Gene Symbol: Guca1b
Description: guanylate cyclase activator 1B
Alias: guanylyl cyclase-activating protein 2
Mendez A, Burns M, Sokal I, Dizhoor A, Baehr W, Palczewski K, et al
. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001;98:9948-53 pubmed
..We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range. ..
Cuenca N, Lopez S, Howes K, Kolb H. The localization of guanylyl cyclase-activating proteins in the mammalian retina. Invest Ophthalmol Vis Sci. 1998;39:1243-50 pubmed
..The occurrence of GCAP2 in inner retinal neurons is indicative of second-messenger chemical transduction, possibly in metabotropic glutamate, gamma-aminobutyric acid (GABA) receptor, and nitric oxide-activated neural circuits. ..
Makino C, Dodd R, Chen J, Burns M, Roca A, Simon M, et al
. Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J Gen Physiol. 2004;123:729-41 pubmed
..We infer that Ca2+-recoverin potentiates light-triggered phosphodiesterase activity, probably by effectively prolonging the catalytic activity of photoexcited rhodopsin...
Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004;322:1123-30 pubmed
..In the absence of GCAP2, GCAP1 supports the generation of wild-type flash responses in both rod and cone cells. Recent progress revealed an unexpected complexity of the GC-GCAP system, pointing, out a number of unsolved questions. ..
Codega P, Della Santina L, Gargini C, Bedolla D, Subkhankulova T, Livesey F, et al
. Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation. J Physiol. 2009;587:2457-72 pubmed publisher
..2 h of an exposure to a bright light, we observed an up-regulation of almost 100% of three genes, Sag, Guca1a and Guca1b, coding for proteins known to play a major role in phototransduction: arrestin, GCAP1 and GCAP2...
Arshavsky V, Burns M. Photoreceptor signaling: supporting vision across a wide range of light intensities. J Biol Chem. 2012;287:1620-6 pubmed publisher
Daiger S, Sullivan L, Bowne S. Genes and mutations causing retinitis pigmentosa. Clin Genet. 2013;84:132-41 pubmed publisher
..In this review, we summarize the current approaches to gene discovery and mutation detection for RP, and indicate pitfalls and unsolved problems. Similar considerations apply to other forms of inherited retinal disease. ..
Wright A, Chakarova C, Abd El Aziz M, Bhattacharya S. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet. 2010;11:273-84 pubmed publisher
..Although genetic and mechanistic diversity creates challenges for therapy, some approaches--particularly gene-replacement therapy--are showing considerable promise. ..
McCue H, Haynes L, Burgoyne R. The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harb Perspect Biol. 2010;2:a004085 pubmed publisher
..In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors. ..