Gsn

Summary

Gene Symbol: Gsn
Description: gelsolin
Alias: gelsolin, ADF, actin-depolymerizing factor, brevin
Species: rat
Products:     Gsn

Top Publications

  1. Apostolova M, Christova T, Templeton D. Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton. Toxicol Sci. 2006;89:465-74 pubmed
    ..We examined the effect of Cd2+ on the distribution of the actin-severing protein, gelsolin. Over 8 h, CdCl2 (10 microM) caused a progressive shift of gelsolin from a diffuse perinuclear and cytoplasmic ..
  2. Smith D, Janmey P, Lind S. Circulating actin-gelsolin complexes following oleic acid-induced lung injury. Am J Pathol. 1988;130:261-7 pubmed
    Plasma gelsolin is one of two extracellular proteins that bind actin, a major body protein, with high affinity...
  3. Kwiatkowski D, Stossel T, Orkin S, Mole J, Colten H, Yin H. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature. 1986;323:455-8 pubmed
    b>Gelsolin is representative of a class of actin-modulating proteins found in lower eukaryotes to mammals, which sever actin filaments...
  4. Huff M, Page L, Balch W, Kelly J. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. J Mol Biol. 2003;334:119-27 pubmed
    ..Mutation of aspartic acid 187 to asparagine (D187N) or tyrosine (D187Y) in domain 2 of the actin-modulating protein gelsolin causes the neurodegenerative disease familial amyloidosis of Finnish type (FAF)...
  5. Witke W, Li W, Kwiatkowski D, Southwick F. Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol. 2001;154:775-84 pubmed
    ..The in vivo function of CapG, a calcium-sensitive barbed end capping protein and member of the gelsolin/villin family, has been assessed using a null Capg allele engineered into mice...
  6. De Clercq S, Boucherie C, Vandekerckhove J, Gettemans J, Guillabert A. L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. PLoS ONE. 2013;8:e78108 pubmed publisher
    ..appear as dot-like structures at the ventral cell surface, enriched in F-actin and actin regulators, including gelsolin and L-plastin...
  7. Jordan J, Moore E, Damle S, Eckels P, Johnson J, Roach J, et al. Gelsolin is depleted in post-shock mesenteric lymph. J Surg Res. 2007;143:130-5 pubmed
    b>Gelsolin is a plasma protein that functions to depolymerize actin filaments preventing capillary plug formation following tissue injury...
  8. Mejillano M, Kojima S, Applewhite D, Gertler F, Svitkina T, Borisy G. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell. 2004;118:363-73 pubmed
    ..The knockdown phenotype was rescued by a CP mutant refractory to shRNA, but not by another barbed-end capper, gelsolin, demonstrating that the phenotype was specific for CP...
  9. Asch H, Head K, Dong Y, Natoli F, Winston J, Connolly J, et al. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Cancer Res. 1996;56:4841-5 pubmed
    Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors...

More Information

Publications40

  1. Van Impe K, Hubert T, De Corte V, Vanloo B, Boucherie C, Vandekerckhove J, et al. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. Traffic. 2008;9:695-707 pubmed publisher
    ..Thus, a ubiquitously expressed protein shuttles to the nucleus through direct association with NTF2 and Ran. The role of NTF2 may therefore not be solely confined to sustaining the Ran gradient in cells. ..
  2. Neubauer K, Baruch Y, Lindhorst A, Saile B, Ramadori G. Gelsolin gene expression is upregulated in damaged rat and human livers within non-parenchymal cells and not in hepatocytes. Histochem Cell Biol. 2003;120:265-75 pubmed
    b>Gelsolin, a 90-kDa protein, was suggested to be involved in cell motility, to inhibit apoptosis and to have a protective role for tissue...
  3. Dong J, Ying G, Liu X, Wang W, Wang Y, Ni Z, et al. Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation. Hippocampus. 2006;16:91-100 pubmed
    b>Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities...
  4. Lena J, Legrand C, Faivre Sarrailh C, Sarlieve L, Ferraz C, Rabie A. High gelsolin content of developing oligodendrocytes. Int J Dev Neurosci. 1994;12:375-86 pubmed
    The actin-binding protein gelsolin that severs and caps the actin microfilaments under the control of the cytoplasmic free calcium and the membranous phosphatidylinositol 4,5-bisphosphate, is essentially restricted to the oligodendroglia ..
  5. Wen J, Garg N. Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats. Mol Cell Proteomics. 2012;11:M111.010918 pubmed publisher
    ..electrophoresis results by Western blotting, and demonstrated that the disease-associated increased expression of gelsolin and vimentin and release of cardiac MYL2 in the plasma of chagasic rats was returned to control level by PBN/BZ ..
  6. Chumnarnsilpa S, Lee W, Nag S, Kannan B, Larsson M, Burtnick L, et al. The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. Proc Natl Acad Sci U S A. 2009;106:13719-24 pubmed publisher
    Adseverin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Adseverin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from gelsolin (G1-G6)...
  7. Matsushita K, Meng W, Wang X, Asahi M, Asahi K, Moskowitz M, et al. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab. 2000;20:396-404 pubmed
    ..Western blots showed cleavage of the cytosolic caspase substrate gelsolin. The density of TUNEL-positive cells at 24 and 48 hours after hemorrhage was significantly reduced by treatment ..
  8. Yamaguchi Y, Miyagi Y, Baba H. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. J Neurosci Res. 2008;86:766-75 pubmed
  9. Page L, Suk J, Bazhenova L, Fleming S, Wood M, Jiang Y, et al. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc Natl Acad Sci U S A. 2009;106:11125-30 pubmed publisher
    ..is a systemic amyloid disease associated with the deposition of proteolytic fragments of mutant (D187N/Y) plasma gelsolin. We report a mouse model of FAF featuring a muscle-specific promoter to drive D187N gelsolin synthesis...
  10. Levy E, Haltia M, Fernandez Madrid I, Koivunen O, Ghiso J, Prelli F, et al. Mutation in gelsolin gene in Finnish hereditary amyloidosis. J Exp Med. 1990;172:1865-7 pubmed
    ..The novel amyloid fibril protein found in these patients is a degradation fragment of gelsolin, an actin-binding protein...
  11. Shao Z, Lee X, Huang G, Sheng G, Henderson C, Louvard D, et al. LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway. J Neurosci. 2017;37:3127-3137 pubmed publisher
    ..discovered that anti-LINGO-1 antibody-promoted OPC differentiation was accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing protein involved in the depolymerization of actin filaments...
  12. Nie D, Chen Z, Ebrahimi Fakhari D, Di Nardo A, Jülich K, Robson V, et al. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015;35:10762-72 pubmed publisher
    ..b>Gelsolin, a known target of Atf3 transcriptional activity, is also upregulated...
  13. Ji L, Chauhan A, Chauhan V. Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein. Neuroreport. 2008;19:463-6 pubmed publisher
    b>Gelsolin exists as secretory (plasma) and cytoplasmic forms. We have reported that plasma gelsolin binds to amyloid beta-protein (Abeta), and inhibits its fibrillization...
  14. Xie G, Wang C, Zhou C, Li H, Zhang X, Zhou X, et al. Expression of Cytoplasmic Gelsolin in Rat Brain After Experimental Subarachnoid Hemorrhage. Cell Mol Neurobiol. 2015;35:723-31 pubmed publisher
    ..b>Gelsolin (GSN) is a Ca(2+)-dependent actin filament severing, capping, and nucleating protein, as well as multifunctional ..
  15. Arora P, Wang Y, Bresnick A, Dawson J, Janmey P, McCulloch C. Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions. Mol Biol Cell. 2013;24:734-47 pubmed publisher
    ..collagen substrate topography, free intracellular calcium ion concentration ([Ca(2+)]i, and the association of gelsolin with nonmuscle myosin IIA (NMMIIA) at collagen adhesions are regulated to enable collagen phagocytosis...
  16. Noda Y, Horikawa S, Katayama Y, Sasaki S. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem Biophys Res Commun. 2005;330:1041-7 pubmed
    ..regulatory light chain smooth muscle isoforms 2-A and 2-B, alpha-tropomyosin 5b, annexin A2 and A6, scinderin, gelsolin, alpha-actinin 4, alpha-II spectrin, and myosin heavy chain nonmuscle type A...
  17. Ahn J, Jang I, Kim D, Cho K, Park Y, Kim K, et al. Aging-associated increase of gelsolin for apoptosis resistance. Biochem Biophys Res Commun. 2003;312:1335-41 pubmed
    b>Gelsolin, a Ca(2+)-dependent actin regulatory protein, was recently suggested to participate in apoptosis regulation...
  18. Natale J, Ahmed F, Cernak I, Stoica B, Faden A. Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. J Neurotrauma. 2003;20:907-27 pubmed
    ..such as ATF3 and lysosomal membrane glycoprotein 2, and to neuroprotection including lipocortin 1, calponin 3, gelsolin, Id-1, and p45 NF-E2...
  19. Liu Y, Templeton D. Involvement of CaMK-II? and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells. J Cell Physiol. 2013;228:78-86 pubmed publisher
    ..The actin capping and severing protein, gelsolin, translocates to the cytoskeleton in the presence of Cd(2+) , dependent upon the phosphorylation of CaMK-II, and ..
  20. Yeh Y, Hu W, Ting W, Shen C, Hsu H, Chung L, et al. Hypoxia Augments Increased HIF-1? and Reduced Survival Protein p-Akt in Gelsolin (GSN)-Dependent Cardiomyoblast Cell Apoptosis. Cell Biochem Biophys. 2016;74:221-8 pubmed publisher
    ..b>Gelsolin (GSN) is one of the actin-binding proteins...
  21. Efebera Y, Sturm A, Baack E, Hofmeister C, Satoskar A, Nadasdy T, et al. Novel gelsolin variant as the cause of nephrotic syndrome and renal amyloidosis in a large kindred. Amyloid. 2014;21:110-2 pubmed publisher
    ..type (FAF) is a rare type of autosomal dominant hereditary amyloidosis associated with genetic variants of gelsolin. Three amyloidogenic mutations have previously been reported characteristically presenting with ophthalmologic ..
  22. García Expósito L, Ziglio S, Barroso González J, de Armas Rillo L, Valera M, Zipeto D, et al. Gelsolin activity controls efficient early HIV-1 infection. Retrovirology. 2013;10:39 pubmed publisher
    ..Here we show that gelsolin restructures cortical F-actin during HIV-1 Env-gp120-mediated signalling, without affecting cell-surface ..
  23. Kim J, Lee J, Heynen Genel S, Suyama E, Ono K, Lee K, et al. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature. 2010;464:1048-51 pubmed publisher
    ..Our results uncover a critical regulatory step that couples actin dynamics and endocytic recycling with ciliogenesis, and also provides potential target molecules for future study. ..
  24. Solomon J, Yonemoto I, Murray A, PRICE J, Powers E, Balch W, et al. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry. 2009;48:11370-80 pubmed publisher
    Familial amyloidosis of Finnish type (FAF), or gelsolin amyloidosis, is a systemic amyloid disease caused by a mutation (D187N/Y) in domain 2 of human plasma gelsolin, resulting in domain 2 misfolding within the secretory pathway...
  25. Rabie A, Ferraz C, Clavel M, Legrand C. Gelsolin immunoreactivity and development of the tectorial membrane in the cochlea of normal and hypothyroid rats. Cell Tissue Res. 1988;254:241-5 pubmed
    b>Gelsolin was localized by immunocytochemistry in the developing cochlea of the rat...
  26. Chaponnier C, Kocher O, Gabbiani G. Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. An immunohistochemical and biochemical study. Eur J Biochem. 1990;190:559-65 pubmed
    b>Gelsolin is a Ca2+ and polyphosphoinositol-phospholipid regulated modulator of actin polymerization present in most mammalian cells and in plasma...
  27. Garcia Rodriguez S, Arguelles S, Llopis R, Murillo M, Machado A, Carreras O, et al. Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid. Free Radic Biol Med. 2003;35:428-37 pubmed
    ..supplementation with folic acid to alcoholic mother rats prevented EF-2, RhoGDI-1, ER-60 protease, and gelsolin depletion...
  28. Mazumdar B, Meyer K, Ray R. N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism. PLoS ONE. 2012;7:e44461 pubmed publisher
    ..shown that antibodies raised against a peptide derived from a linear B-cell epitope in the N-terminal region of gelsolin identified a gelsolin fragment in IHH CM...
  29. Beaulieu V, Da Silva N, Pastor Soler N, Brown C, Smith P, Brown D, et al. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005;280:8452-63 pubmed
    ..now report that modulation of the actin cytoskeleton by the calcium-activated actin-capping and -severing protein gelsolin plays a key role in regulating vacuolar H(+)-ATPase (V-ATPase) recycling...
  30. Mileo A, Abbruzzese C, Vico C, Bellacchio E, Matarrese P, Ascione B, et al. The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin. Carcinogenesis. 2013;34:2424-33 pubmed publisher
    ..We identified a novel cellular partner for the viral oncoprotein: the actin-binding protein gelsolin (GSN), a key regulator of actin filament assembly and disassembly...
  31. Guttman J, Janmey P, Vogl A. Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells. J Cell Sci. 2002;115:499-505 pubmed
    The gelsolin-phosphoinositide pathway may be part of the normal mechanism by which Sertoli cells regulate sperm release and turnover of the blood-testis barrier...