:247-263 pubmed publisher
    ..Global HCN1KO mice exhibit reduced reaching accuracy and atypical movements during a single-pellet reaching task ..
  41. Ohno Y, Shimizu S, Tatara A, Imaoku T, Ishii T, Sasa M, et al. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. PLoS ONE. 2015;10:e0123529 pubmed publisher
    ..1061 C>T, p. A354V) in the hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene...
  42. Negrini D, Marcozzi C, Solari E, Bossi E, Cinquetti R, Reguzzoni M, et al. Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics. Am J Physiol Heart Circ Physiol. 2016;311:H892-H903 pubmed publisher
    ..9 ± 2.7% of control. HCN gene expression and immunostaining confirmed the presence of HCN1-4 channel isoforms, likely arranged in different configurations, in LMCs...
  43. Strauss U, Kole M, Bräuer A, Pahnke J, Bajorat R, Rolfs A, et al. An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci. 2004;19:3048-58 pubmed
    ..layer 2-3 pyramidal neurons with immunohistochemistry, Western blot and RT-PCR analysis of the h-channel subunits HCN1-4...
  44. Li C, Lu Y, Zhou M, Zong X, Li C, Xu X, et al. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Mol Neurobiol. 2014;50:704-20 pubmed publisher
    ..LTP) at the Schaffer collateral-CA1 synapses, and reduction of surface expression of GABAB R1, GABAB R2, and HCN1, but increase in HCN2 surface expression...
  45. Kouranova E, Strassle B, Ring R, Bowlby M, Vasilyev D. Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating. Neuroscience. 2008;153:1008-19 pubmed publisher
    ..We studied HCN1-4 channel mRNA and protein expression and correlated these findings with I(h) functional properties in rat DRG ..
  46. Cho H, Furness J, Jennings E. Postnatal maturation of the hyperpolarization-activated cation current, I(h), in trigeminal sensory neurons. J Neurophysiol. 2011;106:2045-56 pubmed publisher
    ..Western blot analysis of the TG detected immunoreactive bands corresponding to all HCN subtypes. HCN1 and HCN2 band density increased with postnatal age, whereas the low-intensity HCN3 and moderate-intensity HCN4 ..
  47. Poller W, Bernard R, Derst C, Weiss T, Madai V, Veh R. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels. Neuroscience. 2011;193:205-16 pubmed publisher
    ..pacemaker activity of LHb projection neurons, we combined retrograde tracing in rats with in situ hybridization of HCN1 to HCN4 mRNAs. In fact, close to all LHb neurons targeting VTA or raphe nuclei are equipped with HCN subunit mRNAs...
  48. Boyes J, Bolam J, Shigemoto R, Stanford I. Functional presynaptic HCN channels in the rat globus pallidus. Eur J Neurosci. 2007;25:2081-92 pubmed
    ..At the electron microscopic level, immunoperoxidase labelling for HCN1 and HCN2 was localized in GP somata and dendritic processes, myelinated and unmyelinated axons, and axon terminals...
  49. Angelo K, London M, Christensen S, Hausser M. Local and global effects of I(h) distribution in dendrites of mammalian neurons. J Neurosci. 2007;27:8643-53 pubmed
  50. Zha Q, Brewster A, Richichi C, Bender R, Baram T. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem. 2008;105:68-77 pubmed
    ..We have previously demonstrated co-association of the hyperpolarization activated cyclic-nucleotide gated (HCN1/HCN2) channel isoforms that was regulated by network (seizure) activity in developing hippocampus...
  51. Barthel L, Reetz O, Strauss U. Use Dependent Attenuation of Rat HCN1-Mediated Ih in Intact HEK293 Cells. Cell Physiol Biochem. 2016;38:2079-93 pubmed publisher
    ..and relatively cAMP insensitive subtype of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, HCN1, are limited by cytosolic factors in mammalian cells...
  52. Li B, Luo C, Tang W, Chen Z, Li Q, Hu B, et al. Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats. J Neurosci. 2012;32:3164-75 pubmed publisher
    ..Additionally, Hb perfusion scavenged the production of nitric oxide and decreased the expression of HCN1 subunits in CA1 region...
  53. Noam Y, Ehrengruber M, Koh A, Feyen P, Manders E, Abbott G, et al. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014;289:5889-903 pubmed publisher
    ..We focused on the HCN1 channels that conduct Ih, a hyperpolarization-activated current crucial for shaping intrinsic neuronal properties...
  54. Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich D, Bähring R, et al. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. FASEB J. 2014;28:2177-90 pubmed publisher
    ..We identified a PY motif (L/PPxY), the characteristic binding motif for Nedd4-2 in the C terminus of the HCN1 subunit, and showed that HCN1 and Nedd4-2 interacted both in vivo (rat hippocampus, neocortex, and cerebellum) and ..
  55. Shinpo K, Hirai Y, Maezawa H, Totsuka Y, Funahashi M. The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting. Physiol Behav. 2012;107:98-103 pubmed publisher
    ..Finally, we discuss the role of cells expressing H-channels in the mechanism of nausea and/or vomiting. ..
  56. Stradleigh T, Ogata G, Partida G, Oi H, Greenberg K, Krempely K, et al. Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells. J Comp Neurol. 2011;519:2546-73 pubmed publisher
    ..mammalian hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels is formed by subunit isoforms denoted HCN1-4...
  57. Stoenica L, Wilkars W, Battefeld A, Stadler K, Bender R, Strauss U. HCN1 subunits contribute to the kinetics of I(h) in neonatal cortical plate neurons. Dev Neurobiol. 2013;73:785-97 pubmed publisher
    ..Our previous study implied a role for the fastest activating subunit HCN1 in the generation of Ih in rat neonatal cortical plate neurons...
  58. Brewster A, Bernard J, Gall C, Baram T. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis. 2005;19:200-7 pubmed
    ..kinetic and gating properties of HCN-mediated currents are largely determined by the type of subunits--for example, HCN1 and HCN2--that assemble to form homomeric channels...
  59. Chen X, Sirois J, Lei Q, Talley E, Lynch C, Bayliss D. HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents. J Neurosci. 2005;25:5803-14 pubmed
    ..in voltage dependence of activation and a decrease in maximal current amplitude; these effects can be ascribed to HCN1 and HCN2 subunits, respectively, and both actions are recapitulated in heteromeric HCN1-HCN2 channels...
  60. Kole M, Bräuer A, Stuart G. Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. J Physiol. 2007;578:507-25 pubmed
    ..epilepsy (WAG/Rij) that a rapid decline in expression of hyperpolarization-activated cyclic-nucleotide gated (HCN1) channels (I(h)) precedes the onset of seizures, suggesting that the loss of HCN1 channel expression is inherited ..
  61. Luo L, Chang L, Brown S, Ao H, Lee D, Higuera E, et al. Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat. Neuroscience. 2007;144:1477-85 pubmed
    ..Immunohistochemical staining of plantar skin sections detected HCN1-HCN4 expression in mechanosensory structures (e.g., Meissner's corpuscles and Merkel cells)...
  62. Oertel D, Shatadal S, Cao X. In the ventral cochlear nucleus Kv1.1 and subunits of HCN1 are colocalized at surfaces of neurons that have low-voltage-activated and hyperpolarization-activated conductances. Neuroscience. 2008;154:77-86 pubmed publisher
    ..pole, and of similar cells along the ventrolateral edge of the PVCN, were brightly labeled by an antibody against HCN1 that was colocalized with labeling for Kv1.1...
  63. Monteggia L, Eisch A, Tang M, Kaczmarek L, Nestler E. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Res Mol Brain Res. 2000;81:129-39 pubmed
    ..In this study, we report the molecular cloning and localization by in situ hybridization of HCN1-4 in adult rat brain...
  64. Koch U, Braun M, Kapfer C, Grothe B. Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei. Eur J Neurosci. 2004;20:79-91 pubmed
    ..Molecular cloning of the channels underlying Ih revealed four different isoforms (HCN1-4)...
  65. Sheets P, Suter B, Kiritani T, Chan C, Surmeier D, Shepherd G. Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control. J Neurophysiol. 2011;106:2216-31 pubmed publisher
    ..corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits...
  66. Yi E, Roux I, Glowatzki E. Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea. J Neurophysiol. 2010;103:2532-43 pubmed publisher
    ..The HCN channel subunits HCN1, HCN2, and HCN4 were found to be expressed in afferent dendrites using immunolabeling...
  67. Bräuer A, Savaskan N, Kole M, Plaschke M, Monteggia L, Nestler E, et al. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J. 2001;15:2689-701 pubmed
    ..ECL) revealed decreases in mRNA encoding the neuronal hyperpolarization-activated, cyclic nucleotide-gated channel HCN1. In situ hybridization confirmed that hippocampal transcripts of HCN1, but not HCN2/3/4, are down-regulated after ..
  68. Dougherty K, Nicholson D, DIAZ L, Buss E, Neuman K, Chetkovich D, et al. Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J Neurophysiol. 2013;109:1940-53 pubmed publisher
    ..Here we investigated the hyperpolarization-activated current (I(h)) and the expression of HCN1 and HCN2 channel subunits in CA1 pyramidal neurons from the DHC and VHC...