Gstp1

Summary

Gene Symbol: Gstp1
Description: glutathione S-transferase pi 1
Alias: GST-P, Gst3, Gstp, Gstp2, glutathione S-transferase P, GST 7-7, GST class-pi, Glutathione-S-transferase, placental enzyme pi type, chain 7, glutathione S-transferase, pi 2
Species: rat
Products:     Gstp1

Top Publications

  1. Harries L, Stubbins M, Forman D, Howard G, Wolf C. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis. 1997;18:641-4 pubmed
    Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus, which differ by a single base pair (A-G) substitution at nucleotide 313 of the GSTP1 cDNA...
  2. Feuillet Fieux M, Nguyen Khoa T, Loriot M, Kelly M, de Villartay P, Sermet I, et al. Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study. Clin Biochem. 2009;42:57-63 pubmed publisher
    ..However, GST activity was lower in CF children with severe clinical status and infection, and the frequency of GSTP1 wild type genotype AA, prevalent in uninfected CF children (75%), decreased in infected ones (33%)...
  3. Fryer A, Bianco A, Hepple M, Jones P, Strange R, Spiteri M. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med. 2000;161:1437-42 pubmed
    ..We describe an association study designed to examine whether allelic variation at the glutathione-S-transferase GSTP1 locus influences expression of the BHR and atopy phenotypes in asthma...
  4. Henrion Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer A, et al. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology. 2002;36:913-7 pubmed
    ..contributes to the development of liver disease, we hypothesized that 2 members of the GST superfamily, GSTM1 and GSTP1, which are expressed in the biliary epithelium, could influence the hepatic status in patients with CF...
  5. Nickel R, Haider A, Sengler C, Lau S, Niggemann B, Deichmann K, et al. Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations. Pediatr Allergy Immunol. 2005;16:539-41 pubmed
    Glutathione S-Transferase P1 (GSTP1) is an important enzyme in the detoxification of products of oxidative stress...
  6. Yin Z, Ivanov V, Habelhah H, Tew K, Ronai Z. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res. 2000;60:4053-7 pubmed
    To elucidate mechanisms underlying glutathione S-transferase p (GSTp)-mediated cellular protection against oxidative stress-induced cell death, the effect of GSTp on stress signaling pathways was investigated before and after H2O2 ..
  7. Elsby R, Kitteringham N, Goldring C, Lovatt C, Chamberlain M, Henderson C, et al. Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi. J Biol Chem. 2003;278:22243-9 pubmed
    ..to determine whether this interaction results in increased constitutive JNK activity in the absence of GSTP in GstP1/P2(-/-) mice and whether such a phenomenon leads to the up-regulation of genes that are relevant to cell defense...
  8. Vrana D, Pikhart H, Mohelnikova Duchonova B, Holcatova I, Strnad R, Slamova A, et al. The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population. Mutat Res. 2009;680:78-81 pubmed publisher
    ..study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic ..
  9. Chung J, Oh S, Shin Y. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children. Clin Chem Lab Med. 2009;47:1475-81 pubmed publisher
    ..Biomarkers for oxidative stress were also evaluated with respect to GST genotype. The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]...
  10. Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, et al. Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats. Arch Toxicol. 2010;84:319-31 pubmed publisher

Detail Information

Publications62

  1. Harries L, Stubbins M, Forman D, Howard G, Wolf C. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis. 1997;18:641-4 pubmed
    Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus, which differ by a single base pair (A-G) substitution at nucleotide 313 of the GSTP1 cDNA...
  2. Feuillet Fieux M, Nguyen Khoa T, Loriot M, Kelly M, de Villartay P, Sermet I, et al. Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study. Clin Biochem. 2009;42:57-63 pubmed publisher
    ..However, GST activity was lower in CF children with severe clinical status and infection, and the frequency of GSTP1 wild type genotype AA, prevalent in uninfected CF children (75%), decreased in infected ones (33%)...
  3. Fryer A, Bianco A, Hepple M, Jones P, Strange R, Spiteri M. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med. 2000;161:1437-42 pubmed
    ..We describe an association study designed to examine whether allelic variation at the glutathione-S-transferase GSTP1 locus influences expression of the BHR and atopy phenotypes in asthma...
  4. Henrion Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer A, et al. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology. 2002;36:913-7 pubmed
    ..contributes to the development of liver disease, we hypothesized that 2 members of the GST superfamily, GSTM1 and GSTP1, which are expressed in the biliary epithelium, could influence the hepatic status in patients with CF...
  5. Nickel R, Haider A, Sengler C, Lau S, Niggemann B, Deichmann K, et al. Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations. Pediatr Allergy Immunol. 2005;16:539-41 pubmed
    Glutathione S-Transferase P1 (GSTP1) is an important enzyme in the detoxification of products of oxidative stress...
  6. Yin Z, Ivanov V, Habelhah H, Tew K, Ronai Z. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res. 2000;60:4053-7 pubmed
    To elucidate mechanisms underlying glutathione S-transferase p (GSTp)-mediated cellular protection against oxidative stress-induced cell death, the effect of GSTp on stress signaling pathways was investigated before and after H2O2 ..
  7. Elsby R, Kitteringham N, Goldring C, Lovatt C, Chamberlain M, Henderson C, et al. Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi. J Biol Chem. 2003;278:22243-9 pubmed
    ..to determine whether this interaction results in increased constitutive JNK activity in the absence of GSTP in GstP1/P2(-/-) mice and whether such a phenomenon leads to the up-regulation of genes that are relevant to cell defense...
  8. Vrana D, Pikhart H, Mohelnikova Duchonova B, Holcatova I, Strnad R, Slamova A, et al. The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population. Mutat Res. 2009;680:78-81 pubmed publisher
    ..study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic ..
  9. Chung J, Oh S, Shin Y. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children. Clin Chem Lab Med. 2009;47:1475-81 pubmed publisher
    ..Biomarkers for oxidative stress were also evaluated with respect to GST genotype. The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]...
  10. Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, et al. Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats. Arch Toxicol. 2010;84:319-31 pubmed publisher
  11. Carroll W, Lenney W, Child F, Strange R, Jones P, Fryer A. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatr Allergy Immunol. 2005;16:32-9 pubmed
    ..We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma...
  12. Ichimura R, Mizukami S, Takahashi M, Taniai E, Kemmochi S, Mitsumori K, et al. Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model. Toxicol Appl Pharmacol. 2010;246:128-40 pubmed publisher
  13. Kavishe R, Bousema T, Shekalaghe S, Sauerwein R, Mosha F, van der Ven A, et al. Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children. Am J Trop Med Hyg. 2009;81:363-5 pubmed
    ..We studied the genotypic distribution of GSTM1, GSTT1, and GSTP1 polymorphisms between mild malaria (N = 107) and severe malarial anemia (N = 50) in Tanzanian children...
  14. Leonard M, Kieran N, Howell K, Burne M, Varadarajan R, Dhakshinamoorthy S, et al. Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J. 2006;20:2624-6 pubmed
    ..genes including aldehyde dehydrogenases (ALDH1A1 and ALDH1A7), glutathione S-transferases (GSTM5, GSTA2 and GSTP1), and NAD(P)H quinone oxidoreductase (NQO1)...
  15. Hayashi T, Ishiwatari H, Ihara H, Kawano Y, Takada K, Miyanishi K, et al. Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms. J Gastroenterol. 2009;44:964-75 pubmed publisher
    ..Although a larger scale randomized controlled study is needed in future, the present results suggest the promise of chemoprevention of carcinoma derived from BD-IPMNs by sulindac. ..
  16. Seeley S, Poposki J, Maksimchuk J, Tebbe J, Gaudreau J, Mannervik B, et al. Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. Biochim Biophys Acta. 2006;1760:1064-70 pubmed
    ..Finally, both 13-HODE and 13-OXO were shown to be inducers of GST activity in HT-29 and HCT-116 colon tumor cells. These data help to clarify the role of GST in the metabolic disposition of linoleic acid oxidation products. ..
  17. Sun K, Chang K, Clawson S, Ghosh S, Mirzaei H, Regnier F, et al. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011;118:902-14 pubmed publisher
    ..This study identified glutathione-S-transferase pi 1 (GSTP1) as a novel Cdk5 regulatory protein...
  18. Marson F, Bertuzzo C, Ribeiro A, Ribeiro J. Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study. BMC Med Genet. 2014;15:27 pubmed publisher
    ..We analyzed CFTR mutations, polymorphisms (GSTM1 and GSTT1 deletions, GSTP1 + 313A > G, GCLC-129C > T, and GCLC-3506A > G) in modifier genes and CF clinical severity as assessed by ..
  19. Panasevich S, Lindgren C, Kere J, Wickman M, Pershagen G, Nyberg F, et al. Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. Clin Exp Allergy. 2010;40:458-67 pubmed publisher
    ..We studied whether variations in single nucleotide polymorphisms (SNPs) in the TNF, glutathione S transferase P1 (GSTP1) and beta2-adrenoreceptor (ADRB2) genes modify the effect of early maternal smoking on the development of ..
  20. Wylie Modro S, Holt D, Harvey D, Hurley R. The presence and significance of the Pi class glutathione S-transferase isoenzyme in cerebrospinal fluid during the course of meningitis in children. Pediatr Res. 1997;42:232-6 pubmed
    ..We conclude that 1) initial high levels of CSF Pi class GST may be an indicator of the severity of inflammation and thus of prognostic significance and 2) only one Pi class GST occurs in brain tissue. ..
  21. Yu D, Hsieh D, Chang S. Increasing expression of GST-pi MIF, and ID1 genes in chemoresistant prostate cancer cells. Arch Androl. 2006;52:275-81 pubmed
    ..AT3/ADR1000 drug-resistant PCa cells displayed significantly increased expression of GST-pi, MIF, and ID1 proteins when compared with native PCa cells. It indicates these genes may play a role in drug resistance of prostate cancer. ..
  22. Lo Bello M, Nuccetelli M, Caccuri A, Stella L, Parker M, Rossjohn J, et al. Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme. J Biol Chem. 2001;276:42138-45 pubmed
  23. Spiteri M, Bianco A, Strange R, Fryer A. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy. 2000;55 Suppl 61:15-20 pubmed
    ..Our case-control studies show that polymorphisms at the glutathione S-transferase, GSTP1, locus on chromosome 11q13 may account for variation in host response to oxidative stress, a key component of ..
  24. LeCluyse E, Ahlgren Beckendorf J, Carroll K, Parkinson A, Johnson J. Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations. Toxicol In Vitro. 2000;14:101-15 pubmed
    ..Moreover, the matrix and medium conditions influence both the basal and inducible expression of GST subunits in cultured rat hepatocytes. ..
  25. Fan Y, Shimizu T, Yamada T, Nanashima N, Akita M, Asano J, et al. Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis. Cancer Sci. 2008;99:497-501 pubmed
    ..These results showed development of GST-P-negative foci during the early stage of hepatocarcinogenesis and suggested that Nrf2 is not responsible for GST-P expression in rat hepatic preneoplastic foci. ..
  26. Kilfoy B, Zheng T, Lan Q, Han X, Qin Q, Rothman N, et al. Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma. Am J Hematol. 2009;84:279-82 pubmed publisher
    ..An increased risk of DLBCL in nonsmokers was associated with the variant G allele for GSTP1 (OR = 1.6, 95% CI 1.0-2.3) and CYP1A1 (OR = 2.4; 95% CI 1.0-5...
  27. Fietta A, Bardoni A, Salvini R, Passadore I, Morosini M, Cavagna L, et al. Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis. Arthritis Res Ther. 2006;8:R160 pubmed
    ..Whereas levels of glutathione S-transferase P (GSTP), Cu-Zn superoxide dismutase (SOD) and cystatin SN were downregulated in SScFib+ patients compared with SScFib- ..
  28. Yokomizo A, Yamamoto K, Kinukawa N, Tsunoda T, Koga H, Naito S. Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy. Int J Urol. 2007;14:500-4 pubmed
    Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin...
  29. Imboden M, Rochat T, Brutsche M, Schindler C, Downs S, Gerbase M, et al. Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults. Thorax. 2008;63:322-8 pubmed
    ..The relationship of these two risk factors with adult onset asthma in the general population was investigated. GSTP1 Ile105Val single nucleotide polymorphism and GSTM1 and GSTT1 gene deletion polymorphisms were genotyped in the ..
  30. Price R, Scott M, Walters D, Stierum R, Groten J, Meredith C, et al. Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes. Food Chem Toxicol. 2004;42:899-908 pubmed
    ..In addition, TB and BHT markedly induced GSTP1 mRNA levels, but had only a small effect on GSTT1 mRNA levels...
  31. Sanches L, Santos S, Carvalho J, Jeronimo G, Favaro W, Reis M, et al. Protective effect of ?-tocopherol-enriched diet on N-methyl-N-nitrosourea-induced epithelial dysplasia in rat ventral prostate. Int J Exp Pathol. 2013;94:362-72 pubmed publisher
    ..The gelatinolytic activity of pro-MMP-9 returned to the levels observed for the CT group. These results suggest that ?-tocopherol acts as a protective agent against MNU-induced prostatic disorders in the rat ventral prostate...
  32. Nagar R, Khan A, Poonia A, Mishra P, Singh S. Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1. Eur J Drug Metab Pharmacokinet. 2015;40:45-51 pubmed publisher
    ..Using cisplatin as the prototype drug, we investigated if any correlation exists between GSH levels, GSTs/GSTP1 activity and the fate of cisplatin in different organs of Rattus norvegicus...
  33. Satoh K. Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation. Life Sci. 2018;200:42-48 pubmed publisher
    ..A new physiological mechanism was hypothesized for the induction of preneoplastic cell populations in the rat liver instead of a genetic mechanism. ..
  34. Rushmore T, Harris L, Nagai M, Sharma R, Hayes M, Cameron R, et al. Purification and characterization of P-52 (glutathione S-transferase-P or 7-7) from normal liver and putative preneoplastic liver nodules. Cancer Res. 1988;48:2805-12 pubmed
    ..Antibodies to P-52 are proving to be useful as a marker of new cell populations that appear regularly during hepatocarcinogenesis. ..
  35. Gao P, Yang X, Xue Y, Zhang X, Wang Y, Liu W, et al. Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression. Cancer. 2009;115:3222-32 pubmed publisher
    The presence of glutathione S-transferase (GST) pi1 (GSTP1) or multidrug resistance gene 1 (MDR1) promoter methylation in lung cancer was studied for the first time to the authors' knowledge; and, to date, the clinical significance of ..
  36. Schultz E, Devadason S, Khoo S, Zhang G, Bizzintino J, Martin A, et al. The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma. J Asthma. 2010;47:1049-56 pubmed publisher
    ..To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity...
  37. Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir M, Warholm M, et al. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci U S A. 1985;82:7202-6 pubmed
    ..It is suggested that the similarities of the isoenzymes in a class reflect evolutionary relationships and that the classification applies generally. ..
  38. Oyama K, Shiota G, Ito H, Murawaki Y, Kawasaki H. Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats. Carcinogenesis. 2002;23:885-92 pubmed
    ..The data of the present study suggest that UDCA treatment reduces hepatocarcinogenesis via inducing apoptosis of 'initiated hepatocytes' as well as inhibiting proliferation. ..
  39. Shimizu I, Yasuda M, Mizobuchi Y, Ma Y, Liu F, Shiba M, et al. Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats. Gut. 1998;42:112-9 pubmed
    ..It appears that oestrogen receptors may be involved in the inhibition of malignant transformation of preneoplastic liver cells, while androgens and androgen receptors are involved in hepatocarcinogenesis. ..
  40. Reichard J, Vasiliou V, Petersen D. Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Biochim Biophys Acta. 2000;1487:222-32 pubmed
    ..S-transferase (GST) was similar in both cell lines, though differential cell specific expressions of GST isoforms GSTP1-1 and GSTA4-4 were observed...
  41. Manar M, Brown M, Gauthier T, Brown L. Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia. J Perinatol. 2004;24:30-5 pubmed
    ..04) and more likely to possess the less efficient ile isoform (OR 4.5, CI: 1.0-20.7, p=0.05). This pilot study suggests that BPD is associated with the presence of the GST-P1 105ile allele. Future prospective studies are warranted. ..
  42. Wang Y, Wu M, Hong C, Lien L, Hsieh Y, Tseng H, et al. Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. Atherosclerosis. 2007;192:305-12 pubmed
    ..The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3...
  43. Wang T, Arifoglu P, Ronai Z, Tew K. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem. 2001;276:20999-1003 pubmed
    ..pathways are regulated endogenously in part by protein-protein interactions with glutathione S-transferase P1-1 (GSTP1-1) ()...
  44. Luo L, Wang Y, Feng Q, Zhang H, Xue B, Shen J, et al. Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice. Mol Immunol. 2009;46:848-57 pubmed publisher
    We have reported that intracellular glutathione S-transferases P1 (GSTP1) suppresses LPS (lipopolysaccharide)-induced excessive production of pro-inflammatory factors by inhibiting LPS-stimulated MAPKs (mitogen-activated protein kinases) ..
  45. Crawford E, Khuder S, Durham S, Frampton M, Utell M, Thilly W, et al. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res. 2000;60:1609-18 pubmed
    ..0, 6.11), GSTM3 (0.29, 0.09), combined GSTM1,2,4,5 (0.98, 0.60), GSTT1 (0.84, 0.76), GSTP1 (287, 110), GSHPx (140, 62.1), and GSHPxA (0.43, 0.34)...
  46. Tremblay S, Pintor Dos Reis P, Bradley G, Galloni N, Perez Ordonez B, Freeman J, et al. Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes. Arch Otolaryngol Head Neck Surg. 2006;132:958-66 pubmed
    ..OSCCs) from young (</=40 years) and older (>/=60 years) patients have differential expression levels of GSTP1, FANCA, FANCC, FANCD2, and FANCG...
  47. Mir O, Alexandre J, Tran A, Durand J, Pons G, Treluyer J, et al. Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity. Ann Oncol. 2009;20:736-40 pubmed publisher
    ..The GSTM1 (null), GSTT1 (null) and GSTP1 (Ile(105)Val and Ala(114)Val) polymorphisms were determined in a cohort of cancer patients treated with docetaxel ..
  48. Xue B, Wu Y, Yin Z, Zhang H, Sun S, Yi T, et al. Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells. FEBS Lett. 2005;579:4081-7 pubmed
    Glutathione S-transferase P1(GSTP1) plays an important role in the detoxification and xenobiotics metabolism. Here, we show that GSTP1 is also involved in LPS (lipopolysaccharide)-induced inflammatory response...
  49. Zusterzeel P, te Morsche R, Raijmakers M, Roes E, Peters W, Steegers E. Paternal contribution to the risk for pre-eclampsia. J Med Genet. 2002;39:44-5 pubmed
  50. Ichikawa K, Tagawa Y, Kawai M, Asamoto M, Shirai T. Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats. J Toxicol Pathol. 2010;23:125-31 pubmed publisher
    ..The results suggest that hepatic preneoplastic lesions initiated with DEN are promoted by STZ treatment-inducing diabetes. ..
  51. Zachaki S, Stavropoulou C, Kalomoiraki M, Koromila T, Daraki A, Manola K, et al. Association of A(313)G glutathione S-transferase P1 germline polymorphism with susceptibility to de novo myelodysplastic syndrome. Leuk Lymphoma. 2013;54:1756-61 pubmed publisher
    ..b>GSTP1 enzyme plays a key role in the biotransformation of a variety of carcinogens...
  52. Pandey S, Jain M, Nigam P, Choudhuri G, Mittal B. Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India. Biomarkers. 2006;11:250-61 pubmed
    ..with risk of gallbladder cancer, the distribution of polymorphisms in the GST family of genes (GSTT1, GSTM1, GSTP1, and GSTM3) were studied in 106 cancer patients and 201 healthy controls...
  53. Stanulla M, Schrappe M, Brechlin A, Zimmermann M, Welte K. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Blood. 2000;95:1222-8 pubmed
    ..In a case-control study, we investigated the association between polymorphisms within the GSTM1, GSTT1, and GSTP1 genes and risk of relapse in childhood acute lymphoblastic leukemia (ALL). Cases were relapsed patients...
  54. Wenten M, Li Y, Lin P, Gauderman W, Berhane K, Avol E, et al. In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren. Pediatrics. 2009;123:1344-51 pubmed publisher
    The GSTP1 Ile105Val variant and secondhand tobacco smoke exposure have been independently associated with acute respiratory illness; however, susceptibility to in utero and secondhand tobacco smoke has yet to be examined in relation to ..
  55. Lin J, Chang S, Hsieh D, Lee C, Yu D. The association of Id-1, MIF and GSTpi with acquired drug resistance in hormone independent prostate cancer cells. Oncol Rep. 2005;13:983-8 pubmed
    ..Our findings suggest that overproduction of the Id-1, MIF and GSTpi proteins and coinduction of mdr-1 play an important role in the development of acquired drug resistance to various drugs of prostate cancer cells. ..
  56. Cote M, Yoo W, Wenzlaff A, Prysak G, Santer S, Claeys G, et al. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis. 2009;30:626-35 pubmed publisher
    ..Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, GSTT1 and GSTP1 Ile105Val. Lung cancer risk associated with individual SNPs was seen for GSTP1 [A allele; odds ratio (OR) = 1...
  57. Spalletta G, Bernardini S, Bellincampi L, Federici G, Trequattrini A, Ciappi F, et al. Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. Am J Geriatr Psychiatry. 2007;15:879-87 pubmed
    ..76, df = 2, 96, p = 0.0043). Carriers of GSTP1 *C allelic variant had a faster decline in cognitive functions (repeated measures analysis of variance [ANOVA]: F =..
  58. Peng D, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S, et al. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis. 2006;27:1160-8 pubmed
    ..PCR (MSP) to evaluate the DNA methylation status of the p14, p15, p16, p73, APC, hMLH1, MGMT, BRCA1, GSTP1, TIMP-3, CDH1 and DAPK-1 genes...
  59. Suzuki Y, Umemura T, Hibi D, Inoue T, Jin M, Ishii Y, et al. Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats. Arch Toxicol. 2012;86:1593-601 pubmed publisher
    ..These results indicate that ES could be a possible genotoxic hepatocarcinogen in the rat, at least when given at high doses. ..
  60. Menegon A, Board P, Blackburn A, Mellick G, Le Couteur D. Parkinson's disease, pesticides, and glutathione transferase polymorphisms. Lancet. 1998;352:1344-6 pubmed
    ..We genotyped by PCR polymorphisms in four GST classes (GSTM1, GSTT1, GSTP1, and GSTZ1) in 95 Parkinson's disease patients and 95 controls...
  61. Ruscoe J, Rosario L, Wang T, Gate L, Arifoglu P, Wolf C, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001;298:339-45 pubmed
    ..Mouse embryo fibroblasts (MEFs) isolated from mice with a GSTP1-1 [glutathione S-transferase P1-1 (isozyme in nonhepatic tissue)] null genotype (GSTpi(-/-)) doubled their ..
  62. Singh N, Banerjee B, Bala K, Basu M, Chhillar N. Polymorphism in Cytochrome P450 2D6, Glutathione S-Transferases Pi 1 Genes, and Organochlorine Pesticides in Alzheimer Disease: A Case-Control Study in North Indian Population. J Geriatr Psychiatry Neurol. 2014;27:119-27 pubmed publisher
    ..study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD...