Gene Symbol: Hbp1
Description: HMG-box transcription factor 1
Alias: Hmgb1, HMG box-containing protein 1, high mobility group box transcription factor 1, high mobility group protein 1
Lesage F, Hugnot J, Amri E, Grimaldi P, Barhanin J, Lazdunski M. Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. Nucleic Acids Res. 1994;22:3685-8 pubmed
The rat HBP1 cDNA was cloned by its capacity to suppress the potassium transport-defective phenotype of mutant Saccharomyces cerevisiae cells...
Berasi S, Xiu M, Yee A, Paulson K. HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase. Mol Cell Biol. 2004;24:3011-24 pubmed
..In this study, we demonstrate that the transcriptional repressor HBP1 (HMG box-containing protein 1) regulates the gene for the p47phox regulatory subunit of the NADPH oxidase...
Peinado J, Quirós P, Pulido M, Mariño G, Martinez Chantar M, Vazquez Martinez R, et al
. Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing. Mol Cell Proteomics. 2011;10:M111.008094 pubmed publisher
Kyostio Moore S, Nambiar B, Hutto E, Ewing P, Piraino S, Berthelette P, et al
. STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers. Comp Med. 2011;61:346-55 pubmed
..Markers of low-grade inflammatory and oxidative stress-RAGE, AGE, S100A4, and HMGB1-were evaluated through immunohistochemistry...
Lavender P, Vandel L, Bannister A, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene. 1997;14:2721-8 pubmed
A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells...
Kokkola R, Sundberg E, Ulfgren A, Palmblad K, Li J, Wang H, et al
. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 2002;46:2598-603 pubmed
..These findings suggest a pathogenetic role for HMGB-1 in synovitis and indicate a new potential therapeutic target molecule. ..
Raine E, Wreglesworth N, Dodd A, Reynard L, Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Ann Rheum Dis. 2012;71:2020-7 pubmed publisher
..has been mapped to chromosome 7q22, to a region of high-linkage disequilibrium encompassing six genes: PRKAR2B, HBP1, COG5, GPR22, DUS4L and BCAP29...
Tian F, An L, Wang G, Zhu J, Li Q, Zhang Y, et al
. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 2014;103:100-10 pubmed publisher
..Furthermore, ectopic overexpression and knockdown experiments identified that HMG box-transcription protein1 (HBP1) is a novel target of miR-155...