Gene Symbol: H2afy
Description: H2A histone family, member Y
Alias: core histone macro-H2A.1, H2A.y, H2A/y, histone macroH2A1, mH2A1
Species: rat
Products:     H2afy

Top Publications

  1. Gaspar Maia A, Qadeer Z, Hasson D, Ratnakumar K, Leu N, LeRoy G, et al. MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun. 2013;4:1565 pubmed publisher
  2. Gamble M, Frizzell K, Yang C, Krishnakumar R, Kraus W. The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev. 2010;24:21-32 pubmed publisher
    ..Collectively, our results document an unexpected role for macroH2A1 in the escape from heterochromatin-associated silencing and the enhancement of autosomal gene transcription. ..
  3. Buschbeck M, Uribesalgo I, Wibowo I, Rué P, Martin D, Gutierrez A, et al. The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol. 2009;16:1074-9 pubmed publisher
    ..Taken together, our data demonstrate that macroH2A variants constitute an important epigenetic mark involved in the concerted regulation of gene expression programs during cellular differentiation and vertebrate development. ..
  4. Pehrson J, Costanzi C, Dharia C. Developmental and tissue expression patterns of histone macroH2A1 subtypes. J Cell Biochem. 1997;65:107-13 pubmed
    ..These results support the idea that macroH2A1.1 and macroH2A1.2 are functionally distinct, and suggest that changes in their expression may play a role in developmentally regulated changes in chromatin structure and function. ..
  5. Chadwick B, Willard H. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum Mol Genet. 2001;10:1101-13 pubmed
    ..This study provides further information about the nucleosomal composition of chromatin on the inactive X chromosome and indicates that a number of H2A variants are non-randomly distributed on the active and inactive X chromosomes. ..
  6. Pehrson J, Fried V. MacroH2A, a core histone containing a large nonhistone region. Science. 1992;257:1398-400 pubmed
    ..Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins. ..
  7. Mietton F, Sengupta A, Molla A, Picchi G, Barral S, Heliot L, et al. Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome. Mol Cell Biol. 2009;29:150-6 pubmed publisher
    We studied the enrichment and distribution of the histone variant mH2A1 in the condensed inactive X (Xi) chromosome...
  8. Souza P, Volkel P, Trinel D, Vandamme J, Rosnoblet C, Heliot L, et al. The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 2009;10:41 pubmed publisher
    ..Consequently, SUV420H2 may be recruited to heterochromatin in association with HP1, and stably maintained at its heterochromatin sites in an HP1-independent fashion. ..
  9. Weber C, Henikoff S. Histone variants: dynamic punctuation in transcription. Genes Dev. 2014;28:672-82 pubmed publisher
    ..Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states...

More Information


  1. Podrini C, Koffas A, Chokshi S, Vinciguerra M, Lelliott C, White J, et al. MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB J. 2015;29:1676-87 pubmed publisher
    ..This study underlines the importance of the replacement of noncanonical histones in the regulation of genes involved in lipid metabolism in the progression of steatosis. ..
  2. Ganesan S, Silver D, Greenberg R, Avni D, Drapkin R, Miron A, et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 2002;111:393-405 pubmed
    ..These observations suggest that loss of BRCA1 in female cells may lead to Xi perturbation and destabilization of its silenced state. ..
  3. Cong R, Das S, Douet J, Wong J, Buschbeck M, Mongelard F, et al. macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res. 2014;42:181-92 pubmed publisher
    ..These results demonstrate that macroH2A1 is a new factor involved in the regulation of rDNA transcription. ..
  4. Chadwick B, Willard H. Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. J Cell Biol. 2002;157:1113-23 pubmed
    ..Therefore, targeting of macroH2A1 to the centrosome is likely part of a degradation pathway, a mechanism common to a variety of other chromatin proteins. ..
  5. Ramamoorthy M, Smith S. Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell. 2015;28:357-69 pubmed publisher
    ..1-tankyrase axis as a potential therapeutic target in ALT tumors. ..
  6. Acin Perez R, Bayona Bafaluy M, Fernandez Silva P, Moreno Loshuertos R, Pérez Martos A, Bruno C, et al. Respiratory complex III is required to maintain complex I in mammalian mitochondria. Mol Cell. 2004;13:805-15 pubmed
    ..Conversely, complex III stability was not influenced by the absence of complex I. This structural dependence among complexes I and III was confirmed in a muscle biopsy of a patient harboring a nonsense cytochrome b mutation. ..
  7. Chakravarthy S, Gundimella S, Caron C, Perche P, Pehrson J, Khochbin S, et al. Structural characterization of the histone variant macroH2A. Mol Cell Biol. 2005;25:7616-24 pubmed
    ..Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain. ..
  8. Barrero M, Sesé B, Marti M, Izpisua Belmonte J. Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem. 2013;288:16110-6 pubmed publisher
    ..ChIP experiments showed that during differentiation macro histone variants are recruited to the regulatory regions of pluripotency and developmental genes marked with H3K27me3 contributing to the silencing of these genes. ..
  9. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..
  10. Dardenne E, Pierredon S, Driouch K, Gratadou L, Lacroix Triki M, Espinoza M, et al. Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat Struct Mol Biol. 2012;19:1139-46 pubmed publisher
    ..These findings reveal a new regulatory pathway in which splicing factors control the expression of histone variant isoforms that in turn drive a transcription program to switch tumor cells to an invasive phenotype. ..