Gene Symbol: Gstm5
Description: glutathione S-transferase, mu 5
Alias: glutathione S-transferase Mu 5, GST class-mu 5
Rowe J, Patskovsky Y, Patskovska L, Novikova E, Listowsky I. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis. J Biol Chem. 1998;273:9593-601 pubmed
..The identification of this unique mammalian GST subclass could advance strategies for interspecies comparisons of GSTs and provides a rodent model for studies on functions and regulatory mechanisms for human GSTs. ..
Nakamura N, Mori C, Eddy E. Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5. Biol Reprod. 2010;82:504-15 pubmed publisher
..In subsequent yeast two-hybrid screens, the TSR was found to interact with glutathione S-transferase mu class 5 (GSTM5), identified previously as a spermatogenic cell-specific component of the FS...
Patskovsky Y, Patskovska L, Listowsky I. An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Biochemistry. 1999;38:16187-94 pubmed
..The presence of a polar Asn212 in place of a Phe residue found in the cognate position of other mu class glutathione S-transferases, therefore, has a marked influence on catalysis by hGSTM3-3. ..
Strange R, Jones P, Fryer A. Glutathione S-transferase: genetics and role in toxicology. Toxicol Lett. 2000;112-113:357-63 pubmed
..Thus, GST genotypes alone and in combination have been linked with clinical outcome. ..
Krisfalusi M, Miki K, Magyar P, O Brien D. Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol Reprod. 2006;75:270-8 pubmed
..These data support a role for the fibrous sheath as a scaffold for anchoring multiple glycolytic enzymes along the length of the flagellum to provide a localized source of ATP that is essential for sperm motility. ..
Rao A, Shaha C. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. FEBS Lett. 2001;507:174-80 pubmed
..Isoform composition of the germ cell plasma membrane and the cytosolic pool differ, GSTM5 and GSTPi being absent on the plasma membranes...
Yang G, Ross D, Kuang W, Brown P, Weigel R. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 1999;27:1517-23 pubmed
..This approach allowed the identification of differentially expressed genes without the need to obtain previously cloned cDNAs. ..
Maes O, Schipper H, Chong G, Chertkow H, Wang E. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Neurobiol Aging. 2010;31:34-45 pubmed publisher
..Reduced antioxidant defense and genome maintenance associated with the GSTM3 polymorphism suggest a common hub of regulatory networks which, when impaired, may lead to AD. ..
Ross V, Board P. Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochem J. 1993;294 ( Pt 2):373-80 pubmed
..In general, the recombinant enzyme has relatively low activity when compared with all the previously described human Mu class GST isoenzymes. ..