Gene Symbol: Hadh
Description: hydroxyacyl-CoA dehydrogenase
Alias: Hadhsc, hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, hydroxylacyl-Coenzyme A dehydrogenase, short chain, medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, short-chain 3-hydroxyacyl-CoA dehydrogenase
Species: rat
Products:     Hadh

Top Publications

  1. Ianuzzo C, Noble E, Hamilton N, Dabrowski B. Effects of streptozotocin diabetes, insulin treatment, and training on the diaphragm. J Appl Physiol Respir Environ Exerc Physiol. 1982;52:1471-5 pubmed
    ..beta-Oxidation enzyme 3-hydroxyacyl-CoA dehydrogenase (HADH) was 60% higher than normal in the diabetic diaphragm and returned to normal with insulin treatment...
  2. Criswell D, Powers S, Dodd S, Lawler J, Edwards W, Renshler K, et al. High intensity training-induced changes in skeletal muscle antioxidant enzyme activity. Med Sci Sports Exerc. 1993;25:1135-40 pubmed
    ..05) succinate dehydrogenase (SDH) and 3-hydroxyacyl-CoA-dehydrogenase (HADH) activities in the gastrocnemius (G) and soleus (S) muscles compared with controls...
  3. He X, Zhang G, Blecha F, Yang S. Identity of heart and liver L-3-hydroxyacyl coenzyme A dehydrogenase. Biochim Biophys Acta. 1999;1437:119-23 pubmed
    ..J. Birktoft et al., Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 8262-8266) must be re-examined in accordance with this revelation. ..
  4. Furuhashi M, Ura N, Murakami H, Hyakukoku M, Yamaguchi K, Higashiura K, et al. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. J Endocrinol. 2002;174:321-9 pubmed
    ..The serum and muscle triglyceride (sTG and mTG) levels and the activity of 3-hydroxyacyl-CoA dehydrogenase (HADH), a beta-oxidation enzyme, in muscle were also determined...
  5. Seiva F, Ebaid G, Castro A, Okoshi K, Nascimento A, Rocha K, et al. Growth hormone and heart failure: oxidative stress and energetic metabolism in rats. Growth Horm IGF Res. 2008;18:275-83 pubmed publisher
    ..The lower dose, 1mg/kg GH exerted beneficial effects enhancing antioxidant defences, reducing oxidative stress and improving energy generation in myocardium of rats with heart failure. ..
  6. Hirai T, Nohara R, Ogoh S, Chen L, Kataoka K, Li X, et al. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. J Nucl Cardiol. 2001;8:472-81 pubmed
  7. Molven A, Matre G, Duran M, Wanders R, Rishaug U, Njølstad P, et al. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Diabetes. 2004;53:221-7 pubmed
    ..This finding suggests that mitochondrial fatty acid oxidation influences insulin secretion by a hitherto unknown mechanism. ..
  8. Martens G, Vervoort A, Van De Casteele M, Stangé G, Hellemans K, Van Thi H, et al. Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. J Biol Chem. 2007;282:21134-44 pubmed
    ..mutation of the mitochondrial beta-oxidation enzyme l-3-hydroxyacyl-CoA dehydrogenase, short chain (HADHSC), has been associated with hyperinsulinemic hypoglycemia in man...
  9. Furuta S, Hashimoto T. Purification and properties of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from rat liver mitochondria. J Biochem. 1995;118:810-8 pubmed
    ..The pH optimum of the binding activity was from pH 6 to 7 and the binding activity was diminished by increasing the concentration of salt in the medium. ..

More Information


  1. Shekhawat P, Yang H, Bennett M, Carter A, Matern D, Tamai I, et al. Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice. Pediatr Res. 2004;56:323-8 pubmed
  2. Dourmashkin J, Chang G, Gayles E, Hill J, Fried S, Julien C, et al. Different forms of obesity as a function of diet composition. Int J Obes (Lond). 2005;29:1368-78 pubmed
    ..nonesterified fatty acids (NEFA) and glucose, and a significant increase in beta-hydroxyacyl-CoA dehydrogenase (HADH) activity in muscle, reflecting its greater capacity to metabolize fat...