Gene Symbol: Has3
Description: hyaluronan synthase 3
Alias: hyaluronan synthase 3
Species: rat
Products:     Has3

Top Publications

  1. Hoock T, Peters L, Lux S. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997;136:1059-70 pubmed
    ..This is the first evidence for the association of an ankyrin with lysosomes and is an example of two ankyrins present in the same cell that segregate to different locations. ..
  2. Itano N, Sawai T, Yoshida M, Lenas P, Yamada Y, Imagawa M, et al. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem. 1999;274:25085-92 pubmed
    Three mammalian hyaluronan synthase genes, HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and compared the enzymatic properties of these three HAS proteins...
  3. Oishi Y, Kato H, Noguchi T. Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin. Biosci Biotechnol Biochem. 2003;67:736-42 pubmed
    ..These results suggest that protein malnutrition has a primary impact on the gene expression of rhass, which leads to the reduction of hyaluronan content and to disfunction of the skin. ..
  4. Pasonen Seppänen S, Karvinen S, Törrönen K, Hyttinen J, Jokela T, Lammi M, et al. EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation. J Invest Dermatol. 2003;120:1038-44 pubmed
    ..This was associated with upregulation of the hyaluronan synthases Has2 and Has3, and the hyaluronan receptor CD44...
  5. Mrabat H, Beagle J, Hang Z, Garg H, Hales C, Quinn D. Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model. Lung. 2009;187:233-9 pubmed publisher
    Low-molecular-weight hyaluronan produced by hyaluronan synthase 3 (HAS3) has been shown to play a role in acute lung injury secondary to high-tidal-volume ventilation...
  6. Törrönen K, Nikunen K, Kärnä R, Tammi M, Tammi R, Rilla K. Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. Histochem Cell Biol. 2014;141:17-31 pubmed publisher
    ..The three HAS isoenzymes (HAS1, HAS2, and HAS3) expressed in mammalian cells differ in their enzymatic properties and regulation by external stimuli, but clearly ..
  7. Karvinen S, Pasonen Seppänen S, Hyttinen J, Pienimäki J, Törrönen K, Jokela T, et al. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem. 2003;278:49495-504 pubmed
    ..In stratified, organotypic cultures of the same cell line, both Has2 and Has3 with the hyaluronan receptor CD44 were up-regulated and hyaluronan accumulated in the epidermis, the spinous cell ..
  8. Itano N, Sawai T, Atsumi F, Miyaishi O, Taniguchi S, Kannagi R, et al. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. J Biol Chem. 2004;279:18679-87 pubmed
    ..Of three HAS isoforms (HAS1, HAS2, and HAS3), only HAS2 gene expression was increased in the v-Ha-ras transformed 3Y1 cells, which show less malignancy...
  9. Selbi W, de La Motte C, Hascall V, Day A, Bowen T, Phillips A. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney Int. 2006;70:1287-95 pubmed
    ..Overexpression of HAS3 is associated with induction of HA cable formation, and also increased incorporation of HA into pericellular coats...

More Information


  1. Ormiston M, Slaughter G, Deng Y, Stewart D, Courtman D. The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2010;298:L148-57 pubmed publisher
    ..Thus an early increase in the generation of proinflammatory HA fragments may play a role in the onset and progression of pulmonary arterial hypertension. ..
  2. Rauhala L, Hämäläinen L, Salonen P, Bart G, Tammi M, Pasonen Seppänen S, et al. Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling. J Biol Chem. 2013;288:17999-8012 pubmed publisher
    ..In contrast, Has2 and Has3 were persistently elevated from 8 h onward...