Gsk3b

Summary

Gene Symbol: Gsk3b
Description: glycogen synthase kinase 3 beta
Alias: glycogen synthase kinase-3 beta, GSK-3 beta, factor A, serine/threonine-protein kinase GSK3B
Species: rat

Top Publications

  1. pmc Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
    C L Lin
    Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Death Differ 18:1651-63. 2011
  2. ncbi Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection
    Makoto Hashimoto
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0624, USA
    J Biol Chem 277:32985-91. 2002
  3. pmc The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
    Hui Jye Chen
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1933-45. 2006
  4. ncbi A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons
    Erzsebet Szatmari
    Kentucky Spinal Cord Injury Research Center, University of Louisville, KY 40292, USA
    J Biol Chem 280:37526-35. 2005
  5. ncbi Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling
    Ziva Liberman
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 280:4422-8. 2005
  6. ncbi Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
  7. pmc Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity
    Bhupinder P S Vohra
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:9458-68. 2007
  8. pmc Molecular cloning and expression of glycogen synthase kinase-3/factor A
    J R Woodgett
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 9:2431-8. 1990
  9. ncbi Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    D A Cross
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    Nature 378:785-9. 1995
  10. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000

Research Grants

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. pmc Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
    C L Lin
    Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Death Differ 18:1651-63. 2011
    ..Thus, acute upstream Zn(2+)(i) chelation at the start of reperfusion and the use of natural products, that is, flavonoids, may be beneficial in the treatment of cardiac I/R injury...
  2. ncbi Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection
    Makoto Hashimoto
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0624, USA
    J Biol Chem 277:32985-91. 2002
    ..Taken together these results suggest that neuroprotective effects of FGF1 might involve inactivation of GSK3beta by a pathway involving activation of the PI3K-Akt cascades...
  3. pmc The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
    Hui Jye Chen
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1933-45. 2006
    ..These results suggest a new role of MACF1 in the Wnt signaling pathway...
  4. ncbi A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons
    Erzsebet Szatmari
    Kentucky Spinal Cord Injury Research Center, University of Louisville, KY 40292, USA
    J Biol Chem 280:37526-35. 2005
    ..The excessive activation of NR2B-PP1-GSK3beta-PP1 circuitry may contribute to the deficits of CREB-dependent neuronal plasticity in neurodegenerative diseases...
  5. ncbi Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling
    Ziva Liberman
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 280:4422-8. 2005
    ..In summary, our studies identify Ser332 as the GSK-3 phosphorylation target in IRS-1, indicating its physiological relevance and demonstrating its novel inhibitory role in insulin signaling...
  6. ncbi Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
    ....
  7. pmc Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity
    Bhupinder P S Vohra
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:9458-68. 2007
    ....
  8. pmc Molecular cloning and expression of glycogen synthase kinase-3/factor A
    J R Woodgett
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 9:2431-8. 1990
    ..Partial purification of GSK-3 activity from bovine brain results in the isolation of active alpha and beta proteins. The physiological importance of these two proteins in cellular signal transduction is discussed...
  9. ncbi Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    D A Cross
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    Nature 378:785-9. 1995
    ..Like the inhibition of GSK3 (refs 10, 14), the activation of PKB is prevented by inhibitors of phosphatidylinositol (PI) 3-kinase...
  10. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
    ..Thus, GSK-3beta facilitates NF-kappaB function...
  11. ncbi Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons
    N Tong
    Center for Ageing and Developmental Biology, Aab Biomedical Institute, University of Rochester Medical Center, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Eur J Neurosci 13:1913-22. 2001
    ..induces neuronal apoptosis in cultured cerebellar granule neurons (CGNs) in part by activating glycogen synthase kinase 3 beta (GSK-3beta)...
  12. ncbi GSK3beta signalling: casting a wide net in Alzheimer's disease
    Ratan V Bhat
    AstraZeneca R and D, SE 151 85 Södertälje, Sweden
    Neurosignals 11:251-61. 2002
    ..The present review focuses on recent developments in the understanding of GSK3beta with an emphasis on events likely to be critical to the pathophysiology of AD...
  13. ncbi Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 421:753-6. 2003
    ..We conclude that Cdc42 regulates cell polarity through the spatial regulation of GSK-3beta and Apc. This role for Apc may contribute to its tumour-suppressor activity...
  14. pmc Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling
    Joseph F Sanchez
    Program in Genetics, Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Cell Biol 23:4649-62. 2003
    ..These findings therefore implicate GSK-3beta as a regulator of NF-kappaB activation in astrocytes and suggest that the pro-apoptotic effects of GSK-3beta may be mediated at least in part through the inhibition of NF-kappaB pathway...
  15. ncbi Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators
    Hui Jiang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, The Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell 120:123-35. 2005
    ....
  16. ncbi Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta
    Masahiro Nishihara
    Second Dept of Internal Medicine, Sapporo Medical Univ School of Medicine, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 291:H748-55. 2006
    ..0 +/- 2.0% by 1.2 mg/kg SB). These results suggest that EPO and PC afford additive infarct size-limiting effects by additive phosphorylation of GSK-3beta at the time of reperfusion by Akt-dependent and -independent mechanisms...
  17. ncbi Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats
    Hidenori Endo
    Department of Neurosurgery, and Program in Neurosciences, Stanford University School of Medicine, 1201 Welch Rd, MSLS P314, Stanford, California 94305 5487, USA
    Stroke 37:2140-6. 2006
    ..The Akt/glycogen synthase kinase-3beta (GSK3beta) pathway plays an important role in the cell death/survival pathway after a variety of cell death stimuli. However, its role in acute brain injury after SAH remains unknown...
  18. ncbi P2 purinergic receptors signal to glycogen synthase kinase-3beta in astrocytes
    Joseph T Neary
    Research Service, Miami VA Healthcare System, Miami, Florida
    J Neurosci Res 84:515-24. 2006
    ..These findings suggest that purinergic signaling contributes to the regulation of GSK3beta functions, one of which may be the response of astrocytes to CNS injury on release of ATP...
  19. ncbi Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats
    Soo Joo Lee
    Department of Anatomy, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Neurosci Lett 409:134-9. 2006
    ....
  20. ncbi Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1
    R J Vaidya
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Cell Mol Life Sci 63:2871-9. 2006
    ..Thus, our results indicate that sustained activation of Akt in response to polyamine depletion inhibits migration through GSK-3beta and Rac1...
  21. ncbi Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone
    Martin H Maurer
    Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    J Proteome Res 6:1198-208. 2007
    ....
  22. ncbi Glycogen synthase kinase 3: a key regulator of cellular fate
    J E Forde
    Biomedical Sciences Building, Cardiff School of Biosciences, Museum Avenue, CF10 3US, Cardiff, UK
    Cell Mol Life Sci 64:1930-44. 2007
    ..The details of these mechanisms will be discussed in the context of specific signalling pathways...
  23. ncbi Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection
    Masahiro Nishihara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1 W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Mol Cell Cardiol 43:564-70. 2007
    ..These results suggest that reduction in affinity of ANT to cyclophilin D by increased phospho-GSK-3beta binding to ANT may be responsible for suppression of mPTP opening and myocardial protection afforded by IPC+EPO...
  24. pmc The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death
    Vesa Hongisto
    Turku Centre for Biotechnology, Turku University and Abo Akademi University, BioCity, Tykistokatu 6, Turku FIN 20521, Finland
    Mol Cell Biol 28:1515-27. 2008
    ..These data imply that Wnt-regulated GSK-3beta plays a nonredundant role in trophic-deprivation-induced death of neurons...
  25. pmc Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation
    Samarjit Das
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Circ Res 103:983-91. 2008
    ..Both proteomics and adenine nucleotide transport data suggest that GSK regulates VDAC and that VDAC may be an important regulatory site in ischemia/reperfusion injury...
  26. doi GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation
    Ling Qiang Zhu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Neurosci 30:3624-33. 2010
    ..These results indicate that GSK-3beta negatively regulates synaptic vesicle fusion events via interfering with Ca(2+)-dependent SNARE complex formation...
  27. doi Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel
    Yoshiaki Terashima
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Mol Cell Cardiol 49:762-70. 2010
    ..Inhibition of CypD-ANT interaction may contribute to mK(ATP)-induced myocardial protection, though it is not the sole mechanism of phospho-GSK-3β-mediated cytoprotection...
  28. pmc Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice
    Y Liu
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetologia 53:2600-10. 2010
    ..Because of the enzyme's anti-proliferative and pro-apoptotic properties, the hypothesis to be tested here was that beta cell specific deficiency of GSK-3β in mice would result in enhanced beta cell mass and function...
  29. doi GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neurochem Int 61:666-71. 2012
    ..These results demonstrate a role for GSK-3 as a modulator of inflammatory cytokine levels in the brain, and contribute to a mechanistic insight into neurological disorders in which neuroinflammation is a characteristic feature...
  30. ncbi LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...
  31. doi Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures
    Jee Hee Lee
    Department of Microbiology, School of Medicine, Ewha Womans University, Yangcheonku, Seoul, Korea
    J Neurochem 106:1066-77. 2008
    ....
  32. doi Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis
    Katsuhiko Ohori
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 295:H2079-86. 2008
    ....
  33. doi Activation of Akt/GSK-3beta/beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats
    Shangfeng Zhao
    Department of Neurosurgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China
    Neurol Res 34:400-7. 2012
    ..The goal of this study was to determine if the mechanism of cell survival mediated by the Akt/GSK-3beta/beta-catenin pathway is involved in a rat model of TBI...
  34. ncbi Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts
    Eric R Gross
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 94:960-6. 2004
    ..Furthermore, no differences were seen in phosphorylation of GSKalpha (Ser21 or Tyr279) or phosphorylation of GSKbeta (Tyr216). These data indicate that OIC occurs via the phosphorylation of GSKbeta at Ser9 during reperfusion...
  35. pmc Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3
    Rajakishore Mishra
    Department of Internal Medicine, Cardiovascular and Cancer Research Institute, The Texas A and M University System HSC, College of Medicine, Texas 76504, USA
    J Biol Chem 282:30393-405. 2007
    ..Inhibition of GSK-3 is thus a potential therapeutic strategy for neurodegenerative diseases caused by trophic factor deprivation...
  36. ncbi Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria
    M Hoshi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo
    J Biochem 118:683-5. 1995
    ..Although the two GSK-3 isoforms seem to have similar properties, the difference of subcellular localization observed here suggests that TPKI/GSK-3 beta fulfills some specific function in mitochondria...
  37. ncbi Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway
    Takeshi Yoshimura
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 340:62-8. 2006
    ..Taken together, these results suggest that Ras plays critical roles in establishing neuronal polarity upstream of the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway and mitogen-activated protein kinase cascade...
  38. ncbi Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression
    Y Xu
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea
    Cell Death Differ 14:79-91. 2007
    ..Taken together, these results suggest that APLP2-ICDs contribute to the AD pathogenesis, by inducing GSK-3beta expression through the interaction with CP2 transcription factor in the nucleus...
  39. ncbi Increase in GSK3beta gene copy number variation in bipolar disorder
    Herbert M Lachman
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Med Genet B Neuropsychiatr Genet 144:259-65. 2007
    ..002). The finding suggests that GSK3beta may be involved in BD susceptibility in some individuals and that CNVs in this and other candidate genes for psychiatric disorders should be analyzed as causative functional genetic variants...
  40. ncbi GSK-3beta activity is increased in skeletal muscle after burn injury in rats
    Cheng Hui Fang
    Shriners Hospitals for Children, 3229 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1545-51. 2007
    ..The results suggest that burn injury stimulates GSK-3beta activity in skeletal muscle and that GSK-3beta may, at least in part, regulate glucocorticoid-mediated muscle wasting...
  41. doi Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: the role of glycogen-synthase-kinase-3beta
    R Silva
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    Neuroscience 152:656-69. 2008
    ..In summary, these results reveal that lithium, by regulating the activity of GSK-3beta, prevents the deleterious effects of stress on behavior and cellular functions...
  42. doi Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease
    Camila Teixeira Mendes
    Laboratory of Neurosciences LIM27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:16-22. 2009
    There is evidence of increased systemic expression of active GSK3B in Alzheimer's disease patients, which apparently is associated with the formation of senile plaques and neurofibrillary tangles...
  43. doi Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells
    Hee Je Park
    Department of Herbology, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea
    Hear Res 257:53-62. 2009
    ..Collectively, these results suggest that cisplatin-induced ototoxicity might be associated with modulation of GSK-3 activation...
  44. pmc Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis
    Xuemin Wang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:32619-26. 2009
    ....
  45. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
    ..This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5...
  46. pmc Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival
    Bin Song
    Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    J Biol Chem 285:41122-34. 2010
    ..Furthermore, the pro-survival effect of CaMKII was mediated by GSK-3 phosphorylation and inactivation. These findings identify a novel Ca(2+)/calmodulin/CaMKII/GSK-3 pathway that couples depolarization to neuronal survival...
  47. pmc Inhibition of glycogen synthase kinase 3[beta] activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover
    Stephen Bertsch
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Shock 35:266-74. 2011
    ..This lithium-resistant state seems mediated at the level of mTOR and not eIF2/eIF2B. Hence, use of GSK-3[beta] inhibitors in the treatment of sepsis may not be expected to fully correct the imbalance in muscle protein turnover...
  48. pmc PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response
    Thomas Karrasch
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    PLoS ONE 6:e26340. 2011
    ..The glycogen synthase kinase 3ß (GSK3ß) has been implicated in various biological processes such as cellular motility, cell spreading and recently inflammation...
  49. ncbi Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3β-mediated mitochondrial translocation of Bax in PC12 cells
    Xu Hua Ge
    Department of Neurology, Second Affiliated Hospital of Soochow University, and Institute of Neuroscience, Soochow University, Jiangsu Province, China
    Neurol Sci 33:1249-56. 2012
    ..Taken together, GSK3β-mediated mitochondrial cell death pathway is involved in the neuroprotective effect of EPO against 6-OHDA-induced apoptosis...
  50. pmc Lowering glucose level elevates [Ca2+]i in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca2+ channel activation and GSK3β inhibition
    Yu Chen
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 33:594-605. 2012
    ..To identify the mechanisms underlying the elevation of intracellular Ca(2+) level ([Ca(2+)](i)) induced by lowering extracellular glucose in rat hypothalamic arcuate nucleus NPY neurons...
  51. doi Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3
    Xiao Hong Li
    Institute of Traumatic Brain Injury and Neurology, Department of Neurology, Pingjin Hospital, Logistics College of Chinese People s Armed Police Forces, Tianjin, 300162, China
    Mol Neurobiol 48:490-9. 2013
    ..These results suggest that Sirt1 promotes axonogenesis by deacetylating Akt and thereby activates the Akt/GSK3 pathway, which could be a promising therapeutic target for axonopathy...
  52. pmc Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3β
    Yanfang Rui
    1 Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA 2 Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 4:2628. 2013
    ..These findings thus identify GSK3β as a key player in activity-dependent regulation of dendritic development by targeting the excitatory-inhibitory balance of the neuron. ..
  53. pmc Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway
    Yuan Hong
    Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    PLoS ONE 9:e96212. 2014
    ..In the present study, we aimed to evaluate whether hydrogen alleviates EBI after SAH, specifically neuronal apoptosis, partially via the Akt/GSK3β signaling pathway...
  54. doi Glycogen synthase kinase-3β inhibition prevents remifentanil-induced postoperative hyperalgesia via regulating the expression and function of AMPA receptors
    Yi ze Li
    From the Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, China
    Anesth Analg 119:978-87. 2014
    ....
  55. doi Enhanced glycogen synthase kinase-3β activity mediates podocyte apoptosis under diabetic conditions
    Jisun Paeng
    Department of Internal Medicine, Severance Biomedical Science Institute, BK21, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemoon Gu, Seoul, 120 752, Korea
    Apoptosis 19:1678-90. 2014
    ..These findings suggest that enhanced GSK-3β activity within podocytes under diabetic conditions is associated with podocyte loss in diabetic nephropathy...
  56. doi Inhibition of glycogen synthase kinase-3β attenuates acute kidney injury in sodium taurocholate‑induced severe acute pancreatitis in rats
    Kailiang Zhao
    Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P R China
    Mol Med Rep 10:3185-92. 2014
    ..Blocking GSK‑3β protein kinase activity may be a novel approach to the treatment of this inflammatory condition...
  57. doi Limb ischemic preconditioning protects against contrast-induced acute kidney injury in rats via phosphorylation of GSK-3β
    Tongqiang Liu
    Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Division of Nephrology, The Affiliated Changzhou No 2 Hospital of Nanjing Medical College, Changzhou 213003, Jiangsu, China
    Free Radic Biol Med 81:170-82. 2015
    ..The above results demonstrate that LIPC induces protection against CI-AKI, making this procedure a promising strategy for preventing CI-AKI. In particular, this renoprotective effect involves the phosphorylation of GSK-3β...
  58. doi Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease
    Xiang hua Liu
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, CAS Center for Excellence in Brain Science, School of Medicine, Shandong University, Jinan, Shandong 250012, People s Republic of China
    Neurobiol Dis 74:377-91. 2015
    ..These results clarified a role of GSK3β in BDNF-dependent TrkB endocytosis and the subsequent signaling, and provided a potential new strategy by inhibiting GSK3β-induced Dyn1 phosphorylation for AD treatment. ..
  59. pmc Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal
    Shinwon Ha
    Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology DGIST, Daegu, 711 873, Republic of Korea
    Mol Brain 8:30. 2015
    ..However, programmed cell death (PCD) provoked by the harsh conditions evident in the diseased brain greatly undermines the potential of NSCs. Currently, the mechanisms of PCD that effect NSCs remain largely unknown...
  60. pmc Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats
    Yixin Li
    Int J Biol Sci 12:518-31. 2016
    ..The effects may be due to regulating the Nrf2/ARE pathway and decreasing oxidative stress. These results suggest a potential new drug target for clinical treatment of stroke. ..
  61. pmc Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons
    Sonja Bareiss
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Neurosci Res 88:2350-63. 2010
    ....
  62. ncbi [Expression of glycogen synthase kinase-3B in pancreatic tissue of acute edematous pancreatitis rats]
    Li Hui Chen
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 42:194-8. 2011
    ..To investigate the expression of apoptosis related gene glycogen synthase kinase-3B (GSK-3B) in acute edematous pancreatitis (AEP), and the relationship between GSK-3B and AEP...
  63. pmc Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival
    Shaunta Guha
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Basic Res Cardiol 106:773-85. 2011
    The role of glycogen synthase kinase 3 beta (GSK-3β) in modulating Notch control of vascular smooth muscle cell (vSMC) growth (proliferation and apoptosis) was examined in vitro under varying conditions of cyclic strain and validated in ..
  64. doi Delayed ischemic postconditioning protects hippocampal CA1 neurons by preserving mitochondrial integrity via Akt/GSK3β signaling
    Caifeng Zhou
    Institute of Neurobiology, Experimental and Research Center, Hebei United University, 57 South Jianshe Road, Tangshan, Hebei Province 063600, China
    Neurochem Int 59:749-58. 2011
    ..The results suggest that phosphorylation of Akt and subsequent inactivation of GSK3β signaling is critical in mediating Post C beneficial effects upon mitochondrial integrity, function and neuroprotection following GCI injury...
  65. doi Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats
    Shumin Bu
    Capital University of Physical Education and Sport, 11 Beisanhuanxilu, Haidian District, Beijing, 100191, People s Republic of China
    Eur J Appl Physiol 112:3295-304. 2012
    ....
  66. pmc Site-specific phosphorylation protects glycogen synthase kinase-3β from calpain-mediated truncation of its N and C termini
    Shanshan Ma
    Department of Pharmacology and Proteomics Center, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    J Biol Chem 287:22521-32. 2012
    ..These findings also identify a mechanism by which site-specific phosphorylation and calpain-mediated cleavage operate in concert to regulate GSK-3β activity...
  67. doi Involvement of the Akt/GSK-3β/CRMP-2 pathway in axonal injury after hypoxic-ischemic brain damage in neonatal rat
    T Xiong
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    Neuroscience 216:123-32. 2012
    ..Our findings suggest that the Akt/GSK-3β/CRMP-2 pathway mediates axonal injury in neonatal rat brain after HI...
  68. pmc Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons
    Sara Devaux
    Inserm U839, Paris F 75005, France
    J Biol Chem 287:22341-53. 2012
    ..Stathmin proteins can thus be either regulated locally or locally targeted by specific phosphorylation, each phosphoprotein of the stathmin family fulfilling distinct and specific roles in the control of neuronal differentiation...
  69. pmc Hyperdopaminergic modulation of inhibitory transmission is dependent on GSK-3β signaling-mediated trafficking of GABAA receptors
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 122:308-20. 2012
    ..The GSK-3β signaling pathway is involved in DA-induced decrease in BIG2-dependent insertion and an increase in the dynamin-dependent internalization of GABAA receptors, which results in suppression of inhibitory synaptic transmission...
  70. pmc Activation of GABA(B) receptors inhibits protein kinase B/glycogen synthase kinase 3 signaling
    Frances Fangjia Lu
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Brain 5:41. 2012
    ..Our data may help to identify potentially novel targets through which GABA(B) receptor agents may exert therapeutic effects in the treatment of schizophrenia...
  71. ncbi A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule
    S Kobayashi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 335:171-5. 1993
    ..Expression of the 30 kDa subunit mRNA was enhanced in juvenile rat brain. This result supports our previous hypothesis that the kinase works actively in juvenile brain...
  72. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  73. pmc Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  74. pmc Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    J J Lucas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    EMBO J 20:27-39. 2001
    ....
  75. pmc Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway
    Marianna Pap
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Cell Biol 22:578-86. 2002
    ..Regulation of translation resulting from phosphorylation of eIF2B by GSK-3beta thus appears to contribute to the control of cell survival by the PI 3-kinase/Akt signaling pathway, acting upstream of mitochondrial cytochrome c release...
  76. pmc Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
    Minako Hoshi
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Proc Natl Acad Sci U S A 100:6370-5. 2003
    ..Here we describe the identification and characterization of ASPD and discuss its possible role in the neurodegeneration in Alzheimer's disease...
  77. ncbi Exercise training attenuated the PKB and GSK-3 dephosphorylation in the myocardium of ZDF rats
    Claude Lajoie
    Department of Kinesiology, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Appl Physiol (1985) 96:1606-12. 2004
    ..These anomalies in the Zucker diabetic fatty rat were partially normalized with swimming. These data support the premise that exercise training may protect the heart against the deleterious consequences of diabetes...
  78. ncbi Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy
    Stefan E Hardt
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103 2714, USA
    Circ Res 94:926-35. 2004
    ....
  79. ncbi 14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain
    Zongfei Yuan
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Biol Chem 279:26105-14. 2004
    ..Our data indicate that within the tau phosphorylation complex, 14-3-3 connects Ser(9)-phosphorylated GSK3beta to tau and Ser(9)-phosphorylated GSK3beta phosphorylates tau...
  80. ncbi GSK-3beta in cerebrospinal fluid of schizophrenia patients
    N Kozlovsky
    Stanley Research Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, Beersheva, Israel
    J Neural Transm (Vienna) 111:1093-8. 2004
    ..Our results corroborate other studies in which CSF protein levels reflect the alteration found in these proteins in schizophrenia patients' postmortem brain...
  81. ncbi Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center, and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 24:9993-10002. 2004
    ..Our results indicate that GSK-3beta exerts some of its pro-apoptotic effects in neurons by regulating the mitochondrial localization of Bax, a key component of the intrinsic apoptotic cascade...
  82. ncbi Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells
    Maziar Rahmani
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    J Biol Chem 280:13019-28. 2005
    ....
  83. ncbi The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth
    Robert G Goold
    The MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Mol Cell Neurosci 28:524-34. 2005
    ..Thus, NGF drives increased neurite growth rates partly by coupling the MAPK pathway to the activation of GSK3beta and thereby phosphorylation of MAP1B...
  84. ncbi Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells
    Yun Il Lee
    Department of Biochemistry and Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    J Biol Chem 280:22044-52. 2005
    ....
  85. ncbi 14-3-3 proteins regulate glycogen synthase 3beta phosphorylation and inhibit cardiomyocyte hypertrophy
    Wenqiang Liao
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, PR China
    FEBS J 272:1845-54. 2005
    ..These results suggest that 14-3-3s inhibits cardiomyocytes hypertrophy through regulation of the PI3K/PKB/GSK3beta and NFAT pathway...
  86. ncbi Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta
    C Hawkes
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 95:263-72. 2005
    ..The partial protection of these neurons following inhibition of GSK-3beta kinase activity suggests a possible therapeutic role for GSK-3beta inhibitors in attenuating the loss of basal forebrain cholinergic neurons observed in AD...
  87. ncbi NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis
    Agata Habas
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurochem 96:335-48. 2006
    ..Hence, the activation of NR2B and the Ser9-independent inhibition of GSK3beta are two newly identified elements of the signaling network that mediates the pro-survival effects of NMDA...
  88. ncbi Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Neuropsychobiology 53:51-6. 2006
    ..015 for genotypes and p=0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder...
  89. ncbi Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation
    Laura Dugo
    Centre of Experimental Medicine, Nephrology and Critical Care, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Shock 25:485-91. 2006
    ..Thus, we propose that inhibition of GSK-3beta may represent a novel therapeutic approach in the therapy of hemorrhagic shock...
  90. pmc KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner
    Seyha Seng
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:8371-84. 2006
    ..Thus, this study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner...
  91. pmc The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Int J Mol Med 19:263-72. 2007
    ..Elucidating the underlying pathways that can afford endogenous protection and maintain functional integrity of microglia should offer new prospects for the treatment of a broad range of nervous system disorders...
  92. ncbi Inhibition of GSK3 promotes replication and survival of pancreatic beta cells
    Rainer Mussmann
    DeveloGen AG, Marie Curie Strasse 7, Göttingen 37079, Germany
    J Biol Chem 282:12030-7. 2007
    ..We propose that GSK3 is a regulator of beta cell replication and survival. Moreover, our results suggest that specific inhibitors of GSK3 may have practical applications in beta cell regenerative therapies...
  93. ncbi Inhibition of GSK-3beta mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-kappaB in rat primary astrocyte
    Sun Don Kim
    Laboratory of Pharmacology, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Brain Res 1186:12-20. 2007
    ..These data suggest that GSK-3beta inhibition mediates ERK1/2 activation followed by NF-kappaB activation, which directly regulates the induction of MMP-9 in rat primary astrocytes...
  94. ncbi Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3
    Seong Ho Koh
    Department of Neurology, College of Medicine, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
    Brain Res 1188:254-62. 2008
    ..These results suggest that the neurotoxic effect of Abeta42 is mediated by GSK-3beta activation and that inhibition of GSK-3beta can reduce Abeta42-induced neurotoxicity...
  95. doi Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Shock 30:299-307. 2008
    ..The present study demonstrates that TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. Collectively, our data may contribute to focus the role of GSK-3beta in cerebral I/R...
  96. doi Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Int J Dev Neurosci 26:269-76. 2008
    ..We conclude that the GSK-3 inhibitor SB-415286 has antioxidant properties, which may explain the cytoprotective effects against H(2)O(2) damage. Furthermore, inhibition of GSK-3 activity was not involved in this protective effect...
  97. doi The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation
    Fangfang Zhou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    J Biol Chem 283:14506-15. 2008
    ....
  98. pmc Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 283:15469-78. 2008
    ..Inhibition of GSK-3beta activity by inhibitor VIII protects cells from H2O2 similar to ropinirole. These results indicate that GSK-3beta downstream of Akt plays a critical role in cell death and survival in these models...
  99. doi Wnt signalling and its impact on development and cancer
    Alexandra Klaus
    Max Delbruck Centre for Molecular Medicine, Robert Roessle Strasse 10, 13, 125 Berlin, Germany
    Nat Rev Cancer 8:387-98. 2008
    ..Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway...
  100. doi Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation
    Octavio Mercado-Gómez
    Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, P O Box AP 70 228, Mexico, DF, 04510, Mexico
    Neurochem Res 33:1599-609. 2008
    ..These changes correlated with alterations in neuronal morphology...

Research Grants11

  1. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  2. Analysis of apoptotic signaling induced by the mammalian endoplasmic reticulum
    JAY BREWSTER; Fiscal Year: 2008
    ..of ER stress and its signaling mechanisms will offer vital insight into the cell biology of stressed cells, and will be valuable to our understanding of diseases that result from abnormal ER function [unreadable] [unreadable] [unreadable]..
  3. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  4. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  5. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  6. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  7. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  8. GENOME-WIDE ANALYSIS FOR ADDICTION SUSCEPTIBILITY GENES
    Herbert Lachman; Fiscal Year: 2005
    ..By the end of the project, which will coincide with the completion of the human genome project, they will be able to analyze all of the specific candidate genes that map to linked markers. ..
  9. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  10. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  11. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..