Hacl1

Summary

Gene Symbol: Hacl1
Description: 2-hydroxyacyl-CoA lyase 1
Alias: Hpcl2, Phyh2, 2-hydroxyacyl-CoA lyase 1, 2-HPCL, 2-hydroxyphytanoyl-CoA lyase, 2-hydroxyphytanoyl-Coenzyme A lyase, phytanoyl-CoA 2-hydroxylase 2, phytanoyl-Coenzyme A 2-hydroxylase 2
Species: rat
Products:     Hacl1

Top Publications

  1. Foulon V, Antonenkov V, Croes K, Waelkens E, Mannaerts G, Van Veldhoven P, et al. Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. Proc Natl Acad Sci U S A. 1999;96:10039-44 pubmed
  2. Huyghe S, Casteels M, Janssen A, Meulders L, Mannaerts G, Declercq P, et al. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001;353:673-80 pubmed
  3. Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts G, et al. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005;280:9802-12 pubmed
    ..e. the breakdown of 2-hydroxyfatty acids, at least the long chain 2-hydroxyfatty acids. Most likely, the more abundant very long chain 2-hydroxyfatty acids are degraded in a similar manner. ..
  4. Fraccascia P, Casteels M, De Schryver E, Van Veldhoven P. Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase. Biochim Biophys Acta. 2011;1814:1226-33 pubmed publisher
    ..straight chain fatty acids are cleaved into a (n-1) fatty aldehyde and formyl-CoA by 2-hydroxyacyl-CoA lyase (HACL1)...