Gstt1

Summary

Gene Symbol: Gstt1
Description: glutathione S-transferase theta 1
Alias: GSTYRS, glutathione S-transferase theta-1, GST 5-5, GST class-theta-1, Glutathione S-transferase 1 (theta), glutathione S-transferase 5
Species: rat
Products:     Gstt1

Top Publications

  1. Spalletta G, Bernardini S, Bellincampi L, Federici G, Trequattrini A, Ciappi F, et al. Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. Am J Geriatr Psychiatry. 2007;15:879-87 pubmed
    ..A multiple regression analysis indicated that the presence of ApoE epsilon4 allelic variant or GSTT1 null phenotype predicted the faster age at onset of the illness (F = 5.76, df = 2, 96, p = 0.0043)...
  2. Sterpone S, Cornetta T, Angioni A, Fiscarelli E, Lucidi V, Testa A, et al. DNA damage and related modifier genes in Italian cystic fibrosis patients. Biol Res. 2009;42:477-86 pubmed publisher
    ..controls and 93 CF subjects were genotyped for 5 genes by RFLP-PCR (XRCC1,0GG1,GSTP1) and PCR assay (GSTM1, GSTT1)...
  3. Dirksen U, Moghadam K, Mambetova C, Esser C, Fuhrer M, Burdach S. Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children. Pediatr Res. 2004;55:466-71 pubmed
    ..The GSTT1 null genotype (absence of both alleles) was associated with a significantly increased risk for acquired aplastic ..
  4. Zenkel M, Kruse F, Naumann G, Schlötzer Schrehardt U. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci. 2007;48:5558-66 pubmed
    ..set of cytoprotective gene products, including antioxidant defense enzymes (glutathione S-transferases mGST1 and GSTT1), ubiquitin-conjugating enzymes (UBE2A, UBE2B), the DNA repair protein MLH1, and the stress-inducible ..
  5. Sharma V, Kumar B, Saxena R. Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients. Ann Hematol. 2010;89:411-4 pubmed publisher
    ..Glutathione S-transferase genes (GSTT1 and GSTM1) are well known detoxification agents, and any mutation in the gene is known to cause oxidative damage...
  6. Stroombergen M, Waring R. Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease. Hum Exp Toxicol. 1999;18:141-5 pubmed
    1. Correlations between deletions in two glutathione S-transferase (GST) genes, GSTM1 and GSTT1 and susceptibility to Alzheimer's disease (AD), motor neuron disease (MND) and Parkinson's disease (PD) have been investigated by PCR, using ..
  7. Oz O, Aras Ates N, Tamer L, Yildirim O, Adiguzel U. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol. 2006;16:105-10 pubmed
    ..To elucidate whether the gene polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 are associated with the development of exudative age-related macular degeneration...
  8. Abu Amero K, Milcarek B, Bosley T. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Br J Ophthalmol. 2009;93:1101-4 pubmed publisher
    To investigate whether the prevalence GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0 and T0M0) are increased in certain spontaneous optic neuropathies...
  9. Yilmaz A, Tamer L, Ates N, Yildirim O, Yildirim H, Atik U. Is GST gene polymorphism a risk factor in developing exfoliation syndrome?. Curr Eye Res. 2005;30:575-81 pubmed
    To evaluate the distribution of GSTM1, GSTP1, and GSTT1 gene polymorphisms in exfoliation syndrome (XFS) and the possible associations between the presence of exfoliation syndrome and glutathione S-transferase (GST) gene polymorphisms...
  10. Davies S, Radloff G, DeFor T, Levran O, Batish S, Hanenberg H, et al. GST genotype may modify clinical phenotype in patients with Fanconi anaemia. Br J Haematol. 2005;131:118-22 pubmed
    ..the Fanconi anaemia (FA) phenotype, we examined the role of polymorphism in three glutathione s-transferase genes (GSTT1, GSTM1 and GSTP1) in 356 FA patients enrolled in the International Fanconi Anaemia Registry (IFAR)...

Detail Information

Publications62

  1. Spalletta G, Bernardini S, Bellincampi L, Federici G, Trequattrini A, Ciappi F, et al. Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. Am J Geriatr Psychiatry. 2007;15:879-87 pubmed
    ..A multiple regression analysis indicated that the presence of ApoE epsilon4 allelic variant or GSTT1 null phenotype predicted the faster age at onset of the illness (F = 5.76, df = 2, 96, p = 0.0043)...
  2. Sterpone S, Cornetta T, Angioni A, Fiscarelli E, Lucidi V, Testa A, et al. DNA damage and related modifier genes in Italian cystic fibrosis patients. Biol Res. 2009;42:477-86 pubmed publisher
    ..controls and 93 CF subjects were genotyped for 5 genes by RFLP-PCR (XRCC1,0GG1,GSTP1) and PCR assay (GSTM1, GSTT1)...
  3. Dirksen U, Moghadam K, Mambetova C, Esser C, Fuhrer M, Burdach S. Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children. Pediatr Res. 2004;55:466-71 pubmed
    ..The GSTT1 null genotype (absence of both alleles) was associated with a significantly increased risk for acquired aplastic ..
  4. Zenkel M, Kruse F, Naumann G, Schlötzer Schrehardt U. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci. 2007;48:5558-66 pubmed
    ..set of cytoprotective gene products, including antioxidant defense enzymes (glutathione S-transferases mGST1 and GSTT1), ubiquitin-conjugating enzymes (UBE2A, UBE2B), the DNA repair protein MLH1, and the stress-inducible ..
  5. Sharma V, Kumar B, Saxena R. Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients. Ann Hematol. 2010;89:411-4 pubmed publisher
    ..Glutathione S-transferase genes (GSTT1 and GSTM1) are well known detoxification agents, and any mutation in the gene is known to cause oxidative damage...
  6. Stroombergen M, Waring R. Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease. Hum Exp Toxicol. 1999;18:141-5 pubmed
    1. Correlations between deletions in two glutathione S-transferase (GST) genes, GSTM1 and GSTT1 and susceptibility to Alzheimer's disease (AD), motor neuron disease (MND) and Parkinson's disease (PD) have been investigated by PCR, using ..
  7. Oz O, Aras Ates N, Tamer L, Yildirim O, Adiguzel U. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol. 2006;16:105-10 pubmed
    ..To elucidate whether the gene polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 are associated with the development of exudative age-related macular degeneration...
  8. Abu Amero K, Milcarek B, Bosley T. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Br J Ophthalmol. 2009;93:1101-4 pubmed publisher
    To investigate whether the prevalence GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0 and T0M0) are increased in certain spontaneous optic neuropathies...
  9. Yilmaz A, Tamer L, Ates N, Yildirim O, Yildirim H, Atik U. Is GST gene polymorphism a risk factor in developing exfoliation syndrome?. Curr Eye Res. 2005;30:575-81 pubmed
    To evaluate the distribution of GSTM1, GSTP1, and GSTT1 gene polymorphisms in exfoliation syndrome (XFS) and the possible associations between the presence of exfoliation syndrome and glutathione S-transferase (GST) gene polymorphisms...
  10. Davies S, Radloff G, DeFor T, Levran O, Batish S, Hanenberg H, et al. GST genotype may modify clinical phenotype in patients with Fanconi anaemia. Br J Haematol. 2005;131:118-22 pubmed
    ..the Fanconi anaemia (FA) phenotype, we examined the role of polymorphism in three glutathione s-transferase genes (GSTT1, GSTM1 and GSTP1) in 356 FA patients enrolled in the International Fanconi Anaemia Registry (IFAR)...
  11. Shekharyadav C, Bajpai M, Kumar V, Ahmed R, Gupta P, Banerjee B. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Hum Exp Toxicol. 2011;30:1464-74 pubmed publisher
    ..Cytochrome P4501A1 (CYP1A1) and glutathione S-transferases (GSTM1 and GSTT1) of xenobiotic metabolizing enzyme family are involved in the metabolism of various environmental toxicants and ..
  12. Buzio L, De Palma G, Mozzoni P, Tondel M, Buzio C, Franchini I, et al. Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Occup Environ Med. 2003;60:789-93 pubmed
    ..interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC)...
  13. Stanulla M, Schrappe M, Brechlin A, Zimmermann M, Welte K. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Blood. 2000;95:1222-8 pubmed
    ..In a case-control study, we investigated the association between polymorphisms within the GSTM1, GSTT1, and GSTP1 genes and risk of relapse in childhood acute lymphoblastic leukemia (ALL). Cases were relapsed patients...
  14. Mallick S, Romana M, Blanchet P, Multigner L. GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent. Urology. 2007;69:1165-9 pubmed
    To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe...
  15. van Rooij I, Wegerif M, Roelofs H, Peters W, Kuijpers Jagtman A, Zielhuis G, et al. Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction. Epidemiology. 2001;12:502-7 pubmed
    ..in the biotransformation enzymes cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase theta 1-1 (GSTT1) on the risk of nonsyndromic oral clefting in the offspring...
  16. Lourenco G, Ortega M, Nascimento H, Teori M, de Souza C, Costa F, et al. Polymorphisms of glutathione S-transferase mu1 (GSTM1) and theta 1 (GSTT1) genes in chronic myeloid leukaemia. Eur J Haematol. 2005;75:530-1 pubmed
  17. Hiratsuka A, Nishijima T, Okuda H, Ogura K, Watabe T. Rat liver theta-class glutathione S-transferases T1-1 and T2-2: their chromatographic, electrophoretic, immunochemical, and functional properties. Anal Biochem. 1997;252:229-37 pubmed
    ..Cumene hydroperoxide was a better substrate for rGST T1-1 than for rGST T2-2, while the fatty acid hydroperoxides were the better substrates for rGST T2-2 than for rGST T1-1. ..
  18. de Lima Marson F, Bertuzzo C, Secolin R, Ribeiro A, Ribeiro J. Genetic interaction of GSH metabolic pathway genes in cystic fibrosis. BMC Med Genet. 2013;14:60 pubmed publisher
    ..Ligase, Catalytic Subunit (GCLC), Glutathione S-transferase Mu 1 (GSTM1), Glutathione S-transferase Theta 1 (GSTT1), and Glutathione S-transferase P1 (GSTP1), which have been associated to the GSH metabolic pathway and CF ..
  19. Cho H, Eom H, Kim H, Kim I, Lee G, Kong S. Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. Cancer Genet Cytogenet. 2010;198:40-6 pubmed publisher
    ..In this study, we investigated the influence of the genetic polymorphisms GSTM1, GSTT1, and GSTP1 on treatment response in 94 Korean patients with de novo diffuse large B-cell lymphoma, who had ..
  20. Mainwaring G, Williams S, Foster J, Tugwood J, Green T. The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem J. 1996;318 ( Pt 1):297-303 pubmed
    ..Although the distribution of GSTT2-2 in rat liver was similar to that seen in the mouse, GSTT1-1 was not localized in a specific cell type or in the nuclei of either rat or human liver...
  21. Keenan B, Chibnik L, Cui J, Ding B, Padyukov L, Kallberg H, et al. Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis. Arthritis Rheum. 2010;62:3196-210 pubmed publisher
    ..blood by TaqMan and BioTrove assays identified homozygous deletions at the M1 and T1 loci of GST (GSTM1-null and GSTT1-null, respectively) as well as alleles for GSTP1 (rs1695) and HMOX1 (rs2071746)...
  22. Ozer H, Gunesacar R, Dinkci S, Ozbalkan Z, Yildiz F, Erken E. The impact of smoking on clinical features of Behçet's disease patients with glutathione S-transferase polymorphisms. Clin Exp Rheumatol. 2012;30:S14-7 pubmed
    ..Frequency of GSTM1- and/or GSTT1-null polymorphisms were comparable between the Behçet and the control groups...
  23. Arruda V, Lima C, Grignoli C, de Melo M, Lorand Metze I, Alberto F, et al. Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects. Eur J Haematol. 2001;66:383-8 pubmed
    ..Both the GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent...
  24. Gorovenko N, Rossokha Z, Podolskaya S, Pokhylko V, Lundberg G. The role of genetic determinant in the development of severe perinatal asphyxia. Tsitol Genet. 2010;44:41-6 pubmed
    The frequency of GSTT1 and GSTM1 gene deletion polymorphism was determined in a case-control study of full-term Ukrainian newborns including patients with perinatal asphyxia...
  25. Mustafa M, Banerjee B, Ahmed R, Tripathi A, Guleria K. Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides. Mol Hum Reprod. 2013;19:35-42 pubmed publisher
    We investigated the association between glutathione S-transferases mu1 (GSTM1), theta 1 (GSTT1), Cytochrome P450IA1-T6235C (rs4646903, CYP1A1m1) and CYP1A1-1462V (rs1048943, CYP1A1m2) gene polymorphisms, and organochlorine pesticides (..
  26. Hovnik T, Dolzan V, Bratina N, Podkrajsek K, Battelino T. Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes. Diabetes Care. 2009;32:2258-62 pubmed publisher
    ..C-262T in the promoter region of the CAT gene. Multiplex PCR method was used for determination of GSTM1 and GSTT1 polymorphic deletions...
  27. Sanjay P, Mani M, Sweta P, Vineet S, Kumar A, Renu S. Prevalence of glutathione S-transferase gene deletions and their effect on sickle cell patients. Rev Bras Hematol Hemoter. 2012;34:100-2 pubmed publisher
    ..The aim of this study was to estimate the frequency of the GSTM1 and GSTT1 genotypes in sickle cell disease patients and their effect on iron status...
  28. Faramawy M, Mohammed T, Hossaini A, Kashem R, Abu Rahma R. Genetic polymorphism of GSTT1 and GSTM1 and susceptibility to chronic obstructive pulmonary disease (COPD). J Crit Care. 2009;24:e7-10 pubmed publisher
    ..To test the hypothesis that genetic polymorphism of glutathione S-transferase theta 1 (GSTT1)and/or glutathione S-transferase mu 1 (GSTM1) is associated with COPD in smokers...
  29. Delpisheh A, Brabin L, Topping J, Reyad M, Tang A, Brabin B. A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction. Eur J Obstet Gynecol Reprod Biol. 2009;143:38-42 pubmed publisher
    To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction...
  30. Ovsepian V, Vinogradova E, Sherstneva E. [Cytochrome P4501A1, glutathione S-transferase M1 and T1 gene polymorphisms in chronic myeloid leukemia]. Genetika. 2010;46:1360-2 pubmed
    Polymorphic variants of cytochrome P4501A1 (CYP1A1), glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) distribution was studied in patients with chronic myeloid leukemia (CML) and healthy individuals...
  31. Lie R, Wilcox A, Taylor J, Gjessing H, Saugstad O, Aabyholm F, et al. Maternal smoking and oral clefts: the role of detoxification pathway genes. Epidemiology. 2008;19:606-15 pubmed publisher
    ..and assayed for genes related to detoxification of compounds of cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, and GSTM1)...
  32. Goncalves M, Moura Neto J, Souza C, Melo P, Reis M. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. Int J Lab Hematol. 2010;32:e49-56 pubmed publisher
    ..We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, ..
  33. Ghelani A, Samanta A, Jones A, Mastana S. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatol Int. 2011;31:1355-61 pubmed publisher
    ..002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA. ..
  34. Shaheen S, Newson R, Ring S, Rose Zerilli M, Holloway J, Henderson A. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. J Allergy Clin Immunol. 2010;126:1141-8.e7 pubmed publisher
    ..02 and .04, respectively). Risk of asthma associated with late gestation exposure was higher when maternal GSTT1 genotype was present rather than absent (P interaction, ...
  35. Lee H, Lee J, Hur E, Lee M, Lee J, Kim D, et al. Clinical significance of GSTM1 and GSTT1 polymorphisms in younger patients with acute myeloid leukemia of intermediate-risk cytogenetics. Leuk Res. 2009;33:426-33 pubmed publisher
    We investigated the association between GSTM1 or GSTT1 polymorphisms and clinical outcomes in 133 younger patients with AML of intermediate-risk cytogenetics...
  36. Moore L, Brennan P, Karami S, Hung R, Hsu C, Boffetta P, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007;28:1960-4 pubmed
    ..polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution...
  37. Haase D, Binder C, Bünger J, Fonatsch C, Streubel B, Schnittger S, et al. Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1. Leuk Res. 2002;26:249-54 pubmed
    ..The control group consisted of 239 healthy individuals with comparable composition as to race and sex. GSTM1 and GSTT1 were analyzed by multiplex PCR. Comparison between patients and control group revealed a significant (P=0...
  38. Morabito F, Hohaus S, Mammi C, Marcheselli L, Gentile M, Merli F, et al. Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial. Leuk Lymphoma. 2012;53:406-10 pubmed publisher
    ..We aimed to validate the impact of GSTT1 and GSTM1 deletions and of the GSTP1Ile105Val polymorphism on outcome and toxicity in 140 patients with advanced ..
  39. Mandegary A, Rostami S, Alimoghaddam K, Ghavamzadeh A, Ghahremani M. Gluthatione-S-transferase T1-null genotype predisposes adults to acute promyelocytic leukemia; a case-control study. Asian Pac J Cancer Prev. 2011;12:1279-82 pubmed
    ..Particularly concerning acute promyelocytic leukemia (APL), the studies on association between GSTM1, GSTT1 and GSTP1 and the disease predisposition are scarce and contradictory...
  40. Sharma E, Mustafa M, Pathak R, Guleria K, Ahmed R, Vaid N, et al. A case control study of gene environmental interaction in fetal growth restriction with special reference to organochlorine pesticides. Eur J Obstet Gynecol Reprod Biol. 2012;161:163-9 pubmed publisher
    ..The objectives of the present study were (i) to determine the frequencies of polymorphic alleles of GSTM1 and GSTT1 genes in women with idiopathic FGR, (ii) to analyze the maternal and cord blood levels of the OCPs, and (iii) to ..
  41. Gordeeva L, Voronina E, Sokolova E, Ermolenko N, Gareeva J, Sutulina I, et al. Association GSTT1, GSTM1 and GSTP1 (Ile105Val) genetic polymorphisms in mothers with risk of congenital malformations in their children in Western Siberia: a case-control study. Prenat Diagn. 2013;33:1095-101 pubmed publisher
    ..Null genotypes of GSTM1 and GSTT1 were identified through multiplex real-time polymerase chain reaction, and GSTP1 gene (Ile105Val) polymorphism was ..
  42. Yuan J, Chan K, Coetzee G, Castelao J, Watson M, Bell D, et al. Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer. Carcinogenesis. 2008;29:1386-93 pubmed publisher
    ..The associations between the genotypes of glutathione S-transferase (GST) M1, GSTP1, GSTT1 and N-acetyltransferase (NAT) 1 and the phenotypes of NAT2 and cytochrome P450 (CYP) 1A2 and bladder cancer risk ..
  43. Fujimoto K, Arakawa S, Watanabe T, Yasumo H, Ando Y, Takasaki W, et al. Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene. Drug Metab Dispos. 2007;35:2196-202 pubmed
    Glutathione S-transferase (GST) theta 1 (GSTT1) has been regarded as one of the key enzymes involved in phase II reactions because of its unique substrate specificity...
  44. Sherratt P, Manson M, Thomson A, Hissink E, Neal G, van Bladeren P, et al. Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1. Biochem J. 1998;335 ( Pt 3):619-30 pubmed
    ..The level of the GSTT1 subunit within tissues is an important determinant of susceptibility to the carcinogenic effects of these ..
  45. Strange R, Jones P, Fryer A. Glutathione S-transferase: genetics and role in toxicology. Toxicol Lett. 2000;112-113:357-63 pubmed
    ..Thus, GST genotypes alone and in combination have been linked with clinical outcome. ..
  46. Zivkovic M, Zivotić I, Dincic E, Stojković L, Vojinovic S, Stankovic A. The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. J Neurol Sci. 2013;334:6-9 pubmed publisher
    ..The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 ..
  47. Tan E, Khajavi M, Thornby J, Nagamitsu S, Jankovic J, Ashizawa T. Variability and validity of polymorphism association studies in Parkinson's disease. Neurology. 2000;55:533-8 pubmed
    ..MAOA and MAOB), catechol-O-methyltransferase (COMT), N-acetyltransferase 2 (NAT2), APOE, glutathione transferase (GSTT1, GSTM1, GSTP1, and GSTZ1), and mitochondrial genes (tRNAGlu and ND2)...
  48. Vavilin V, Chasovnikova O, Liakhovich V, Gavalov S, Riabova O. [Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma]. Vopr Med Khim. 2000;46:388-97 pubmed
    ..deletions of the glutathione S-transferase class mu and theta genes (null genotypes, GSTM1"-" and GSTT1"-", respectively)...
  49. Jemth P, Mannervik B. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. Arch Biochem Biophys. 1997;348:247-54 pubmed
    ..One of these differences causes a change in the deduced amino acid sequence and involves the nucleotide triplet encoding amino acid 126, which was determined as GAG (Glu), instead of the published GGG (Gly). ..
  50. Gra O, Kozhekbaeva Z, Litvinov V. [Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. Genetika. 2010;46:262-71 pubmed
    ..risk factors of TB development, the frequencies of polymorphisms of genes CYP1A1, CYP2D6, CYP2C9, CYP2C 19, GSTT1, GSTM1, NAT2, MDR1, and NRAMP1 in 73 TB patients and 352 healthy individuals were determined by allele-specific ..
  51. Lu Y, Shi Y, Yin J, Huang Z. Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. Gene. 2013;527:311-5 pubmed publisher
    ..In this study, we performed a meta-analysis to assess the association between GSTM1 and GSTT1 null genotypes and the risk for POAG. Published literature from PubMed and EMBASE databases was retrieved...
  52. Basu T, Gale R, Langabeer S, Linch D. Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia. Lancet. 1997;349:1450 pubmed
  53. Bohanec Grabar P, Logar D, Tomsic M, Rozman B, Dolzan V. Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis. Clin Exp Rheumatol. 2009;27:229-36 pubmed
    Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1) and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the main feature of rheumatoid arthritis (RA)...
  54. Nagle C, Chenevix Trench G, Spurdle A, Webb P. The role of glutathione-S-transferase polymorphisms in ovarian cancer survival. Eur J Cancer. 2007;43:283-90 pubmed
    ..Common polymorphisms in the glutathione-S-transferase (GSTM1, GSTP1 and GSTT1) family have been implicated in chemoresistence and ovarian cancer survival...
  55. Barahmani N, Carpentieri S, Li X, Wang T, Cao Y, Howe L, et al. Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Neuro Oncol. 2009;11:292-300 pubmed publisher
    ..We investigated the relationship between GSTM1 and GSTT1 polymorphisms and survival and toxicity in 42 children with medulloblastoma diagnosed and treated at the Texas ..
  56. Li Y, Wen F, Xiao Z, Chen Y, Zhang Z, Chen L. [Genetic polymorphism of GST gene in children with infectious mononucleosis and acute lymphocytic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2012;14:260-3 pubmed
    To study the relationship between glutathione S-transferase genes GSTT1 and GSTM1 polymorphisms and the susceptibility to infectious mononucleosis (IM) and acute lymphocytic leukemia (ALL) in children...
  57. Gisi D, Maillard J, Flanagan J, Rossjohn J, Chelvanayagam G, Board P, et al. Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants. Eur J Biochem. 2001;268:4001-10 pubmed
    ....
  58. Juronen E, Tasa G, Uuskula M, Pooga M, Mikelsaar A. Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochem Mol Biol Int. 1996;39:21-9 pubmed
    A high activity glutathione S-transferase T1-1 (GSTT1-1) towards dichloromethane was isolated from human liver cytosol and purified to homogenity in 18.5% yield with a purification factor of 4400-fold...
  59. Mainwaring G, Nash J, Davidson M, Green T. Isolation of a mouse theta glutathione S-transferase active with methylene chloride. Biochem J. 1996;314 ( Pt 2):445-8 pubmed
    ..This protein, which was sequenced from a band on a gel, was extremely labile and could not be isolated to homogeneity. The partially purified enzyme was not active with methylene chloride. ..
  60. Marson F, Bertuzzo C, Ribeiro A, Ribeiro J. Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study. BMC Med Genet. 2014;15:27 pubmed publisher
    ..We analyzed CFTR mutations, polymorphisms (GSTM1 and GSTT1 deletions, GSTP1 + 313A > G, GCLC-129C > T, and GCLC-3506A > G) in modifier genes and CF clinical ..
  61. Garcia Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, et al. Glutathione S-transferase mu and theta polymorphisms and breast cancer susceptibility. J Natl Cancer Inst. 1999;91:1960-4 pubmed
    The enzymes encoded by the glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism (mainly inactivation, but activation is possible) of a wide range of carcinogens that are ubiquitous in the ..
  62. Chung J, Oh S, Shin Y. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children. Clin Chem Lab Med. 2009;47:1475-81 pubmed publisher
    ..62, p<0.05]. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p<0.01)...